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Showing 1–24 of 62 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Amputation of Upper Limb Clear all
Completed Not applicable Interventional

Feasibility of Implantable Myoelectric Sensors to Control Upper Limb Prostheses

NCT01901081
View directory record Official record
Conditions
Amputation, Traumatic
Interventions
IMES
Device
Lead sponsor
The Alfred E. Mann Foundation for Scientific Research
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Sep 18, 2026, 12:23 AM EDT
Not yet recruiting Not applicable Interventional

Determining the Effects of Ischemic Conditioning and Neuromuscular Electrical Stimulation on Overall Function After Lower Limb Amputation

NCT07664995
View directory record Official record
Conditions
Lower Limb Amputation Above Knee, Below Knee Amputation
Interventions
Blood pressure cuff, Neuromuscular Electrical Stimulation
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 18, 2026, 12:23 AM EDT
Completed Not applicable Interventional

Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation

NCT05880251
View directory record Official record
Conditions
Phantom Limb Pain After Amputation, Lower Limb Amputation, Upper Limb Amputation, Phantom Pain, Chronic Pain
Interventions
Operant Conditioning with Peripheral Stimulation, Control Group with Peripheral Stimulation Only
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 18, 2026, 12:23 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Assessment of Gesture Accuracy of a Prosthesis Control System

NCT06446037
View directory record Official record
Conditions
Upper Limb Amputation Below Elbow (Injury)
Interventions
Non-invasive EMG band instrumentation
Device
Lead sponsor
Phantom Neuro Inc.
Industry
Eligibility
21 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Sep 18, 2026, 12:23 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Development of a Simulation Tool for Upper Extremity Prostheses

NCT01622530
View directory record Official record
Conditions
Traumatic Amputation of Upper Limb, Level Unspecified
Interventions
Not listed
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2017
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Sep 18, 2026, 12:23 AM EDT
Active, not recruiting Not applicable Interventional

VR to Evaluate Phantom Limb Pain

NCT05915065
View directory record Official record
Conditions
Phantom Limb Pain, Phantom Pain, Phantom Sensation, Phantom Limb Syndrome With Pain, Phantom Pain Following Amputation of Lower Limb, Phantom Pain Following Amputation of Upper Limb, Amputation, Upper Limb Amputation at the Hand, Upper Limb Amputation at the Wrist, Upper Limb Amputation Below Elbow (Injury), Upper Limb Amputation Above Elbow (Injury), Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation at Ankle (Injury)
Interventions
Coapt Phantom Limb Pain Management System
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Sep 18, 2026, 12:23 AM EDT
Completed Not applicable Interventional Results available

Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study

NCT03578237
View directory record Official record
Conditions
Mastectomy, Upper Limb Amputation Below Elbow, Upper Limb Amputation Above Elbow, Lower Limb Amputation Below Knee, Lower Limb Amputation Above Knee, Knee Arthropathy, Shoulder Arthroplasty, Rotator Cuff Repair, Video-Assisted Thoracoscopic Surgery (VATS), Skin Grafting
Interventions
Cryoneurolysis (active), Sham cryoneurolysis procedure
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2023 · Synced Sep 18, 2026, 12:23 AM EDT
Completed No phase listed Observational

Pilot Study to Assess the Use of Spy Elite for Assessment of Amputation Healing

NCT02440295
View directory record Official record
Conditions
Wound Healing, Lower Extremity Amputation, Above Knee Amputation, Below Knee Amputation
Interventions
Lower Extremity Amputation, SPY Elite Imaging System, Indocyaine Green
Procedure · Device · Drug
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 18, 2026, 12:23 AM EDT
Completed Not applicable Interventional

SoftHand Comparison Study

NCT05328934
View directory record Official record
Conditions
Upper Extremity Injury, Upper Extremity Deformities, Congenital, Amputation, Traumatic, Amputation, Congenital
Interventions
SoftHand Pro, Ossur i-Limb
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Tempe, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 18, 2026, 12:23 AM EDT
Completed Not applicable Interventional

Vascularized Composite Allotransplantation of the Hand and Upper Extremity (Hand Transplant)

NCT02165865
View directory record Official record
Conditions
Traumatic Amputation of Arm, Traumatic Amputation of Hand
Interventions
upper extremity/ hand transplantation
Procedure
Lead sponsor
Southern Illinois University
Other
Eligibility
18 Years to 69 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
3
States / cities
Springfield, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 1, 2019 · Synced Sep 18, 2026, 12:23 AM EDT
Completed Not applicable Interventional

Functional Importance of a Powered Multifunction Wrist Protocol

NCT04069793
View directory record Official record
Conditions
Upper Limb Amputation at the Hand, Upper Limb Amputation at the Wrist, Amputation, Amputation; Traumatic, Limb
Interventions
Commercially available device, Non FDA registered device
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 95 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Sep 18, 2026, 12:23 AM EDT
Recruiting Phase 2 Interventional

Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees.

