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ClinicalTrials.gov public records Last synced Oct 3, 2026, 4:13 PM EDT

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Showing 25–48 of 141 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Amputation, Limb Loss Clear all
Completed Not applicable Interventional

Self-Management Program for Persons With Limb Loss

NCT00198692
View directory record Official record
Conditions
Amputation, Depression, Pain, Anxiety
Interventions
self-management
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years to 85 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 28, 2008 · Synced Oct 3, 2026, 4:13 PM EDT
Completed Not applicable Interventional Results available

Evaluation of a Modified Running-specific Prosthetic Foot

NCT02440711
View directory record Official record
Conditions
Transtibial Amputation
Interventions
Energy storing foot (ESF), Modified running specific foot (mRSF)
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 2, 2023 · Synced Oct 3, 2026, 4:13 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Active Knee Prosthesis Study for Improvement of Locomotion for Above Knee Amputees

NCT00771589
View directory record Official record
Conditions
Amputation
Interventions
Active Knee Prosthesis
Device
Lead sponsor
Providence VA Medical Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
2
States / cities
Cambridge, Massachusetts • North Andover, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2008 · Synced Oct 3, 2026, 4:13 PM EDT
Withdrawn Not applicable Interventional

Evaluation of a Multi-electrode Prosthesis Control System for Real-world Tasks Performance in Individuals With Upper Limb Transradial Amputation

NCT07071584
View directory record Official record
Conditions
Upper Limb Amputation Below Elbow
Interventions
Cutaneous Prosthesis Control System
Device
Lead sponsor
Phantom Neuro Inc.
Industry
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Buffalo, New York • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 3, 2026, 4:13 PM EDT
Terminated Not applicable Interventional Results available

Investigation on a New Power Knee Firmware Update on Gait and Daily Life Activities for Transfemoral Amputees

NCT06620861
View directory record Official record
Conditions
Amputation, Transfemoral Amputation
Interventions
Power Knee Firmware Update, Power Knee Current Marketed Firmware
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Bay City, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 30, 2026 · Synced Oct 3, 2026, 4:13 PM EDT
Terminated Not applicable Interventional Results available

Neuromodulation in Lower Limb Amputees

NCT04543786
View directory record Official record
Conditions
Amputation, Phantom Limb Pain, Hoffman's Reflex
Interventions
Transcutaneous spinal cord stimulation
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
21 Years to 70 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 3, 2026, 4:13 PM EDT
Recruiting Not applicable Interventional

R21: An Easy-to-use, iNtelligent, Affordable LinEr (ENABLE) System for Socket Fit Assessment

NCT05425810
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury)
Interventions
Apply ENABLE sensing pad, Insert small pads at pressure tolerant locations
Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 99 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Oct 3, 2026, 4:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Upper Limb Loss Perturbation Response

NCT04274218
View directory record Official record
Conditions
Amputation
Interventions
Perturbation
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 14, 2024 · Synced Oct 3, 2026, 4:13 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Motor Learning in Individuals With Lower Limb Loss and Chronic Diabetes

NCT03989063
View directory record Official record
Conditions
Amputation, Diabetes Mellitus, Neuropathy, Diabetic
Interventions
Instructions to perform a motor task (external vs. internal focus instructions)
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Oct 3, 2026, 4:13 PM EDT
Completed Not applicable Interventional

e-OPRA Implant System for Lower Limb Amputees

NCT03720171
View directory record Official record
Conditions
Amputation
Interventions
e-OPRA Implant System
Device
Lead sponsor
Integrum
Industry
Eligibility
22 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Oct 3, 2026, 4:13 PM EDT
Recruiting Not applicable Interventional

Feasibility of Neural Feedback for Lower Limb Amputees

NCT03409133
View directory record Official record
Conditions
Amputation
Interventions
Stimulating nerve electrodes and intramuscular recording electrodes
Device
Lead sponsor
Louis Stokes VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 3, 2026, 4:13 PM EDT
Completed Phase 1Phase 2 Interventional

