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ClinicalTrials.gov public records Last synced Oct 21, 2026, 3:17 AM EDT

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Showing 145–168 of 235 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol Effect Clear all
Completed Phase 2 Interventional Results available

Combined Treatment for Alcohol-Dependent Individuals With PTSD

NCT00262223
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
Interventions
Seeking Safety, Sertraline, Pill placebo
Behavioral · Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Assess Potential Interaction Between ASP8062 and Alcohol in Healthy Adult Subjects

NCT04003402
View directory record Official record
Conditions
Healthy Volunteers
Interventions
ASP8062, Alcohol, ASP8062 Placebo, Alcohol Placebo
Drug
Lead sponsor
Astellas Pharma Global Development, Inc.
Industry
Eligibility
21 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 5, 2024 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Phase 4 Interventional Results available

ALK21-018: Effects of Medisorb® Naltrexone (VIVITROL®) on Alcohol Craving in Treatment-seeking, Alcohol-dependent Adults

NCT00511836
View directory record Official record
Conditions
Alcohol Dependence
Interventions
VIVITROL 380 mg, Placebo
Drug
Lead sponsor
Alkermes, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Early Phase 1 Interventional

Physiological Study of the Efficacy and Mechanistic Effects of Alcohol Renal Denervation

NCT03465917
View directory record Official record
Conditions
Hypertension
Interventions
Renal Denervation
Combination Product
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 11, 2020 · Synced Oct 21, 2026, 3:17 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Ketogenic Diet on Alcohol Intoxication

NCT07602270
View directory record Official record
Conditions
Ketogenic Diet, Alcohol Drinking, Alcohol Use Disorder, Magnetic Resonance Imaging, Alcohol Intoxication
Interventions
Ketogenic diet
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Phase 1 Interventional Results available

Effect of Allopregnanolone on Stress-induced Craving

NCT04015869
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Allopregnanolone, Placebos
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Social Effects of Alcohol

NCT05826951
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Alcohol, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
21 Years to 35 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 21, 2026, 3:17 AM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

The Impact of Dose on the Impairing, Intoxicating, and Abuse-Related Effects of Psilocybin

NCT07877987
View directory record Official record
Conditions
Psilocybin Intoxication
Interventions
0mg Psilocybin Capsule + 0.00% BAC Alcoholic Drink, 1mg Psilocybin Capsule + 0.00% BAC Alcoholic Drink, 5mg Psilocybin Capsule + 0.00% BAC Alcoholic Drink, 15mg Psilocybin Capsule + 0.00% BAC Alcoholic Drink, 25mg Psilocybin Capsule + 0.00% BAC Alcoholic Drink, 0mg Psilocybin Capsule + 0.08% BAC Alcoholic Drink
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2030
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 21, 2026, 3:17 AM EDT
Terminated Phase 1 Interventional Results available

Pitolisant Effects on Alcohol Self-Administration in Heavy Drinkers

NCT04596267
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Drinking
Interventions
Pitolisant, Placebo
Drug
Lead sponsor
Boston Medical Center
Other
Eligibility
21 Years to 55 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 4, 2023 · Synced Oct 21, 2026, 3:17 AM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study I

NCT02709954
View directory record Official record
Conditions
Cannabis, Alcohol Effect, Driving Under the Influence of Alcohol and Other Drugs
Interventions
Active inhaled delta-9-THC, Placebo, Active Oral Ethanol
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 21, 2026, 3:17 AM EDT
Active, not recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Acute Effects of Ketone Supplement on Responses to Alcohol Challenge in Healthy Volunteers

NCT05551754
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Ketone Supplement, Alcohol Beverage
Dietary Supplement · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Cannabidiol in Youth Alcohol Use Disorder

NCT05317546
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Cannabidiol
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
16 Years to 22 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Residual Effects of Intoxication on Student Performance

NCT00183170
View directory record Official record
Conditions
Alcoholic Intoxication, Neurobehavioral Manifestations
Interventions
Alcohol, Placebo
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
21 Years to 30 Years
Enrollment
239 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Oct 21, 2026, 3:17 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Imaging Biomarker for Addiction Treatment Outcome

NCT03427424
View directory record Official record
Conditions
Opioid-Related Disorders, Alcohol-Related Disorders
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Oct 21, 2026, 3:17 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics

NCT06624137
View directory record Official record
Conditions
OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer, Migraine, PTSD, PTSD - Post Traumatic Stress Disorder, Addiction, Tobacco Use Disorder, Obsessive Compulsive Disorder (OCD), Opioid Use Disorder
Interventions
Serotonergic Psychedelic, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Hamden, Connecticut • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 21, 2026, 3:17 AM EDT
Recruiting Phase 1 Interventional

The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

NCT06070649
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Alcohol-Related Disorders, Alcohol Use
Interventions
0.3mg/kg/min Dimethyltryptamine + Normal Saline infusion, 0.2 mg/kg/min + Dimethyltryptamine 0.01mg/kg/min infusion, 25 mg Diphenhydramine (5 min) + Normal Saline
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 21, 2026, 3:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Dissecting the Genetics of Fetal Alcohol Spectrum Disorders

NCT04072809
View directory record Official record
Conditions
Fetal Alcohol Spectrum Disorders
Interventions
No intervention
Other
Lead sponsor
Indiana University
Other
Eligibility
1 Month to 110 Years
Enrollment
751 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 6, 2023 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Hangover, Congeners, Sleep and Occupational Performance

NCT00247585
View directory record Official record
Conditions
Sleep, Neurobehavioral Manifestations
Interventions
Ethanol (Bourbon or Vodka)
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 30 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 6, 2006 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Not applicable Interventional Results available

Effects of Sulfasalazine on BOLD Response to Alcohol Cues

NCT01312129
View directory record Official record
Conditions
Alcohol Dependence
Interventions
Sulfasalazine, Placebo
Drug
Lead sponsor
The Mind Research Network
Other
Eligibility
21 Years to 55 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Sep 22, 2014 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Phase 2 Interventional Results available

Gabapentin for Alcohol Relapse Prevention

NCT02349477
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Withdrawal
Interventions
Gabapentin, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 70 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 4, 2019 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Alcohol History on Effects of Nitrous Oxide - 9

NCT00000257
View directory record Official record
Conditions
Alcohol-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
Interventions
0% N2O and 10% N2O, 0% N2O and 20% N2O, 0% N2O and 30% N2O, 0% N2O and 40% N2O
Drug
Lead sponsor
University of Chicago
Other
Eligibility
21 Years to 37 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1995 – 1997
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Not applicable Interventional

Effects of tDCS Paired With Cognitive Training on Brain Networks Associated With Alcohol Use Disorder in Veterans

NCT04574167
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Active Transcranial Direct Current Stimulation (tDCS), Sham Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
22 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 21, 2026, 3:17 AM EDT
Completed Not applicable Interventional

Effect of CBT Microinterventions on Mechanisms of Behavior Change Among Adults With AUD

NCT03661853
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Control, Functional Analysis, Cognitive Restructuring, Dealing With Cravings
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Oct 21, 2026, 3:17 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Biphasic Effects of Acute Alcohol Intoxication on Bystander Intervention

NCT05701865
View directory record Official record
Conditions
Alcohol Intoxication
Interventions
Alcohol Intoxication- Ascending Limb, Alcohol Intoxication- Descending Limb, No Alcohol Control
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 30 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 21, 2026, 3:17 AM EDT