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ClinicalTrials.gov public records Last synced Oct 23, 2026, 7:47 AM EDT

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Showing 169–192 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention

NCT06852170
View directory record Official record
Conditions
Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making, Organizations, Substance-related Disorders, Policy
Interventions
Co-Design Sessions (CDS), Data products
Other
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older
Enrollment
341 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Not yet recruiting Phase 2 Interventional

Substance Use in Pregnancy - Optimizing Retention in Treatment by Maximizing Opportunities for Management

NCT07776457
View directory record Official record
Conditions
Pregnancy, Substance Use Disorder (SUD)
Interventions
Contingency Management, Social Drivers of Health Screening
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smartphone Intervention for Overdose and COVID-19

NCT05518461
View directory record Official record
Conditions
Substance Use Disorders, Overdose, COVID-19
Interventions
iThrive WI Intervention
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Oct 23, 2026, 7:47 AM EDT
Completed Not applicable Interventional Results available

Web-based Addiction Treatment: Cultural Adaptation With American Indians

NCT03363256
View directory record Official record
Conditions
Substance Use Disorders
Interventions
TES-NAV, TAU
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 99 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Withdrawn Phase 1 Interventional

Trial of Computerized MET for Adolescent Substance Use

NCT01784653
View directory record Official record
Conditions
Drug Abuse, Alcohol Abuse, Nicotine Dependence
Interventions
iMET, MET
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2017 · Synced Oct 23, 2026, 7:47 AM EDT
Completed Phase 1Phase 2 Interventional

Reducing Health Risk Behavior and Improving Health in Adolescents With Depression

NCT00461539
View directory record Official record
Conditions
Depression, Adolescent Health
Interventions
Treatment as usual, Behavioral health intervention
Other · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
13 Years to 18 Years
Enrollment
217 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 3, 2022 · Synced Oct 23, 2026, 7:47 AM EDT
Recruiting Not applicable Interventional

Utilizing Battlefield Acupuncture to Treat Chronic Pain

NCT06128772
View directory record Official record
Conditions
Chronic Pain, Substance Use Disorders
Interventions
Battlefield Acupuncture
Other
Lead sponsor
Edith Nourse Rogers Memorial Veterans Hospital
Federal
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 28, 2024 · Synced Oct 23, 2026, 7:47 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Adaptation of the Family Check-Up Online

NCT07025083
View directory record Official record
Conditions
Substance Use (Drugs, Alcohol)
Interventions
Adapted Family Check-Up Online, Original Family Check-Up Online
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
11 Years to 14 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Not listed Not applicable Interventional

IT to Support Integration of Social Determinant of Health Services to Reduce Avoidable Emergency Department Visits

NCT04125433
View directory record Official record
Conditions
Mental Health Issue, Substance Use Disorders
Interventions
Peer Integrated Care Services
Behavioral
Lead sponsor
Northern New York Rural Behavioral Health Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Saranac Lake, New York
Source: ClinicalTrials.gov public record
Updated Oct 14, 2019 · Synced Oct 23, 2026, 7:47 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Community Driven Substance Use Recovery for High Opioid Overdose Areas

NCT05260047
View directory record Official record
Conditions
Substance Use, Mental Health Issue, Opioid Use, Medication Assisted Treatment
Interventions
IMANI, Telehealth MAT, Traditional MAT plus Referral and Linkage
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
525 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
8
States / cities
Bridgeport, Connecticut • Hartford, Connecticut • New Britain, Connecticut + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Completed Not applicable Interventional

Opioid Use and Criminal Justice: Intervening to Improve the Outcomes of Women

NCT06682364
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Trauma-informed case management for women who use drugs, CRS Only Intervention
Behavioral
Lead sponsor
Abenaa Jones, Ph.D.
Other
Eligibility
18 Years and older · Female only
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Harrisburg, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Not yet recruiting Not applicable Interventional

