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Showing 1–24 of 467 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Anesthetics Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Buffered Local Anesthetic

NCT05757648
View directory record Official record
Conditions
Dental Pain
Interventions
Non-buffered Anesthetic, Buffered Anesthetic, Onset
Drug · Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
2 Years to 6 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic

NCT00508976
View directory record Official record
Conditions
Pain, Postoperative, Morbid Obesity
Interventions
Injected bupivacaine post-operatively, Streamed bupivacaine versus streamed normal saline, Aerosolized bupivacaine versus aerosolized saline, Injected lidocaine pre-incision vs saline pre-incision
Drug
Lead sponsor
Pinnacle Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Harrisburg, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2012 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Not applicable Interventional Results available

Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation.

NCT02697448
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
propofol, sevoflurane
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 19, 2024 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Phase 4 Interventional Results available

Optimizing Local Anesthetic Concentration for Continuous Femoral Nerve Blocks

NCT00923598
View directory record Official record
Conditions
Total Knee Arthroplasty, Knee Pain
Interventions
0.1% and 0.4% perineural ropivicaine
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 1, 2019 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Transversus Abdominis Plane Block Versus Local Injection of Pain Medication

NCT02314104
View directory record Official record
Conditions
Pain, Postoperative
Interventions
ropivacaine
Drug
Lead sponsor
Liberman, Eric, D.O.
Individual
Eligibility
18 Years and older · Female only
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Livingston, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 13, 2015 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Neuroimaging of Anesthetic Modulation of Human Consciousness

NCT03361605
View directory record Official record
Conditions
Healthy
Interventions
Propofol
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Trigger Finger Corticosteroid Injection With and Without Local Anesthetic

NCT04023695
View directory record Official record
Conditions
Trigger Finger
Interventions
Corticosteroid with lidocaine with epinephrine, Corticosteroid with normal saline
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.

NCT02379221
View directory record Official record
Conditions
Anesthesia
Interventions
Injectable, Topical
Drug
Lead sponsor
David Grant U.S. Air Force Medical Center
Federal
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Travis Air Force Base, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2020 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures

NCT01048658
View directory record Official record
Conditions
Blood Loss, Anesthesia
Interventions
Sevoflurane, No Sevoflurane
Drug · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 8, 2017 · Synced Jun 27, 2026, 4:11 AM EDT
Completed No phase listed Observational

Provider Variability in the Use of Neuromuscular Blocking Drugs and Reversal

NCT03585348
View directory record Official record
Conditions
Neuromuscular Blockade, Residual Curarisation, Postoperative, Surgery Under General Anaesthesia
Interventions
Neuromuscular blocking agents
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
265,537 participants
Timeline
2018 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 24, 2021 · Synced Jun 27, 2026, 4:11 AM EDT
Withdrawn Phase 4 Interventional

Safety and Efficacy Study of Correcting Hyperglycemia in Patients With Diabetes Having Out-patient Surgery

NCT01971047
View directory record Official record
Conditions
Type 1 Diabetes, Type 2 Diabetes
Interventions
Regular Insulin, Humalog
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 14, 2017 · Synced Jun 27, 2026, 4:11 AM EDT
Withdrawn Phase 1 Interventional

Cool Pre-operative TAP Blocks

NCT04761887
View directory record Official record
Conditions
Anesthetics, Local
Interventions
Cool Ropivacaine Block, Room Temp Ropivacaine Block
Drug
Lead sponsor
Daniel Wambold
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Jun 27, 2026, 4:11 AM EDT
Completed No phase listed Observational

Retrospective Review of Anesthetic Considerations for Pulmonary Artery Rehabilitation

NCT02586740
View directory record Official record
Conditions
Pulmonary Artery Stenosis, Tetralogy of Fallot, Pulmonary Atresia
Interventions
Pulmonary artery rehabilitation
Procedure
Lead sponsor
Aymen N Naguib
Other
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 15, 2017 · Synced Jun 27, 2026, 4:11 AM EDT
Terminated Phase 4 Interventional Results available

