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Showing 1–24 of 178 matching trials from the live ClinicalTrials.gov search.
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Conditions
Mastectomy, Upper Limb Amputation Below Elbow, Upper Limb Amputation Above Elbow, Lower Limb Amputation Below Knee, Lower Limb Amputation Above Knee, Knee Arthropathy, Shoulder Arthroplasty, Rotator Cuff Repair, Video-Assisted Thoracoscopic Surgery (VATS), Skin Grafting
Interventions
Cryoneurolysis (active), Sham cryoneurolysis procedure
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
San Diego, California
Conditions
Phantom Limb Pain After Amputation, Lower Limb Amputation, Upper Limb Amputation, Phantom Pain, Chronic Pain
Interventions
Operant Conditioning with Peripheral Stimulation, Control Group with Peripheral Stimulation Only
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Albany, New York
Conditions
Phantom Limb Pain
Interventions
Graded motor imagery mobile app
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Minneapolis, Minnesota
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Outcomes Assessment of the C-Leg With a New Knee Prosthesis

NCT01473992
Conditions
Other and Unspecified Complications of Amputation Stump
Interventions
Otto Bock C-Leg, Otto Bock Genium
Device
Lead sponsor
Jason Highsmith
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Tampa, Florida
Conditions
Limb Amputation, Extremity Amputation
Interventions
Limb transplantation
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions
Ischemic Conditioning Low - Sham Comparator, Ischemic Conditioning High - Active Comparator
Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Limb Health Associated With a Prosthetic Vacuum Socket System

NCT01839123
Conditions
Lower Limb Amputation
Interventions
Prosthetic Suction or Pin Socket, Prosthetic LimbLogic Vacuum Socket
Device
Lead sponsor
Ohio Willow Wood
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Columbus, Ohio • Mount Sterling, Ohio
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
10
States / cities
San Francisco, California • Tampa, Florida • Baltimore, Maryland + 7 more
Conditions
Diabetes, Foot Ulcer
Interventions
Tailored Intervention (TI), Current Practice (CP)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years and older
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
New York, New York
Conditions
Amputation, Anesthesia, Local, Opioid Use
Interventions
Liposomal bupivacaine
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Conditions
Amputation; Traumatic, Leg, Lower
Interventions
Tap dance program
Other
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Las Vegas, Nevada
Completed Not applicable Interventional Accepts healthy volunteers

Adaptive Recalibration of Prosthetic Leg Neural Control System

NCT02355912
Conditions
Amputation
Interventions
Powered knee and ankle prosthesis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Powered ankle-foot prosthesis
Device
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2020
U.S. locations
1
States / cities
Boulder, Colorado
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Investigation of Motorized Lower-limb Prostheses

NCT07584707
Conditions
Ambulation With the "Take Home" or Passive Prosthesis, Ambulation With the Motorized Prosthesis in the "Off" Configuration, Ambulation With the Motorized Prosthesis in the "Transparent" Condition, Ambulation With the Motorized Prosthesis in the "Powered" Condition
Interventions
Passive prosthesis, Motorized prosthesis
Device
Lead sponsor
Northern Arizona University
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Flagstaff, Arizona
Conditions
Amputation
Interventions
Clinical Descriptive Measures related to amputation collected, GPS device education/distributed, activPAL device education/distributed, Questionnaire Assessments completed
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Withdrawn Not applicable Interventional Accepts healthy volunteers

Targeted Muscle Reinnervation Study (TMR)

NCT05408520
Conditions
Amputation
Interventions
Targeted Muscle Reinnervation
Procedure
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 99 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Conditions
Foot Ulcers, Osteomyelitis, Amputation
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Dallas, Texas
Conditions
Peripheral Vascular Disease
Interventions
Ecraprost in lipid emulsion
Drug
Lead sponsor
Tanabe Pharma Corporation
Industry
Eligibility
40 Years and older
Enrollment
560 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
20
States / cities
Phoenix, Arizona • Tucson, Arizona • Glendale, California + 17 more
Conditions
Lower Extremity Amputation
Interventions
Torsionally adaptive prosthesis with 0:1 coupling ratio, Torsionally adaptive prosthesis with 1:6 coupling ratio, Torsionally adaptive prosthesis with 1:4 coupling ratio, Torsionally adaptive prosthesis with 1:3 coupling ratio, Torsionally adaptive prosthesis with 1:2 coupling ratio
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Completed Not applicable Interventional Results available

Dysvascular Amputation Self-Management of Health

NCT04083456
Conditions
Amputation, Diabetes Mellitus, Peripheral Artery Disease
Interventions
Walking Biobehavioral Intervention, Attention Control
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Terminated Phase 1Phase 2 Interventional Results available

Hyperbaric Oxygen and Outcome After Below Knee Amputations

NCT04717557
Conditions
Amputation; Postoperative, Sequelae
Interventions
Hyperbaric Oxygen
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Amputation, Amputation; Postoperative, Sequelae, Wound Dehiscence, Seroma, Wound Infection, Surgical, Lymph Leakage
Interventions
PREVENA™ PEEL & PLACE™ Dressing Kit
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
272 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
2
States / cities
Valhalla, New York • Philadelphia, Pennsylvania
Recruiting Not applicable Interventional

Impact of Improving Footwear Options

NCT05601869
Conditions
Amputation
Interventions
RECOVER Prosthetic Ankle-Feet System
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Lower Extremity Amputation
Interventions
Coached group, Self-directed control group, Screened only
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 69 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Seattle, Washington