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ClinicalTrials.gov public records Last synced Oct 20, 2026, 2:09 AM EDT

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Showing 97–120 of 168 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Amputee Clear all
Terminated No phase listed Observational

Patient Reported Outcomes Following Targeted Muscle Reinnervation

NCT04658368
View directory record Official record
Conditions
Amputation
Interventions
Primary TMR, Secondary TMR
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Oct 20, 2026, 2:09 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Analysis of Human Movement With Assistive Devices

NCT05729061
View directory record Official record
Conditions
Limb Loss, Limb Weakness, Limb Paralysis, Movement Disorders
Interventions
Assist-Knee, Prosthetic Knee, Prosthetic Ankle, Prosthetic Foot, Ankle-Foot Orthosis
Device
Lead sponsor
Orthocare Innovations, LLC
Industry
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Edmonds, Washington
Source: ClinicalTrials.gov public record
Updated Oct 10, 2023 · Synced Oct 20, 2026, 2:09 AM EDT
Completed Not applicable Interventional

Exercise Intervention for Unilateral Amputees With Low Back Pain

NCT03300375
View directory record Official record
Conditions
Low Back Pain
Interventions
Home exercise program, Post Op instructions
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 20, 2026, 2:09 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Arm Motor Control on Bi and Uni ADLs

NCT02778529
View directory record Official record
Conditions
Stroke, Peripheral Neuropathy, Spinal Cord Injuries, Cerebral Palsy
Interventions
Bilateral assessment robots (BiAS)
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 20, 2026, 2:09 AM EDT
Completed Not applicable Interventional Results available

Functional Outcomes in Dysvascular Transfemoral Amputees

NCT01537211
View directory record Official record
Conditions
Transfemoral Amputation, Unilateral Traumatic Amputation of Leg at or Above Knee
Interventions
C leg compared to subject's mechanical leg (Otto Bock)
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 6, 2019 · Synced Oct 20, 2026, 2:09 AM EDT
Withdrawn Not applicable Interventional

Evaluation of a Multi-electrode Prosthesis Control System for Real-world Tasks Performance in Individuals With Upper Limb Transradial Amputation

NCT07071584
View directory record Official record
Conditions
Upper Limb Amputation Below Elbow
Interventions
Cutaneous Prosthesis Control System
Device
Lead sponsor
Phantom Neuro Inc.
Industry
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Buffalo, New York • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 20, 2026, 2:09 AM EDT
Active, not recruiting Not applicable Interventional

Impact of Powered Knee-Ankle Prosthesis Leg on Everyday Community Mobility and Social Interaction

NCT03204513
View directory record Official record
Conditions
Transfemoral Amputees
Interventions
Vanderbilt Powered Knee-Ankle Prosthesis, Microprocessor (MP) Knee Prosthesis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 20, 2026, 2:09 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Falls in Older Persons With Limb Loss

NCT03670004
View directory record Official record
Conditions
Amputation, Elderly
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 85 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 7, 2022 · Synced Oct 20, 2026, 2:09 AM EDT
Not listed Phase 1 Interventional

Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation

NCT00388752
View directory record Official record
Conditions
Phantom Limb, Residual Limb Pain, Traumatic Amputation, Amputation
Interventions
Acupuncture
Procedure
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 6, 2007 · Synced Oct 20, 2026, 2:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Upper Limb Loss Perturbation Response

NCT04274218
View directory record Official record
Conditions
Amputation
Interventions
Perturbation
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 14, 2024 · Synced Oct 20, 2026, 2:09 AM EDT
Recruiting Not applicable Interventional

Metabolic Cost of Walking With Passive vs. Powered Prosthetic Knees Among Persons With Limb Loss

NCT05831696
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
Powered Microprocessor-controlled Knee (PMPK)
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 20, 2026, 2:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Pain in Amputees Reduced by Administration of Diet Examination

NCT05460845
View directory record Official record
Conditions
Amputation, Phantom Limb Pain, Residual Limb Pain
Interventions
Low-Carbohydrate Diet
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 30, 2023 · Synced Oct 20, 2026, 2:09 AM EDT
Recruiting No phase listed Observational