US Guided GNB vs Saline Injection for TKA

NCT03316118
View directory record Official record
Conditions
Postoperative Pain, Total Knee Arthroplasty, Nerve Block
Interventions
bupivacaine, saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
40 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops

NCT01925391
View directory record Official record
Conditions
Glaucoma, Intraocular Pressure, Anesthesia
Interventions
Tono-pen XL Applanation tonometer + Ocu-film +
Drug
Lead sponsor
University of Miami
Other
Eligibility
1 Year to 18 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 15, 2014 · Synced Jun 27, 2026, 4:11 AM EDT
Completed No phase listed Observational

Intraoperative Anaesthesia Awareness Following Induction of Anaesthesia

NCT02248623
View directory record Official record
Conditions
Anaesthesia
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
2
States / cities
Ann Arbor, Michigan • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 5, 2016 · Synced Jun 27, 2026, 4:11 AM EDT
Terminated Not applicable Interventional Results available

Clinical Study to Evaluate the Effect of pH on Pain Upon Local Anesthetic Administration.

NCT01304082
View directory record Official record
Conditions
Local Anesthetics
Interventions
Lidocaine, normal saline, alkalinized lidocaine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
19 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Not applicable Interventional

Anesthetic Optimization in Scoliosis Surgery

NCT02481570
View directory record Official record
Conditions
Adolescent Idiopathic Scoliosis, Respiratory Depression, Postoperative Pain
Interventions
pharmacokinetic simulation
Other
Lead sponsor
University of Florida
Other
Eligibility
10 Years to 18 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 11, 2019 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Not applicable Interventional Results available

The Effect of Anesthesia on Neurodevelopmental Outcome (NDO)

NCT03882788
View directory record Official record
Conditions
Anesthesia; Adverse Effect, Congenital Heart Disease, Neurodevelopmental Disorders
Interventions
Isoflurane, Fentanyl (high dose), Fentanyl (low dose)
Drug
Lead sponsor
Stanford University
Other
Eligibility
1 Day to 36 Months
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 8, 2022 · Synced Jun 27, 2026, 4:11 AM EDT
Completed Not applicable Interventional

Local Infiltration Analgesia for Hip Arthroscopy

NCT01454518
View directory record Official record
Conditions
Pain
Interventions
Infiltration of local anesthetic, Normal Saline Injection
Procedure
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 10, 2013 · Synced Jun 27, 2026, 4:11 AM EDT
Not listed No phase listed Observational

Perioperative Vaping Complications

NCT05912023
View directory record Official record
Conditions
Vaping, Complication of Anesthesia
Interventions
Not listed
Lead sponsor
Navy Medical Center San Diego
Federal
Eligibility
12 Years to 80 Years
Enrollment
300 participants
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Jun 27, 2026, 4:11 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Study of a Mental Fitness Intervention for Anesthesiology Resident Wellbeing and Self-Compassion

NCT07639827
View directory record Official record
Conditions
Wellness, Self Compassion, Burnout, Anxiety, Depression
Interventions
App-based bundled mental fitness intervention, App-based wellness module collection
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Jun 27, 2026, 4:11 AM EDT
Terminated No phase listed Observational

Anticipated Versus Actual Patient and Caregiver Burden Following Ambulatory Orthopedic Surgery

NCT02550886
View directory record Official record
Conditions
Stress, Psychological, Pain
Interventions
Survey
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 85 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 31, 2022 · Synced Jun 27, 2026, 4:11 AM EDT
Recruiting Not applicable Interventional

Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

NCT06528288
View directory record Official record
Conditions
Fusion of Spine, Lumbar Region, Anesthesia, Local, Pain, Postoperative, Opioid Use
Interventions
Erector Spinae Plane Block, Subcutaneous Anesthesia
Procedure
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Jun 27, 2026, 4:11 AM EDT