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Showing 1–24 of 141 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Alteration of Cognitive Function Clear all
Completed Not applicable Interventional

Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly

NCT00212147
View directory record Official record
Conditions
Avitaminosis, Delirium, Dementia, Amnestic, Cognitive Disorders
Interventions
General anesthesia with nitrous oxide, General anesthesia without nitrous oxide
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
60 Years and older
Enrollment
444 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
2
States / cities
Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 4, 2026, 5:16 AM EDT
Recruiting Not applicable Interventional

Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

NCT05457725
View directory record Official record
Conditions
Aging, Cognitive Change, Neurocognitive Disorders, Mild
Interventions
Contingent rtfMRI neurofeedback training, Non-contingent/sham rtfMRI neurofeedback training
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 100 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Head Impact Exposure in Hawaii High School Football

NCT04020874
View directory record Official record
Conditions
Head Trauma, Cognitive Change, Confidence, Self, Sports Injuries in Children
Interventions
HuTT-2x, HuTT-4x
Behavioral
Lead sponsor
University of Massachusetts, Lowell
Other
Eligibility
14 Years to 19 Years
Enrollment
496 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Dec 4, 2023 · Synced Sep 4, 2026, 5:16 AM EDT
Completed No phase listed Observational

Cognitive Changes in Adult Cancer Survivors

NCT01569932
View directory record Official record
Conditions
Effects of Chemotherapy, Cognitive Impairment
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
40 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 25, 2013 · Synced Sep 4, 2026, 5:16 AM EDT
Terminated Not applicable Interventional

Exercise and Learning and Memory in Multiple Sclerosis

NCT03319771
View directory record Official record
Conditions
Multiple Sclerosis, Physical Activity, Memory Impairment, Cognitive Change
Interventions
Treadmill Walking Exercise Training, Stretching-and-toning Exercise Training
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 54 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 10, 2021 · Synced Sep 4, 2026, 5:16 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Chemotherapy-Induced Changes to Cognition and DNA in Breast Cancer Survivors

NCT00496613
View directory record Official record
Conditions
Breast Cancer, Long-Term Survivors
Interventions
Mini-Mental State Exam and Blood Draw
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
50 Years to 70 Years · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2022
U.S. locations
3
States / cities
Commack, New York • New York, New York • Rockville Centre, New York
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Sep 4, 2026, 5:16 AM EDT
Recruiting Not applicable Interventional

Remote Evaluation of MIND Diet

NCT06450977
View directory record Official record
Conditions
Multiple Sclerosis, Cognitive Change, Nutrition, Healthy
Interventions
MIND Diet, Control Diet
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 64 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Sep 4, 2026, 5:16 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Mindfulness Training for Senior Leaders

NCT04576832
View directory record Official record
Conditions
Cognitive Change
Interventions
Mindfulness-Based Attention Training (MBAT) web-course
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Jun 27, 2024 · Synced Sep 4, 2026, 5:16 AM EDT
Not listed Not applicable Interventional

Non-exercise Physical Activity Intervention

NCT04410055
View directory record Official record
Conditions
Diabete Mellitus, Aging, Cognitive Change
Interventions
Sitting, Static standing, Dynamic standing
Behavioral
Lead sponsor
Science and Research Centre Koper
Other
Eligibility
65 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 31, 2020 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of PeakATP on Mood, Reaction Time and Cognition

NCT05100589
View directory record Official record
Conditions
Cognitive Change, Mood
Interventions
PeakATP, Placebo
Dietary Supplement
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Mirtoselect®, Virtiva®, and Enovita® on Cognitive Performance and Mood States

NCT06309914
View directory record Official record
Conditions
Mental Processes, Cognitive Change, Mood Change
Interventions
Placebo, Enovita Grape Seed Extract, Mirtoselect Bilberry Extract, Virtiva Plus Ginko Biloba Extract
Dietary Supplement
Lead sponsor
Applied Science & Performance Institute
Industry
Eligibility
25 Years to 55 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dairy Based Probiotic Intervention and Cognitive, Emotional, and Inflammatory Outcomes

NCT04643080
View directory record Official record
Conditions
Cognitive Decline, Cognitive Change, Inflammation, Emotions
Interventions
Yogurt
Other
Lead sponsor
University of Idaho
Other
Eligibility
50 Years and older
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
4
States / cities
Boise, Idaho • Coeur d'Alene, Idaho • Pocatello, Idaho + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Working Memory Training for People Aging With HIV

