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ClinicalTrials.gov public records Last synced Oct 24, 2026, 1:49 AM EDT

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Showing 1–24 of 371 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol Abuse Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Tailored Interventions to Prevent Substance Abuse

NCT01482975
View directory record Official record
Conditions
Prevention Harmful Effects
Interventions
Tailored computer based intervention, Tailored computer intervention
Other
Lead sponsor
University of Rhode Island
Other
Eligibility
10 Years to 14 Years
Enrollment
4,158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 12, 2016 · Synced Oct 24, 2026, 1:49 AM EDT
Terminated Phase 2 Interventional Results available

Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD

NCT03852628
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Alcohol Abuse
Interventions
2mg Buprenex and 380mg Vivitrol, Placebo (SL pill qd, IM injection q4weeks)
Drug
Lead sponsor
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Other
Eligibility
18 Years to 70 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Tuscaloosa, Alabama • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Phase 4 Interventional Results available

Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder

NCT00572117
View directory record Official record
Conditions
Bipolar Disorder, Alcoholism, Alcohol Dependence
Interventions
Topiramate
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional

Project Guard: Reducing Alcohol Misuse/Abuse in the National Guard

NCT02860442
View directory record Official record
Conditions
Alcohol Use
Interventions
Smartphone brief intervention (SP-BI), Enhanced Usual Care (EUC)
Behavioral · Other
Lead sponsor
Keming Gao
Other
Eligibility
Not listed
Enrollment
850 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
2
States / cities
Cleveland, Ohio • Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Family Intervention for Teen Drinking in the ER

NCT01229748
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Standard Care, Multidimensional Family Therapy, Family Motivational Interviewing Intervention
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 18 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
3
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 1, 2015 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional

Improving Health Behaviors Through Telephone Linked Care

NCT00314197
View directory record Official record
Conditions
Diet, Physical Activity, Smoking, Alcohol Abuse
Interventions
Telephone Linked Care - Behavior Change Counseling System, Telephone-linked behavioral counseling
Behavioral
Lead sponsor
American Academy of Family Physicians
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Leawood, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 26, 2007 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The EARN-Health Trial of Financial Savings and Health

NCT02185612
View directory record Official record
Conditions
Depression, Anxiety, Alcohol Abuse, Tobacco Abuse
Interventions
Savings program
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
678 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tailored Mobile Text Messaging to Reduce Problem Drinking

NCT01885312
View directory record Official record
Conditions
Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions
Adaptive Tailored Intervention, Consequence-based Intervention, Tailored, not adaptive, based Intervention, Assessment only
Behavioral · Other
Lead sponsor
Northwell Health
Other
Eligibility
21 Years to 65 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Phase 2 Interventional

Aftercare for Adolescents Treated for Alcohol Abuse and Dependence

NCT00561041
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Brief phone aftercare intervention, individual aftercare therapy
Behavioral
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
13 Years to 18 Years
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 20, 2007 · Synced Oct 24, 2026, 1:49 AM EDT
Recruiting Not applicable Interventional

Virtual Incentive Treatment for Alcohol

NCT06265506
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
Interventions
Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT)
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Oct 24, 2026, 1:49 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The STop UNhealthy Substance Use Now Trial

NCT06524232
View directory record Official record
Conditions
Risky Health Behavior, Substance Use Disorders, Substance Abuse, Alcohol Use Disorder, Drinking, Alcohol, Substance Use
Interventions
Practice Facilitation (PF), Learning Collaborative (LC), Performance Incentives (PI)
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
3
States / cities
Cincinnati, Ohio • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 24, 2026, 1:49 AM EDT
Not listed No phase listed Observational

Substance Abuse Pre-Treatment Screening Study

NCT00439049
View directory record Official record
Conditions
Cocaine Abuse, Cocaine Dependence, Opiate Dependence, Alcohol Dependence, Substance Abuse
Interventions
modafinil, d-amphetamine, L-Dopa, Naltrexone
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
7,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Oct 24, 2026, 1:49 AM EDT
Not yet recruiting Not applicable Interventional

