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Showing 1–24 of 1,083 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Alcohol Dependence Clear all
Completed Phase 2 Interventional

Sertraline and Naltrexone for Alcohol Dependence

NCT00000440
View directory record Official record
Conditions
Alcoholism
Interventions
naltrexone (Revia), sertraline (Zoloft)
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2002
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jul 22, 2026, 6:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence

NCT02438969
View directory record Official record
Conditions
Fear, Stress, Alcohol Dependence
Interventions
Not listed
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mentored Research on Improving Alcohol Brief Interventions in Medical Settings

NCT02978027
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Brief Advice, NIAAA Clinician's Guide, Motivational Interviewing (MI)
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Jul 22, 2026, 6:40 PM EDT
Recruiting Phase 1 Interventional

Diclofenac Dose Response Study

NCT06636227
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Alcohol-Related Disorders
Interventions
Diclofenac 100mg, Diclofenac 75mg, Diclofenac 50mg, Placebo control
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 4 Interventional

Use of Naltrexone in a Clinical Setting

NCT00000445
View directory record Official record
Conditions
Alcoholism
Interventions
naltrexone (Revia)
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2002
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 2 Interventional Results available

Enhancing the Effects of Adolescent Alcohol Treatment With Atomoxetine

NCT04565288
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Atomoxetine, Placebo
Drug
Lead sponsor
Brown University
Other
Eligibility
14 Years to 20 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 2 Interventional

The MEADOW PROJECT (Mending the Effects of Alcohol and Depression on Women) and The Bridge Program (Connecting Recovery Treatment and Behavioral Health)

NCT00851669
View directory record Official record
Conditions
Alcohol Dependence, Depression
Interventions
Interpersonal Psychotherapy for Co-occurring Alcohol Dependence and Major Depression (IPT-ADMD), Treatment as Usual
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 65 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2013 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 2 Interventional Results available

Therapeutic Substance Abuse Treatment in Pregnancy - 1

NCT00227903
View directory record Official record
Conditions
Alcohol Abuse, Cocaine Abuse, Marijuana Abuse
Interventions
MI-CBT, Brief Advice
Behavioral
Lead sponsor
Yale University
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
2
States / cities
Bridgeport, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 14, 2020 · Synced Jul 22, 2026, 6:40 PM EDT
Completed No phase listed Observational Results available

STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse

NCT00369746
View directory record Official record
Conditions
Major Depressive Disorder, Alcohol Use Disorder
Interventions
citalopram
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
674 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 8, 2014 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cognitive Remediation for Alcohol Use Disorder and Posttraumatic Stress Disorder

NCT02929979
View directory record Official record
Conditions
Alcohol Use Disorder, PTSD, Cognitive Dysfunction
Interventions
Cognitive Training, Cognitive training placebo control
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 10, 2021 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 1 Interventional

Ketamine for Depression and Alcohol Dependence

NCT01551329
View directory record Official record
Conditions
Depression, Alcohol Dependence
Interventions
Ketalar (ketamine)
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 8, 2020 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Not applicable Interventional Results available

Reducing Alcohol Use & Post-traumatic Stress Disorder (PTSD) With Cognitive Restructuring & Experiential Acceptance

NCT00760994
View directory record Official record
Conditions
Alcoholism, Stress Disorders, Post-Traumatic
Interventions
Experiential acceptance, Cognitive restructuring, No-intervention control: Nutrition information
Behavioral · Other
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 9, 2020 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Not applicable Interventional Results available

CBT4CBT With Spanish Alcohol Users

NCT03474588
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Standard treatment (ST) PLUS web-based CBT4CBT, Standard Treatment (ST)
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
5
States / cities
Bridgeport, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Not applicable Interventional

Navigation Services to Avoid Rehospitalization (NavSTAR)

NCT02599818
View directory record Official record
Conditions
Opioid-use Disorder, Cocaine Use Disorder, Alcohol Use Disorder
Interventions
NavSTAR
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Jul 22, 2026, 6:40 PM EDT
Recruiting Phase 1Phase 2 Interventional

Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease

NCT05548452
View directory record Official record
Conditions
Liver Disease; Alcohol-Related, Cirrhosis, Alcohol Use Disorder
Interventions
Intestinal Microbiota Transplant (IMT) Capsules, Placebo Capsules
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

An Inflammatory Challenge Using Endotoxin

NCT04310423
View directory record Official record
Conditions
Alcohol Use Disorder, Inflammatory Response, Craving, Depressed Mood
Interventions
Placebo, Endotoxin
Drug · Biological
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Not applicable Interventional Results available

Automated Reinforcement Management System (ARMS)

NCT04656925
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Contingency management
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 22, 2026, 6:40 PM EDT
Recruiting Phase 2 Interventional

Guanfacine for Alcohol Use Disorder (AUD)

NCT06629259
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Guanfacine Extended Release (XR), Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
2
States / cities
Indianapolis, Indiana • Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 2 Interventional Results available

Levetiracetam for the Treatment of Alcohol Dependence and Anxiety

NCT00141115
View directory record Official record
Conditions
Alcoholism, Generalized Anxiety Disorder, Panic Disorder, Social Phobia, Anxiety Disorders
Interventions
levetiracetam
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

ALK29-002: A Study of Baclofen Formulations in Healthy Adults

NCT00802035
View directory record Official record
Conditions
Alcohol Dependence
Interventions
Baclofen IR, Baclofen ER
Drug
Lead sponsor
Alkermes, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 22, 2011 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 2 Interventional

Screening and Brief Intervention in the ED Among Mexican-origin Young Adults

NCT02056535
View directory record Official record
Conditions
Problem Drinking, Alcohol Dependence
Interventions
Brief Motivational Intervention
Behavioral
Lead sponsor
Public Health Institute, California
Other
Eligibility
18 Years to 30 Years
Enrollment
698 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Feb 5, 2014 · Synced Jul 22, 2026, 6:40 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Ambulatory Alcohol Detoxification With Remote Monitoring

NCT03582150
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Remote Monitoring with Ambulatory Detox
Device
Lead sponsor
Stanford University
Other
Eligibility
21 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 15, 2022 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 4 Interventional

Substance Dependent Teens - Impact of Treating Depression Study 1 - 1

NCT00061113
View directory record Official record
Conditions
Alcohol-Related Disorders, Marijuana Abuse, Substance-Related Disorders
Interventions
Fluoxetine + outpatient cognitive behavioral therapy, fluoxetine, placebo + CBT
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 19 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jul 22, 2026, 6:40 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Human Laboratory Study of Varenicline for Alcohol Use Disorder

NCT03035708
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Varenicline, Placebo oral capsule
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
New Haven, Connecticut • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 22, 2019 · Synced Jul 22, 2026, 6:40 PM EDT