Written Exposure in Substance Treatment (WEST 3.0): Randomized Controlled Trial

NCT07782268
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
Interventions
Written Exposure Therapy, Treatment as Usual
Behavioral
Lead sponsor
Potomac Health Foundations
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Integrated Care (iCare) at Mount Sinai to Improve Substance Use Diagnosis and Treatment Practices in HIV Clinic Settings

NCT03092596
View directory record Official record
Conditions
Substance Abuse
Interventions
Patient-administered screening tool, Patient health navigator-administered screening tool, Patient health navigator-assisted linkage to treatment
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
3,358 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2020 · Synced Oct 23, 2026, 7:47 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing

NCT07141394
View directory record Official record
Conditions
Homelessness, Substance Use Disorder (SUD)
Interventions
Medication for Addiction Treatment (MAT), Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
7,908 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Not yet recruiting Phase 4 Interventional

Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment

NCT07809854
View directory record Official record
Conditions
Cigarette Smoking, Veterans
Interventions
Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling, Healthy Changes Counseling
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Developing a Novel Human Laboratory Paradigm for AUD Medication Screening

NCT06489782
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Model 1, Model 2
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Completed Not applicable Interventional Results available

Feasibility of SBIRT-PN

NCT03057119
View directory record Official record
Conditions
Substance Use, HIV/AIDS, Older Adults, Behavioral Intervention, Infectious Disease
Interventions
Psycho-educational content (5 Minutes), Readiness Assessment (10 minutes), Goal-Setting (5 minutes), Identifying and prioritizing needs (5 minutes), Explanation of Peer Navigator and Session wrap (5 minutes)
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 85 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
3
States / cities
Gainesville, Florida • Jacksonville, Florida • Lake City, Florida
Source: ClinicalTrials.gov public record
Updated Sep 11, 2023 · Synced Oct 23, 2026, 7:47 AM EDT
Completed No phase listed Observational

Using mHealth to Aid Opioid Addicts

NCT01955902
View directory record Official record
Conditions
Opiate Dependency Relapse
Interventions
Not listed
Lead sponsor
Care Team Solutions
Industry
Eligibility
21 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 11, 2013 · Synced Oct 23, 2026, 7:47 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Study on the Impact of Patient Navigators on the Health Education and Quality of Life in Formerly Incarcerated Patients

NCT02259634
View directory record Official record
Conditions
HIV/AIDS, Diabetes Mellitus, Hypertension, Substance Use
Interventions
Patient Navigation
Behavioral
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2015 · Synced Oct 23, 2026, 7:47 AM EDT
Completed Not applicable Interventional

Overcoming Psychiatric Barriers to the Treatment of Hepatitis C

NCT00407732
View directory record Official record
Conditions
Hepatitis C, Substance Use Disorders, Mental Disorder
Interventions
psychosocial intervention
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2012 · Synced Oct 23, 2026, 7:47 AM EDT
Completed Not applicable Interventional Results available

Pilot Randomized Controlled Trial (RCT): Remote SBIRT Vs. In-Person SBIRT

NCT04630249
View directory record Official record
Conditions
Pregnancy, Substance Use, Depression, Anxiety
Interventions
Listening to Women and Pregnant and Postpartum People
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 41 Years · Female only
Enrollment
415 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 18, 2024 · Synced Oct 23, 2026, 7:47 AM EDT
Enrolling by invitation No phase listed Observational

Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl

NCT06995885
View directory record Official record
Conditions
Substance Use Disorders (SUDs)
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 23, 2026, 7:47 AM EDT
Withdrawn Phase 4 Interventional

Improving Outcomes in Psychosis Associated With Substance Use Using Aripiprazole

NCT01155544
View directory record Official record
Conditions
Substance Abuse, Substance Dependence
Interventions
Behavioral Intervention
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
16 Years to 44 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Glen Oaks, New York • Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Mar 19, 2018 · Synced Oct 23, 2026, 7:47 AM EDT
Completed Not applicable Interventional

Treatment for Psychological and Drug Abuse Problems

NCT01140334
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Voucher Reinforcement, Standard Control
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 20, 2013 · Synced Oct 23, 2026, 7:47 AM EDT