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ClinicalTrials.gov public records Last synced Oct 23, 2026, 12:26 AM EDT

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Showing 121–144 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Terminated Early Phase 1 Interventional

Brief Intervention and Referral to Treatment With Substance Use Disorders in the Emergency Room Setting

NCT01661517
View directory record Official record
Conditions
Substance Use
Interventions
Motivational interviewing and referral to treatment
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
5,271 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 18, 2016 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional

Screening, Brief Intervention and Referral to Treatment for Substance Abuse in Mental Health Treatment Settings

NCT01883791
View directory record Official record
Conditions
Substance Use Disorders, Mental Illness
Interventions
SBIRT, Health Education
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
1,080 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Los Angeles, California • Oxnard, California
Source: ClinicalTrials.gov public record
Updated Nov 2, 2018 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional Results available

Digital Mindfulness-Based Treatment for Substance Use Disorder Recovery

NCT05852015
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Treatment-as-Usual (TAU), Digital Mindfulness Treatment
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional

MISSION-CJ for Justice-Involved Homeless Veterans

NCT04523337
View directory record Official record
Conditions
Substance Use Disorder, Mental Health Disorder, Homelessness
Interventions
Maintaining Maintaining Independence and Sobriety through Systems Integration Outreach and Networking- Criminal Justice, Maintaining Maintaining Independence and Sobriety through Systems Integration Outreach and Networking Peer Support
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
3
States / cities
Little Rock, Arkansas • Palo Alto, California • Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional

Early Family-Centered Prevention of Drug Use Risk (Aka Early Steps)

NCT01098695
View directory record Official record
Conditions
Substance Use, Conduct Disorder, Depression, Anxiety
Interventions
Ecological Family Intervention and Treatment (EcoFIT)
Other
Lead sponsor
University of Oregon
Other
Eligibility
2 Years to 3 Years
Enrollment
731 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2015
U.S. locations
3
States / cities
Eugene, Oregon • Pittsburgh, Pennsylvania • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Youth Mentoring Program

NCT00158353
View directory record Official record
Conditions
Self Concept
Interventions
GirlPOWER! mentoring program, Traditional mentoring
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
10 Years to 13 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 14, 2020 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional Results available

Mindful Moms in Recovery

NCT04584502
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Mindful Moms Yoga Mindfulness Intervention
Behavioral
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
18 Years and older · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implementing Technology-Assisted Drug Treatment and Relapse Prevention in Federally Qualified Health Centers (FQHCs)

NCT01963234
View directory record Official record
Conditions
Substance Use Disorders, HIV
Interventions
Seva
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
439 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
3
States / cities
Missoula, Montana • The Bronx, New York • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 31, 2018 · Synced Oct 23, 2026, 12:26 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

The Rise of Ride Sharing Companies and Trends in Impaired Driving Accidents

NCT04564599
View directory record Official record
Conditions
Ride Sharing, Alcohol Drinking, Alcohol Intoxication, Drug Use, Motor Collision, Sexual Assault
Interventions
Not listed
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional Results available

Non-Invasive Brain Stimulation and Substance Use

NCT03122587
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Transcranial Alternating Current Stimulation at 10 Hz, Transcranial Alternating Current Stimulation at 40 Hz, Active sham transcranial alternating current stimulation
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 55 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 23, 2026, 12:26 AM EDT
Active, not recruiting Not applicable Interventional

Supporting Treatment Access and Recovery Through Linkage and Support

NCT05713695
View directory record Official record
Conditions
Mental Health Disorders, Substance Use Disorders
Interventions
Full MISSION, Linkage Only Delivered by a Peer Specialist
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 23, 2026, 12:26 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Testing the CrOss Systems Technical Assistance for Retaining Staff (COSTARS) Model for Improving Staff Retention Among Child Welfare Workers and Peer Supporters, and Implementation of Evidence Based Interventions.

