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Showing 1–24 of 138 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Anterior Cruciate Ligament (ACL) Reconstruction Clear all
Recruiting Phase 4 Interventional

IPACK on Early Pain Scores After ACL Reconstruction

NCT05985629
View directory record Official record
Conditions
Pain, Postoperative, Anterior Cruciate Ligament Injuries, Analgesics, Opioid
Interventions
IPACK, PLACEBO
Drug
Lead sponsor
Loyola University
Other
Eligibility
16 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Jul 23, 2026, 10:04 AM EDT
Active, not recruiting Not applicable Interventional

A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction

NCT03776162
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL Reconstruction (Bone Patellar Tendon Bone Graft), Bridge Enhanced ACL Restoration (BEAR)
Procedure · Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
6
States / cities
Boulder, Colorado • Bloomington, Minnesota • Cleveland, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Jul 23, 2026, 10:04 AM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Continuous Vs Single Shot Block After ACL

NCT04101682
View directory record Official record
Conditions
ACL Injury
Interventions
Bupivacaine
Drug
Lead sponsor
Northwell Health
Other
Eligibility
16 Years and older
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Plainview, New York
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Jul 23, 2026, 10:04 AM EDT
Not listed Phase 3 Interventional

Evaluation of Exparel Adductor Canal Field Block for Pain Control After ACL Reconstruction

NCT04764916
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Pain, Postoperative, Opioid Use
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Jul 23, 2026, 10:04 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of Biocleanse Allografts For ACL Reconstruction

NCT00187876
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL reconstruction control, ACL Biocleanse, surgical
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 55 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 3, 2014 · Synced Jul 23, 2026, 10:04 AM EDT
Completed Not applicable Interventional Results available

Anterior Cruciate Ligament Reconstruction and Plyometric Exercise

NCT01851655
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
Plyometric Exercise
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
15 Years to 30 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 17, 2014 · Synced Jul 23, 2026, 10:04 AM EDT
Completed Not applicable Interventional Results available

Opiates Prescribing for Knee Arthroscopies and ACL Reconstruction

NCT03876743
View directory record Official record
Conditions
Knee Injuries, ACL Injury
Interventions
Group 1-Knee Arthroscopy, Group 2-Knee Arthroscopy, Group 1-ACL reconstruction, Group 2-ACL reconstruction
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 89 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 13, 2020 · Synced Jul 23, 2026, 10:04 AM EDT
Not listed Not applicable Interventional

Augmentation of Anterior Cruciate Ligament Reconstruction Using Mesenchymal Stem Cells and Collagen Matrix Carrier

NCT05582226
View directory record Official record
Conditions
ACL Tear
Interventions
ACL reconstruction, Mesenchymal stem cell implantation
Procedure
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
14 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Feb 9, 2023 · Synced Jul 23, 2026, 10:04 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Exparel vs Block for ACL Reconstruction

NCT06006624
View directory record Official record
Conditions
ACL, Postoperative Pain
Interventions
Exparel 30 mL, 0.5% bupivacaine, Dexamethasone, iPACK block
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Jul 23, 2026, 10:04 AM EDT
Terminated Not applicable Interventional

ACL Bone Health and Loading Study

NCT04682392
View directory record Official record
Conditions
ACL Tear
Interventions
Delfi's PTS Personalized Tourniquet System for Blood Flow Restriction Group, Standard ACL rehab
Device · Other
Lead sponsor
Candice Dunkin, MS, LAT, ATC
Other
Eligibility
16 Years to 22 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 23, 2026, 10:04 AM EDT
Not listed Not applicable Interventional

Does Bone Grafting at the Time of Bone-Patellar Tendon-Bone ACL Reconstruction Reduce the Incidence of Post-operative Anterior Knee Pain: A Randomized Controlled Clinical Study

NCT04958733
View directory record Official record
Conditions
ACL Injury
Interventions
Autologous bone grafting, Absence of autologous bone grafting
Procedure
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Jul 23, 2026, 10:04 AM EDT
Completed Not applicable Interventional

Werewolf Flow 50 During ACL Reconstruction

NCT04998656
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Arthrofibrosis of Knee
Interventions
Werewolf FLOW 50, Control
Device · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 18 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Aurora, Colorado • Broomfield, Colorado • Highlands Ranch, Colorado
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Jul 23, 2026, 10:04 AM EDT
Terminated Phase 3 Interventional Results available

Opioid Use in Single Shot Nerve Block vs Continuous Peripheral Nerve Infusion in Anterior Cruciate Ligament (ACL) Repair

