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ClinicalTrials.gov public records Last synced Oct 20, 2026, 8:26 AM EDT

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Showing 49–72 of 252 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Anesthesia, General Clear all
Completed No phase listed Observational

POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

NCT01199913
View directory record Official record
Conditions
1. Postoperative Cognitive Dysfunction
Interventions
The intervention will be Mini-Mental Status Examination (MMSE)
Other
Lead sponsor
Loma Linda University
Other
Eligibility
65 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Sep 9, 2014 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Phase 4 Interventional Results available

Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion

NCT00808665
View directory record Official record
Conditions
Spinal Fusion Acquired, Spinal Stenosis, Lesions of Lumbosacral Intervertebral Disc, Spinal Diseases
Interventions
Dexmedetomidine, 0.9% Saline
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 25, 2018 · Synced Oct 20, 2026, 8:26 AM EDT
Withdrawn Phase 2 Interventional

Compare the Effect of Propofol vs. "Ketofol" on Hemodynamic Stability During Induction of General Anesthesia

NCT02282891
View directory record Official record
Conditions
Patients With "ASA 3" Designation
Interventions
Propofol, Propofol-Ketamine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 15, 2016 · Synced Oct 20, 2026, 8:26 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients

NCT04443517
View directory record Official record
Conditions
Postoperative Delirium
Interventions
Alpha Optimization, Emergence from anesthesia with Dexmedetomidine
Procedure · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
60 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Not applicable Interventional Results available

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

NCT05279898
View directory record Official record
Conditions
Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
Interventions
EEG Monitoring, Ropivacaine, Ketamine, Remifentanil, Dexmedetomidine, Rocuronium, Propofol
Device · Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 20, 2026, 8:26 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Does Spinal Anesthesia for Prolapse Surgery With Lead to Urinary Retention?

NCT02547155
View directory record Official record
Conditions
Urinary Retention, Uterine Prolapse
Interventions
Spinal anesthesia, General anesthesia
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
40 Years and older · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Weston, Florida
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Early Phase 1 Interventional

The PATHFINDER Study: A Feasibility Trial

NCT04016740
View directory record Official record
Conditions
Coronary Artery Disease, Delirium
Interventions
Ropivacaine, Ketamine, Remifentanil, Dexmedetomidine, Rocuronium, Propofol, Sevoflurane, EEG monitoring
Drug · Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 20, 2026, 8:26 AM EDT
Enrolling by invitation No phase listed Observational

PPV vs PVI in the Supine and Prone Position

NCT07415603
View directory record Official record
Conditions
Surgeries Undergoing General Anesthesia
Interventions
Observation
Other
Lead sponsor
Joseph D. Tobias
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 20, 2026, 8:26 AM EDT
Recruiting Not applicable Interventional

Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study

NCT07334418
View directory record Official record
Conditions
Cesarean Section, Delivery; Trauma
Interventions
General anesthetic, Intravenous anesthetic
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Not applicable Interventional

The Optimal Time to Put Laryngeal Mask Airway in the Mouth Under General Anesthesia

NCT00972491
View directory record Official record
Conditions
General Anesthesia
Interventions
Insertion of Laryngeal Mask Airway
Procedure
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 4, 2013 · Synced Oct 20, 2026, 8:26 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

A Comparison of UGSB and GA to IV Narcotics and GA for Post-Op Pain in Children With Supracondylar Fractures.

NCT02056288
View directory record Official record
Conditions
Supracondylar Fractures
Interventions
Fentanyl, Ropivacaine
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
2 Years to 17 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2021 · Synced Oct 20, 2026, 8:26 AM EDT
Completed No phase listed Observational

The Effect of General Anesthesia on the Risk for Arrhythmia

NCT01174251
View directory record Official record
Conditions
Arrhythmia
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 8, 2013 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Not applicable Interventional

The Effect of a Reduced Noise Environment on Induction and Emergence Behavior in Children Undergoing General Anesthesia

