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Showing 25–42 of 18 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Altitude Sickness Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy

NCT03154645
View directory record Official record
Conditions
Acute Mountain Sickness
Interventions
Ibuprofen, Acetazolamide
Drug
Lead sponsor
Grant S Lipman
Other
Eligibility
18 Years to 65 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Bishop, California
Source: ClinicalTrials.gov public record
Updated Nov 25, 2018 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude

NCT04111263
View directory record Official record
Conditions
Gastrointestinal Injury, Acute Mountain Sickness
Interventions
FP, Placebo, High altitude, Sea level
Dietary Supplement · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Sep 23, 2026, 3:27 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude

NCT07517068
View directory record Official record
Conditions
Hypoxemia, Acute Mountain Sickness (AMS), Inflammation, Immune Response
Interventions
ACETAZOLAMIDE oral capsule, Placebo Arm
Drug · Device
Lead sponsor
University of California, Riverside
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 23, 2026, 3:27 AM EDT
Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Advair HFA in Healthy and HAPE Predisposed Subjects

NCT06040268
View directory record Official record
Conditions
Altitude Edema
Interventions
Advair HFA, Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Safety and Efficacy of T89 in the Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)

NCT04993729
View directory record Official record
Conditions
Acute Mountain Sickness (AMS)
Interventions
T89 capsule, Placebo capsule
Drug
Lead sponsor
Tasly Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
853 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Overnight Low Oxygen Exposure on Energy Balance

NCT04151927
View directory record Official record
Conditions
Resting Metabolic Rate, Appetite, Heart Rate Variability
Interventions
Normobaric Hypoxia, Normobaric Normoxia
Device
Lead sponsor
Florida State University
Other
Eligibility
20 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Nov 28, 2021 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude

NCT02024386
View directory record Official record
Conditions
Hypertension, Pulmonary, Altitude Sickness
Interventions
Riociguat
Drug
Lead sponsor
Richard Moon
Other
Eligibility
18 Years to 40 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 11, 2017 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Safety Evaluation of Aminophylline and Methazolamide

NCT01587027
View directory record Official record
Conditions
Mountain Sickness
Interventions
Aminophylline, Methazolamide, Aminophylline and Methazolamide
Drug
Lead sponsor
Poudre Valley Health System
Other
Eligibility
18 Years to 40 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Loveland, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 9, 2017 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Oxygen Transport in Normobaric vs. Hypobaric Hypoxia

NCT03335917
View directory record Official record
Conditions
Hypoxia, Altitude, Exercise
Interventions
Hypoxia, Exercise
Other
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of Pioglitazone on Exogenous Carbohydrate Oxidation During Steady-State Exercise at High Altitude

NCT06164665
View directory record Official record
Conditions
High Altitude
Interventions
Pioglitazone 15mg, Placebo
Drug · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 39 Years · Male only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

High Altitude and Exogenous Carbohydrate Oxidation

NCT03851744
View directory record Official record
Conditions
Glucose Metabolism, High Altitude
Interventions
Sea Level, High Altitude
Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 39 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 1, 2021 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Mild Hypobaric Hypoxia on Sleep and Post-sleep Performance

NCT00498563
View directory record Official record
Conditions
Altitude, Hypoxia, Environmental Sleep Disorder
Interventions
altitude exposure in hypobaric chamber
Procedure
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
30 Years to 60 Years · Male only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 23, 2015 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude.

NCT03368352
View directory record Official record
Conditions
Altitude Hypoxia, Ventilation, Sleep, Oxidative Stress, Neurocognitive Dysfunction
Interventions
Melatonin, Hypoxia
Dietary Supplement · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2019 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDS) on Acclimatization to High Altitude

NCT02233582
View directory record Official record
Conditions
High Altitude
Interventions
Ibuprofen, Sugar pill
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
2
States / cities
Bishop, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 5, 2021 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing

NCT01993667
View directory record Official record
Conditions
Prophylaxis of Acute Mountain Sickness
Interventions
Low Dose Acetazolamide, Normal Dose Acetazolamide
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 28, 2019 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Colorado-Oregon Altitude Study

NCT05734716
View directory record Official record
Conditions
Acute Mountain Sickness
Interventions
Erythropoietin, Iron sucrose (Venofer), Sterile Sodium Chloride
Drug
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 40 Years
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
2
States / cities
Leadville, Colorado • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 9, 2023 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Test the Safety of Combined Dosing With Aminophylline and Ambrisentan in Exercising Healthy Human Volunteers at Simulated High Altitude

NCT01794078
View directory record Official record
Conditions
Acute Mountain Sickness and Fatigue
Interventions
Aminophylline 400 mg, Ambrisentan 5 mg, Placebo
Drug · Other
Lead sponsor
Robert J Noveck, M.D.
Other
Eligibility
18 Years to 50 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 12, 2015 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Decompression Tables for Diving at Altitude

NCT03390335
View directory record Official record
Conditions
Decompression Sickness, Acute Mountain Sickness
Interventions
Pressure, Breathing Gas
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 40 Years
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Sep 23, 2026, 3:27 AM EDT