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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Amputation Clear all
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Metabolic Cost Savings for Transtibial Amputees Wearing the Controlled Energy Storage and Return (CESR) Foot

NCT00494143
View directory record Official record
Conditions
Transtibial Amputation
Interventions
CESR Prosthetic Foot, typical prosthetic foot, standardized prosthetic foot
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 8, 2014 · Synced Sep 9, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Targeted Reinnervation for Neuromas as a Means to Improve Prosthesis Control in Major Limb Amputation

NCT02316262
View directory record Official record
Conditions
Neuroma, Pain, Prosthesis User, Prosthesis Failure
Interventions
Targeted Muscle Reinnervation
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 85 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
6
States / cities
Chicago, Illinois • Bethesda, Maryland • Columbus, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 2, 2018 · Synced Sep 9, 2026, 1:51 AM EDT
Completed Not applicable Interventional Results available

Biomechanical Evaluation of a Novel, Compliant Low Profile Prosthetic Foot

NCT06468059
View directory record Official record
Conditions
Amputation
Interventions
Layered Low Profile Foot, Prescribed Ankle
Device
Lead sponsor
Little Room Innovations, LLC
Industry
Eligibility
18 Years to 89 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Kennesaw, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 9, 2026, 1:51 AM EDT
Completed Not applicable Interventional Results available

Comparative Performance of Dynamic Elastic Response Feet

NCT02542761
View directory record Official record
Conditions
Transtibial Amputation - Unilateral
Interventions
Fiberglass Composite foot, Carbon Fiber Composite Foot
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
21 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 19, 2018 · Synced Sep 9, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Pain in Amputees Reduced by Administration of Diet Examination

NCT05460845
View directory record Official record
Conditions
Amputation, Phantom Limb Pain, Residual Limb Pain
Interventions
Low-Carbohydrate Diet
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Sep 9, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Agonist-Antagonist Myoneural Interface for Functional Limb Restoration After Transtibial Amputation

NCT03913273
View directory record Official record
Conditions
Amputation
Interventions
AMI transtibial amputation, Standard transtibial amputation
Procedure
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 9, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Somatotopic Configuration of Distal Residual Limb Tissues in Lower Extremity Amputations

NCT03374319
View directory record Official record
Conditions
Amputation
Interventions
Modified amputation procedure
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Sep 9, 2026, 1:51 AM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System

NCT01996254
View directory record Official record
Conditions
Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain
Interventions
SPRINT Peripheral Nerve Stimulation (PNS) System
Device
Lead sponsor
SPR Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
10
States / cities
Scottsdale, Arizona • La Jolla, California • Denver, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Sep 9, 2026, 1:51 AM EDT
Withdrawn Phase 3 Interventional

Pre-operative Pregabalin and Ketamine to Prevent Phantom Pain

NCT02311777
View directory record Official record
Conditions
Phantom Pain
Interventions
Pregabalin, Ketamine, Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Sep 9, 2026, 1:51 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Wearable Airbag Technology to Mitigate Falls in Individuals With High Fall Risk

NCT05076565
View directory record Official record
Conditions
Stroke, Parkinson Disease, Lower Limb Amputation Knee, Fall Injury, Fall Patients, Falling
Interventions
Airbag Belt Fall Protection System
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 28, 2025 · Synced Sep 9, 2026, 1:51 AM EDT
Not yet recruiting Not applicable Interventional

Personalized Prosthetic Foot Prescription and Rehabilitation for Veterans With Lower Limb Loss

NCT06844305
View directory record Official record
Conditions
Amputation of Lower Limb
Interventions
Prosthetic foot, Physical therapy
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 9, 2026, 1:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Virtual Integrated Environment in Decreasing Phantom Limb Pain

NCT01462461
View directory record Official record
Conditions
Phantom Limb
Interventions
Not listed
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 15, 2015 · Synced Sep 9, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Gait Correction in Reducing Diabetic Foot Ulceration Or Subsequent Amputation in Patients With a History of a Diabetic Foot Ulceration

NCT04164641
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 90 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 9, 2026, 1:51 AM EDT
Not listed Not applicable Interventional

Intuitive Control of a Hybrid Prosthetic Leg During Ambulation

NCT04038151
View directory record Official record
Conditions
Amputation
Interventions
Hybrid Leg, Prescribed Passive Prosthesis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 95 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Sep 9, 2026, 1:51 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Thermoregulation in Individuals With a Leg Amputation

NCT06458426
View directory record Official record
Conditions
Amputation, Diabetes
Interventions
shock-absorbing prosthesis
Device
Lead sponsor
University of Utah
Other
Eligibility
19 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 9, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Spinal Root and Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees

NCT03027947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Sep 9, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Impact of a Lower Extremity Amputation Pathway Protocol in Dysvascular Patients

NCT03592316
View directory record Official record
Conditions
Lower Extremity Amputation
Interventions
Lower Extremity Amputation Pathway
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Feb 11, 2021 · Synced Sep 9, 2026, 1:51 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Musculoskeletal Measurements in Transfemoral Amputees

NCT00909922
View directory record Official record
Conditions
Lower Limb Loss
Interventions
Not listed
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 28, 2009 · Synced Sep 9, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Quantifying Bone and Skin Movement in the Residual Limb of Individuals With Transtibial Amputation Using Dynamic Stereo X-Ray

NCT05287646
View directory record Official record
Conditions
Amputation, Lower Limb
Interventions
Suction Suspension First, Elevated Vacuum Suspension First
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 9, 2026, 1:51 AM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

NCT02504216
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Rivaroxaban (Xarelto, BAY59-7939), Rivaroxaban-Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
50 Years and older
Enrollment
6,564 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
105
States / cities
Alexander City, Alabama • Birmingham, Alabama • Fort Payne, Alabama + 91 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2020 · Synced Sep 9, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Regenerative Peripheral Nerve Interface for Control of Lower Limb Prostheses

NCT06275282
View directory record Official record
Conditions
Amputation, Prostheses and Implants
Interventions
Intramuscular electrodes
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 75 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 9, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

DExterous Hand Control Through Fascicular Targeting (DEFT) - (Human Subjects)

NCT02994160
View directory record Official record
Conditions
Amputation; Traumatic, Hand
Interventions
Fast electrode
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 95 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Sep 9, 2026, 1:51 AM EDT
Withdrawn Not applicable Interventional

Evaluation of a Multi-electrode Prosthesis Control System for Real-world Tasks Performance in Individuals With Upper Limb Transradial Amputation

NCT07071584
View directory record Official record
Conditions
Upper Limb Amputation Below Elbow
Interventions
Cutaneous Prosthesis Control System
Device
Lead sponsor
Phantom Neuro Inc.
Industry
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Buffalo, New York • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 9, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Reliability and Validity of Continuous Inter-limb Stability

NCT06987019
View directory record Official record
Conditions
Amputation, Lower Limb
Interventions
3D motion capture, wearable devices, and functional outcome measures
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 9, 2026, 1:51 AM EDT