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ClinicalTrials.gov public records Last synced Oct 20, 2026, 7:18 AM EDT

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Showing 1–24 of 60 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Ankle Sprains Clear all
Completed Phase 3 Interventional

Efficacy and Safety of SST 0225, a Topical Ibuprofen Cream, in the Treatment of Pain Associated With Acute Ankle Sprain

NCT01874626
View directory record Official record
Conditions
Acute Ankle Sprain
Interventions
Placebo, SST-0225 Topical Ibuprofen Cream
Drug
Lead sponsor
Strategic Science & Technologies, LLC
Industry
Eligibility
16 Years and older
Enrollment
305 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Guilford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 21, 2021 · Synced Oct 20, 2026, 7:18 AM EDT
Completed Not applicable Interventional

Manual Therapy and Exercise Versus Home Exercises in the Management of Patients Status Post Ankle Sprain

NCT00797368
View directory record Official record
Conditions
Ankle Sprain
Interventions
Manual Therapy and Exercise, Home exercises
Other
Lead sponsor
Franklin Pierce University
Other
Eligibility
16 Years to 60 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Denver, Colorado • Concord, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 9, 2013 · Synced Oct 20, 2026, 7:18 AM EDT
Withdrawn Not applicable Interventional

The Effect of Low-Intensity Blood Flow Restriction Therapy on the Management of Acute Ankle Sprains

NCT05596162
View directory record Official record
Conditions
Ankle Sprain 1St Degree, Ankle Sprain 2Nd Degree, Musculoskeletal Injury
Interventions
Blood Flow Restriction Therapy, Standard Physical Therapy
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Oct 20, 2026, 7:18 AM EDT
Completed Not applicable Interventional

Cognitive Behavioral Based Physical Therapy for Patients With Chronic Ankle Instability

NCT07237581
View directory record Official record
Conditions
Ankle Sprains, Chronic Ankle Instability
Interventions
CBPT/HEP, HEP Only
Behavioral
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 35 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Oct 20, 2026, 7:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Five-Toed Socks on Postural Control Among Active Individuals Who Have Chronic Ankle Instabilities

NCT01210612
View directory record Official record
Conditions
Ankle Sprain
Interventions
Unilateral CAI
Device
Lead sponsor
University of Toledo Health Science Campus
Other
Eligibility
18 Years to 30 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 13, 2024 · Synced Oct 20, 2026, 7:18 AM EDT
Completed Early Phase 1 Interventional

Effects of Gait Retraining With Auditory Feedback

NCT04302961
View directory record Official record
Conditions
Ankle Injuries, Ankle Inversion Sprain
Interventions
Auditory Feedback, No Feedback
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 40 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 19, 2024 · Synced Oct 20, 2026, 7:18 AM EDT
Not listed Phase 3 Interventional

Effects of Gait Biofeedback and Impairment-based Rehabilitation in Individuals With Chronic Ankle Instability

NCT03507803
View directory record Official record
Conditions
Ankle Sprains, Ankle Injuries
Interventions
Gait Biofeedback
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 30 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 16, 2018 · Synced Oct 20, 2026, 7:18 AM EDT
Terminated Phase 3 Interventional

Chiropractic Care and a Specific Regimen of Nutritional Supplementation for Patients With Acute Ankle Sprain

NCT01824095
View directory record Official record
Conditions
Ankle Sprains
Interventions
Dietary supplement
Dietary Supplement
Lead sponsor
Logan University, Inc.
Other
Eligibility
18 Years to 50 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
9
States / cities
Columbia, Maryland • Ft. Washington, Maryland • Landover, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Oct 20, 2026, 7:18 AM EDT
Completed Phase 1Phase 2 Interventional

Ankle Sprains and Corticospinal Excitability

NCT00847769
View directory record Official record
Conditions
Ankle Sprain
Interventions
High velocity, low amplitude stretch, Slow, mobilization stretch, Passive Positioning
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 60 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 20, 2026, 7:18 AM EDT
Completed Not applicable Interventional

A Comparison of Early Mobilization Versus Traditional Treatment for Acute Ankle Sprains.

NCT01134653
View directory record Official record
Conditions
Ankle Sprain
Interventions
Jump Stretch
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
8 Years to 21 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Oct 20, 2026, 7:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Progressing Ankle Brace Restriction on Walking and Running Gait Characteristics in Healthy Individuals

NCT03641066
View directory record Official record
Conditions
Ankle Sprains
Interventions
Ankle Brace
Device
Lead sponsor
Sport and Spine Rehab Clinical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 25, 2019 · Synced Oct 20, 2026, 7:18 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability

NCT06868316
View directory record Official record
Conditions
Ankle Sprains, Ankle Injuries and Disorders
Interventions
Walking, Rucking, Running
Other
Lead sponsor
Danielle Torp
Other
Eligibility
18 Years to 45 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Lexington, Kentucky • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 20, 2026, 7:18 AM EDT
Suspended Phase 2Phase 3 Interventional

