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ClinicalTrials.gov public records Last synced Sep 10, 2026, 2:25 PM EDT

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Showing 1–24 of 50 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Amputation of Knee Clear all
Active, not recruiting Not applicable Interventional

VR to Evaluate Phantom Limb Pain

NCT05915065
View directory record Official record
Conditions
Phantom Limb Pain, Phantom Pain, Phantom Sensation, Phantom Limb Syndrome With Pain, Phantom Pain Following Amputation of Lower Limb, Phantom Pain Following Amputation of Upper Limb, Amputation, Upper Limb Amputation at the Hand, Upper Limb Amputation at the Wrist, Upper Limb Amputation Below Elbow (Injury), Upper Limb Amputation Above Elbow (Injury), Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation at Ankle (Injury)
Interventions
Coapt Phantom Limb Pain Management System
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Not applicable Interventional Results available

Clinical Investigation (Beta) of Power Knee Mainstream - Dynamic

NCT04787627
View directory record Official record
Conditions
Prosthesis User, Amputation
Interventions
Power Knee
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Silver Spring, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Sep 10, 2026, 2:25 PM EDT
Not yet recruiting Not applicable Interventional

Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators

NCT07103798
View directory record Official record
Conditions
Transfemoral Amputation, Limb Loss, Limb Absence
Interventions
College Park ICON, Conventional NMPK
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Chicago, Illinois • Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 10, 2026, 2:25 PM EDT
Recruiting Not applicable Interventional

Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

NCT06937242
View directory record Official record
Conditions
Amputation, Prosthesis User, Amputation; Traumatic, Leg: Thigh, Between Hip and Knee, Limb; Absence, Congenital, Lower, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Above Knee
Interventions
Ottobock C-Leg 4 Microprocessor Knee, Ottobock Kenevo
Device
Lead sponsor
Hanger Institute for Clinical Research and Education, LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Not applicable Interventional Results available

Determining the Potential Benefit of Powered Prostheses

NCT02828982
View directory record Official record
Conditions
Unilateral Traumatic Amputation, Amputation, Traumatic
Interventions
Powered ankle prosthesis, Dynamic Response Foot
Device
Lead sponsor
Deanna H Gates
Other
Eligibility
21 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 17, 2022 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Not applicable Interventional Results available

An Investigation on Function and Performance of a New Microprocessor Controlled Prosthetic Knee

NCT05523349
View directory record Official record
Conditions
Prosthesis User, Amputation
Interventions
NAVii
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
3
States / cities
Merrillville, Indiana • Bay City, Michigan • Perrysburg, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Sep 10, 2026, 2:25 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Wearable Airbag Technology to Mitigate Falls in Individuals With High Fall Risk

NCT05076565
View directory record Official record
Conditions
Stroke, Parkinson Disease, Lower Limb Amputation Knee, Fall Injury, Fall Patients, Falling
Interventions
Airbag Belt Fall Protection System
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 28, 2025 · Synced Sep 10, 2026, 2:25 PM EDT
Not yet recruiting Not applicable Interventional

Determining the Effects of Ischemic Conditioning and Neuromuscular Electrical Stimulation on Overall Function After Lower Limb Amputation

NCT07664995
View directory record Official record
Conditions
Lower Limb Amputation Above Knee, Below Knee Amputation
Interventions
Blood pressure cuff, Neuromuscular Electrical Stimulation
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 10, 2026, 2:25 PM EDT
Recruiting Not applicable Interventional

Metabolic Cost of Walking With Passive vs. Powered Prosthetic Knees Among Persons With Limb Loss

NCT05831696
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
Powered Microprocessor-controlled Knee (PMPK)
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 10, 2026, 2:25 PM EDT
Recruiting Not applicable Interventional

Bio Leg: Advancing Mobility (BAM)

NCT07613502
View directory record Official record
Conditions
Amputation of Lower Limb Above Knee, Amputee, Amputation
Interventions
Bio Leg
Device
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Phase 1 Interventional