NCT02075411
View directory record Official record
Conditions
Injury of Anterior Cruciate Ligament
Interventions
bupivacaine, continuous perineural infusion catheter
Drug · Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
14 Years to 18 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 17, 2016 · Synced Jul 23, 2026, 10:04 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety of OMS103HP in Patients Undergoing Autograft Anterior Cruciate Ligament (ACL) Reconstruction

NCT00226772
View directory record Official record
Conditions
Knee Injuries
Interventions
OMS103HP, Vehicle
Drug
Lead sponsor
Omeros Corporation
Industry
Eligibility
15 Years to 65 Years
Enrollment
326 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
15
States / cities
Encinitas, California • Denver, Colorado • Englewood, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2012 · Synced Jul 23, 2026, 10:04 AM EDT
Completed Not applicable Interventional

Impact of Counseling and Education on Opioid Consumption After ACL Reconstruction

NCT04885231
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use
Interventions
Perioperative Pain Management Education and Counseling
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
14 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Jul 23, 2026, 10:04 AM EDT
Completed No phase listed Observational

BioCleanse Tibialis Tendon Anterior Cruciate Ligament (ACL) Study

NCT00975845
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
BioCleanse Tibialis tendon
Other
Lead sponsor
RTI Surgical
Industry
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 31, 2021 · Synced Jul 23, 2026, 10:04 AM EDT
Not yet recruiting No phase listed Observational

MRI Evaluation of Graft Maturation Following ACL Reconstruction

NCT07046000
View directory record Official record
Conditions
ACL Tears
Interventions
MRI
Diagnostic Test
Lead sponsor
Skye Biologics Holdings, LLC
Industry
Eligibility
14 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Sugar Land, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Jul 23, 2026, 10:04 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

Bridge-Enhanced ACL Repair vs ACL Reconstruction

NCT02664545
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
BEAR Scaffold, Tendon Graft
Device · Procedure
Lead sponsor
Miach Orthopaedics
Industry
Eligibility
14 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Jul 23, 2026, 10:04 AM EDT
Recruiting Early Phase 1 Interventional

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

NCT04572256
View directory record Official record
Conditions
ACL Injury, Meniscus Tear, Post-traumatic Osteoarthritis
Interventions
Montelukast, Placebo
Drug
Lead sponsor
Austin V Stone
Other
Eligibility
25 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jul 23, 2026, 10:04 AM EDT
Withdrawn Not applicable Interventional

OrthoPure™ XT Pilot Clinical Study

NCT03562299
View directory record Official record
Conditions
Knee Injuries, Anterior Cruciate Ligament (ACL) Reconstruction
Interventions
OrthoPure™ XT
Device
Lead sponsor
TRX Orthopedics
Industry
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
3
States / cities
Phoenix, Arizona • Greenwood, Indiana • Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Jul 23, 2026, 10:04 AM EDT
Active, not recruiting No phase listed Observational

Multicenter Orthopaedics Outcomes Network for ACL Reconstructions

NCT00463099
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
10 Years to 80 Years
Enrollment
3,294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2028
U.S. locations
8
States / cities
Boulder, Colorado • Iowa City, Iowa • St Louis, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jul 23, 2026, 10:04 AM EDT
Recruiting Not applicable Interventional

Quadriceps Strengthening ACL Reconstruction

NCT07015541
View directory record Official record
Conditions
ACL Tear
Interventions
NMES and BFR, Standard physical therapy
Other
Lead sponsor
Stanford University
Other
Eligibility
13 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Sunnyvale, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 23, 2026, 10:04 AM EDT
Completed Not applicable Interventional

Factors Affecting the Speed of Recovery After ACL Reconstruction

NCT03770806
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, ACL Injury, ACL - Anterior Cruciate Ligament Rupture
Interventions
Femoral Nerve Block, Adductor Nerve Block, No Block
Procedure · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 75 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 9, 2018 · Synced Jul 23, 2026, 10:04 AM EDT
Recruiting No phase listed Observational

BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures

NCT06948591
View directory record Official record
Conditions
ACL Tears
Interventions
Anterior cruciate ligament reconstruction with BioBrace® augmentation, Arthroscopic anterior cruciate ligament reconstruction
Device · Procedure
Lead sponsor
CONMED Corporation
Industry
Eligibility
14 Years to 70 Years
Enrollment
500 participants
Timeline
2025 – 2030
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jul 23, 2026, 10:04 AM EDT