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ClinicalTrials.gov public records Last synced Sep 30, 2026, 2:41 PM EDT

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Showing 1–24 of 256 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Anterior Cruciate Ligament Clear all
Completed Not applicable Interventional

Comparison of 3 Techniques for Recreation of Anterior Cruciate Ligament Anatomic Footprint

NCT02795247
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
Anterior Cruciate Ligament Reconstruction
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Sep 30, 2026, 2:41 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Ultrasound for Rectus Femoris Measurement

NCT04105816
View directory record Official record
Conditions
Muscle Atrophy, Proximal, Muscle Atrophy, ACL Tear, Quadriceps Muscle Atrophy
Interventions
892.1550 Ultrasonic pulsed doppler imaging system, Thigh circumference measurement
Device · Diagnostic Test
Lead sponsor
Robert Westermann
Other
Eligibility
18 Years to 99 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Sep 30, 2026, 2:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non- Vs Partial Controlled Weightbearing After Multiple Knee Ligament Reconstruction

NCT05073276
View directory record Official record
Conditions
Knee Injuries
Interventions
Physical Therapy
Other
Lead sponsor
Twin Cities Orthopedics
Other
Eligibility
14 Years to 59 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Edina, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 22, 2024 · Synced Sep 30, 2026, 2:41 PM EDT
Completed Phase 2 Interventional Results available

Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears

NCT04088227
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
Interventions
Experimental Group, Control Group
Drug · Other
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
14 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Feb 17, 2025 · Synced Sep 30, 2026, 2:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Knowledge Translation Intervention for ACL Injury Prevention Program in Youth Soccer

NCT05442879
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Lower Extremity Problem
Interventions
Knowledge Translation Intervention, Educational handout
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 19 Years
Enrollment
671 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 30, 2026, 2:41 PM EDT
Completed Not applicable Interventional Results available

Blood Flow Restriction Following ACL Reconstruction

NCT03758755
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Blood Flow Restriction Therapy, ACL Reconstruction rehabilitation
Device · Other
Lead sponsor
Inova Health Care Services
Other
Eligibility
13 Years to 50 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Sep 30, 2026, 2:41 PM EDT
Enrolling by invitation Not applicable Interventional

Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament Reconstruction

NCT04650568
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Interventions
Autologous Bone Marrow Derived Mesenchymal Stem Cells, Sham incision
Device · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Sep 30, 2026, 2:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of Blood Flow Restriction Therapy Following ACL Tear

NCT04374968
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Knee Injuries, Sport Injury
Interventions
Blood flood restriction cuff
Device
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
West Bloomfield, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 19, 2023 · Synced Sep 30, 2026, 2:41 PM EDT
Terminated Phase 3 Interventional Results available

IPACK Versus Popliteal Sciatic Nerve Block in ACL Reconstruction

NCT03983941
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
Ropivacaine injection
Drug
Lead sponsor
Sujana Dontukurthy
Other
Eligibility
Up to 21 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Sep 30, 2026, 2:41 PM EDT
Recruiting Not applicable Interventional

Assessment of Gait Adaptation Due to an Asymmetric Walking Protocol

NCT05968729
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
Active Comparator: 0.25 m/s asymmetric session first, Active Comparator: 0.50 m/s asymmetric session first
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 30 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Sep 30, 2026, 2:41 PM EDT
Terminated Not applicable Interventional Results available

Moderated Blood Flow Restriction After Anterior Cruciate Ligament Reconstruction

NCT02911909
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
Delfi, Standard rehabilitation
Device · Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 30 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 11, 2020 · Synced Sep 30, 2026, 2:41 PM EDT
Not yet recruiting Phase 2 Interventional

Evaluation of Pain Management After Surgery When Using Nerve Blocks in the Pediatric Population

NCT06559137
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Tear, Sports Injuries in Children, Analgesia, Pain, Postoperative
Interventions
Ropivacaine 0.2% Injectable Solution
Drug
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
13 Years to 21 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Frisco, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 30, 2026, 2:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

MR Imaging of Knee Osteoarthritis and Acute Knee Injuries

NCT00504114
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
ACL Reconstruction Surgery, Cartilage Resurfacing Surgery, Total Knee Replacement
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2013 · Synced Sep 30, 2026, 2:41 PM EDT
Completed Not applicable Interventional