NCT03504553
View directory record Official record
Conditions
Surgery, Noise Exposure
Interventions
Noise reduction
Other
Lead sponsor
Joshua Uffman
Other
Eligibility
2 Years to 7 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Oct 20, 2026, 8:26 AM EDT
Terminated Not applicable Interventional

Electrical and Formocresol Pulpotomy in Primary Molars

NCT01622153
View directory record Official record
Conditions
Reversible Pulpitis, Caries
Interventions
Formocresol application after pulpotomy preparation, GENTLEray 980 Soft Tissue diode laser
Procedure
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
3 Years to 8 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Not applicable Interventional

Nasal Mask Ventilation During the Induction of General Anesthesia

NCT01651286
View directory record Official record
Conditions
Mechanical Ventilation Complication, Upper Airway Obstruction
Interventions
nasal mask, full face mask
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 18, 2017 · Synced Oct 20, 2026, 8:26 AM EDT
Not yet recruiting Phase 3 Interventional

Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)

NCT07565870
View directory record Official record
Conditions
Postoperative Pain, Recovery
Interventions
Intravenous Methadone, Short-acting Opioids Intraoperative analgesia
Drug
Lead sponsor
Alexandre P. Joosten
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Not applicable Interventional

Cohort 2 Efficacy of Nasopharyngeal Ventilation With Endotracheal Tube for Surgery

NCT02018146
View directory record Official record
Conditions
General Anesthesia With Endotracheal Intubation in Surgery
Interventions
Mask then nasopharyngeal, Nasopharyngeal then mask
Other
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Not applicable Interventional

Lower Extremity Elevation to Minimize Hemodynamic Instability During Induction of General Anesthesia

NCT06513169
View directory record Official record
Conditions
Post Induction Hypotension
Interventions
Group 1: LEE
Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 70 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 20, 2026, 8:26 AM EDT
Active, not recruiting No phase listed Observational

Gastric Ultrasound in Pediatric Trauma Patients

NCT05330351
View directory record Official record
Conditions
Trauma; Complications, Aspiration
Interventions
Gastric Ultrasound
Diagnostic Test
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
0 Years to 17 Years
Enrollment
40 participants
Timeline
2022 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Not applicable Interventional Results available

Comparative Analysis of CO2 Monitoring Methods in Patients With CF Undergoing General Anesthesia

NCT03734822
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
End tidal CO2 (EtCO2), Transcutaneous CO2 (TCO2), Capillary CO2 (CapCO2), Arterial blood gas (ABG)
Other · Device · Diagnostic Test
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 14, 2019 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Monitored Anesthesia Care vs. General Anesthesia for Transcatheter Aortic Valve Replacement

NCT04107038
View directory record Official record
Conditions
Transcatheter Aortic Valve Replacement
Interventions
General Endotracheal Anesthesia, Monitored anesthesia care
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reconstructing Consciousness and Cognition

NCT01911195
View directory record Official record
Conditions
Postoperative Cognitive Dysfunction
Interventions
ISOFLURANE- Experimental Arm, Control Group: Cognitive Testing
Drug · Other
Lead sponsor
University of Michigan
Other
Eligibility
20 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
3
States / cities
Ann Arbor, Michigan • St Louis, Missouri • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Oct 20, 2026, 8:26 AM EDT
Completed Phase 3 Interventional Results available

Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis

NCT02740127
View directory record Official record
Conditions
Malignant Neoplasms of Male Genital Organs
Interventions
Caudal Nerve Block (CNB), Ropivacaine, Epinephrine, Decadron, Clonidine, Propofol, Phone Call
Procedure · Drug · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Male only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 24, 2022 · Synced Oct 20, 2026, 8:26 AM EDT
Not listed Not applicable Interventional

SuperNO2VA™ and General Anesthesia Postoperative Care

NCT03969615
View directory record Official record
Conditions
Hypoxemia, Acute Respiratory Failure
Interventions
SuperNO2VA nasal positive airway pressure devic, Supplemental oxygen
Device
Lead sponsor
Vyaire Medical
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Oct 20, 2026, 8:26 AM EDT