Ankle Manual Therapy for Ankle Sprains

NCT00888498
View directory record Official record
Conditions
Sprains and Strains
Interventions
Passive Positioning, High-Velocity, Low-Amplitude Stretch, Slow, Mobilization Stretch
Other
Lead sponsor
University of the Pacific
Other
Eligibility
16 Years to 60 Years
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Stockton, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2015 · Synced Oct 20, 2026, 7:18 AM EDT
Terminated Phase 2 Interventional Results available

Investigation of Corticosteroid Versus Placebo Injection in Patients With Syndesmotic Ligament Injury or High Ankle Sprain

NCT02892500
View directory record Official record
Conditions
Ankle Injuries
Interventions
bupivacaine hydrochloride and betamethasone sodium phosphate, bupivacaine hydrochloride
Drug
Lead sponsor
Sanford Health
Other
Eligibility
16 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Oct 20, 2026, 7:18 AM EDT
Withdrawn Not applicable Interventional

Efficacy of PENNSAID® for Pain Management in the Emergency Department

NCT01350622
View directory record Official record
Conditions
Pain, Ankle Sprain
Interventions
PENNSAID, Diclofenac hydroxyethylpyrrolidine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 21, 2016 · Synced Oct 20, 2026, 7:18 AM EDT
Completed Not applicable Interventional

Effects of Ankle Support on Muscle Activation and Function

NCT01423513
View directory record Official record
Conditions
Ankle Sprain
Interventions
Fibular Taping, Sham Taping
Other
Lead sponsor
Creighton University
Other
Eligibility
16 Years to 45 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 4, 2016 · Synced Oct 20, 2026, 7:18 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain

NCT00351104
View directory record Official record
Conditions
Sprain, Strain
Interventions
Ketoprofen Topical Patch 20%
Drug
Lead sponsor
Alkemira SA
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 20, 2026, 7:18 AM EDT
Withdrawn Not applicable Interventional

Waterproof Casting Versus Standard Casting for Short Leg Walking Casts

NCT04961957
View directory record Official record
Conditions
Ankle Fractures, Foot Fracture, Ankle Sprains, Foot Sprain, Toe-walking, Tendonitis of Foot, Apophysitis; Juvenile
Interventions
Waterproof padding, Non-waterproof padding
Device
Lead sponsor
West Virginia University
Other
Eligibility
5 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Oct 20, 2026, 7:18 AM EDT
Recruiting Not applicable Interventional

A Proprioceptive Training Program Using an Uneven Terrain Treadmill for Patients With Ankle Instability

NCT04999904
View directory record Official record
Conditions
Instability; Ankle (Ligaments) (Old Injury), Sprain of Ankle
Interventions
Uneven Treadmill Intervention, Standard of Care Physical Therapy
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 49 Years
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Oceanside, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 18, 2025 · Synced Oct 20, 2026, 7:18 AM EDT
Recruiting Not applicable Interventional

Semiconductor Embedded Socks for Ankle Sprains

NCT07025733
View directory record Official record
Conditions
Ankle Sprain
Interventions
Semiconductor Embedded Sock, Control Compression Sock
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 20, 2026, 7:18 AM EDT
Not listed Not applicable Interventional

The Effects of Gentle Movements at the Ankle in Individuals With Diminished Range of Motion

NCT01119092
View directory record Official record
Conditions
Lateral Ankle Sprain
Interventions
Sham ("laying of hands") intervention, Grade IV AP joint mobilizations
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 30, 2011 · Synced Oct 20, 2026, 7:18 AM EDT
Not listed Not applicable Interventional

Effects of Talocrural Joint Mobilizations in the Treatment of Subacute Lateral Ankle Sprains

NCT01117909
View directory record Official record
Conditions
Ankle Sprain
Interventions
Mobilization therapy in addition to standard therapy, Sham intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 30, 2011 · Synced Oct 20, 2026, 7:18 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of Strain-counterstrain on Ankle Instability

NCT02025569
View directory record Official record
Conditions
Other Instability, Ankle and Foot
Interventions
Strain Counterstrain, Sham strain counterstrain
Other
Lead sponsor
Long Island University
Other
Eligibility
18 Years to 55 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jan 1, 2014 · Synced Oct 20, 2026, 7:18 AM EDT
Completed Not applicable Interventional

Impact of Hyperarch Fascia Training on Ankle Health and Exercise Performance

NCT06959472
View directory record Official record
Conditions
Ankle Injuries, Sprains and Strains, Joint Instability
Interventions
Hyperarch Fascia Training
Behavioral
Lead sponsor
Applied Science & Performance Institute
Industry
Eligibility
20 Years to 45 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 20, 2026, 7:18 AM EDT