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Showing 1–24 of 168 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Amputee Clear all
Not yet recruiting Not applicable Interventional

Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators

NCT07103798
View directory record Official record
Conditions
Transfemoral Amputation, Limb Loss, Limb Absence
Interventions
College Park ICON, Conventional NMPK
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Chicago, Illinois • Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 3, 2026, 5:34 PM EDT
Not listed Phase 1 Interventional

Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation

NCT00388752
View directory record Official record
Conditions
Phantom Limb, Residual Limb Pain, Traumatic Amputation, Amputation
Interventions
Acupuncture
Procedure
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 5, 2007 · Synced Sep 3, 2026, 5:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Mirror Therapy for Phantom Limb Pain

NCT00623818
View directory record Official record
Conditions
Amputation
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 75 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2019
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Not applicable Interventional Results available

Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees

NCT02684201
View directory record Official record
Conditions
Phantom Limb
Interventions
Boston Scientific Stimulator Lead
Device
Lead sponsor
Lee Fisher, PhD
Other
Eligibility
18 Years to 70 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Not applicable Interventional

Comparative Effectiveness of Microprocessor Controlled and Carbon Fiber Prosthetic Feet in Transtibial Amputees

NCT02864693
View directory record Official record
Conditions
Amputation
Interventions
Kinnex, Pacifica LP
Device
Lead sponsor
Ability Prosthetics and Orthotics, Inc.
Industry
Eligibility
18 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
3
States / cities
Hagerstown, Maryland • Charlotte, North Carolina • York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 9, 2018 · Synced Sep 3, 2026, 5:34 PM EDT
Recruiting Phase 1 Interventional

Epidermal Sensors for Wireless and Enhanced Amputee Skin Tracking (E-SWEAT) Part 1

NCT07216183
View directory record Official record
Conditions
Transtibial Amputation
Interventions
Walk, Yuga post, E-SWEAT Sensor
Procedure · Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Phase 1 Interventional

Effect of Socket Wall Height With Vacuum Suspension for Above Knee Amputees

NCT01559909
View directory record Official record
Conditions
Amputation
Interventions
Vacuum assisted socket technology (Harmony System, Otto Bock Healthcare)
Device
Lead sponsor
Stony Brook University
Other
Eligibility
21 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Stony Brook, New York • West Babylon, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2014 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Phase 2 Interventional Results available

Qbrexza Cloths for Hyperhidrosis of Amputation Sites

NCT04924036
View directory record Official record
Conditions
Amputation, Hyperhidrosis
Interventions
glycopyrronium cloths, Placebo
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Not applicable Interventional Results available

Evaluation of a Modified Running-specific Prosthetic Foot

NCT02440711
View directory record Official record
Conditions
Transtibial Amputation
Interventions
Energy storing foot (ESF), Modified running specific foot (mRSF)
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Not applicable Interventional Results available

EmPOWERing Active Seniors With Energy

NCT02958553
View directory record Official record
Conditions
Amputation
Interventions
emPOWER Ankle, Subject's own passive prosthesis
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
55 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 3, 2026, 5:34 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Physical Activity in Adults With Amputation

NCT03722797
View directory record Official record
Conditions
Amputees
Interventions
Metabolic Cost Testing Procedures
Procedure
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 60 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Sep 3, 2026, 5:34 PM EDT
Withdrawn Not applicable Interventional

Surgical Treatments for Neuroma Pain in Amputees

NCT04204668
View directory record Official record
Conditions
Pain, Neuropathic, Amputation Neuroma, Phantom Limb Pain
Interventions
TMR, RPNI, VDMT
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 2, 2025 · Synced Sep 3, 2026, 5:34 PM EDT
Not listed Phase 2 Interventional

Prosthetic Limbs After Leg Amputation: Alternative Method of Socket Design

NCT00061217
View directory record Official record
Conditions
Amputation
Interventions
Unrectified prosthetic socket, Rectified prosthetic socket
Device
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Not applicable Interventional Results available

Clinical Investigation (Beta) of a New Developed Prosthetic Knee

NCT06748729
View directory record Official record
Conditions
Amputation
Interventions
Navii Knee
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years to 80 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Not applicable Interventional Results available

Auto Control of Volume Management for Limb Loss

NCT03550118
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury)
Interventions
Adjustable socket
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Sep 3, 2026, 5:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Longitudinal Study of Weight Change Following Lower Limb Amputation

NCT00932399
View directory record Official record
Conditions
Amputation Wound, Traumatic Amputation of Toe, Dysvascular Amputation of Lower Limb
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
27 Years to 89 Years · Male only
Enrollment
4,549 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 7, 2016 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Not applicable Interventional

Prosthetic Socket Interface Design on Socket Comfort, Residual Limb Health, and Function for the Transfemoral Amputee

NCT02773056
View directory record Official record
Conditions
Amputation
Interventions
Ischial Ramus Containment (IRC), Dynamic Socket Ischial Ramus Containment (IRC), Sub-Ischial Interface (Sub-I)
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 44 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Sep 3, 2026, 5:34 PM EDT
Completed No phase listed Observational

Extremity Trauma At a Level 1 Trauma Center

NCT06402669
View directory record Official record
Conditions
Trauma Injury, Trauma Blunt, Vascular Trauma
Interventions
Packed Red Blood Cell Administration
Other
Lead sponsor
Arrowhead Regional Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Colton, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Pain in Amputees Reduced by Administration of Diet Examination

NCT05460845
View directory record Official record
Conditions
Amputation, Phantom Limb Pain, Residual Limb Pain
Interventions
Low-Carbohydrate Diet
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Sep 3, 2026, 5:34 PM EDT
Not yet recruiting Not applicable Interventional

Altius Peripheral Nerve Stimulation in Amputees After TMR/RPNI

NCT07571239
View directory record Official record
Conditions
Amputation; Lower Extremity, Pain, Persistent Postsurgical
Interventions
Surgical Implantation
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Not applicable Interventional

e-OPRA Implant System for Lower Limb Amputees

NCT03720171
View directory record Official record
Conditions
Amputation
Interventions
e-OPRA Implant System
Device
Lead sponsor
Integrum
Industry
Eligibility
22 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Sep 3, 2026, 5:34 PM EDT
Not yet recruiting Not applicable Interventional

Personalized Prosthetic Foot Prescription and Rehabilitation for Veterans With Lower Limb Loss

NCT06844305
View directory record Official record
Conditions
Amputation of Lower Limb
Interventions
Prosthetic foot, Physical therapy
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 3, 2026, 5:34 PM EDT
Completed Phase 1 Interventional

Transcranial Magnetic Stimulation for the Treatment of Phantom Pain

NCT00001923
View directory record Official record
Conditions
Pain
Interventions
Transcranial magnetic stimulation
Procedure
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 3, 2026, 5:34 PM EDT
Terminated Not applicable Interventional Results available

Effects of Shrinker Use on Healing and Volume

NCT00693628
View directory record Official record
Conditions
Transtibial Amputation
Interventions
compression shrinker
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 4, 2017 · Synced Sep 3, 2026, 5:34 PM EDT