- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
- Interventions
- Ischemic Conditioning Low - Sham Comparator, Ischemic Conditioning High - Active Comparator
- Procedure
- Lead sponsor
- University of Illinois at Chicago
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 21 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
Search Results
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Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.
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Showing 1–24
of 50
matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
- Conditions
- Diabetes Mellitus, Critical Limb Ischemia, Lower Limb Amputation Knee, Peripheral Arterial Disease
- Interventions
- Active Arm N-acetyl cysteine (NAC), Placebo Arm
- Drug
- Lead sponsor
- Washington University School of Medicine
- Other
- Eligibility
- 30 Years to 90 Years
- Enrollment
- 33 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2022
- U.S. locations
- 1
- States / cities
- St Louis, Missouri
- Conditions
- Transfemoral Amputation, Unilateral Traumatic Amputation of Leg at or Above Knee
- Interventions
- C leg compared to subject's mechanical leg (Otto Bock)
- Device
- Lead sponsor
- Shirley Ryan AbilityLab
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2019
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
- Conditions
- Transfemoral Amputation
- Interventions
- Powered Microprocessor-controlled Knee (PMPK)
- Other
- Lead sponsor
- Loma Linda University
- Other
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 12 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2026
- U.S. locations
- 1
- States / cities
- Loma Linda, California
- Conditions
- Lower Limb Amputation Above Knee (Injury), Congenital Amputation of Lower Limb, Lower Limb Amputation Knee
- Interventions
- Kenevo or C-Leg 4, Non microprocessor controlled knee (NMPK)
- Device
- Lead sponsor
- Otto Bock Healthcare Products GmbH
- Industry
- Eligibility
- 65 Years and older
- Enrollment
- 107 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2026
- U.S. locations
- 90
- States / cities
- Dothan, Alabama • Gilbert, Arizona • Phoenix, Arizona + 85 more
- Conditions
- Unilateral Traumatic Amputation, Amputation, Traumatic
- Interventions
- Powered ankle prosthesis, Dynamic Response Foot
- Device
- Lead sponsor
- Deanna H Gates
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 12 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2019
- U.S. locations
- 1
- States / cities
- Ann Arbor, Michigan
- Conditions
- Pain, Postoperative, Amputation
- Interventions
- Liposomal bupivacaine, Bupivacaine Hydrochloride 0.5 % Injectable Solution
- Drug
- Lead sponsor
- Aurora Quaye
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 11 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2025
- U.S. locations
- 1
- States / cities
- Portland, Maine
- Conditions
- Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Knee
- Interventions
- Revo-M, Taleo, Proflex XC
- Device
- Lead sponsor
- Otto Bock Healthcare Products GmbH
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 27 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 4
- States / cities
- Mesa, Arizona • Linthicum, Maryland • Dayton, Ohio + 1 more
- Conditions
- Amputation
- Interventions
- Ropivacaine 0.2% + nerve stimulator set, Ropivacaine 0.2%
- Device · Drug
- Lead sponsor
- Stanford University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 62 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 3
- States / cities
- Stanford, California • Jacksonville, Florida • Iowa City, Iowa
- Conditions
- Traumatic Amputation of Lower Extremity
- Interventions
- Powered ankle-foot prosthesis, No device
- Device · Other
- Lead sponsor
- US Department of Veterans Affairs
- Federal
- Eligibility
- 18 Years to 60 Years
- Enrollment
- 16 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2009 – 2013
- U.S. locations
- 1
- States / cities
- Providence, Rhode Island
- Conditions
- Lower Limb Amputation Below Knee (Injury)
- Interventions
- Adjustable socket
- Device
- Lead sponsor
- University of Washington
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 104 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2022
- U.S. locations
- 1
- States / cities
- Seattle, Washington
- Conditions
- Transfemoral Amputation
- Interventions
- Active knee (Ossur Power Knee II), Adaptive knee (Ossur Rheo), Passive knee (Various manufacturers)
- Device
- Lead sponsor
