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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Ankle Surgery Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of Tranexamic Acid in Foot and Ankle Surgeries

NCT03653429
View directory record Official record
Conditions
Foot and Ankle Surgeries, Bunion
Interventions
Tranexamic Acid, Normal saline
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2020 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional

Ideal Anatomic Location for Saphenous Nerve Blocks: A Prospective Clinical Evaluation

NCT02645097
View directory record Official record
Conditions
Foot Injury, Ankle Injury
Interventions
Saphenous Nerve Block
Procedure
Lead sponsor
Paul J. Juliano, M.D.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Jun 10, 2026, 6:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluating Muscle Function After Ankle Surgery

NCT00060970
View directory record Official record
Conditions
Muscle Atrophy, Muscle Weakness, Fractures
Interventions
Physical Therapy
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1995 – 2000
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jun 10, 2026, 6:09 PM EDT
Active, not recruiting Early Phase 1 Interventional

Temporal Profile of Serum Vitamin D Levels in Foot and Ankle Fusion Surgery

NCT04772196
View directory record Official record
Conditions
Ankle Arthrodesis, MTP Arthrodesis
Interventions
Vitamin D3
Drug
Lead sponsor
Prisma Health-Midlands
Other
Eligibility
18 Years to 99 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
2
States / cities
Charleston, South Carolina • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional

NeoPatch Used as Adjunct in Foot and Ankle Tendon Surgery

NCT03307499
View directory record Official record
Conditions
Tendinopathy, Tendon Tear, Tendon Injuries, Foot Ankle Injuries
Interventions
NeoPatch
Other
Lead sponsor
CryoLife, Inc.
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sycamore, Illinois
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Phase 4 Interventional Results available

Anesthesia for Pain After Ankle Fracture Surgery

NCT02950558
View directory record Official record
Conditions
Chronic Pain, Ankle Fracture Surgery, Regional Anesthesia
Interventions
Ropivacaine, Nerve block
Drug · Procedure
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Cincinnati, Ohio • West Chester, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Phase 4 Interventional Results available

Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery

NCT01975285
View directory record Official record
Conditions
Foot and Ankle Procedures
Interventions
Dexamethasone, Saline
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 5, 2016 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Phase 4 Interventional Results available

Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Nerve Blocks

NCT02523235
View directory record Official record
Conditions
Post-surgical Pain, Total Knee Arthroplasty, Foot/Ankle Surgery, Catheterization for Postop Analgesia
Interventions
ropivacaine 0.2%
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 2, 2019 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Excess Opioid Disposal Following Orthopedic Foot and Ankle Surgery

NCT03285061
View directory record Official record
Conditions
Medication Disposal, Behavior
Interventions
Deterra Drug Deactivation System
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 5, 2021 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional Results available

AMPLEX Ankle Fusion and Hindfoot

NCT03028415
View directory record Official record
Conditions
Arthrodesis Surgery Involving the Hindfoot or Ankle
Interventions
AMPLEX, Autogenous Bone Graft (ABG)
Device · Procedure
Lead sponsor
Ferring Pharmaceuticals
Industry
Eligibility
18 Years to 74 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
28
States / cities
Gilbert, Arizona • Phoenix, Arizona • San Francisco, California + 23 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Jun 10, 2026, 6:09 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Pre-post Spinal Popliteal Block

NCT05354791
View directory record Official record
Conditions
Foot Surgery, Ankle Surgery
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
Not listed
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Jun 10, 2026, 6:09 PM EDT
Recruiting Not applicable Interventional

Opioid-Free Pain Treatment in Trauma Patients

NCT06078371
View directory record Official record
Conditions
Femoral Neck Fractures, Intertrochanteric Fractures, Femoral Shaft Fracture, Distal Femur Fracture, Patella Fracture, Tibial Shaft Fracture with or Without Associated Fibula Fracture, Ankle Fracture (bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Tibial Pilon Fracture, Talar Head, Neck, Body, or Process Fractures, Calcaneus Fractures, Lisfranc Injuries, Isolated or Multiple Metatarsal Fractures, Phalanx Fractures of the Foot, Single or Multiple, Clavicle Fractures, Proximal Humerus Fractures, Humeral Shaft Fractures, Distal Humerus Fractures (intra or Extra-articular), Olecranon Fractures, Radial Head or Neck Fractures, Elbow Fractures Involving a Combination of Fractures of the Radius and Uln, Forearm Fractures (both Bone Forearm Fractures, Isolated Ulnar Shaft, Isolated Radial Shaft), Distal Radius Fractures
Interventions
Opioid-free pain treatment
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Jun 10, 2026, 6:09 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Effect of Ropivacaine During Popliteal Nerve Block in Foot and Ankle Surgery

