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ClinicalTrials.gov public records Last synced Oct 17, 2026, 3:03 PM EDT

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Showing 457–480 of 1,088 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol Addiction Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Brief Intervention for Families of Teens Treated in the Emergency Department for an Alcohol-Related Event

NCT00247221
View directory record Official record
Conditions
Alcohol Abuse
Interventions
MI/Family Check-up, MI only
Behavioral
Lead sponsor
Brown University
Other
Eligibility
13 Years to 17 Years
Enrollment
208 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2008
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 31, 2012 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 4 Interventional Results available

Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.

NCT00366626
View directory record Official record
Conditions
Alcohol Dependence
Interventions
Naltrexone, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 65 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 5, 2017 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 2Phase 3 Interventional

Aripiprazole and Topiramate on Free-Choice Alcohol Use

NCT00884884
View directory record Official record
Conditions
Alcohol Dependence
Interventions
Double Placebo, Aripiprazole 15, placebo, Aripiprazole 7.5, Placebo, Topiramate 100, Placebo, Topiramate 200, Placebo, Topiramate 100, Aripiprazole 15, Topiramate 100, Aripiprazole 7.5, Topiramate 100, Aripiprazole 15mg, Topiramate 200, Aripiprazole 7.5mg, Topiramate 200, Aripiprazole 15
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Not applicable Interventional

Motivational Incentives for Alcohol Abstinence in American Indian and Native Alaskan Adults

NCT02174315
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Contingency Management
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Pullman, Washington
Source: ClinicalTrials.gov public record
Updated May 1, 2023 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 2 Interventional Results available

ABT-436 for Alcohol Dependence

NCT01613014
View directory record Official record
Conditions
Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorders, Alcoholism
Interventions
ABT-436, Matched Placebo - Sugar Pill
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
5
States / cities
Baltimore, Maryland • Boston, Massachusetts • Quincy, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 17, 2026, 3:03 PM EDT
Not listed Not applicable Interventional

Harm Reduction Talking Circles for American Indians and Alaska Natives With Alcohol Use Disorders

NCT04267692
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
HaRTC
Other
Lead sponsor
Washington State University
Other
Eligibility
21 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 1 Interventional

Development of Ibudilast for Alcohol Use Disorder

NCT02025998
View directory record Official record
Conditions
Alcohol Use Disorders
Interventions
Ibudilast, Matched placebo
Drug · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2016 · Synced Oct 17, 2026, 3:03 PM EDT
Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms

NCT06484075
View directory record Official record
Conditions
Healthy Volunteers, Alcohol Use Disorder (AUD)
Interventions
Siemens 3T PRISMA MR Scanner, PET/CT Scanner, Suvorexant, Placebo
Device · Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 75 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Neuroimmune Dysfunction in Alcohol Use Disorder

NCT04210713
View directory record Official record
Conditions
Alcohol Drinking, Alcohol-Related Disorders, Disease, Inflammation, Alcoholism, Cognitive Dysfunction, Pathologic Processes, Drinking Behavior, Substance-Related Disorders, Chemically-Induced Disorders, Mental Disorder, Cognition Disorder, Neurocognitive Disorders, Minocycline, Anti-Bacterial Agents, Anti-Infective Agents
Interventions
Minocycline, Sugar pill
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
25 Years to 65 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 1, 2023 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neural Mechanisms Underlying Nicotine and Alcohol Combinations

NCT02049268
View directory record Official record
Conditions
Focus: Effects of Nicotine and Alcohol on Brain Circuits
Interventions
Nicotine + Alcohol, Placebo Nicotine + Alcohol, Nicotine + Placebo Alcohol
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 40 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 3, 2017 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Effectiveness of Extended Telephone Monitoring

NCT00194103
View directory record Official record
Conditions
Alcohol Dependence
Interventions
Telephone Monitoring and Feedback, Telephone Monitoring and Counseling
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
252 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 28, 2010 · Synced Oct 17, 2026, 3:03 PM EDT
Recruiting Not applicable Interventional

Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis

NCT05665179
View directory record Official record
Conditions
Opioid Use Disorder, Alcohol Use Disorder, Health Risk Behaviors, Criminal Behavior, Housing Problems, Overdose of Opiate
Interventions
Removing Barriers to Recovery
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Ann Arbor, Michigan • Ypsilanti, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 29, 2024 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 3 Interventional Results available

Mecamylamine for the Treatment of Patients With Depression and Alcohol Dependence

NCT00563797
View directory record Official record
Conditions
Alcohol Dependence, Depression
Interventions
Mecamylamine, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 18, 2016 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 2 Interventional Results available

Human Behavioral Pharmacology Laboratory (HBPL) Study of Varenicline's Impact on Cocaine and Alcohol Craving

NCT01151813
View directory record Official record
Conditions
Alcohol Dependence, Cocaine Dependence
Interventions
Varenicline, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Oct 17, 2026, 3:03 PM EDT
Terminated Phase 2 Interventional Results available

Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD

NCT03852628
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Alcohol Abuse
Interventions
2mg Buprenex and 380mg Vivitrol, Placebo (SL pill qd, IM injection q4weeks)
Drug
Lead sponsor
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Other
Eligibility
18 Years to 70 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Tuscaloosa, Alabama • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Text-based Alcohol Prevention for First Year College Students

NCT03864237
View directory record Official record
Conditions
College Drinking
Interventions
Alcohol texts, Attention control
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 20 Years
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 1 Interventional Results available

Non-invasive Vagal Nerve Stimulation in Alcohol Use Disorder

NCT05226130
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Cervical transcutaneous vagus nerve stimulation (active comparator), Cervical transcutaneous vagus nerve stimulation (sham comparator)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 65 Years · Male only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 4 Interventional

Improving Hepatitis C Treatment in Injection Drug Users

NCT00148031
View directory record Official record
Conditions
Hepatitis C, Liver Diseases, Drug Abuse, Alcoholism
Interventions
Pegylated Interferon and Ribavirin, Psychosocial, On-site (MMT Clinic) HCV evaluation and treatment, Off-site HCV evaluation and treatment
Drug · Behavioral
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 65 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
2
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Apr 24, 2013 · Synced Oct 17, 2026, 3:03 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics

NCT00001675
View directory record Official record
Conditions
Alcoholism, Healthy
Interventions
Not listed
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
12 Years to 65 Years
Enrollment
1,194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 9, 2019 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 4 Interventional Results available

Combination Nicotine Replacement for Alcoholic Smokers

NCT00064844
View directory record Official record
Conditions
Smoking, Alcoholism
Interventions
Cognitive Behavior Therapy for alcohol and smoking cessation, Nicoderm CQ nicotine patch, Placebo gum, Nicotine gum - Nicorette®
Behavioral · Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Newington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 13, 2021 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 1 Interventional

Individualized Treatment Program for Alcohol Problems

NCT00298792
View directory record Official record
Conditions
Alcohol Dependence
Interventions
Cognitive-behavioral treatment
Behavioral
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 15, 2009 · Synced Oct 17, 2026, 3:03 PM EDT
Terminated Phase 4 Interventional Results available

Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism

NCT00449007
View directory record Official record
Conditions
Depression, Alcoholism, Suicidal Behavior
Interventions
fluoxetine, bupropion
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Oct 17, 2026, 3:03 PM EDT
Completed Phase 2Phase 3 Interventional Results available

New Treatment for Alcohol and Nicotine Dependence

NCT01182766
View directory record Official record
Conditions
Alcohol Dependence, Nicotine Dependence
Interventions
Low-Dose Topiramate, Placebo, High-Dose Topiramate
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
4
States / cities
La Jolla, California • Houston, Texas • Charlottesville, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 17, 2026, 3:03 PM EDT
Terminated Phase 2 Interventional Results available

Role of Proinflammatory Signaling in Alcohol Craving

NCT01631630
View directory record Official record
Conditions
Alcohol Dependence, Alcohol Drinking, Stress, Alcohol-Related Disorders
Interventions
Pioglitazone, Placebo
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 9, 2017 · Synced Oct 17, 2026, 3:03 PM EDT