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ClinicalTrials.gov public records Last synced Oct 2, 2026, 11:22 PM EDT

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Showing 73–96 of 988 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol or Other Drugs Use Clear all
Recruiting Not applicable Interventional

Prevent Language Delays and Disorders Among Children of Caregivers With Substance Use Disorders With Community Groups and Individualized Services

NCT07529327
View directory record Official record
Conditions
Language Delay, Substance Use Disorders, Language Disorders in Children, Language Development, Prevention Intervention
Interventions
Comilia Group, Interaction Review Enhancement, Practical Support Enhancement
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
18 Years and older
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 2, 2026, 11:22 PM EDT
Active, not recruiting Not applicable Interventional

Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use

NCT06682468
View directory record Official record
Conditions
Substance Use Disorders, HIV
Interventions
Population level patient portal based substance involvement screening, Usual Care Substance Use Involvement Screening
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Controlled Trial of Patient Centered Telepsychiatry Interventions

NCT02084979
View directory record Official record
Conditions
Mood Disorder, Anxiety Disorder, Substance Use Disorder
Interventions
telepsychiatry evaluation
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
3
States / cities
Auburn, California • Sacramento, California • West Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 11, 2019 · Synced Oct 2, 2026, 11:22 PM EDT
Recruiting Not applicable Interventional

Neuroimaging of Adolescent Cannabis Use Treatment

NCT07340554
View directory record Official record
Conditions
Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse, Cannabis Intoxication, Cannabis Smoking, Cannabis Withdrawal, Cannabis-Related Disorder, Cannabis Abuse, in Remission, Cannabis Abuse, Episodic Use, Marijuana, Marijuana Abuse, Marijuana Use, Marijuana Smoking, Marijuana Dependence, Marijuana User, Marijuana-Related Disorder, Marijuana Use Disorder, Addiction, Addiction, Substance, Substance Use, Substance Use Disorders, Substance Dependence, Substance Abuse, Substance Related Problem, Substance Abuse Drug Chronic
Interventions
Contingency Management, Elastic Net Regression
Behavioral · Device
Lead sponsor
Indiana University
Other
Eligibility
14 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 2, 2026, 11:22 PM EDT
Active, not recruiting Not applicable Interventional

Clinic-level Implementation of mHealth to Improve HIV Viral Suppression for Patients With Substance Use Disorders

NCT06109571
View directory record Official record
Conditions
HIV Infections, Substance Use Disorders
Interventions
Connections App
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
433 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
8
States / cities
Denver, Colorado • Kansas City, Missouri • St Louis, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Not applicable Interventional Results available

Brief Intervention for Justice-Involved Substance Users

NCT03308877
View directory record Official record
Conditions
Substance Use, Violence
Interventions
BMI, Stadard Care (SC)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
2
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Not applicable Interventional

Inpatient Link to Addiction Recovery

NCT04098601
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Recovery Coach Intervention
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 4, 2024 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Not applicable Interventional

Integrating Substance Abuse Assessment & Intervention in Primary Care Settings

NCT01751672
View directory record Official record
Conditions
Drug Use, Alcohol Use
Interventions
SBIRT+
Behavioral
Lead sponsor
Treatment Research Institute
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
3
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 28, 2023 · Synced Oct 2, 2026, 11:22 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Gii'Igoshimong: Sitting With Your First Family

NCT07075081
View directory record Official record
Conditions
Substance Use, Mental Health Issue
Interventions
Ceremony
Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Duluth, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Not applicable Interventional

Impact of Work Activity on SUD Outcomes

NCT04969081
View directory record Official record
Conditions
Substance-related Disorders
Interventions
referral to work focused program, treatment as usual
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 2, 2026, 11:22 PM EDT
Recruiting Not applicable Interventional

Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

NCT07214467
View directory record Official record
Conditions
Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Interventions
Deep Brain Stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Not applicable Interventional

Enhancing Early-Phase Care for Primary Care Patients With Unhealthy Substance Use

NCT01887665
View directory record Official record
Conditions
Substance Use Disorders
Interventions
incentives
Behavioral
Lead sponsor
Brandeis University
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Oct 2, 2026, 11:22 PM EDT
Terminated Not applicable Interventional