The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veterans

NCT06746727
View directory record Official record
Conditions
Alcohol Problems, Post-Traumatic Stress Disorder
Interventions
Acceptance and Commitment Therapy for Social Health, Achievement, and Relationship Effectiveness (ACT-SHARE)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2028 – 2030
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional

Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological Treatment for Alcohol Use Disorder

NCT03842670
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Abuse, Alcohol Drinking, Alcohol Dependence
Interventions
Cognitive Behavior Therapy, Mindfulness Based Relapse Prevention
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
22 Years to 85 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
2
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sex Differences in Risk for Alcohol Abuse

NCT04543942
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Alcohol, Saline
Drug
Lead sponsor
Mark Fillmore
Other
Eligibility
21 Years to 29 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 4, 2024 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacogenetics of Alcohol: Treatment Implications

NCT00734656
View directory record Official record
Conditions
Alcohol Related Disorders, Alcoholism, Alcohol Abuse
Interventions
dutasteride + ethanol, placebo medication + ethanol, dutasteride + placebo alcohol, placebo medication + placebo alcohol
Drug
Lead sponsor
UConn Health
Other
Eligibility
21 Years to 45 Years · Male only
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 28, 2012 · Synced Oct 24, 2026, 1:49 AM EDT
Not yet recruiting Phase 2 Interventional

A Study of the Safety and Exploratory Efficacy of Oral AFA-281 in Patients with Alcohol Use Disorder

NCT06710431
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Abuse/addiction, Anxiety, Pain Threshold, Depression Disorders, Sleep Disorder
Interventions
AFA-281
Drug
Lead sponsor
Afasci Inc
Industry
Eligibility
21 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 29, 2024 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional Results available

Computer-based Intervention for Alcohol-using HIV/HCV+ Women

NCT03362476
View directory record Official record
Conditions
Human Immunodeficiency Virus, Hepatitis C, Alcohol Abuse
Interventions
Computer-based alcohol reduction intervention, Brief clinician-delivered MET, Standard of care
Behavioral
Lead sponsor
New York University
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional

A Brief Intervention

NCT01632176
View directory record Official record
Conditions
Dating Violence, Dating Abuse
Interventions
Brief, motivational interview and one booster session
Behavioral
Lead sponsor
Boston University
Other
Eligibility
15 Years to 19 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Residual Effects of Intoxication on Student Performance

NCT00183170
View directory record Official record
Conditions
Alcoholic Intoxication, Neurobehavioral Manifestations
Interventions
Alcohol, Placebo
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
21 Years to 30 Years
Enrollment
239 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Personal Values and Mandated Students

NCT03247647
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Enhanced Intervention, Standard Intervention
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 24 Years
Enrollment
486 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
2
States / cities
Binghamton, New York • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Phase 4 Interventional

Naltrexone Treatment of Alcohol Abuse in Schizophrenia

NCT00145847
View directory record Official record
Conditions
Schizophrenia, Mental Disorders, Alcohol Abuse, Alcoholism, Alcohol-related Disorders
Interventions
Naltrexone or Placebo
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 69 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
4
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jan 8, 2013 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Attitudes & College Experiences

NCT04026633
View directory record Official record
Conditions
Alcohol Abuse
Interventions
CAA, Control
Behavioral
Lead sponsor
Brooklyn College of the City University of New York
Other
Eligibility
18 Years to 26 Years
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2022 · Synced Oct 24, 2026, 1:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Choices4Health: Intervention to Prevent Substance-exposed Pregnancy

NCT03633149
View directory record Official record
Conditions
Prenatal Alcohol Exposure, Prenatal Tobacco Exposure, Prenatal Marijuana Exposure
Interventions
Computer tablet-delivered C4H, Person-delivered C4H, Brief Advice
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
219 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2022 · Synced Oct 24, 2026, 1:49 AM EDT