- Conditions
- Opioid Use Disorder, Overdose, Drug, Overdose, Substance Use (Drugs, Alcohol)
- Interventions
- Community Paramedic Standard of Care (CP SOC), CROSSROADS
- Behavioral
- Lead sponsor
- Duke University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 400 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2030
- U.S. locations
- 4
- States / cities
- Miami, Florida • Boston, Massachusetts • Durham, North Carolina + 1 more
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- Conditions
- Alcohol Use Disorder, Alcohol-associated Liver Disease
- Interventions
- Implementation Intervention
- Behavioral
- Lead sponsor
- Yale University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 30 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2029
- U.S. locations
- 1
- States / cities
- New Haven, Connecticut
- Conditions
- Substance Use Disorders, Alcohol Use Disorder, Opioid Use Disorder
- Interventions
- Not listed
- Lead sponsor
- Boston University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 185,810 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2029
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Opioid-use Disorder, Alcohol Use Disorder
- Interventions
- Not listed
- Lead sponsor
- Boston VA Research Institute, Inc.
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 110 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2023
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Substance Abuse, Risk Reduction, RIsky Sexual Behavior
- Interventions
- Handbook condition, Handbook plus condition
- Behavioral
- Lead sponsor
- Washington State University
- Other
- Eligibility
- 17 Years to 22 Years
- Enrollment
- 910 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2021
- U.S. locations
- 1
- States / cities
- Pullman, Washington
- Conditions
- Mild to Heavy Alcohol Consumption
- Interventions
- Oxycodone
- Other
- Lead sponsor
- University of Washington
- Other
- Eligibility
- 35 Years and older
- Enrollment
- 128 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2015 – 2021
- U.S. locations
- 1
- States / cities
- Seattle, Washington
- Conditions
- Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
- Interventions
- iMET, iMET/TE
- Behavioral
- Lead sponsor
- Boston Children's Hospital
- Other
- Eligibility
- 12 Years to 21 Years
- Enrollment
- 121 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2012
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Alcohol Use, E-cigarette Use, Cigarette Use
- Interventions
- Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks
- Behavioral
- Lead sponsor
- Mark J Rzeszutek, PhD
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 737 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2025
- U.S. locations
- 1
- States / cities
- Lexington, Kentucky
- Conditions
- Substance Use (Drugs, Alcohol)
- Interventions
- ED-SMART intervention, Substance use information
- Behavioral
- Lead sponsor
- Purdue University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 650 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2029
- U.S. locations
- 1
- States / cities
- Columbus, Ohio
- Conditions
- Substance Use Disorders
- Interventions
- Critical Dialogue, Capacity Building Project, Quality of Life Wheel, PF, LC
- Behavioral
- Lead sponsor
- University of Illinois at Urbana-Champaign
- Other
- Eligibility
- 18 Years and older · Male only
- Enrollment
- 602 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2020
- U.S. locations
- 1
- States / cities
- Newark, New Jersey
- Conditions
- Alcohol Abuse, Drug Use, Violence, Domestic, Child Abuse, Diet Modification, Health Behavior, Health Knowledge, Attitudes, Practice, Relationship, Family, Relation, Parent-Child, Emotional Stress
- Interventions
- Weaving Healthy Families Program
- Behavioral
- Lead sponsor
- Tulane University
- Other
- Eligibility
- 5 Years to 120 Years
- Enrollment
- 1,000 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2020 – 2025
- U.S. locations
- 1
- States / cities
- New Orleans, Louisiana
- Conditions
- Alcohol Abuse, Drug Abuse
- Interventions
- Strengthening Families Program (SFP), Family Matters
- Behavioral
- Lead sponsor
- Pacific Institute for Research and Evaluation
- Other
- Eligibility
- 11 Years to 12 Years
- Enrollment
- 1,228 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2005 – 2011
- U.S. locations
- 2
- States / cities
- Berkeley, California • Oakland, California
- Conditions