Evaluating the Experience of Upper Limb Prosthesis Use

NCT04855214
View directory record Official record
Conditions
Prosthesis User, Amputation, Upper Limb Amputation at the Wrist, Upper Limb Amputation Above Elbow (Injury), Upper Limb Amputation Below Elbow (Injury)
Interventions
Qualitative Analysis
Other
Lead sponsor
Louis Stokes VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
178 participants
Timeline
2020 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 20, 2026, 2:09 AM EDT
Completed No phase listed Interventional Results available

Predicting Pain Response to Transcranial Direct Current Stimulation for Phantom Limb Pain in Limb Amputees

NCT02627495
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
transcranial Direct Current Stimulation (tDCS): (Soterix ©)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 11, 2021 · Synced Oct 20, 2026, 2:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bioimpedance as a Diagnostic Tool for Assessing the Need for Socket Modification in Transtibial Amputees

NCT03164356
View directory record Official record
Conditions
Transtibial Amputee
Interventions
Bioimpedance monitor
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 3, 2023 · Synced Oct 20, 2026, 2:09 AM EDT
Completed No phase listed Observational

Comparing Active and Passive Ankle-foot Prostheses

NCT01684501
View directory record Official record
Conditions
Trans-tibial Amputation
Interventions
Not listed
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2017 · Synced Oct 20, 2026, 2:09 AM EDT
Not yet recruiting Not applicable Interventional

Neuromusculoskeletal Interface for Bionic Arms

NCT07032753
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation, Surgical, Upper Limb Amputation Above Elbow (Injury)
Interventions
eOPRA, OPRA, eOPRA with sensory feedback, eOPRA without sensory feedback
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Oct 20, 2026, 2:09 AM EDT
Recruiting Not applicable Interventional

Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation

NCT06840262
View directory record Official record
Conditions
Amputation
Interventions
Questionnaire Administration, Regenerative Peripheral Nerve Interface Surgery, Targeted Muscle Reinnervation
Other · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 20, 2026, 2:09 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Limb Health Associated With a Prosthetic Vacuum Socket System

NCT01839123
View directory record Official record
Conditions
Lower Limb Amputation
Interventions
Prosthetic Suction or Pin Socket, Prosthetic LimbLogic Vacuum Socket
Device
Lead sponsor
Ohio Willow Wood
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Columbus, Ohio • Mount Sterling, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 1, 2013 · Synced Oct 20, 2026, 2:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Moisture Management Liner Effectiveness Study

NCT04427007
View directory record Official record
Conditions
Amputation Stumps, Amputees, Amputation, Lower Limb Deformities, Congenital, Prosthesis User, Prosthesis
Interventions
Moisture Management Liner, Control Liner
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Holliston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 11, 2025 · Synced Oct 20, 2026, 2:09 AM EDT
Completed Not applicable Interventional

Feasibility of Implantable Myoelectric Sensors to Control Upper Limb Prostheses

NCT01901081
View directory record Official record
Conditions
Amputation, Traumatic
Interventions
IMES
Device
Lead sponsor
The Alfred E. Mann Foundation for Scientific Research
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 1, 2017 · Synced Oct 20, 2026, 2:09 AM EDT
Completed Not applicable Interventional

Self-Management Program for Persons With Limb Loss

NCT00198692
View directory record Official record
Conditions
Amputation, Depression, Pain, Anxiety
Interventions
self-management
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years to 85 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 28, 2008 · Synced Oct 20, 2026, 2:09 AM EDT
Recruiting No phase listed Observational

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

NCT06908538
View directory record Official record
Conditions
Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss, Amputation, Traumatic/Surgery, Cryo Analgesia
Interventions
cryoablation
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
6
States / cities
Pittsfield, Massachusetts • Manchester, New Hampshire • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 20, 2026, 2:09 AM EDT
Completed Not applicable Interventional Results available

Evidence Based Amputee Rehabilitation (EBAR) Program

NCT00126126
View directory record Official record
Conditions
Amputation Stumps, Diabetes Mellitus
Interventions
EBAR Program
Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
40 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 20, 2015 · Synced Oct 20, 2026, 2:09 AM EDT