- University of Washington
- Other
- Eligibility
- 45 Years to 75 Years
- Enrollment
- 12 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2013
- U.S. locations
- 1
- States / cities
- Seattle, Washington
- Conditions
- Lower Extremity Amputation
- Interventions
- Dynamic Air Exchange - Rising Edge Design (DAE-RED), Perforated elastomeric liner, As-prescribed prosthesis
- Device
- Lead sponsor
- Seattle Institute for Biomedical and Clinical Research
- Other
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2022
- U.S. locations
- 1
- States / cities
- Seattle, Washington
- Conditions
- Peripheral Artery Disease, Critical Limb Ischemia
- Interventions
- Temsirolimus, Saline placebo
- Drug
- Lead sponsor
- Mercator MedSystems, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 250 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2032
- U.S. locations
- 2
- States / cities
- Houma, Louisiana • Dallas, Texas
- Conditions
- Peripheral Arterial Disease
- Interventions
- Ewing Below Knee Amputation, Standard Below Knee Amputation
- Procedure
- Lead sponsor
- VA Office of Research and Development
- Federal
- Eligibility
- Not listed
- Enrollment
- 120 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2030
- U.S. locations
- 3
- States / cities
- Decatur, Georgia • Nashville, Tennessee • Houston, Texas
- Conditions
- Amputation
- Interventions
- Vacuum assisted socket technology (Harmony System, Otto Bock Healthcare)
- Device
- Lead sponsor
- Stony Brook University
- Other
- Eligibility
- 21 Years to 75 Years
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2013
- U.S. locations
- 2
- States / cities
- Stony Brook, New York • West Babylon, New York
- Conditions
- Wound Healing, Lower Extremity Amputation, Above Knee Amputation, Below Knee Amputation
- Interventions
- Lower Extremity Amputation, SPY Elite Imaging System, Indocyaine Green
- Procedure · Device · Drug
- Lead sponsor
- Corewell Health West
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 18 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2016
- U.S. locations
- 1
- States / cities
- Grand Rapids, Michigan
- Conditions
- Amputation of Lower Limb Above Knee, Amputee, Amputation
- Interventions
- Bio Leg
- Device
- Lead sponsor
- University of Florida
- Other
- Eligibility
- 40 Years to 70 Years
- Enrollment
- 12 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2028
- U.S. locations
- 1
- States / cities
- Jacksonville, Florida
- Conditions
- Lower Limb Amputation Below Knee (Injury)
- Interventions
- direct EMG controlled prosthetic ankle, PT guided prosthetic training
- Device · Behavioral
- Lead sponsor
- North Carolina State University
- Other
- Eligibility
- 18 Years to 99 Years
- Enrollment
- 50 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2028
- U.S. locations
- 1
- States / cities
- Raleigh, North Carolina
- Conditions
- Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
- Interventions
- Ossur Power Knee, Reboocon Intuy Knee
- Device
- Lead sponsor
- Liberating Technologies, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 26 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2026
- U.S. locations
- 1
- States / cities
- Austin, Texas
- Conditions
- Amputation
- Interventions
- META-Arc foot locked, META-Arc foot unlocked
- Device
- Lead sponsor
- University of Washington
- Other
- Eligibility
- 16 Years and older
- Enrollment
- 96 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2027
- U.S. locations
- 3
- States / cities
- Tampa, Florida • Mount Sterling, Ohio • Seattle, Washington
- Conditions
- Transfemoral Amputation
- Interventions
- MIT Powered Leg
- Device
- Lead sponsor
- Massachusetts Institute of Technology
- Other
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 1
- States / cities
- Cambridge, Massachusetts
- Conditions
- Prosthesis User, Amputation
- Interventions
- NAVii
- Device
- Lead sponsor
- Össur Iceland ehf
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 14 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022
- U.S. locations
- 3
- States / cities
- Merrillville, Indiana • Bay City, Michigan • Perrysburg, Ohio
- Conditions
- Transfemoral Amputation, Limb Loss, Limb Absence
- Interventions
- College Park ICON, Conventional NMPK
- Other
- Lead sponsor
- VA Office of Research and Development
- Federal
- Eligibility
- 45 Years to 85 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2028
- U.S. locations
- 2
- States / cities
- Chicago, Illinois • Hines, Illinois