NCT04872322
View directory record Official record
Conditions
Popliteal Nerve Block, Foot Surgery, Ankle Surgery
Interventions
Ropivacaine 0.5% Injectable Solution, Ropivacaine 0.25% Injectable Solution, Percocet Pill, Norco Pill, Foot/Ankle Surgery
Drug · Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 3, 2021 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Phase 4 Interventional

Continuous Popliteal Nerve Blocks: Effect of Perineural Catheter Tip Location Relative to the Sciatic Nerve Bifurcation on Postoperative Analgesia

NCT01229696
View directory record Official record
Conditions
Popliteal Nerve Block, Foot Surgery, Ankle Surgery, Popliteal Bifurcation
Interventions
Catheter Placed At Bifurcation, Catheter Placed 5cm Above Bifurcation
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 10, 2016 · Synced Jun 10, 2026, 6:09 PM EDT
Completed No phase listed Observational

Artoss Foot and Ankle Surgery Registry

NCT04503759
View directory record Official record
Conditions
Arthritis Foot, Trauma Injury, Deformity; Bone
Interventions
NanoBone Bone Graft Substitute
Other
Lead sponsor
Artoss Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
8
States / cities
Scottsdale, Arizona • Sarasota, Florida • Joliet, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated May 12, 2024 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional

Foot and Ankle Post-operative Oedema Management Using Geko™

NCT04927234
View directory record Official record
Conditions
Surgery, Edema
Interventions
geko™ therapy
Device
Lead sponsor
Firstkind Ltd
Industry
Eligibility
18 Years and older
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Capitola, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Phase 4 Interventional

Ankle Block Versus Popliteal Fossa Block as Primary Anesthesia for Forefoot Surgical Procedures

NCT01376960
View directory record Official record
Conditions
Anesthesia, Forefoot Surgery
Interventions
elective forefoot surgery
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
Not listed
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 21, 2016 · Synced Jun 10, 2026, 6:09 PM EDT
Not yet recruiting Phase 1 Interventional

Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.

NCT07004764
View directory record Official record
Conditions
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Calcaneus Fractures, Talus Fracture, Wound Infection Deep, Wound Infection Post-Traumatic, Wound Dehiscence, Surgical
Interventions
Nitroglycerin Ointment 2%
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jun 10, 2026, 6:09 PM EDT
Not listed Not applicable Interventional

Nerve Block for Pain Control After Fracture Surgery

NCT05391464
View directory record Official record
Conditions
Ankle Fractures, Distal Radius Fracture
Interventions
Peripheral Nerve Block
Procedure
Lead sponsor
MaineGeneral Health
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Augusta, Maine
Source: ClinicalTrials.gov public record
Updated May 25, 2022 · Synced Jun 10, 2026, 6:09 PM EDT
Active, not recruiting Not applicable Interventional

Early vs Delayed Weightbearing After Surgical Fixation of Unstable Ankle Fractures With Syndesmosis Disruption

NCT05587842
View directory record Official record
Conditions
Unstable Ankle Fractures With Syndesmotic Disruption
Interventions
Early Weightbearing management post operation, Delayed Weightbearing management post operation (Traditional)
Procedure
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jun 10, 2026, 6:09 PM EDT
Withdrawn Phase 3 Interventional

Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery

NCT06264596
View directory record Official record
Conditions
Intraoperative Bleeding
Interventions
Epinephrine, Normal Saline irrigation fluid
Drug · Procedure
Lead sponsor
The Guthrie Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Sayre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jun 10, 2026, 6:09 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

CMF Bone Stimulation as Adjunct to Surgical Treatment of Ankle Fractures

NCT02688855
View directory record Official record
Conditions
Bimalleolar Ankle Fractures
Interventions
Active Combined Magnetic Field OL1000 Bone Growth Stimulator, Sham Combined Magnetic Field OL1000 Bone Growth Stimulator
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
21 Years and older
Enrollment
217 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
9
States / cities
Tucson, Arizona • Los Angeles, California • Hollywood, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2022 · Synced Jun 10, 2026, 6:09 PM EDT
Completed Phase 4 Interventional

Ultrasound Guidance Versus Electrical Stimulation for Continuous Popliteal-Sciatic Nerve Blocks

NCT00876681
View directory record Official record
Conditions
Postoperative Pain, Foot Numbness
Interventions
Popliteal catheter placed via ultrasound or electrical stimulation
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2009 · Synced Jun 10, 2026, 6:09 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Effectiveness of Perineural Clonidine as an Adjuvant With Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery

NCT01986751
View directory record Official record
Conditions
Pain
Interventions
Clonidine, ropivacaine
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Jun 10, 2026, 6:09 PM EDT