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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Anesthesia, Local Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years

NCT03562481
View directory record Official record
Conditions
Anesthesia, Local, Pain
Interventions
1% Buffered Lidocaine 1:100,000 Epinephrine, 2% Unbuffered Lidocaine 1:100,000 Epinephrine
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
10 Years to 12 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2020 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Bupivacaine for Post-operative Pain in Mohs

NCT04362566
View directory record Official record
Conditions
Pain, Postoperative, Narcotic Use
Interventions
Bupivacaine, Placebo Saline
Drug · Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 20, 2021 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Not applicable Interventional

A Randomized, Equivalence Trial of Percutaneous Lumbar Adhesiolysis and Caudal Epidural Steroid Injections

NCT01053273
View directory record Official record
Conditions
Low Back Pain
Interventions
Caudal Epidural Injection, percutaneous adhesiolysis
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Sep 8, 2026, 4:33 PM EDT
Recruiting Phase 3 Interventional

Pharmacokinetics, Safety, and Tolerability Study of GOPRELTO® Nasal Solution and NUMBRINO™ Nasal Solution

NCT04792034
View directory record Official record
Conditions
ENT Disorder, Nasal Procedures, Nasal Anesthesia, Nasal Mucosa Surgery
Interventions
Cocaine Hydrochloride Nasal Solution
Drug
Lead sponsor
Noden Pharma
Industry
Eligibility
12 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
Columbia, South Carolina • Lugoff, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 25, 2025 · Synced Sep 8, 2026, 4:33 PM EDT
Recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Can PLIA Reduce Early Post-operative Pain After PAO Surgery?

NCT06519955
View directory record Official record
Conditions
Hip Dysplasia
Interventions
Ropivacaine, Epinephrine, Ketorolac, NaCl (Saline)
Combination Product
Lead sponsor
Michael C Willey
Other
Eligibility
13 Years to 50 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block

NCT03117140
View directory record Official record
Conditions
Anesthesia, Local
Interventions
Ropivacaine 0.75%, Ropivacaine 0.75% + 300 mcg Buprenorphine, Ropivacaine 0.75% + 75 mcg clonidine, Ropivacaine 0.75% + 8 mg dexamethasone
Drug
Lead sponsor
Melinda Seering
Other
Eligibility
18 Years to 70 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 2, 2018 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Not applicable Interventional

Tap Block vs Conventional Pain Medication for Patients Undergoing Robotic Sacrocolpopexy

NCT04440475
View directory record Official record
Conditions
Anesthesia, Local, Prolapse, Prolapse; Female, Prolapse, Vaginal, Prolapse; Vagina, Posthysterectomy, Pain, Postoperative
Interventions
TAP block
Procedure
Lead sponsor
ProMedica Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Pain Outcomes Following Intralesional Corticosteroid Injections

NCT03630198
View directory record Official record
Conditions
Keloid, Alopecia Areata, Acne, Hypertrophic Scar, Epidermal Inclusion Cyst, Frontal Fibrosing Alopecia, Lichen Plano-Pilaris, Keratoacanthoma, Plaque Psoriasis, Lichen Simplex Chronicus, Prurigo Nodularis, Nummular Eczema, Granuloma Annulare, Morphea, Lichen Planus
Interventions
Corticosteroid with lidocaine, Corticosteroid with normal saline
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
12 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Sep 8, 2026, 4:33 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Surgical Outcomes Following Neurectomy Based Upon Response to Local Anesthetic Injection in Chronic Groin Pain

NCT05386693
View directory record Official record
Conditions
Hernia, Inguinal, Chronic Postoperative Pain
Interventions
Ilioinguinal nerve block
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 4, 2024 · Synced Sep 8, 2026, 4:33 PM EDT
Completed No phase listed Observational

Comparison of Epidural and TAP Block in Abdominal Surgery

NCT01848951
View directory record Official record
Conditions
Acute Pain, Surgery, Regional Anesthesia
Interventions
Epidural, TAP Block
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Phase 4 Interventional Results available

3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty

NCT03948386
View directory record Official record
Conditions
Osteoarthritis, Hip
Interventions
isobaric bupivacaine, hyperbaric bupivacaine, isobaric mepivacaine
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 84 Years
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
2
States / cities
Bensalem, Pennsylvania • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2021 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Not applicable Interventional Results available

Voiding Function After Mid-Urethral Slings With and Without Local Anesthetic: Randomized Controlled Trial

NCT01583166
View directory record Official record
Conditions
Stress Urinary Incontinence
Interventions
Bupivacaine, Saline, Epinephrine
Drug
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 27, 2018 · Synced Sep 8, 2026, 4:33 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Exploration of the Utility of Dental-dedicated MRI for Dentistry