ENTRUST - Economic Navigation and Strengthening to Realize Unrestricted Services for Transgender Women

NCT06667713
View directory record Official record
Conditions
Substance Use Disorder (SUD), HIV
Interventions
ENTRUST - substance use and HIV counseling and goal setting with economic empowerment and photovoice training, SBIRT-T only
Behavioral
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years and older · Male only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Phase 1 Interventional

Substance Use Prevention in Teen Psychiatric Patients

NCT01170013
View directory record Official record
Conditions
Adolescent Substance Use
Interventions
Family Check-up, Parent psychoeducation
Behavioral
Lead sponsor
Brown University
Other
Eligibility
12 Years to 16 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 31, 2012 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Not applicable Interventional

Expanding Reach of Evidence-based Psychotherapy for Veterans With Co-occurring Anxiety and Substance Use Disorders.

NCT05372185
View directory record Official record
Conditions
Anxiety Disorders, Substance Use Disorders
Interventions
VA Coordinated Anxiety Learning and Management- Substance Use Version, Usual care
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Preventing Drug Abuse Among Sexual Minority Youth

NCT03954535
View directory record Official record
Conditions
Substance Abuse
Interventions
Free2b, Attention-Placebo
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
15 Years to 17 Years
Enrollment
1,216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Oct 2, 2026, 11:22 PM EDT
Not listed Not applicable Interventional

Floatation-REST in Methamphetamine Use Disorder: A Pilot Study

NCT05799209
View directory record Official record
Conditions
Amphetamine-Type Substance Use Disorder
Interventions
Float Pool, Float Chair
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 6, 2023 · Synced Oct 2, 2026, 11:22 PM EDT
Terminated Phase 4 Interventional Results available

Buprenorphine as a Treatment in Opiate Dependent Pain Patients

NCT00552578
View directory record Official record
Conditions
Opiate Addiction, Refractory Pain
Interventions
buprenorphine/naloxone
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2011 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Early Intervention for Minors in Possession of Alcohol/Drugs: A Feasibility Study

NCT01616212
View directory record Official record
Conditions
Substance Use Disorder, Delinquency
Interventions
Motivational Enhancement Therapy /Adol and PW for parents, Motivational Enhancement Therapy for adolescents, Drug Education for adolescents, Parenting Wisely for parents, Drug Education for adolescents
Other
Lead sponsor
Oregon Research Institute
Other
Eligibility
13 Years to 17 Years
Enrollment
239 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 10, 2014 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Not applicable Interventional Results available

Varenicline and Motivational Advice for Smokers With Substance Use Disorders

NCT00756275
View directory record Official record
Conditions
Smoking Cessation, Nicotine Dependence
Interventions
Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
Drug · Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 75 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 2, 2026, 11:22 PM EDT
Not yet recruiting Phase 2 Interventional

Randomized Controlled Trial of Tirzepatide for Methamphetamine Use Disorder

NCT07825857
View directory record Official record
Conditions
Methamphetamine Use Disorder
Interventions
Tirzepatide, Placebo (saline)
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
4
States / cities
Los Angeles, California • San Francisco, California • Tulsa, Oklahoma + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 2, 2026, 11:22 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Disrupting SRFOH to Improve Substance Use and Mental Health Outcomes for Parents in Rural Regions

NCT06560866
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Just Care for Families
Behavioral
Lead sponsor
Chestnut Health Systems
Other
Eligibility
Not listed
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 2, 2026, 11:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Collaborating to Implement Cross-System Interventions in Child Welfare and Substance Use

NCT03931005
View directory record Official record
Conditions
Substance Use, Implementation, Child Maltreatment, System Fragmentation
Interventions
Collaboration Decision Support Guide
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 2, 2026, 11:22 PM EDT
Suspended Not applicable Interventional

Co-Active Therapeutic Theatre (Co-ATT) for Dual-Diagnosis Patients

NCT06187701
View directory record Official record
Conditions
Mental Health Issue, Substance Use Disorders
Interventions
Co-Active Therapeutic Theatre (Co-ATT)
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 2, 2026, 11:22 PM EDT