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Showing 1–24 of 412 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Anesthetic Clear all
Completed Phase 3 Interventional Results available

Sphenopalatine Nerve Block for Headache Tx360

NCT01939314
View directory record Official record
Conditions
Headache, Migraine
Interventions
Bupivacaine, Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 65 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 26, 2015 · Synced Jul 21, 2026, 8:56 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

NCT04814433
View directory record Official record
Conditions
Opioid Pain Medication
Interventions
Tranexamic acid, Aminocaproic acid, Recombinant Human Thrombin, Lidocaine Hydrochloride with Epinephrine, Bupivacaine Hydrochloride with Epinephrine
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 99 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Jul 21, 2026, 8:56 AM EDT
Terminated Not applicable Interventional Results available

Isoflurane Preconditioning for Liver Resections

NCT01031550
View directory record Official record
Conditions
Liver Disease
Interventions
isoflurane, propofol
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 19, 2017 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Repeated Ketamine Infusions for Treatment-resistant Depression

NCT02360280
View directory record Official record
Conditions
Treatment-resistant Depression
Interventions
ketamine, midazolam
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Not applicable Interventional

Anesthetic to Reduce Dysphagia After Anterior Cervical Discectomy and Fusion Surgery

NCT02376205
View directory record Official record
Conditions
Dysphagia
Interventions
bupivacaine hydrochloride 0.5% solution, 0.9% NaCl solution
Drug
Lead sponsor
Justin Parker Neurological Institute
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 12, 2020 · Synced Jul 21, 2026, 8:56 AM EDT
Not listed Phase 2 Interventional

Study to Determine if Pre- and Post- Operative TAP Catheters With Ropivacaine Versus Placebo Affects Anesthetic, Narcotic Dosing, and Pain Scores

NCT03149783
View directory record Official record
Conditions
Pain, Postoperative, Delirium, Anesthesia, Local
Interventions
Ropivacaine HCL, sodium chloride
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 26, 2021 · Synced Jul 21, 2026, 8:56 AM EDT
Recruiting Phase 2 Interventional

Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment

NCT06655454
View directory record Official record
Conditions
Pain Assessment, Quality of Life (QOL), Analgesic Use
Interventions
Supplemental Postoperative Bupivacaine, Placebo Injection
Drug
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Phase 4 Interventional Results available

Control of Pain in Intravitreal Injections Using Topical NSAIDs

NCT04343222
View directory record Official record
Conditions
Intravitreal Injections, IVI
Interventions
Bromfenac, Artificial tears
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 11, 2023 · Synced Jul 21, 2026, 8:56 AM EDT
Terminated Phase 4 Interventional Results available

Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines

NCT02090998
View directory record Official record
Conditions
Transformed Migraine, Chronic Daily Headache
Interventions
SPG Block with 5% Lidocaine gel, Amitriptyline
Procedure · Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Not applicable Interventional

Ultrasound Guided Sciatic Nerve Block

NCT02688439
View directory record Official record
Conditions
Sciatic Nerve
Interventions
Sciatic Nerve block, Leg raised 30°, Distal tourniquet placed on the lower part of the leg, Leg in a neutral position
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 70 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2019 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intraoperative Bleeding During Endoscopic Sinus Surgery

NCT01014728
View directory record Official record
Conditions
Blood Loss
Interventions
propofol, sevoflurane
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 85 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 13, 2014 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Not applicable Interventional Results available

Perineural Local Anesthetic Administration With a Continuous Infusion Versus Automatic Intermittent Boluses

NCT04458467
View directory record Official record
Conditions
Pain, Acute, Anesthesia, Local, Trauma Injury
Interventions
Continuous Infusion, Automated Intermittent Boluses
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2022 · Synced Jul 21, 2026, 8:56 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Pain After Buffered Vs Non Buffered Articaine

NCT06538233
View directory record Official record
Conditions
Pain
Interventions
Buffered articaine, Non buffered articaine
Drug
Lead sponsor
Cleveland Dental Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 4, 2024 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Phase 3 Interventional Results available

Bupivacaine Effectiveness and Safety in SABER® Trial

NCT01052012
View directory record Official record
Conditions
Postoperative Pain, Abdominal Surgery
Interventions
SABER-Bupivacaine, Bupivacaine HCl, SABER-Placebo
Drug
Lead sponsor
Durect
Industry
Eligibility
18 Years and older
Enrollment
331 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
22
States / cities
Birmingham, Alabama • Florence, Alabama • Mobile, Alabama + 18 more
Source: ClinicalTrials.gov public record
Updated May 31, 2021 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Not applicable Interventional

Peripheral Nerve Stimulation to Reduce Hypoxic Events

NCT02554110
View directory record Official record
Conditions
Apnea, Hypoventilation, Hypoxemia
Interventions
Stimulator active device, Stimulator sham Device
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Anesthetic Effect Duration Assessment

NCT01545765
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Lidocaine 7% + Tetracaine 7% cream
Drug
Lead sponsor
Galderma R&D
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Rochelle Park, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 1, 2021 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Not applicable Interventional

Cutaneous Administration of Local Anesthetic for Spine Injection Procedures

NCT00756301
View directory record Official record
Conditions
Spinal Diseases
Interventions
Lidocaine local anesthesia- Alternative
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2012 · Synced Jul 21, 2026, 8:56 AM EDT
Completed No phase listed Observational

Cocaine Use and Outcomes of General Anesthesia

NCT02692534
View directory record Official record
Conditions
Anesthesia
Interventions
Urine cocaine negative, Urine cocaine positive
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 9, 2019 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Randomized Control Trial of a Topical Anesthetic to Evaluate Pain and Anxiety During Venipuncture

NCT00676364
View directory record Official record
Conditions
Pain, Anxiety
Interventions
4% lidocaine topical anesthetic cream, Placebo cream
Drug
Lead sponsor
Jenny Boucher, PharmD
Other
Eligibility
5 Years to 18 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Allentown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 24, 2012 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.

NCT02379221
View directory record Official record
Conditions
Anesthesia
Interventions
Injectable, Topical
Drug
Lead sponsor
David Grant U.S. Air Force Medical Center
Federal
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Travis Air Force Base, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2020 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics

NCT01402869
View directory record Official record
Conditions
Methemoglobinemia
Interventions
4% prilocaine plain, 2% Lidocaine with 1:100,000 epinephrine
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
3 Years to 5 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2014 · Synced Jul 21, 2026, 8:56 AM EDT
Terminated Phase 4 Interventional Results available

Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage

NCT01673061
View directory record Official record
Conditions
Abscess
Interventions
Lidocaine, Vapocoolant
Drug
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Jul 21, 2026, 8:56 AM EDT
Completed Phase 4 Interventional

Bupivacaine Versus Lidocaine on Inflammatory Regulation

NCT01060774
View directory record Official record
Conditions
Pain
Interventions
Lidocaine, Bupivacaine
Drug
Lead sponsor
University of Maryland
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 30, 2018 · Synced Jul 21, 2026, 8:56 AM EDT
Withdrawn No phase listed Observational

Effect of Local Anesthetic on Hemodynamic Measures During Nasal Surgery

NCT01701960
View directory record Official record
Conditions
Heart Rate, Blood Pressure, Blood Loss During Surgery, Surgical Field
Interventions
Not listed
Lead sponsor
Loma Linda University
Other
Eligibility
16 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 19, 2015 · Synced Jul 21, 2026, 8:56 AM EDT