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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Anterior Cruciate Ligament (ACL) Reconstruction Surgery Clear all
Active, not recruiting No phase listed Observational

Multicenter Orthopaedics Outcomes Network for ACL Reconstructions

NCT00463099
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
10 Years to 80 Years
Enrollment
3,294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2028
U.S. locations
8
States / cities
Boulder, Colorado • Iowa City, Iowa • St Louis, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jul 21, 2026, 9:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of HMB Supplementation on Recovery Following ACL Surgery

NCT02602561
View directory record Official record
Conditions
ACL Injury
Interventions
HMB, Placebo
Dietary Supplement
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 49 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Ames, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Jul 21, 2026, 9:50 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Incrediwear ACL MCL Arthroscopic Surgery Recovery Study

NCT06240780
View directory record Official record
Conditions
Arthroscopic Surgical Procedures, Anterior Cruciate Ligament Reconstruction
Interventions
Activated Incrediwear Products, Sham Incrediwear Products
Other
Lead sponsor
Oklahoma Joint Reconstruction Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Jul 21, 2026, 9:50 PM EDT
Enrolling by invitation Phase 3 Interventional

ACL-R Opioid Sparing Study

NCT06561035
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Opiate Sparing, Opiate Based
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
14 Years to 85 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Jul 21, 2026, 9:50 PM EDT
Not yet recruiting Phase 2 Interventional

Evaluation of Pain Management After Surgery When Using Nerve Blocks in the Pediatric Population

NCT06559137
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Tear, Sports Injuries in Children, Analgesia, Pain, Postoperative
Interventions
Ropivacaine 0.2% Injectable Solution
Drug
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
13 Years to 21 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Frisco, Texas
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Jul 21, 2026, 9:50 PM EDT
Recruiting Not applicable Interventional

Does Blood Flow Restriction Training Improve Quadriceps Function After Arthroscopic Knee Surgery?

NCT03096366
View directory record Official record
Conditions
Quadriceps Atrophy, ACL Reconstruction
Interventions
Blood flow restriction, Physical therapy
Device · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
14 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 3, 2022 · Synced Jul 21, 2026, 9:50 PM EDT
Completed Phase 2 Interventional

Single- vs. Double-Bundle ACL Reconstruction

NCT01319409
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Anatomic Double-Bundle ACL Reconstruction, Anatomic Single-Bundle ACL Reconstruction
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 50 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 4, 2016 · Synced Jul 21, 2026, 9:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Initial Graft Tension and ACL Surgery

NCT00434837
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Initial graft tension during ACL reconstruction surgery
Procedure
Lead sponsor
Rhode Island Hospital
Other
Eligibility
15 Years to 50 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2024
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Jul 21, 2026, 9:50 PM EDT
Recruiting Not applicable Interventional

A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products

NCT06979804
View directory record Official record
Conditions
ACL Reconstruction, Meniscus Tears, Anterior Cruciate Ligament Rupture
Interventions
Semiconducting fabric sleeves, Non-semiconducting fabric sleeves
Device
Lead sponsor
Illinois Center for Orthopaedic Research and Education
Other
Eligibility
16 Years to 65 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Westmont, Illinois
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Jul 21, 2026, 9:50 PM EDT
Withdrawn Phase 4 Interventional

Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction

NCT07115056
View directory record Official record
Conditions
ACL Injury, ACL Tears, ACL Surgery
Interventions
Tranexamic Acid (TXA), Placebo
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
14 Years to 22 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
6
States / cities
Evanston, Illinois • Chesterfield, Missouri • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 21, 2026, 9:50 PM EDT
Active, not recruiting Not applicable Interventional

Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial

NCT04039971
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
Interventions
ACL Reconstruction
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 19 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 21, 2026, 9:50 PM EDT
Completed Phase 3 Interventional

Double-Blind, Randomized Study Of The Analgesic Efficacy And Safety Of Valdecoxib 20 Mg Daily And Valdecoxib 20 Mg Twice Daily Compared To Placebo For Management Of Acute Postsurgical Pain In Anterior Cruciate Ligament (ACL) Reconstruction

