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ClinicalTrials.gov public records Last synced Oct 7, 2026, 10:39 AM EDT

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Showing 49–72 of 257 matching trials from the live ClinicalTrials.gov search.
Conditions
ACL Reconstruction, ACL Surgery, ACL Injury, Electrotherapy, Muscle Atrophy or Weakness
Interventions
Zynex NexWave Electrotherapy Device
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
15 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Kansas City, Kansas
Completed Not applicable Interventional

BFRT MPFL and ACL Reconstruction Rehab

NCT05426954
Conditions
Medial Patellar Femoral Ligament Reconstruction Rehabilitation, Anterior Cruciate Ligament Reconstruction Rehabilitation
Interventions
Rehabilitation utilizing blood flow restrictive therapy
Other
Lead sponsor
Richard Watson, PT
Other
Eligibility
13 Years to 40 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Completed Not applicable Interventional Accepts healthy volunteers Results available

Personalized Blood Flow Restriction for Anterior Cruciate Ligament Rehabilitation

NCT04635579
Conditions
Anterior Cruciate Ligament Tear
Interventions
Blood flow restriction
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Conditions
Pain and Anterior Cruciate Ligament Reconstruction
Interventions
Dry needling and STM
Other
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
18 Years to 40 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
West Point, New York
Conditions
Injury of Anterior Cruciate Ligament
Interventions
aNMT Biofeedback, Sham Biofeedback, Neuromuscular Training
Other
Lead sponsor
Emory University
Other
Eligibility
12 Years to 18 Years · Female only
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
2
States / cities
Flowery Branch, Georgia • Cincinnati, Ohio
Conditions
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Interventions
Intraosseous Morphine
Drug
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years to 40 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Houston, Texas
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
526 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Boston, Massachusetts • Waltham, Massachusetts
Conditions
ACL - Anterior Cruciate Ligament Rupture
Interventions
Bio-ACL, amnion wrap and BMAC
Procedure · Device
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
18 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Gulf Breeze, Florida
Conditions
Acute Injury of Anterior Cruciate Ligament
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
13 Years to 70 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Francisco, California
Completed No phase listed Observational Results available

MDR EZ Pass and Precision Flexible Reamer

NCT03914703
Conditions
Anterior Cruciate Ligament Injury, Rotator Cuff Tear
Interventions
EZ Pass Suture Passer
Procedure
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Conditions
Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Knee Injuries, Cartilage, Articular, Gait
Interventions
Real-time gait biofeedback, Sham real-time gait biofeedback
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Completed Not applicable Interventional

Safe Options for ACL Recovery

NCT04225468
Conditions
Anterior Cruciate Ligament Injuries, Opioid Use
Interventions
ACL Opioid Exposure Reduction Program
Behavioral
Lead sponsor
Karen Derefinko, PhD
Other
Eligibility
12 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Memphis, Tennessee
Conditions
ACL Tears
Interventions
Progressive strengthening program
Other
Lead sponsor
Creighton University
Other
Eligibility
14 Years to 35 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Omaha, Nebraska
Conditions
Anterior Cruciate Ligament Injury
Interventions
Electrical Stimulation, Eccentric Exercise
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 35 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Conditions
ACL Injury
Interventions
Blood Flow Restriction (BFR) therapy, Standard REHAB
Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
15 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Terminated Not applicable Interventional Results available

Blood Flow Restriction Training in ACL Surgery

NCT05245864
Conditions
Anterior Cruciate Ligament Injuries
Interventions
blood flow restriction, physical therapy standard of care
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 34 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Little Rock, Arkansas
Completed Phase 4 Interventional Results available

Anterior Cruciate Ligament Pain Study

NCT02604550
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
Ropivacaine 0.5%, Percocet 7.5/325, Naprosyn 500 mg
Drug
Lead sponsor
Emory University
Other
Eligibility
Not listed
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Atlanta, Georgia
Conditions
Complete Tear, Knee, Anterior Cruciate Ligament, Rupture of Anterior Cruciate Ligament
Interventions
ACL Reconstruction: Anterior Tunnel, ACL Reconstruction: Posterior Tunnel
Procedure
Lead sponsor
University of Virginia
Other
Eligibility
16 Years to 50 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Charlottesville, Virginia
Not listed Not applicable Interventional Accepts healthy volunteers

Training of Falling Techniques on Landing Mechanics

NCT04768088
Conditions
Sports Injury, Orthopedic Disorder, Knee Injuries, Anterior Cruciate Ligament Injuries
Interventions
Falling Training
Other
Lead sponsor
University of Wyoming
Other
Eligibility
14 Years to 30 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Laramie, Wyoming
Conditions
Anterior Cruciate Ligament Injury, ACL Injury, ACL - Anterior Cruciate Ligament Rupture
Interventions
Femoral Nerve Block, Adductor Nerve Block, No Block
Procedure · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 75 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Conditions
Anterior Cruciate Ligament Reconstruction Rehabilitation
Interventions
Rehabilitation with Exercise and Psychological Support (REPS)
Behavioral
Lead sponsor
HealthPartners Institute
Other
Eligibility
15 Years to 25 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Bloomington, Minnesota
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL Reconstruction with Hybrid Remnant Repair, ACL Reconstruction without Hybrid Remnant Repair
Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
13 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bone Tunnel Widening Following ACL Reconstruction

NCT00198042
Conditions
Anterior Cruciate Ligament Injury, Knee Injuries
Interventions
Surgical reconstruction of the ACL
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 55 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2015
U.S. locations
1
States / cities
New York, New York
Conditions
Anterior Cruciate Ligament Injury
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
10 Years to 70 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Houston, Texas