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Showing 1–24 of 168 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Amputees Clear all
Terminated Not applicable Interventional Results available

Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees, 90-Day

NCT04547582
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
Lee Fisher, PhD
Other
Eligibility
22 Years to 70 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 8, 2026, 5:38 PM EDT
Recruiting Not applicable Interventional

Immersive Healing: The Therapeutic Potential of Virtual Reality

NCT06077227
View directory record Official record
Conditions
Phantom Limb Pain (PLP)
Interventions
virtual reality therapy, matched control group
Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparison of External Mechanical Work Between Different Prosthetic Feet

NCT01340807
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Specialized Functional Prosthetic Training
Other
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
40 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 24, 2011 · Synced Sep 8, 2026, 5:38 PM EDT
Not yet recruiting Not applicable Interventional

Altius Peripheral Nerve Stimulation in Amputees After TMR/RPNI

NCT07571239
View directory record Official record
Conditions
Amputation; Lower Extremity, Pain, Persistent Postsurgical
Interventions
Surgical Implantation
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Not applicable Interventional Results available

Validation of Point Partial User Needs With Partial Finger Amputees

NCT05012657
View directory record Official record
Conditions
Amputation; Traumatic, Hand
Interventions
Point Partial
Device
Lead sponsor
Point Designs
Industry
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Aurora, Colorado • Lafayette, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 7, 2024 · Synced Sep 8, 2026, 5:38 PM EDT
Completed No phase listed Observational

Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles Tendon

NCT01382628
View directory record Official record
Conditions
Diabetic Foot Ulcers, Equinus Deformity
Interventions
Not listed
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Sep 8, 2026, 5:38 PM EDT
Withdrawn Not applicable Interventional

Surgical Treatments for Neuroma Pain in Amputees

NCT04204668
View directory record Official record
Conditions
Pain, Neuropathic, Amputation Neuroma, Phantom Limb Pain
Interventions
TMR, RPNI, VDMT
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 2, 2025 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Metabolic Cost Savings for Transtibial Amputees Wearing the Controlled Energy Storage and Return (CESR) Foot

NCT00494143
View directory record Official record
Conditions
Transtibial Amputation
Interventions
CESR Prosthetic Foot, typical prosthetic foot, standardized prosthetic foot
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 8, 2014 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Pain in Amputees Reduced by Administration of Diet Examination

NCT05460845
View directory record Official record
Conditions
Amputation, Phantom Limb Pain, Residual Limb Pain
Interventions
Low-Carbohydrate Diet
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System

NCT01996254
View directory record Official record
Conditions
Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain
Interventions
SPRINT Peripheral Nerve Stimulation (PNS) System
Device
Lead sponsor
SPR Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
10
States / cities
Scottsdale, Arizona • La Jolla, California • Denver, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Not applicable Interventional

Thigh Reduction Surgery of Above Knee Amputee Residual Limbs to Improve Prosthesis Fit and Patient Outcomes

NCT02346019
View directory record Official record
Conditions
Transfemoral Amputees
Interventions
Medial thighplasty with or without thigh liposuction
Procedure
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 22, 2020 · Synced Sep 8, 2026, 5:38 PM EDT
Not yet recruiting Not applicable Interventional

Personalized Prosthetic Foot Prescription and Rehabilitation for Veterans With Lower Limb Loss

NCT06844305
View directory record Official record
Conditions
Amputation of Lower Limb
Interventions
Prosthetic foot, Physical therapy
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Not applicable Interventional

Spinal Root and Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees

NCT03027947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Sep 8, 2026, 5:38 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Musculoskeletal Measurements in Transfemoral Amputees

NCT00909922
View directory record Official record
Conditions
Lower Limb Loss
Interventions
Not listed
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 28, 2009 · Synced Sep 8, 2026, 5:38 PM EDT
Withdrawn Not applicable Interventional

Evaluation of a Multi-electrode Prosthesis Control System for Real-world Tasks Performance in Individuals With Upper Limb Transradial Amputation

NCT07071584
View directory record Official record
Conditions
Upper Limb Amputation Below Elbow
Interventions
Cutaneous Prosthesis Control System
Device
Lead sponsor
Phantom Neuro Inc.
Industry
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Buffalo, New York • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 8, 2026, 5:38 PM EDT
Recruiting Not applicable Interventional

Reliability and Validity of Continuous Inter-limb Stability

NCT06987019
View directory record Official record
Conditions
Amputation, Lower Limb
Interventions
3D motion capture, wearable devices, and functional outcome measures
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reduction of Shear Forces Using Semi-flexible Sockets on Transtibial Amputees

NCT03390153
View directory record Official record
Conditions
Amputation
Interventions
semi flexible socket, rigid fiber socket
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Sep 24, 2018 · Synced Sep 8, 2026, 5:38 PM EDT
Completed No phase listed Observational

The Effect of Implementing a Limb Loss Prevention Program on Amputation Rates

NCT03978715
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
No intervention-retrospective study
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2023 · Synced Sep 8, 2026, 5:38 PM EDT
Completed No phase listed Observational

Comparing Active and Passive Ankle-foot Prostheses

NCT01684501
View directory record Official record
Conditions
Trans-tibial Amputation
Interventions
Not listed
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 11, 2017 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Not applicable Interventional Results available

Development of Adaptive Vacuum Suspension to Improve Prosthetic Fit and Residual Limb Health

NCT03927404
View directory record Official record
Conditions
Lower Limb Amputation
Interventions
Active vacuum test prosthesis
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study to Assess the Efficacy of Botulinum Toxin B (Myobloc) for the Treatment of Prosthesis-associated Sweating

NCT01671800
View directory record Official record
Conditions
Hyperhidrosis
Interventions
Botulinum Type B, Placebo
Drug
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 9, 2013 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Phase 1 Interventional

Transcranial Magnetic Stimulation for the Treatment of Phantom Pain

NCT00001923
View directory record Official record
Conditions
Pain
Interventions
Transcranial magnetic stimulation
Procedure
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Not applicable Interventional

e-OPRA Implant System for Lower Limb Amputees

NCT03720171
View directory record Official record
Conditions
Amputation
Interventions
e-OPRA Implant System
Device
Lead sponsor
Integrum
Industry
Eligibility
22 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Sep 8, 2026, 5:38 PM EDT
Completed Phase 4 Interventional Results available

Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study

NCT01824082
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
Perineural infusion [continuous peripheral nerve block(s)]
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
4
States / cities
Palo Alto, California • San Diego, California • Bethesda, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Sep 8, 2026, 5:38 PM EDT