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ClinicalTrials.gov public records Last synced Sep 13, 2026, 10:28 AM EDT

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Showing 25–41 of 17 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 1 Interventional Accepts healthy volunteers

Alcohol Inhibits Drug Metabolism by Carboxylesterases

NCT01708369
Conditions
Drug Interactions
Interventions
Placebo, Ethanol, Oseltamivir, Aspirin
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
21 Years to 45 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Memphis, Tennessee
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism

NCT00330434
Conditions
Alcohol Drinking, Depression, Smoking Cessation, Attention Deficit Disorder
Interventions
Trial Withdrawn 1, Trial Withdrawn 2
Other
Lead sponsor
Tufts University
Other
Eligibility
21 Years to 55 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Completed No phase listed Observational Accepts healthy volunteers

Parent-Adolescent Interactions and Adolescent Development

NCT01572441
Conditions
Substance Abuse
Interventions
Not listed
Lead sponsor
George Mason University
Other
Eligibility
12 Years to 14 Years
Enrollment
245 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
2
States / cities
New Haven, Connecticut • Fairfax, Virginia
Conditions
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Interventions
Placebo, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg, Ethanol Infusion, PTSD Reactivity Condition, Alcohol Cue Reactivity
Drug · Procedure · Behavioral
Lead sponsor
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Other
Eligibility
21 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
West Haven, Connecticut
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

INIA Stress and Chronic Alcohol Interactions: Glucocorticoid Antagonists in Heavy Drinkers

NCT02989662
Conditions
Alcohol Use Disorder
Interventions
Mifepristone, Placebo - Cap
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 55 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Completed Early Phase 1 Interventional Accepts healthy volunteers

Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans

NCT00616746
Conditions
Alcohol Consumption, Tobacco Use
Interventions
Nicotine, Ethanol
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 50 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
West Haven, Connecticut
Completed Phase 2 Interventional Accepts healthy volunteers

Healthy Living as You Age

NCT00379093
Conditions
Alcohol Related Disorders, Alcohol Drug Interactions
Interventions
Brief advice
Behavioral
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
55 Years and older
Enrollment
631 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Los Angeles, California
Recruiting Not applicable Interventional Accepts healthy volunteers

Approach-Avoidance and Alcohol Challenge Study in PTSD

NCT06002633
Conditions
Post-Traumatic Stress Disorder, Alcohol Drinking
Interventions
Alcohol, Placebo
Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
21 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Austin, Texas
Conditions
Alcohol Drinking
Interventions
Naltrexone and memantine first, Naltrexone and Placebo first
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 55 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Conditions
Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder, Alcohol Use Disorder, Depression
Interventions
Negative Emotions and Addiction Tools Program (NEAT)- Cognitive Behavioral Therapy, Progressive Muscle Relaxation Training (PMRT)
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Completed Phase 1 Interventional Accepts healthy volunteers

GSK1521498 Alcohol Interaction Study

NCT01366573
Conditions
Alcoholism
Interventions
GSK1521498, Placebo
Drug · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
21 Years to 55 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Austin, Texas
Conditions
Psychological Stress, Social Interaction
Interventions
Stress, Social Context
Other
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 50 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Conditions
Healthy
Interventions
KADIAN Capsule + alcohol (under fasting conditions), KADIAN Capsule + water (under fasting conditions), morphine sulfate IR oral solution + water, KADIAN Capsule + alcohol (under fed conditions)
Drug
Lead sponsor
Actavis Inc.
Industry
Eligibility
21 Years to 40 Years · Male only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Lincoln, Nebraska
Not listed Not applicable Interventional Accepts healthy volunteers

First Years Away From Home: Letting Go and Staying Connected

NCT03227809
Conditions
Substance Abuse, Risk Reduction, RIsky Sexual Behavior
Interventions
Handbook condition, Handbook plus condition
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
17 Years to 22 Years
Enrollment
910 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pullman, Washington
Completed Phase 1 Interventional Accepts healthy volunteers Results available

The Behavioral Effects of Opioids and Alcohol

NCT04300751
Conditions
Opioid Use, Alcohol Drinking
Interventions
Alcohol, Opioid Agonist
Drug
Lead sponsor
Sharon Walsh
Other
Eligibility
21 Years to 55 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Not listed Not applicable Interventional Accepts healthy volunteers

Designing a Mobile App for Veterans With Substance Use Problems

NCT01812187
Conditions
Substance Abuse Problem, Alcohol Abuse, Alcohol Dependence
Interventions
SHIFT Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Michael E. DeBakey VA Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Houston, Texas
Conditions
Healthy Volunteers
Interventions
ASP8062, Alcohol, ASP8062 Placebo, Alcohol Placebo
Drug
Lead sponsor
Astellas Pharma Global Development, Inc.
Industry
Eligibility
21 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Baltimore, Maryland