BFRT MPFL and ACL Reconstruction Rehab

NCT05426954
View directory record Official record
Conditions
Medial Patellar Femoral Ligament Reconstruction Rehabilitation, Anterior Cruciate Ligament Reconstruction Rehabilitation
Interventions
Rehabilitation utilizing blood flow restrictive therapy
Other
Lead sponsor
Richard Watson, PT
Other
Eligibility
13 Years to 40 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 17, 2024 · Synced Sep 30, 2026, 2:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Initial Graft Tension and ACL Surgery

NCT00434837
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Initial graft tension during ACL reconstruction surgery
Procedure
Lead sponsor
Rhode Island Hospital
Other
Eligibility
15 Years to 50 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2024
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 30, 2026, 2:41 PM EDT
Completed Not applicable Interventional Results available

Blood Flow Restriction Training (BFR) in an Adolescent Population

NCT04285879
View directory record Official record
Conditions
Blood Flow Restriction, ACL Tear, ACL Injury
Interventions
Blood Flow Restriction using Delfi Personalized Tourniquet System
Device
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
12 Years to 18 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Sep 30, 2026, 2:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Neuromuscular Warm-up on Injuries in Female Athletes

NCT01092286
View directory record Official record
Conditions
Knee Injuries, Anterior Cruciate Ligament Injuries, Ankle Injuries, Lower Extremity Injuries
Interventions
neuromuscular warm-up
Other
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
14 Years to 80 Years
Enrollment
1,653 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 25, 2018 · Synced Sep 30, 2026, 2:41 PM EDT
Recruiting Not applicable Interventional

Dynamic Muscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction in Military Academy Cadets

NCT06341868
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
KneeStim
Device
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
17 Years to 27 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Jan 2, 2026 · Synced Sep 30, 2026, 2:41 PM EDT
Terminated Phase 4 Interventional Results available

Effect of Dexamethasone on Duration of Lower Extremity Blocks With Bupivacaine in Subjects Having ACL Repair

NCT01756560
View directory record Official record
Conditions
Duration of Pain Relief
Interventions
dexamethsone, Bupivacaine
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 75 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 14, 2019 · Synced Sep 30, 2026, 2:41 PM EDT
Enrolling by invitation Not applicable Interventional

Use of Simplified Pain Questionnaire Among People Receiving Anterior Cruciate Ligament (ACL) Knee Surgery?

NCT07065266
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Reconstruction, Anterior Cruciate Ligament/Surgery
Interventions
Binary pain questionnaire, Numerical Pain Rating Scale (NPRS)
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 30, 2026, 2:41 PM EDT
Enrolling by invitation No phase listed Observational

Blood Flow Restriction Following ACLR w/Quad Autograft

NCT06636045
View directory record Official record
Conditions
Autografts, Blood Flow Restriction Therapy, Rehabilitation Outcome, Quadriceps Muscle Strength, Anterior Cruciate Ligament Reconstruction
Interventions
Not applicable- observational study
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
14 Years to 40 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Sep 30, 2026, 2:41 PM EDT
Withdrawn Not applicable Interventional

BFR Therapy After ACL Reconstruction

NCT03794570
View directory record Official record
Conditions
ACL Injury, Quadriceps Muscle Atrophy
Interventions
Blood flow restriction therapy - with Delfi Personalized Tourniquet System, Sham blood flow restriction therapy - with Delfi Personalized Tourniquet System
Device
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
14 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Sep 30, 2026, 2:41 PM EDT
Not listed Not applicable Interventional

Quadriceps Function Prior to Anterior Cruciate Ligament Reconstruction

NCT00971451
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament
Interventions
cryotherapy, TENS
Other
Lead sponsor
University of Virginia
Other
Eligibility
15 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2011 · Synced Sep 30, 2026, 2:41 PM EDT
Recruiting Phase 4 Interventional

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

NCT06311513
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee, Bone Marrow Aspirate Concentrate, ACL Injury
Interventions
Concentrated Bone Marrow Aspirate Injection, Sham Incision, Revision Anterior Cruciate Ligament Reconstruction
Biological · Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Atlanta, Georgia • New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Sep 30, 2026, 2:41 PM EDT