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Showing 1–24 of 985 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Alcohol or Other Drugs Use Clear all
Completed Not applicable Interventional

Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment

NCT01376570
View directory record Official record
Conditions
HIV, Opiate Dependence
Interventions
Abstinence-reinforcing contingency management intervention, Performance Feedback intervention
Behavioral
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
3
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 2, 2020 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional

Cardiac Surgery Peer Recovery Support Program

NCT03590106
View directory record Official record
Conditions
IV Drug Usage, Infective Endocarditis, Substance Use Disorders
Interventions
Peer Recovery Support Program
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 12, 2019 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Treating Violence-Prone Substance Use Disorder Patients

NCT00700973
View directory record Official record
Conditions
Substance-related Disorders, Violence
Interventions
Interpersonal Violence Prevention Intervention, Usual care
Behavioral · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2015 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing the Leadership and Organizational Change for Implementation (LOCI) Intervention

NCT03042832
View directory record Official record
Conditions
Substance Use Disorder, Mental Health Disorder
Interventions
LOCI, Internet Based Webinar Leadership Training
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
448 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 10, 2021 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Phase 2 Interventional

Risk Reduction for Urban Substance Using Men Who Have Sex With Men (MSM)

NCT01327898
View directory record Official record
Conditions
HIV Infection, Substance Abuse
Interventions
empowerment theory-based small group discussion, individual resilience counseling
Behavioral
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
515 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
2
States / cities
Miami Beach, Florida • Wilton Manors, Florida
Source: ClinicalTrials.gov public record
Updated Jul 24, 2014 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional

Measurement Training and Feedback System: Family-Based Services

NCT03342872
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Core Training: FBS System Mapping and MTFS-I Installation, Core Training & Facilitation: FBS System Mapping and MTFS-I Installation plus monthly on-site meetings
Behavioral
Lead sponsor
The National Center on Addiction and Substance Abuse at Columbia University
Other
Eligibility
12 Years to 21 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Brentwood, New York • Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 2, 2021 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Organization-level Youth Engagement Approach for Substance Misuse Prevention

NCT05736211
View directory record Official record
Conditions
Drug Use, Substance Use, Opioid Use, Substance Misuse
Interventions
Organization-level Youth Engagement prevention strategy
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
11 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 23, 2026, 7:07 AM EDT
Not listed Not applicable Interventional

tDCS and Impulsivity

NCT05845164
View directory record Official record
Conditions
Substance Use Disorders, Substance Abuse, Substance Use
Interventions
tDCS, tDCS Sham
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 79 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 23, 2026, 7:07 AM EDT
Recruiting Not applicable Interventional

HIV, Equity, and Addiction Training (HEAT) Program

NCT06370481
View directory record Official record
Conditions
Substance Use Disorders, Hiv, Opioid Use Disorder, Stimulant Use (Diagnosis)
Interventions
Telemedicine, Standard of care
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implementing Technology-Assisted Drug Treatment and Relapse Prevention in Federally Qualified Health Centers (FQHCs)

NCT01963234
View directory record Official record
Conditions
Substance Use Disorders, HIV
Interventions
Seva
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
439 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
3
States / cities
Missoula, Montana • The Bronx, New York • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 30, 2018 · Synced Sep 23, 2026, 7:07 AM EDT
Completed No phase listed Observational Results available

Strategies to Enhance Recruitment and Retention of Black Individuals Into Clinical Trials for Substance Use Disorders

NCT05124119
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
63 participants
Timeline
2022 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Phase 1 Interventional

Computer-Based Training in Cognitive Behavior Therapy (CBT4CBT)

NCT01406899
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Computer Based Treatment
Behavioral
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Newington, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 22, 2014 · Synced Sep 23, 2026, 7:07 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Successful Transitions and Reintegration Tools for Veterans (START-VETS)

NCT04366531
View directory record Official record
Conditions
Substance Use Disorder, Mental Illness, Recently Incarcerated
Interventions
START-VET, Treatment as usual
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional

Evaluating The Efficacy Of A Mind-Body Intervention In Overcoming Opioid Addiction

NCT03791645
View directory record Official record
Conditions
Opioid Use, Opioid-use Disorder, Substance Use Disorders
Interventions
Sky Intervention
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 70 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional Results available

Secondary HIV Prevention and Adherence Among HIV-infected Drug Users

NCT01741311
View directory record Official record
Conditions
Risk Behavior, Medication Adherence, HIV
Interventions
3H+ (Holistic Health for HIV), HHRP+ (Holistic Health Recovery Program)
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Sep 23, 2026, 7:07 AM EDT
Recruiting Not applicable Interventional

Utilizing Battlefield Acupuncture to Treat Chronic Pain

NCT06128772
View directory record Official record
Conditions
Chronic Pain, Substance Use Disorders
Interventions
Battlefield Acupuncture
Other
Lead sponsor
Edith Nourse Rogers Memorial Veterans Hospital
Federal
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

PrEP at a Syringe Services Program

NCT04782180
View directory record Official record
Conditions
Hiv, Substance Use Disorders
Interventions
Descovy 200Mg 25Mg Tablet, PrEP
Drug · Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Youth to Text or Telehealth for Engagement in HIV Care

NCT03681145
View directory record Official record
Conditions
HIV/AIDS, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Depression, Substance Use
Interventions
Counselor delivered telehealth intervention
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 29 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Sep 23, 2026, 7:07 AM EDT
Recruiting No phase listed Observational

EMS-Initiated Buprenorphine

NCT07475728
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
495 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
Oakland, California • Minneapolis, Minnesota • Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Developing SUPPORT, a Community-Driven, Recovery-Oriented System of Care

NCT03132753
View directory record Official record
Conditions
Substance Use
Interventions
SUPPORT
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 2, 2022 · Synced Sep 23, 2026, 7:07 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluating MyPath to Enhance Reproductive Autonomy and Liberate Decision-making

NCT04627805
View directory record Official record
Conditions
Substance Use Disorders, Reproductive Issues, Contraception
Interventions
MyPath tool
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 13, 2022 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional

Juvenile Justice Translational Research on Interventions for Adolescents in the Legal System

NCT02672150
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Core, Enhanced
Behavioral
Lead sponsor
Chestnut Health Systems
Other
Eligibility
Not listed
Enrollment
839 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
8
States / cities
Atlanta, Georgia • Bloomington, Illinois • Lexington, Kentucky + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 23, 2026, 7:07 AM EDT
Completed Not applicable Interventional Results available

Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations

NCT05286879
View directory record Official record
Conditions
Opioid Use Disorder, Infectious Disease, Risk Reduction Behavior, Substance Use, Substance Abuse, Stimulant Use Disorder
Interventions
Patient Navigator, Mobile Health Unit
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
601 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
3
States / cities
New Haven, Connecticut • Dallas, Texas • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 23, 2026, 7:07 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Study on the Impact of Patient Navigators on the Health Education and Quality of Life in Formerly Incarcerated Patients

NCT02259634
View directory record Official record
Conditions
HIV/AIDS, Diabetes Mellitus, Hypertension, Substance Use
Interventions
Patient Navigation
Behavioral
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2015 · Synced Sep 23, 2026, 7:07 AM EDT