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ClinicalTrials.gov public records Last synced Oct 10, 2026, 7:11 AM EDT

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Showing 145–168 of 247 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Analgesic Efficacy Clear all
Terminated Phase 2 Interventional

Percocet vs. Bupivicaine for Toothaches in the ED

NCT02862691
View directory record Official record
Conditions
Toothache
Interventions
Acetaminophen/Oxycodone (Oral analgesic), Bupivicaine (Injectable local anesthetic)
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine Single-Injection Interscalene Block vs. Continuous Interscalene Block for Primary Total Shoulder Arthroplasty

NCT05005260
View directory record Official record
Conditions
Pain, Postoperative, Brachial Plexus Block
Interventions
Bupivacaine HCl, Liposomal bupivacaine + Bupivacaine Hcl 0.5% Inj
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 2 Interventional

Bunionectomy Trial With GRT6005

NCT00872885
View directory record Official record
Conditions
Post Operative Pain
Interventions
GRT6005, Morphine, Placebo
Drug
Lead sponsor
Tris Pharma, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 15, 2021 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Efficacy of XP20B Following Bunionectomy Surgery

NCT00655291
View directory record Official record
Conditions
Acute Pain
Interventions
XP20B, Placebo
Drug
Lead sponsor
Xanodyne Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
6
States / cities
Anaheim, California • Owings Mills, Maryland • Austin, Texas + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2008 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 2 Interventional Results available

Veterans' Pain Care Organizational Improvement Comparative Effectiveness Study

NCT03026790
View directory record Official record
Conditions
Chronic Pain
Interventions
Medication management, Non-pharmacological pain management, Buprenorphine-Naloxone
Other · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
820 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Not applicable Interventional Results available

Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair

NCT01500109
View directory record Official record
Conditions
Cleft Palate
Interventions
Oral acetaminophen, Ofirmev®, Opioid only
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
5 Months to 5 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Oct 10, 2026, 7:11 AM EDT
Completed No phase listed Interventional Results available

Comparison of Analgesic Efficacy Between of Interscalene Block With Liposomal Bupivacaine With Bupivacaine and Dexamethasone

NCT03969875
View directory record Official record
Conditions
Total Shoulder Arthroplasty, Shoulder Osteoarthritis
Interventions
Interscalene catheter, Liposomal bupivacaine, Dexamethasone, Bupivacaine
Device · Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain.

NCT00290901
View directory record Official record
Conditions
Back Pain
Interventions
Tramadol Hydrochloride 50mg, Celebrex 200mg
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
18 Years and older
Enrollment
754 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2006
U.S. locations
53
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Tucson, Arizona + 50 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 3 Interventional Results available

Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)

NCT00763321
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
ABT-712, Placebo
Drug
Lead sponsor
AbbVie (prior sponsor, Abbott)
Industry
Eligibility
21 Years to 75 Years
Enrollment
287 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
31
States / cities
Huntsville, Alabama • Burbank, California • San Diego, California + 27 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2014 · Synced Oct 10, 2026, 7:11 AM EDT
Withdrawn Phase 4 Interventional

Liposomal Bupivacaine in Total Knee Arthroplasty

NCT02426164
View directory record Official record
Conditions
Pain, Postoperative, Arthroplasty, Replacement, Knee, Osteoarthritis
Interventions
Liposomal bupivacaine, bupivacaine HCl, morphine, epinephrine, methylprednisolone
Drug
Lead sponsor
Miller Orthopedic Specialists
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Council Bluffs, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 22, 2016 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Not applicable Interventional Results available

Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic

NCT02268955
View directory record Official record
Conditions
Biliary Colic
Interventions
IV Ibuprofen, Saline
Drug
Lead sponsor
Valleywise Health
Other
Eligibility
18 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 14, 2019 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 3 Interventional Results available

Tanezumab in Osteoarthritis Of The Hip

NCT00744471
View directory record Official record
Conditions
Arthritis, Osteoarthritis, Osteoarthritis, Hip
Interventions
tanezumab, Placebo
Biological
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 99 Years
Enrollment
627 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
99
States / cities
Mobile, Alabama • Paradise Valley, Arizona • Peoria, Arizona + 74 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2021 · Synced Oct 10, 2026, 7:11 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Human Experimental Models of Pain (HEMP)