NCT07439783
View directory record Official record
Conditions
Substance Use Disorder, Opioid Use Disorder, Child Maltreatment, Implementation, Peer Recovery Supporters
Interventions
COSTARS, Implementation As Usual
Other
Lead sponsor
Alicia Bunger
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 23, 2026, 12:26 AM EDT
Recruiting Early Phase 1 Interventional

Psilocybin for Methamphetamine Addiction

NCT06899594
View directory record Official record
Conditions
Methamphetamine Use Disorder
Interventions
Psilocybin 25 mg
Drug
Lead sponsor
Kevin Murnane
Other
Eligibility
25 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 23, 2026, 12:26 AM EDT
Recruiting Not applicable Interventional

Peer-Delivered Behavioral Activation in a CCBHC

NCT07219394
View directory record Official record
Conditions
Major Depressive Disorder, Substance Use Disorders
Interventions
Peer Activate, Peer-delivered non-specific services
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 23, 2026, 12:26 AM EDT
Completed No phase listed Observational

Mindfulness and Meditation-Based Relapse Prevention for Substance Use Disorders

NCT07417579
View directory record Official record
Conditions
Substance Use Disorders, Behavioral Health, Addiction Psychological, Addiction Disorders, Meditation, Mindfulness Based Stress Reduction, Prevention
Interventions
Mindfulness and Meditation-Based Relapse Prevention Program
Behavioral
Lead sponsor
Bout Me Healing
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 23, 2026, 12:26 AM EDT
Terminated Phase 4 Interventional Results available

Anchoring Sequential Intermittent Long Acting Antimicrobials With Medication for Opioid Use Disorder (MOUD) for Invasive Infections Related to Opioid Use

NCT05521880
View directory record Official record
Conditions
Substance Use Disorders, Infection, Soft Tissue, Bacteremia, Osteomyelitis Acute, Septic Arthritis
Interventions
Oritavancin
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Individual vs. Group Community Reinforcement Training to Help Parents of Substance-using Treatment-refusing Youth

NCT01829789
View directory record Official record
Conditions
Substance Use Disorders, Treatment Refusal
Interventions
Group Community Reinforcement Training for Parents, Individual Community Reinforcement Training for Parents
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 30, 2016 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional

CBT for Spanish Speakers

NCT02043210
View directory record Official record
Conditions
Substance Use
Interventions
Standard Treatment as Usual, CBT4CBT plus Standard treatment as usual
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
4
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

PrEP at a Syringe Services Program

NCT04782180
View directory record Official record
Conditions
Hiv, Substance Use Disorders
Interventions
Descovy 200Mg 25Mg Tablet, PrEP
Drug · Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Reinforcement-Based Treatment for Pregnant Drug Abusers

NCT01177982
View directory record Official record
Conditions
Drug Use Disorders During Pregnancy
Interventions
Usual RBT (t-RBT), Reduced RBT (r-RBT), Abbreviated RBT (a-RBT), Enhanced RBT (e-RBT), Early compliant t-RBT, Early non-compliant t-RBT, Early compliant r-RBT, Early non-compliant r-RBT
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 46 Years · Female only
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional

Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment

NCT01376570
View directory record Official record
Conditions
HIV, Opiate Dependence
Interventions
Abstinence-reinforcing contingency management intervention, Performance Feedback intervention
Behavioral
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
3
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders

NCT03732248
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Dependence
Interventions
Rapamycin, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Oct 23, 2026, 12:26 AM EDT
Recruiting Not applicable Interventional

Mindfulness-based Relapse Prevention for Peer Workers

NCT07741825
View directory record Official record
Conditions
Relapse/Recurrence, Substance Use (Drugs, Alcohol), Burnout
Interventions
Mindfulness Based Relapse Prevention, Standard of Care
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 23, 2026, 12:26 AM EDT
Completed Not applicable Interventional

Virtual Behavioral Health Integration

NCT04106388
View directory record Official record
Conditions
Depression, Substance Use Disorder, Anxiety
Interventions
Virtual Behavioral Health Integration
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
5,777 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
20
States / cities
Albemarle, North Carolina • Charlotte, North Carolina • Concord, North Carolina + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2022 · Synced Oct 23, 2026, 12:26 AM EDT