- Corneal Toxicity, Ototoxicity, Surgical Site Infection
- Interventions
- Not listed
- Lead sponsor
- Mayo Clinic
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 600 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2011 – 2013
- U.S. locations
- 1
- States / cities
- Rochester, Minnesota
- Conditions
- Tobacco Abuse, Alcohol Abuse, Drug Abuse
- Interventions
- Computer Screening, Brief Intervention, Referral toTreatment
- Behavioral
- Lead sponsor
- Boston Children's Hospital
- Other
- Eligibility
- 12 Years to 21 Years
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2013
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Hiv, Alcohol Problem
- Interventions
- Alcohol Brief Intervention (BI), Common Elements Treatment Approach (CETA) via Telemedicine
- Behavioral
- Lead sponsor
- University of Alabama at Birmingham
- Other
- Eligibility
- 18 Years to 99 Years
- Enrollment
- 308 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2026
- U.S. locations
- 1
- States / cities
- Birmingham, Alabama
- Conditions
- Alcohol Use Disorder (AUD), HIV
- Interventions
- semaglutide
- Drug
- Lead sponsor
- Yale University
- Other
- Eligibility
- 18 Years to 99 Years
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- Decatur, Georgia
- Conditions
- Unhealthy Alcohol Use, Alcohol Use Disorder, Alcohol Disorders
- Interventions
- Relational Agent Intervention
- Behavioral
- Lead sponsor
- VA Office of Research and Development
- Federal
- Eligibility
- 18 Years and older
- Enrollment
- 178 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2015 – 2018
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Alcohol Use Disorder
- Interventions
- Emergency Department Initiated Oral Naltrexone
- Drug
- Lead sponsor
- Icahn School of Medicine at Mount Sinai
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2023
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Alcohol Use Disorder With Insomnia
- Interventions
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene Education
- Behavioral
- Lead sponsor
- VA Office of Research and Development
- Federal
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 82 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2025
- U.S. locations
- 2
- States / cities
- Coatesville, Pennsylvania • Philadelphia, Pennsylvania
- Conditions
- Stress Disorders, Post-Traumatic, Substance-Related Disorders
- Interventions
- Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure, Relapse Prevention Treatment, Active Monitoring Control Group
- Behavioral
- Lead sponsor
- The City College of New York
- Other
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 110 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2014
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Tobacco Use Disorder, Alcohol Use Disorder, Drug Use Disorder, Smoking, Alcohol Drinking, Drug Abuse
- Interventions
- Family-Skills Training
- Behavioral
- Lead sponsor
- University of Minnesota
- Other
- Eligibility
- Not listed
- Enrollment
- 800 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2011 – 2015
- U.S. locations
- 1
- States / cities
- Minneapolis, Minnesota
- Conditions
- Substance Use Disorders, Drug Abuse, Alcohol Abuse, Posttraumatic Stress Disorder, PTSD, Recidivism, Depression
- Interventions
- Cognitive Processing Therapy, Control Group
- Behavioral
- Lead sponsor
- University of Arkansas
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 148 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2019 – 2025
- U.S. locations
- 2
- States / cities
- Osceola, Arkansas • West Memphis, Arkansas
- Conditions
- Addictive Behavior, Alcohol Use Disorder, Alcohol Abuse, Drug Abuse, Drug Use Disorders
- Interventions
- Treatment - Workit Health Online Program, Control - Resource List
- Behavioral
- Lead sponsor
- Workit Health
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017
- U.S. locations
- 1
- States / cities
- Ann Arbor, Michigan
- Conditions
- Depression, Anxiety, Substance Use, Stress, Psychological, Stress, Emotional, Alcohol Use, Unspecified, Drug Use, Covid19
- Interventions
- Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell, Internet Cognitive Behavioral Therapy plus CHAMindWell, CHAMindWell
- Behavioral
- Lead sponsor
- Cambridge Health Alliance
- Other
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 113 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2023
- U.S. locations
- 1
- States / cities
- Cambridge, Massachusetts