A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

NCT02685098
View directory record Official record
Conditions
Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease, Vascular Disease, Arterial Occlusive Disease, Arteriosclerosis, Atherosclerosis, Cardiovascular Disease, Pathologic Processes, Orthopedic Procedures, Amputation
Interventions
Allogeneic bone marrow derived mesenchymal stem cells
Biological
Lead sponsor
Indiana University
Other
Eligibility
40 Years to 90 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Wearing a Powered Ankle-Foot Prosthesis on Amputee Walking

NCT00869947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Powered ankle-foot prosthesis, No device
Device · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 24, 2014 · Synced Sep 10, 2026, 2:25 PM EDT
Recruiting Not applicable Interventional

Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis

NCT06214026
View directory record Official record
Conditions
Amputation
Interventions
META-Arc foot locked, META-Arc foot unlocked
Device
Lead sponsor
University of Washington
Other
Eligibility
16 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
3
States / cities
Tampa, Florida • Mount Sterling, Ohio • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Not applicable Interventional Results available

Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot

NCT04239222
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Knee
Interventions
Revo-M, Taleo, Proflex XC
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
4
States / cities
Mesa, Arizona • Linthicum, Maryland • Dayton, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2024 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Early Phase 1 Interventional Results available

N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes

NCT03253328
View directory record Official record
Conditions
Diabetes Mellitus, Critical Limb Ischemia, Lower Limb Amputation Knee, Peripheral Arterial Disease
Interventions
Active Arm N-acetyl cysteine (NAC), Placebo Arm
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
30 Years to 90 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 15, 2024 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Socket Cooling Effectiveness Take Home Study

NCT04484805
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Amputation Stump, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Interventions
ICE Condition, Sham Condition
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Holliston, Massachusetts • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Sep 10, 2026, 2:25 PM EDT
Active, not recruiting Not applicable Interventional

Assessing Outcomes With Microprocessor Knee Utilization in a K2 Population

NCT04784429
View directory record Official record
Conditions
Lower Limb Amputation Above Knee (Injury), Congenital Amputation of Lower Limb, Lower Limb Amputation Knee
Interventions
Kenevo or C-Leg 4, Non microprocessor controlled knee (NMPK)
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
65 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
90
States / cities
Dothan, Alabama • Gilbert, Arizona • Phoenix, Arizona + 85 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Not applicable Interventional Results available

Clinical Investigation (Beta) of a New Developed Prosthetic Knee

NCT06748729
View directory record Official record
Conditions
Amputation
Interventions
Navii Knee
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years to 80 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Outcomes Assessment of the C-Leg With a New Knee Prosthesis

NCT01473992
View directory record Official record
Conditions
Other and Unspecified Complications of Amputation Stump
Interventions
Otto Bock C-Leg, Otto Bock Genium
Device
Lead sponsor
Jason Highsmith
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Sep 10, 2026, 2:25 PM EDT
Terminated Phase 4 Interventional Results available

Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations

NCT05140499
View directory record Official record
Conditions
Pain, Postoperative, Amputation
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride 0.5 % Injectable Solution
Drug
Lead sponsor
Aurora Quaye
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 10, 2026, 2:25 PM EDT
Recruiting Phase 3 Interventional

Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee

NCT04433572
View directory record Official record
Conditions
Peripheral Artery Disease, Critical Limb Ischemia
Interventions
Temsirolimus, Saline placebo
Drug
Lead sponsor
Mercator MedSystems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
2
States / cities
Houma, Louisiana • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Sep 10, 2026, 2:25 PM EDT
Recruiting Not applicable Interventional

Randomized Clinical Trial for Ewing Amputation in the VA

NCT05437562
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Ewing Below Knee Amputation, Standard Below Knee Amputation
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Decatur, Georgia • Nashville, Tennessee • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 10, 2026, 2:25 PM EDT
Completed Not applicable Interventional Results available

Assist-Knee: Energy-Harvesting Knee Prosthesis

NCT04023045
View directory record Official record
Conditions
Transfemoral Amputation, Artificial Limbs
Interventions
Assist-Knee, Habitual Prosthesis
Device
Lead sponsor
Orthocare Innovations, LLC
Industry
Eligibility
21 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Edmonds, Washington
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Sep 10, 2026, 2:25 PM EDT
Recruiting Not applicable Interventional

Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks

NCT07204912
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
MIT Powered Leg
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 10, 2026, 2:25 PM EDT