NCT04839497
View directory record Official record
Conditions
Amputation
Interventions
Autologous Volar Fibroblast Injection into the Terminal Limb of Amputees
Combination Product
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 18, 2026, 12:23 AM EDT
Completed Not applicable Interventional Results available

Interface Kinematics of Transhumeral Prosthetic Sockets Using XROMM

NCT01546675
View directory record Official record
Conditions
Traumatic Amputation of Arm
Interventions
Skeletal Stabilization
Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
New York, New York • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 23, 2014 · Synced Sep 18, 2026, 12:23 AM EDT
Recruiting Not applicable Interventional

Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis

NCT06214026
View directory record Official record
Conditions
Amputation
Interventions
META-Arc foot locked, META-Arc foot unlocked
Device
Lead sponsor
University of Washington
Other
Eligibility
16 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
3
States / cities
Tampa, Florida • Mount Sterling, Ohio • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Sep 18, 2026, 12:23 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Virtual Reality Prosthetic Training and Rehabilitation

NCT02666859
View directory record Official record
Conditions
Amputation of Upper Limb
Interventions
Virtual Reality
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 11, 2019 · Synced Sep 18, 2026, 12:23 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving Prosthetic Arms for Amputee: A Better Fit and More Functionality

NCT05990062
View directory record Official record
Conditions
Amputation, Surgical
Interventions
K-Socket-Harness
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 18, 2026, 12:23 AM EDT
Not listed Not applicable Interventional

mGain - sEMG-based Gamified Therapy for Improved Upper Limb Rehabilitation

NCT06023316
View directory record Official record
Conditions
Upper Limb Weakness Due to Central Neurologic Injury, Upper Limb Weakness Due to Peripheral Neurologic Injury, Upper Limb Weakness Due to Nerve Reconstruction, Upper Limb Weakness Due to Tendon Transfer Surgery, Stroke, Upper Limb Amputation
Interventions
mGain system
Device
Lead sponsor
Orthocare Innovations, LLC
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Edmonds, Washington
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Sep 18, 2026, 12:23 AM EDT
Recruiting No phase listed Observational

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

NCT06908538
View directory record Official record
Conditions
Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss, Amputation, Traumatic/Surgery, Cryo Analgesia
Interventions
cryoablation
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
6
States / cities
Pittsfield, Massachusetts • Manchester, New Hampshire • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 18, 2026, 12:23 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

GaMA Metric to Quantify Functional Importance of Various Upper Limb Prosthetic Devices

NCT06420687
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation; Traumatic, Hand, Amputation; Traumatic, Limb
Interventions
Clinically prescribed prosthesis, Experimental prosthesis - Wrist rotation + 1-DOF, Experimental prosthesis - Wrist rotation + Wrist flexion +1-DOF, Experimental prosthesis - Wrist rotation + Multi DOF hand, Experimental prosthesis - Wrist rotation + wrist flexion + Multi DOF hand
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Sep 18, 2026, 12:23 AM EDT
Not listed Phase 1 Interventional

Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation

NCT00388752
View directory record Official record
Conditions
Phantom Limb, Residual Limb Pain, Traumatic Amputation, Amputation
Interventions
Acupuncture
Procedure
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 5, 2007 · Synced Sep 18, 2026, 12:23 AM EDT
Recruiting Not applicable Interventional

Regulatory Clearance of the Glide Control Strategy for Upper Limb Prostheses

NCT06539936
View directory record Official record
Conditions
Amputation, Upper Limb
Interventions
Glide, Direct Control
Device
Lead sponsor
Infinite Biomedical Technologies
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Redondo Beach, California
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 18, 2026, 12:23 AM EDT
Active, not recruiting Not applicable Interventional

The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes

NCT01047735
View directory record Official record
Conditions
Type 2 Diabetes Mellitus, Obesity
Interventions
Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
Procedure · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
25 Years to 55 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 18, 2026, 12:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dexterous Partial Hand Prosthesis Outcomes

NCT05038566
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Hand, Limb; Absence, Congenital, Upper, Prosthesis User, Upper Limb Amputation at the Hand
Interventions
Pointdexter
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
Not listed
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Holliston, Massachusetts • Dublin, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 16, 2025 · Synced Sep 18, 2026, 12:23 AM EDT
Not listed Phase 2 Interventional

Vascularized Composite Allotransplantation of the Hand

NCT00711373
View directory record Official record
Conditions
Upper Extremity Injuries
Interventions
Allogeneic hand transplantation
Procedure
Lead sponsor
Christina L. Kaufman PhD
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2019
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Sep 18, 2026, 12:23 AM EDT