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ClinicalTrials.gov public records Last synced Oct 21, 2026, 6:16 AM EDT

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Showing 433–456 of 1,300 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol Use Clear all
Terminated Phase 2 Interventional Results available

Topiramate's Effects on Heavy Drinking

NCT02074904
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Topiramate, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 60 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 21, 2018 · Synced Oct 21, 2026, 6:16 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Suvorexant and Alcohol

NCT06326684
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Alcohol, Placebo, Suvorexant
Drug
Lead sponsor
William Stoops
Other
Eligibility
21 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Phase 2 Interventional Results available

ABT-436 for Alcohol Dependence

NCT01613014
View directory record Official record
Conditions
Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorders, Alcoholism
Interventions
ABT-436, Matched Placebo - Sugar Pill
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
5
States / cities
Baltimore, Maryland • Boston, Massachusetts • Quincy, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 21, 2026, 6:16 AM EDT
Withdrawn Phase 3 Interventional

The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder

NCT00571246
View directory record Official record
Conditions
Alcohol Dependence, Post Traumatic Stress Disorder
Interventions
Topiramate, lamotrigine, Placebo
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Not applicable Interventional Results available

Transcranial Magnetic Stimulation for the Treatment of Veterans With Alcohol Use Disorders

NCT03191266
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Active rTMS, Sham rTMS
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Not applicable Interventional

Present- Versus Past-focused Therapy for PTSD and Substance Use Disorder

NCT01274741
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Substance Use Disorder, Alcohol Use Disorder
Interventions
Creating Change (CC), Seeking Safety (SS)
Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
18 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 3, 2019 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)

NCT04331288
View directory record Official record
Conditions
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Interventions
PT150, Beverage
Drug · Other
Lead sponsor
Pop Test Oncology LLC
Industry
Eligibility
21 Years to 64 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 4, 2023 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Not applicable Interventional Results available

Implementing Mobile Technology for Unhealthy Alcohol Use

NCT05350878
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Implementation Intervention
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Psychodynamic Therapy For Co-occurring Borderline Personality Disorder and Alcohol Use Disorder

NCT00145678
View directory record Official record
Conditions
Borderline Personality Disorder, Alcohol Use Disorder
Interventions
Psychodynamic Therapy, Optimized Community Care
Behavioral
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 45 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2010
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2015 · Synced Oct 21, 2026, 6:16 AM EDT
Withdrawn Phase 2 Interventional

Use of Kudzu Extract in the Study of Its Ability to Reduce Alcohol Drinking in Treatment Seeking Alcohol Dependent Persons

NCT01853293
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Dependence, Heavy Drinking Days
Interventions
Kudzu extract, Placebo, Medical Management
Drug · Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Not applicable Interventional Results available

Brief Interventions in the Emergency Department for Alcohol and HIV/Sexual Risk

NCT01351389
View directory record Official record
Conditions
Alcohol Consumption, Unsafe Sex
Interventions
Brief Motivational Intervention (BMI), Brief Advice
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 65 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
3
States / cities
Pawtucket, Rhode Island • Providence, Rhode Island • Warwick, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 19, 2025 · Synced Oct 21, 2026, 6:16 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder

NCT05957159
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Detoxification Program, PKAB, CFN
Other · Radiation
Lead sponsor
Yale University
Other
Eligibility
21 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)

NCT03575403
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Alcohol, Placebos, Duloxetine (60 MG), Methylphenidate, Duloxetine (30 MG)
Drug
Lead sponsor
Craig Rush
Other
Eligibility
21 Years to 55 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 21, 2026, 6:16 AM EDT
Terminated Phase 4 Interventional Results available

Study of Acamprosate to Prevent Alcohol Relapse in Criminal Justice Supervisees

NCT00249379
View directory record Official record
Conditions
Alcohol Dependence
Interventions
Acamprosate
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 11, 2016 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Not applicable Interventional Results available

Pioglitazone for the Treatment of Alcohol Use Disorder

NCT03864146
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Brief Behavioral Compliance Enhancement Treatment
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
2
States / cities
Long Beach, California • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Not applicable Interventional Results available

Talk Therapy by Phone to Promote Treatment for Alcohol Problems

NCT03758274
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Abuse
Interventions
CBT by Phone to Promote Treatment, Reading the Subject a Pamphlet on Obtaining Alcohol Use Disorder Treatment
Behavioral · Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 4, 2023 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing Housing First Programs With a Social Network Substance Use Intervention

NCT02140359
View directory record Official record
Conditions
Alcohol Drinking, Drug Abuse, HIV
Interventions
Motivational Network Interview
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
2
States / cities
Los Angeles, California • Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Nov 24, 2017 · Synced Oct 21, 2026, 6:16 AM EDT
Not listed Phase 2 Interventional

Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders

NCT06434818
View directory record Official record
Conditions
Substance Use Disorders, Opioid Use Disorder, Alcohol Use Disorder, Cocaine Use Disorder, Methamphetamine-dependence
Interventions
EDITOR (CBOT with olfactory stimulants, OFC tasks & remote monitoring of treatment compliance), CBOT with olfactory stimulants & OFC tasks, CBOT Sham
Combination Product
Lead sponsor
Evon Medics LLC
Industry
Eligibility
18 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Oct 21, 2026, 6:16 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

WayToServePlus: Improving Responsible Alcohol Service Ph I

NCT05146024
View directory record Official record
Conditions
Driving While Intoxicated
Interventions
Way To Serve Plus: Improving Responsible Alcohol Service
Behavioral
Lead sponsor
Klein Buendel, Inc.
Industry
Eligibility
19 Years and older
Enrollment
183 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Berkeley, California • Golden, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Oct 21, 2026, 6:16 AM EDT
Terminated Not applicable Interventional

Use of tAN® in Alcohol Withdrawal Management

NCT06771037
View directory record Official record
Conditions
Alcohol Withdrawal
Interventions
Transcutaneous Auricular Neurostimulation (tAN)
Device
Lead sponsor
Erin Takemoto
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Wernersville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 21, 2026, 6:16 AM EDT
Recruiting Phase 3 Interventional

A Study of Brenipatide in Participants With Alcohol Use Disorder

NCT07219953
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
LY3537031, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 75 Years
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
29
States / cities
Scottsdale, Arizona • Little Rock, Arkansas • Los Angeles, California + 24 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 21, 2026, 6:16 AM EDT
Withdrawn Phase 2 Interventional

Zonisamide Outpatient Study

NCT03376139
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Alcohol Use Disorder
Interventions
Zonisamide, Placebo Comparator
Drug
Lead sponsor
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Other
Eligibility
18 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2021 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Phase 4 Interventional Results available

Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders

NCT02582905
View directory record Official record
Conditions
Alcohol Use Disorder, Bipolar Disorder, Schizoaffective Disorder Bipolar Type
Interventions
Placebo, Citicoline, Pregnenolone
Drug · Dietary Supplement
Lead sponsor
Sherwood Brown, MD, PhD
Other
Eligibility
18 Years to 70 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
3
States / cities
Miami, Florida • Dallas, Texas • Edinburg, Texas
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Oct 21, 2026, 6:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Behavioral Interventions to Reduce Heavy Drinking Among MSM in HIV Primary Care

NCT02709759
View directory record Official record
Conditions
Alcohol Drinking, HIV
Interventions
Motivational intervention, Brief Advice, Interactive text messaging
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Male only
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
2
States / cities
Boston, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Oct 21, 2026, 6:16 AM EDT