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ClinicalTrials.gov public records Last synced Oct 30, 2026, 8:26 PM EDT

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Showing 1–24 of 169 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Amputees Clear all
Active, not recruiting Not applicable Interventional

Functional and Neuroprotective Effects of Restoring Lower Limb Sensation After Diabetic Peripheral Neuropathy

NCT04658693
View directory record Official record
Conditions
Lower Extremity Amputee, Diabetic Peripheral Neuropathy
Interventions
Implanted Multi contact stimulating electrode and intramuscular electromyography recording electrode
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 30, 2026, 8:26 PM EDT
Not listed No phase listed Observational

Comparing Running-Specific and Traditional Prostheses During Running: Assessing Performance and Risk

NCT02875197
View directory record Official record
Conditions
Amputees, Running With Prosthesis
Interventions
Running on a treadmill at 6 different speeds
Other
Lead sponsor
Regis University
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 2, 2017 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional

e-OPRA Implant System for Lower Limb Amputees

NCT03720171
View directory record Official record
Conditions
Amputation
Interventions
e-OPRA Implant System
Device
Lead sponsor
Integrum
Industry
Eligibility
22 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional

Prosthetic Socket Interface Design on Socket Comfort, Residual Limb Health, and Function for the Transfemoral Amputee

NCT02773056
View directory record Official record
Conditions
Amputation
Interventions
Ischial Ramus Containment (IRC), Dynamic Socket Ischial Ramus Containment (IRC), Sub-Ischial Interface (Sub-I)
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 44 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 3, 2018 · Synced Oct 30, 2026, 8:26 PM EDT
Recruiting Phase 1 Interventional

Epidermal Sensors for Wireless and Enhanced Amputee Skin Tracking (E-SWEAT) Part 1

NCT07216183
View directory record Official record
Conditions
Transtibial Amputation
Interventions
Walk, Yuga post, E-SWEAT Sensor
Procedure · Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Qualitative & Quantitative Comparison of Hydrostatic vs Vacuum Casting Methods in Trans-Tibial Amputees

NCT03891017
View directory record Official record
Conditions
Hydrostatic Vacuum Casting
Interventions
vacuum casting, hydrostatic casting
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2019 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Wearing a Powered Ankle-Foot Prosthesis on Amputee Walking

NCT00869947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Powered ankle-foot prosthesis, No device
Device · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 25, 2014 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Biomechanical Assessment of Gait in Lower-Extremity-Amputees

NCT01332123
View directory record Official record
Conditions
Prosthesis User
Interventions
Alignment perturbations
Device
Lead sponsor
University of Wisconsin, Milwaukee
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 9, 2016 · Synced Oct 30, 2026, 8:26 PM EDT
Not listed Not applicable Interventional

Early Feasibility Study of the Percutaneous Osseointegrated Prosthesis (POP)

NCT02720159
View directory record Official record
Conditions
Traumatic Amputee
Interventions
Percutaneous Osseintegrated Prosthesis
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 25, 2016 · Synced Oct 30, 2026, 8:26 PM EDT
Withdrawn Not applicable Interventional

Surgical Treatments for Neuroma Pain in Amputees

NCT04204668
View directory record Official record
Conditions
Pain, Neuropathic, Amputation Neuroma, Phantom Limb Pain
Interventions
TMR, RPNI, VDMT
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reduction of Shear Forces Using Semi-flexible Sockets on Transtibial Amputees

NCT03390153
View directory record Official record
Conditions
Amputation
Interventions
semi flexible socket, rigid fiber socket
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2018 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional

Self-Management Program for Persons With Limb Loss

NCT00198692
View directory record Official record
Conditions
Amputation, Depression, Pain, Anxiety
Interventions
self-management
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years to 85 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 28, 2008 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

LASER Pilot Project

NCT05966636
View directory record Official record
Conditions
Acquired Absence of Lower Limb, Scar Condition and Fibrosis of the Skin
Interventions
Fractional CO2 Laser Ablative Resurfacing
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Miami, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional

Thigh Reduction Surgery of Above Knee Amputee Residual Limbs to Improve Prosthesis Fit and Patient Outcomes

NCT02346019
View directory record Official record
Conditions
Transfemoral Amputees
Interventions
Medial thighplasty with or without thigh liposuction
Procedure
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Measures of Gait Efficiency of Three Multi-Axial, Vertical Shock and Energy Storing-Return Prosthetic Feet During Simple & Complex Mobility Activities

NCT01404559
View directory record Official record
Conditions
Amputation
Interventions
Ossur Variflex prosthetic foot, Ossur Ceterus prosthetic foot, Endolite Elite Blade prosthetic foot
Device
Lead sponsor
University of South Florida
Other
Eligibility
21 Years to 45 Years · Male only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 15, 2014 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional Results available

Auto Control of Volume Management for Limb Loss

NCT03550118
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury)
Interventions
Adjustable socket
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 3, 2023 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physiologic Range of Step-by-step Variations in Lower Limb Prosthesis Forces During Walking

NCT02234505
View directory record Official record
Conditions
Trans-tibial Limb Loss
Interventions
Prosthetic alignment perturbation
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 4, 2015 · Synced Oct 30, 2026, 8:26 PM EDT
Active, not recruiting Not applicable Interventional

Magnetic Bead Tracking System and eOPRA Implant System With Bionic Prosthesis for Transtibial Amputees

NCT06391697
View directory record Official record
Conditions
Amputation
Interventions
eOPRA Implant System for Transtibial Amputees and Magnetic Bead Tracking System
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
22 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 29, 2026 · Synced Oct 30, 2026, 8:26 PM EDT
Terminated No phase listed Observational

Patient Reported Outcomes Following Targeted Muscle Reinnervation

NCT04658368
View directory record Official record
Conditions
Amputation
Interventions
Primary TMR, Secondary TMR
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Oct 30, 2026, 8:26 PM EDT
Completed No phase listed Observational

The Effect of Implementing a Limb Loss Prevention Program on Amputation Rates

NCT03978715
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
No intervention-retrospective study
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 30, 2026, 8:26 PM EDT
Completed No phase listed Observational

Extremity Trauma At a Level 1 Trauma Center

NCT06402669
View directory record Official record
Conditions
Trauma Injury, Trauma Blunt, Vascular Trauma
Interventions
Packed Red Blood Cell Administration
Other
Lead sponsor
Arrowhead Regional Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Colton, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Oct 30, 2026, 8:26 PM EDT
Recruiting No phase listed Observational

Evaluating the Experience of Upper Limb Prosthesis Use

NCT04855214
View directory record Official record
Conditions
Prosthesis User, Amputation, Upper Limb Amputation at the Wrist, Upper Limb Amputation Above Elbow (Injury), Upper Limb Amputation Below Elbow (Injury)
Interventions
Qualitative Analysis
Other
Lead sponsor
Louis Stokes VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
178 participants
Timeline
2020 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional Results available

EmPOWERing Active Seniors With Energy

NCT02958553
View directory record Official record
Conditions
Amputation
Interventions
emPOWER Ankle, Subject's own passive prosthesis
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
55 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 30, 2026, 8:26 PM EDT
Completed Not applicable Interventional

Controlled Study of Farabloc for Chronic Phantom Limb Pain Among Veteran Amputees

NCT00797849
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
Farabloc Limb Cover, Sham Limb Cover
Device
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Mar 14, 2012 · Synced Oct 30, 2026, 8:26 PM EDT