NCT00650039
View directory record Official record
Conditions
Pain
Interventions
placebo, valdecoxib
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
488 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
68
States / cities
Birmingham, Alabama • Northport, Alabama • Glendale, Arizona + 46 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2008 · Synced Jul 21, 2026, 9:50 PM EDT
Active, not recruiting Not applicable Interventional

Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, and Surgical Outcomes

NCT05273463
View directory record Official record
Conditions
ACL Injury, Anterior Cruciate Ligament Injuries
Interventions
Video-Based Intervention, Classroom-Based Intervention
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
15 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 9:50 PM EDT
Completed Not applicable Interventional

Bioactive Knee Sleeves After ACL Reconstruction

NCT07707128
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Reconstruction Surgery
Interventions
Bioactive Knee Sleeve
Device
Lead sponsor
Western Kentucky Heart and Lung Research Foundation and Educational Trust
Other
Eligibility
16 Years to 40 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Bowling Green, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Jul 21, 2026, 9:50 PM EDT
Enrolling by invitation Not applicable Interventional

Use of Simplified Pain Questionnaire Among People Receiving Anterior Cruciate Ligament (ACL) Knee Surgery?

NCT07065266
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Reconstruction, Anterior Cruciate Ligament/Surgery
Interventions
Binary pain questionnaire, Numerical Pain Rating Scale (NPRS)
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Jul 21, 2026, 9:50 PM EDT
Terminated Not applicable Interventional

Effects of Femoral vs Saphenous Nerve Blocks on Function After ACL Repair

NCT01919658
View directory record Official record
Conditions
Anterior Cruciate Ligament
Interventions
nerve block
Procedure
Lead sponsor
Robert A. Gallo
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Jul 21, 2026, 9:50 PM EDT
Active, not recruiting Not applicable Interventional

Mindfulness and ACL Surgery

NCT05542563
View directory record Official record
Conditions
ACL, ACL Injury
Interventions
Healthy Minds Program (HMP) App
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
16 Years to 40 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jul 21, 2026, 9:50 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery

NCT04246554
View directory record Official record
Conditions
ACL Injury, Postoperative Pain
Interventions
Ketorolac, Oxycodone-Acetaminophen
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Jul 21, 2026, 9:50 PM EDT
Completed No phase listed Observational

Effect of Patient Resilience on Return to Sport Post ACL Reconstruction Surgery

NCT03013231
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
Brief Resilience Scale
Behavioral
Lead sponsor
St. Louis University
Other
Eligibility
14 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 5, 2019 · Synced Jul 21, 2026, 9:50 PM EDT
Completed No phase listed Observational

Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): Onsite Follow-up

NCT00478894
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament, Osteoarthritis
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
14 Years to 55 Years
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2025
U.S. locations
4
States / cities
St Louis, Missouri • Cleveland, Ohio • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jul 21, 2026, 9:50 PM EDT
Active, not recruiting Not applicable Interventional

A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction

NCT03776162
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL Reconstruction (Bone Patellar Tendon Bone Graft), Bridge Enhanced ACL Restoration (BEAR)
Procedure · Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
6
States / cities
Boulder, Colorado • Bloomington, Minnesota • Cleveland, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Jul 21, 2026, 9:50 PM EDT
Recruiting Not applicable Interventional

KRONOS Versus Breg T-Scope Post-operative Knee Braces Following Anterior Cruciate Ligament (ACL) Reconstruction

NCT07090616
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Reconstruction Surgery
Interventions
Arm 1-Kronos brace, Arm 2-Breg T-Scope brace
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jul 21, 2026, 9:50 PM EDT
Enrolling by invitation Not applicable Interventional

Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients

NCT07171346
View directory record Official record
Conditions
ACL Reconstruction, ACL Surgery, ACL Injury, Electrotherapy, Muscle Atrophy or Weakness
Interventions
Zynex NexWave Electrotherapy Device
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
15 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Jul 21, 2026, 9:50 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

BFRT in Adolescents After ACL Reconstruction

NCT04390035
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Blood Flow Restriction using Delfi Personalized Tourniquet System
Device
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
12 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 1, 2021 · Synced Jul 21, 2026, 9:50 PM EDT