NCT06948162
View directory record Official record
Conditions
Dental Crowding, Dental Occlusion, Traumatic, Endodontic Disease, Orthodontic Treatment, Endodontic Lesions, PeriodontalConditions, Oral Surgery Conditions, Tooth Extractions, Local Anesthesia, Traumatic Dental Pain, TMJ, Orthodontics, Endodontic Histopathology, Periodontal Diseases
Interventions
dental-dedicated MRI (ddMRI)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Erector Spinae Plane vs. Paravertebral Nerve Block for Thoracic Surgery

NCT03758261
View directory record Official record
Conditions
Thoracic Surgical Procedures
Interventions
Paravertebral nerve block, Erector Spinae nerve block
Drug
Lead sponsor
Charles Luke
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Not applicable Interventional

Regional Anesthesia EMG Study

NCT06287151
View directory record Official record
Conditions
Surgery
Interventions
BlockSynop surface electromyography device, Clonidine, Sevoflurane
Device · Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
0 Years to 5 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Phase 2 Interventional Results available

Balloon REmodeling Antrostomy THErapy Study

NCT00645762
View directory record Official record
Conditions
Sinusitis
Interventions
RS-Series Rhinosinusitis Treatment System, FinESS Balloon
Device
Lead sponsor
Entellus Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
13
States / cities
Fresno, California • Evanston, Illinois • Maywood, Illinois + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2013 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Not applicable Interventional

Regional Anesthesia for Cardiothoracic Enhanced Recovery (RACER) Study

NCT03611374
View directory record Official record
Conditions
Congenital Heart Defect, Congenital Heart Disease, Anesthesia, Local, Opioid Use
Interventions
Bilateral Erector Spinae Plane Block (ESPB)
Procedure
Lead sponsor
Stanford University
Other
Eligibility
0 Years to 99 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar

NCT01567839
View directory record Official record
Conditions
Anesthetic Effectiveness
Interventions
Mandibular buccal Infiltration injection
Procedure
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 31, 2013 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Phase 3 Interventional

S-Caine™ Peel (Skin Numbing Cream) to Treat Pain During Laser-Assisted Tattoo Removal in Adults

NCT00110734
View directory record Official record
Conditions
Pain
Interventions
S-Caine™ Peel (lidocaine and tetracaine cream 7%/7%)
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2005
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 22, 2005 · Synced Sep 8, 2026, 4:33 PM EDT
Terminated Not applicable Interventional Results available

Infrared Pupillometry During General Anesthesia to Predict Pain

NCT02058511
View directory record Official record
Conditions
Postoperative Pain, Objective Assessment of Sedation
Interventions
Anesthesia Premedication, Induction and Maintenance, Pupillometry after administration of anesthetic drugs
Drug · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 99 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Sep 8, 2026, 4:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Comparison of Two Injection Locations in Obese Patients Having Lower Leg/Foot Surgery

NCT01550094
View directory record Official record
Conditions
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/ or Foot, Complete Tear, Ankle and/or Foot Ligament, Pathological Fracture - Ankle and/or Foot, Loose Body in Joint of Ankle and/or Foot
Interventions
Not listed
Lead sponsor
Jose Soberon, MD
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2015 · Synced Sep 8, 2026, 4:33 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy

NCT01099605
View directory record Official record
Conditions
Hemorrhoids
Interventions
placement of a continuous infusion pump, continuous infusion pump of bupivacaine
Device
Lead sponsor
United States Naval Medical Center, Portsmouth
Federal
Eligibility
18 Years to 99 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Sep 8, 2026, 4:33 PM EDT
Completed Not applicable Interventional

Pain Management After TKA: Comparison of Short- and Long-term Nerve Blocks

NCT03245359
View directory record Official record
Conditions
Anesthesia, Local, Pain, Postoperative
Interventions
Short-term ON-Q, Short-term ON-Q, Long-term ON-Q, Long-term ON-Q
Device · Drug
Lead sponsor
AdventHealth
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Aug 1, 2019 · Synced Sep 8, 2026, 4:33 PM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

Subcutaneous Injection of Large Volumes of Tumescent Lidocaine and Epinephrine by Laypersons

NCT04733781
View directory record Official record
Conditions
Venomous Snakebites, Local Anesthesia, Painless Injection, Regional Anesthesia, Dermatologic Surgery, Cutaneous Pain, Musculoskeletal Pain
Interventions
Tumescent Lidocaine and Epinephrine
Drug
Lead sponsor
Jeffrey Alan Klein, MD
Industry
Eligibility
16 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
San Juan Capistrano, California
Source: ClinicalTrials.gov public record
Updated Feb 7, 2021 · Synced Sep 8, 2026, 4:33 PM EDT