NCT07549490
View directory record Official record
Conditions
Acute Pain
Interventions
Placebo, Naproxen, Pregabalin
Drug
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 100 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 10, 2026, 7:11 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A 6 Month Study to Evaluate the Safety, Analgesic Efficacy of ACUVAIL™ (Ketorolac Tromethamine Ophthalmic Solution) 0.45%, in Post-PRK Corneal Wound Healing

NCT01193231
View directory record Official record
Conditions
Must be PRK Candidate
Interventions
Not listed
Lead sponsor
Durrie Vision
Other
Eligibility
18 Years to 39 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Feb 14, 2012 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 2 Interventional

A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain

NCT01345045
View directory record Official record
Conditions
Diabetic Neuropathic Pain
Interventions
ABT-639, pregabalin, Placebo
Drug
Lead sponsor
AbbVie (prior sponsor, Abbott)
Industry
Eligibility
18 Years to 75 Years
Enrollment
193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
19
States / cities
Little Rock, Arkansas • Anaheim, California • Long Beach, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2013 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Not applicable Interventional

Analgesic Efficacy of Anterior Femoral, Genicular and Adductor Canal Nerve Block

NCT02548104
View directory record Official record
Conditions
Pain, Postoperative
Interventions
ACB, ACB + iPACK
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 19, 2025 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 4 Interventional Results available

A Trial to Compare the Duration of Analgesic Efficacy and Safety of Naproxen Sodium Tablets and Ibuprofen Tablets in Postsurgical Dental Pain

NCT03404206
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Naproxen Sodium (Aleve, BAY117031), Ibuprofen (Advil), Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
16 Years to 40 Years
Enrollment
387 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 18, 2019 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 2 Interventional

Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Colorectal Surgery

NCT02489526
View directory record Official record
Conditions
Post-Operative Pain
Interventions
VVZ-149 Injections, Placebo
Drug
Lead sponsor
Vivozon, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
3
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 25, 2020 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 3 Interventional

Evaluate Analgesic Efficacy of Fast Release Aspirin

NCT01117636
View directory record Official record
Conditions
Drugs, Investigational
Interventions
Acetylsalicylic acid (Fast release Aspirin, BAY1019036), Acetylsalicylic Acid (Aspirin, BAYE4465), Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
16 Years to 45 Years
Enrollment
514 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
2
States / cities
Austin, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 19, 2018 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Not applicable Interventional

Randomized Study of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery

NCT07052721
View directory record Official record
Conditions
Rotator Cuff Tears, Shoulder Injuries, Hallux Valgus, Ankle Arthropathy, Clavicle Fracture
Interventions
Experimental Treatment, Sham Comparator
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Assessing the Analgesic Efficacy of Naproxen Sodium in Postsurgical Dental Pain.

NCT00720057
View directory record Official record
Conditions
Toothache
Interventions
Naproxen Sodium ER (BAYH6689), Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
16 Years to 45 Years
Enrollment
312 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
3
States / cities
Austin, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 25, 2015 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Dental Pain Study of Analgesics in Patients Undergoing Molar Removal

NCT03652818
View directory record Official record
Conditions
Dental Pain
Interventions
Pre-Op pregabalin, Pre-Op Placebo 1, Post-Op pregabalin, Post-Op Placebo 1, Post-Op Placebo 2, Post-Op acetaminophen
Drug
Lead sponsor
Nevakar, Inc.
Industry
Eligibility
17 Years to 55 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Oct 10, 2026, 7:11 AM EDT
Not yet recruiting Not applicable Interventional

Marine Lipids Ease Painful TMD

NCT07437313
View directory record Official record
Conditions
Temporomandibular Disorder (TMD)
Interventions
SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 10, 2026, 7:11 AM EDT
Completed Phase 4 Interventional Results available

Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery

NCT01975285
View directory record Official record
Conditions
Foot and Ankle Procedures
Interventions
Dexamethasone, Saline
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 6, 2016 · Synced Oct 10, 2026, 7:11 AM EDT