NCT06699927
View directory record Official record
Conditions
Cognitive Change
Interventions
Span
Behavioral
Lead sponsor
Northeastern University
Other
Eligibility
50 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of a Fermented Soy Product on Cognition, Immune Status and Vaccine

NCT04866576
View directory record Official record
Conditions
Cognitive Change, Inflammation, Immune Response
Interventions
Q CAN PLUS, Placebo
Dietary Supplement
Lead sponsor
Loma Linda University
Other
Eligibility
65 Years to 80 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Effectiveness of a Cognitive Behavioral Intervention (CBI)

NCT05782348
View directory record Official record
Conditions
Adolescent Behavior, Dental Plaque, Gingivitis, Cognitive Change
Interventions
Cognitive behavioral intervention, Colgate smart toothbrush
Behavioral · Other
Lead sponsor
Howard University
Other
Eligibility
14 Years to 17 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Phase 2 Interventional Results available

Improving Cognitive Health in COVID-19 Survivors

NCT04843930
View directory record Official record
Conditions
Cognitive Dysfunction, Covid19
Interventions
AKL-T01
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 89 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Sep 4, 2026, 5:16 AM EDT
Active, not recruiting No phase listed Observational

DIAMOND-Lewy Guidelines for Antipsychotic Use in Older Patients

NCT06357195
View directory record Official record
Conditions
Emergency Psychiatric, Cognition Disorder, Movement Disorders, Antipsychotics and Neuroleptics Toxicity, Dementia With Lewy Bodies, Alteration in Mental Status, Behavior, Aging
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
54 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced Sep 4, 2026, 5:16 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Interventions in Mathematics and Cognitive Skills

NCT05201534
View directory record Official record
Conditions
Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities, Learning Disabled, Learning Curve, Mathematics Disorder, Dyscalculia, Dyscalculia, Primary, Dyscalculia, Acquired, Specific Learning Disorder, With Impairment in Mathematics, Individuality, Behavior, Child, Behavior and Behavior Mechanisms, Behavior, Decision Making, Neuronal Plasticity, Cognition, Cognition Disorder, Cognitive Dysfunction, Cognitive Change, Cognitive Impairment, Mild, Cognitive Developmental Delay, Cognitive Orientation, Cognitive Delay, Mild, Cognitive Deficits, Mild, Cognitive Abnormality, Neuroscience
Interventions
Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
Other
Lead sponsor
Stanford University
Other
Eligibility
6 Years to 12 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Peripheral Vision Training Study

NCT03141164
View directory record Official record
Conditions
Visual Impairment, Cognitive Change
Interventions
computerized training
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 89 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 7, 2021 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

NAD+ Oral Supplement Pilot Intervention in Adult Females

NCT06579209
View directory record Official record
Conditions
Cognitive Change, Inflammation, Neurodegenerative Diseases
Interventions
Treatment, Placebo
Dietary Supplement · Other
Lead sponsor
University of Rhode Island
Other
Eligibility
40 Years to 80 Years · Female only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Kingston, Rhode Island • Pawtucket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Results available

Computerized Cognitive Training in Breast Cancer Survivors

NCT05570604
View directory record Official record
Conditions
Breast Cancer, Cognitive Change, Cognitive Impairment, Quality of Life
Interventions
Sweep Seeker, Bird Safari, Jewel Diver, Master Gardener, Road Tour, Computerized Crossword Puzzles
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
21 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 23, 2025 · Synced Sep 4, 2026, 5:16 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

SPARK Healthy Sleep

NCT07119268
View directory record Official record
Conditions
Schizophrenia and Related Disorders, Sleep Disturbance
Interventions
SPARK Healthy Sleep
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep, Diet, Exercise and Older Persons

NCT05735353
View directory record Official record
Conditions
Cognitive Change, Cognitive Decline
Interventions
High-Speed Circuit Resistance Training, High-Speed Multidirectional Yoga
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
60 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 4, 2026, 5:16 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

HomeStyles-2: Shaping HOME Environments and LifeSTYLES to Prevent Childhood Obesity

NCT04802291
View directory record Official record
Conditions
Healthy Lifestyle, Home Environment Related Disease, Cognitive Change, Child Behavior, Child Obesity, Parenting, Parents, Parent-Child Relations
Interventions
HomeStyles-2: Obesity Prevention Program for Families with Children in Middle Childhood
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
24 Years to 50 Years
Enrollment
459 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 4, 2026, 5:16 AM EDT