Improving Outcomes Following Limb Loss: PALS Plus

NCT00447655
View directory record Official record
Conditions
Amputation
Interventions
Self-management and peer support
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 85 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 13, 2017 · Synced Oct 3, 2026, 4:13 PM EDT
Not listed Phase 2 Interventional

Prosthetic Limbs After Leg Amputation: Alternative Method of Socket Design

NCT00061217
View directory record Official record
Conditions
Amputation
Interventions
Unrectified prosthetic socket, Rectified prosthetic socket
Device
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 3, 2026, 4:13 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Falls in Older Persons With Limb Loss

NCT03670004
View directory record Official record
Conditions
Amputation, Elderly
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 85 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 7, 2022 · Synced Oct 3, 2026, 4:13 PM EDT
Completed Not applicable Interventional

Vascularized Composite Allotransplantation of the Hand and Upper Extremity (Hand Transplant)

NCT02165865
View directory record Official record
Conditions
Traumatic Amputation of Arm, Traumatic Amputation of Hand
Interventions
upper extremity/ hand transplantation
Procedure
Lead sponsor
Southern Illinois University
Other
Eligibility
18 Years to 69 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
3
States / cities
Springfield, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 2, 2019 · Synced Oct 3, 2026, 4:13 PM EDT
Recruiting Not applicable Interventional

Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

NCT06937242
View directory record Official record
Conditions
Amputation, Prosthesis User, Amputation; Traumatic, Leg: Thigh, Between Hip and Knee, Limb; Absence, Congenital, Lower, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Above Knee
Interventions
Ottobock C-Leg 4 Microprocessor Knee, Ottobock Kenevo
Device
Lead sponsor
Hanger Institute for Clinical Research and Education, LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 3, 2026, 4:13 PM EDT
Completed No phase listed Observational

Study of Medial-Lateral Center of Pressure Displacement in Unilateral Transfemoral Amputees

NCT02299674
View directory record Official record
Conditions
Unilateral Transfemoral Amputation
Interventions
Level overground ambulation
Other
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Oct 3, 2026, 4:13 PM EDT
Completed Not applicable Interventional

Prosthetic Socket Interface Design on Socket Comfort, Residual Limb Health, and Function for the Transfemoral Amputee

NCT02773056
View directory record Official record
Conditions
Amputation
Interventions
Ischial Ramus Containment (IRC), Dynamic Socket Ischial Ramus Containment (IRC), Sub-Ischial Interface (Sub-I)
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 44 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 3, 2018 · Synced Oct 3, 2026, 4:13 PM EDT
Completed Not applicable Interventional Results available

Functional Outcomes in Dysvascular Transfemoral Amputees

NCT01537211
View directory record Official record
Conditions
Transfemoral Amputation, Unilateral Traumatic Amputation of Leg at or Above Knee
Interventions
C leg compared to subject's mechanical leg (Otto Bock)
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 6, 2019 · Synced Oct 3, 2026, 4:13 PM EDT
Completed No phase listed Observational

Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles Tendon

NCT01382628
View directory record Official record
Conditions
Diabetic Foot Ulcers, Equinus Deformity
Interventions
Not listed
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Oct 3, 2026, 4:13 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Novel Transfemoral Prosthetic Socket System

NCT01846845
View directory record Official record
Conditions
Lower Limb Amputation
Interventions
Conventional Prosthetic Transfemoral Socket System, Novel Prosthetic transfemoral socket system
Device
Lead sponsor
Ohio Willow Wood
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Columbus, Ohio • Mount Sterling, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 1, 2013 · Synced Oct 3, 2026, 4:13 PM EDT
Completed Not applicable Interventional

Spinal Root and Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees

NCT03027947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Oct 3, 2026, 4:13 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Investigation of Embodiment for Upper Limb Amputees

NCT04578327
View directory record Official record
Conditions
Amputation
Interventions
Prosthetic hand, Peripheral Nerve Interface
Device · Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 3, 2026, 4:13 PM EDT
Recruiting Not applicable Interventional

Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation

NCT06840262
View directory record Official record
Conditions
Amputation
Interventions
Questionnaire Administration, Regenerative Peripheral Nerve Interface Surgery, Targeted Muscle Reinnervation
Other · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 3, 2026, 4:13 PM EDT