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Showing 1–24 of 1,077 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Alcohol Dependence Clear all
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder

NCT05957159
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Detoxification Program, PKAB, CFN
Other · Radiation
Lead sponsor
Yale University
Other
Eligibility
21 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Results available

Stress, Emotion Regulation, and Alcohol in Women Veterans

NCT04393623
View directory record Official record
Conditions
Alcohol Use Disorder, Post Traumatic Stress Disorder
Interventions
Cognitive Reappraisal, Psychoeducation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Female only
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Leeds, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Phase 1 Interventional Results available

Effect of Allopregnanolone on Stress-induced Craving

NCT04015869
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Allopregnanolone, Placebos
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Phase 4 Interventional

Identifying Multiple Mechanisms of Change in Alcoholism Treatment

NCT01168960
View directory record Official record
Conditions
Alcohol Dependence
Interventions
Cognitive behavioral therapy for alcohol dependence
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Understanding Genetic Risk for Alcohol Use Disorder

NCT05143073
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Alcohol use disorder and strategies to reduce risk educational material, Complex polygenic risk scores, alcohol use disorder, and strategies to reduce risk educational material
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
338 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 18, 2022 · Synced Jun 7, 2026, 7:29 AM EDT
Recruiting Not applicable Interventional

Amplification of Positivity for Alcohol Use

NCT06030154
View directory record Official record
Conditions
Alcohol Use Disorder, Anxiety, Depression
Interventions
Cognitive Behavioral Therapy, Amplification of Positivity Therapy, Surveys and Interviews
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jun 7, 2026, 7:29 AM EDT
Completed No phase listed Observational

The Stress-Hormone System in Alcohol-Dependent Subjects

NCT00536146
View directory record Official record
Conditions
Alcoholism
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
21 Years to 60 Years · Male only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 7, 2026, 7:29 AM EDT
Suspended Not applicable Interventional

The Effect of rTMS to the Prefrontal Cortex in Alcohol Use Disorder

NCT03809286
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
active rTMS, Inpatient admission, sham rTMS
Device · Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
22 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Jun 7, 2026, 7:29 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

Imaging Inflammation With Alcohol Use Disorder: an [18F]NOS Study

NCT05885594
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
[18F]NOS
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Acamprosate to Reduce Symptoms of Alcohol Withdrawal

NCT00106106
View directory record Official record
Conditions
Alcohol-Related Disorders, Alcohol Dependence, Alcoholism, Healthy Volunteer
Interventions
NMR-spectroscopy, Oral acamprosate
Procedure · Drug
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
21 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2012 · Synced Jun 7, 2026, 7:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use Outcomes

NCT03056872
View directory record Official record
Conditions
Alcohol Use Disorder, Anxiety Disorder/Anxiety State, Stress Disorder, Hypothalamic Pituitary Adrenal, Drinking to Cope
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Influence of n-Acetylcysteine Maintenance on Alcohol Effects

NCT03216954
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Alcohol, Placebos, N-acetyl cysteine
Drug
Lead sponsor
William Stoops
Other
Eligibility
21 Years to 55 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 25, 2021 · Synced Jun 7, 2026, 7:29 AM EDT
Not listed No phase listed Observational

Preliminary Analysis of the Soberlink Alcohol Breath Analyzer System's (SABA) Clinical Utility During Aftercare

NCT02544581
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Soberlink combined with aftercare services
Other
Lead sponsor
SoberLink, LLC
Industry
Eligibility
18 Years to 90 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Juno Beach, Florida
Source: ClinicalTrials.gov public record
Updated Sep 8, 2015 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional

Reducing Unsafe Alcohol Use in HIV-Positive Individuals

NCT00371969
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Enhanced Motivational Interview, Standard Motivational Interview or viewing DVD
Behavioral
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 29, 2015 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional

D-Cycloserine to Enhance Extinction to Alcohol Cues

NCT01362309
View directory record Official record
Conditions
Alcohol Use Disorders.
Interventions
d-cycloserine.
Drug
Lead sponsor
University of Georgia
Other
Eligibility
21 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 18, 2014 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Phase 1 Interventional Results available

The Women's Recovery Group Study: Stage I Trial

NCT00230100
View directory record Official record
Conditions
Alcohol-Related Disorders, Substance-Related Disorders
Interventions
The Women's Recovery Group, mixed-gender Group Drug Counseling
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 31, 2023 · Synced Jun 7, 2026, 7:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design

NCT07125534
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder (AUD), Alcohol Intoxication, Alcohol; Harmful Use, Alcoholism, Binge Drinking
Interventions
Alcohol beverage, Control - non alcoholic beverage
Drug · Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
21 Years to 30 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Champaign, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Phase 2 Interventional

Acamprosate Treatment: Mechanisms of Action

NCT00004552
View directory record Official record
Conditions
Alcoholism
Interventions
acamprosate (Campral)
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 55 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2002
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 1, 2015 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Loneliness and Health Outcomes in the High Need Population

NCT05484258
View directory record Official record
Conditions
Anxiety, Loneliness, Depression, Alcohol Use Disorder, Utilization, Health Care
Interventions
Shared Medical Visit
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Phase 2 Interventional

New Medications to Treat Alcohol Dependence

NCT00223639
View directory record Official record
Conditions
Alcoholism
Interventions
Topiramate
Drug
Lead sponsor
Bankole Johnson
Other
Eligibility
21 Years to 45 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
2
States / cities
Charlottesville, Virginia • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 6, 2012 · Synced Jun 7, 2026, 7:29 AM EDT
Not yet recruiting Phase 2 Interventional

Pilot Study: Effects of Nimodipine on Alcohol Drinking

NCT06900998
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Nimodipine
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 50 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional

CM Treatment for Alcohol Dependence Using New Technology

NCT02143037
View directory record Official record
Conditions
Alcohol Use Disorder, Contingency Management
Interventions
prize contingency management for attending treatment, usual care
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Bridgeport, Connecticut • Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 16, 2019 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Results available

Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Alcoholics

NCT01899521
View directory record Official record
Conditions
Alcoholism
Interventions
Bronchoscopy, Zinc sulfate 220 mg once daily, S-adenosylmethionine 400 mg twice daily
Procedure · Dietary Supplement
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 60 Years
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jun 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Results available

Talk Therapy by Phone to Promote Treatment for Alcohol Problems

NCT03758274
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Abuse
Interventions
CBT by Phone to Promote Treatment, Reading the Subject a Pamphlet on Obtaining Alcohol Use Disorder Treatment
Behavioral · Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Jun 7, 2026, 7:29 AM EDT