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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Alcohol Problem Drinking Clear all
Terminated Phase 4 Interventional Accepts healthy volunteers

Long-Acting Injectable Naltrexone Treatment of Alcohol Dependence in Primary Care vs. in Specialized Chemical Dependence Treatment: A Pilot Trial

NCT00461890
View directory record Official record
Conditions
Alcohol Dependence, Veterans
Interventions
Injectable Naltrexone
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 69 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Oct 23, 2011 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Not applicable Interventional Results available

Telephone Coaching of Family Members of Veterans With Substance Abuse Problems

NCT03246646
View directory record Official record
Conditions
Substance Abuse
Interventions
Coaching
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Not applicable Interventional Results available

Improving Outcomes for Emergency Department Patients With Alcohol Problems

NCT03536546
View directory record Official record
Conditions
Drinking, Alcohol
Interventions
Alcohol Peer Mentor Intervention, Brief Advice
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 29, 2024 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Not applicable Interventional

The Teachable Moment: Screening and Brief Intervention for Admitted Trauma Patients

NCT00865774
View directory record Official record
Conditions
Alcoholism
Interventions
Quantity Frequency Model, Targets Subjective Drunkenness
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 8, 2018 · Synced Jun 10, 2026, 3:05 PM EDT
Active, not recruiting No phase listed Observational

Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism

NCT07189988
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
psilocybin
Other
Lead sponsor
Healing Advocacy Fund
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Phase 2 Interventional Results available

NAC for Treating Comorbid PTSD and SUD

NCT02911285
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), Substance Use Disorder (SUD)
Interventions
N-acetylcysteine, Placebo, Cognitive behavioral therapy
Drug · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2021 · Synced Jun 10, 2026, 3:05 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Ketogenic Diet on Alcohol Intoxication

NCT07602270
View directory record Official record
Conditions
Ketogenic Diet, Alcohol Drinking, Alcohol Use Disorder, Magnetic Resonance Imaging, Alcohol Intoxication
Interventions
Ketogenic diet
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jun 10, 2026, 3:05 PM EDT
Enrolling by invitation Not applicable Interventional

LDART for Alcohol Use Disorder

NCT07221383
View directory record Official record
Conditions
Alcohol Use Disorder, Hazardous Alcohol Use
Interventions
LDART, Psychoeducational control
Device · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Quetiapine Fumarate (SEROQUEL®) in the Treatment of Alcohol Dependency in Patients With Bipolar Disorder

NCT00114686
View directory record Official record
Conditions
Bipolar I Disorder, Alcohol Dependence
Interventions
Quetiapine fumarate, lithium, divalproex
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
21 Years to 60 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
38
States / cities
Cerritos, California • San Diego, California • New Haven, Connecticut + 35 more
Source: ClinicalTrials.gov public record
Updated Jan 3, 2013 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Understanding Genetic Risk for Alcohol Use Disorder

NCT05143073
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Alcohol use disorder and strategies to reduce risk educational material, Complex polygenic risk scores, alcohol use disorder, and strategies to reduce risk educational material
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
338 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 18, 2022 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Step Away: Comparing a Chatbot-delivered Alcohol Intervention With a Smartphone App

NCT04447794
View directory record Official record
Conditions
Alcohol Consumption, Alcohol Use Disorder
Interventions
Step Away Chatbot, Step Away App
Behavioral
Lead sponsor
University of Alaska Anchorage
Other
Eligibility
18 Years and older
Enrollment
191 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Jun 10, 2026, 3:05 PM EDT
Suspended Not applicable Interventional

Decision Making in Chronic Pain and Alcohol Use Disorder

NCT05901610
View directory record Official record
Conditions
Alcohol Use Disorder, Chronic Pain
Interventions
Episodic Future Thinking, Control Episodic Thinking, Low-intensity Focused Ultrasound, Sham Low-intensity Focused Ultrasound
Behavioral · Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Phase 1Phase 2 Interventional

Alcohol Counseling for Telephone Quitline Callers

NCT01120080
View directory record Official record
Conditions
Smoking, Nicotine Dependence, Alcohol Dependence
Interventions
Practical Counseling, Alcohol Intervention Counseling
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
1,948 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 1, 2020 · Synced Jun 10, 2026, 3:05 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Addictions Neuroclinical Assessment (ANA)

NCT04946851
View directory record Official record
Conditions
Normal Physiology, Alcohol Use Disorder
Interventions
Not listed
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years to 99 Years
Enrollment
1,400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2031
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Phase 4 Interventional

Behavioral Therapy Plus Naltrexone for Alcoholism

NCT00000456
View directory record Official record
Conditions
Alcoholism, Alcohol Dependence
Interventions
naltrexone (Revia), cognitive behavior therapy, motivational enhancement therapy
Drug · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 70 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1992 – 2002
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 3, 2010 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Relational Agent for Alcohol Screening and Treatment

NCT02030288
View directory record Official record
Conditions
Unhealthy Alcohol Use, Alcohol Use Disorder, Alcohol Disorders
Interventions
Relational Agent Intervention
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Jun 10, 2026, 3:05 PM EDT
Not yet recruiting Early Phase 1 Interventional

PTSD and Alcohol Couples Treatment for Veterans

NCT07388654
View directory record Official record
Conditions
PTSD, AUD
Interventions
COPE + BFIT
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Not applicable Interventional Results available

Pilot: Digital Therapeutic vs Education for the Management of Problematic Substance Use

NCT04974645
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Substance Use Disorders
Interventions
W-SUDs, Digitally-delivered Psychoeducation
Device · Other
Lead sponsor
Woebot Health
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Palo Alto, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Early Phase 1 Interventional

The Effect of Naltrexone on Alcohol Craving and on Brain Activity During Alcohol Infusion

NCT00667771
View directory record Official record
Conditions
Alcohol Dependence, Alcoholism
Interventions
Naltrexone
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 50 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 10, 2026, 3:05 PM EDT
Not yet recruiting Phase 2Phase 3 Interventional

Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

NCT06807918
View directory record Official record
Conditions
Alcohol Use Disorder, Ketosis
Interventions
Kenetik, magnetic resonance imaging scan, fludeoxyglucose-18 positron emission tomography scan, Alcohol bar lab, Placebo beverage
Dietary Supplement · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 10, 2026, 3:05 PM EDT
Terminated Phase 2 Interventional Results available

Topiramate to Reduce Heavy Drinking in HIV-Positive Heavy Drinkers

NCT01764685
View directory record Official record
Conditions
Heavy Drinking, HIV, Alcohol Dependence
Interventions
Topiramate, Medical Management, Placebo
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 14, 2016 · Synced Jun 10, 2026, 3:05 PM EDT
Active, not recruiting Not applicable Interventional

A Female-Specific CBT Group for Veteran Women With Alcohol Use Disorder in VA Primary Care Settings

NCT06118346
View directory record Official record
Conditions
Alcohol Use Disorder, Risky Health Behavior
Interventions
Female-Specific Cognitive Behavioral Therapy (FS-CBT), Usual Care
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older · Female only
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jun 10, 2026, 3:05 PM EDT
Recruiting Phase 2 Interventional

Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD

NCT03667846
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Alcohol Use Disorder
Interventions
Topiramate, Placebo
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 70 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Jun 10, 2026, 3:05 PM EDT
Completed Phase 2 Interventional Results available

N-Acetylcysteine for Adolescent Alcohol Use Disorder

NCT03707951
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
N-acetylcysteine, Placebo oral capsule
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
13 Years to 25 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Jun 10, 2026, 3:05 PM EDT