- Conditions
- Blood Flow Restriction, ACL Tear, ACL Injury
- Interventions
- Blood Flow Restriction using Delfi Personalized Tourniquet System
- Device
- Lead sponsor
- Connecticut Children's Medical Center
- Other
- Eligibility
- 12 Years to 18 Years
- Enrollment
- 47 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2023
- U.S. locations
- 1
- States / cities
- Farmington, Connecticut
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Showing 25–48
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- Conditions
- ACL Injury, ACL Tear
- Interventions
- Patients will be randomized into one of two study arms: (1) concomitant ACL and ALL reconstruction or (2) ACL reconstruction alone.
- Procedure
- Lead sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
- Other
- Eligibility
- Up to 18 Years
- Enrollment
- 240 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2030
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
- Conditions
- Anterior Cruciate Ligament Tear, Pain, Postoperative, Opioid Use
- Interventions
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Drug
- Lead sponsor
- Carilion Clinic
- Other
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2022
- U.S. locations
- 1
- States / cities
- Roanoke, Virginia
- Conditions
- Anterior Cruciate Ligament (ACL) Tear
- Interventions
- Single-injection sciatic PNB, Continuous sciatic PNB
- Drug
- Lead sponsor
- Children's Hospital Medical Center, Cincinnati
- Other
- Eligibility
- 10 Years to 18 Years
- Enrollment
- 141 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2015 – 2024
- U.S. locations
- 1
- States / cities
- Cincinnati, Ohio
- Conditions
- ACL, ACL Injury, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture, Anesthesia
- Interventions
- Acupuncture + Standard of Care
- Other
- Lead sponsor
- Hospital for Special Surgery, New York
- Other
- Eligibility
- 12 Years to 80 Years
- Enrollment
- 40 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2018 – 2019
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- ACL Tear
- Interventions
- Safe Return to Play Following ACL Reconstruction Checklist
- Diagnostic Test
- Lead sponsor
- Rothman Institute Orthopaedics
- Other
- Eligibility
- 15 Years to 35 Years
- Enrollment
- 222 participants
- Timeline
- 2016 – 2020
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- ACL Tear
- Interventions
- ACL reconstruction with BTB autograft with internal brace augmentation (suture tape), ACL reconstruction with BTB autograft without internal brace augmentation (suture tape), Standardized Rehabilitation Protocol
- Procedure · Other
- Lead sponsor
- Columbia University
- Other
- Eligibility
- 12 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2032
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Posttraumatic Osteoarthritis, Anterior Cruciate Ligament (ACL) Rupture
- Interventions
- Synovial Fluid withdrawal at the preoperative clinic visit, Platelet-Rich Plasma (PRP) preparation and injection, Synovial fluid withdrawal at the time of surgery, 3mL synovial fluid withdrawn at the preoperative visit
- Procedure
- Lead sponsor
- Rush University Medical Center
- Other
- Eligibility
- 18 Years to 50 Years
- Enrollment
- 99 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2028
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
- Conditions
- Rupture of Anterior Cruciate Ligament, Tear of Anterior Cruciate Ligament
- Interventions
- Mepivacaine, adductor canal continuous nerve catheter, Normal Saline as bolus followed by bupivacaine, adductor canal nerve block, ropivacaine and dexamethasone, Propofol, Fentanyl
- Drug · Procedure
- Lead sponsor
- Vanderbilt University Medical Center
- Other
- Eligibility
- 14 Years and older
- Enrollment
- 59 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2018
- U.S. locations
- 1
- States / cities
- Nashville, Tennessee
- Conditions
- Bone Diseases, Infectious, Musculoskeletal Diseases, Joint Diseases, Osteoarthritis, ACL Tear, Cartilage Degeneration
- Interventions
- MRI
- Diagnostic Test
- Lead sponsor
- Xiaojuan Li
- Other
- Eligibility
- 18 Years to 50 Years
- Enrollment
- 88 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2026
- U.S. locations
- 1
- States / cities
- Cleveland, Ohio
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
- Interventions
- 3D printed knee extender device
- Device
- Lead sponsor
- Sanford Health
- Other
- Eligibility
- 14 Years to 60 Years
- Enrollment
- 28 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2025
- U.S. locations
- 2
- States / cities
- Fargo, North Dakota • Sioux Falls, South Dakota
- Conditions
- Anterior Cruciate Ligament Injury, ACL Injury, ACL - Anterior Cruciate Ligament Rupture
- Interventions
- Femoral Nerve Block, Adductor Nerve Block, No Block
- Procedure · Other
- Lead sponsor
- University of Washington
- Other
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 48 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2018
- U.S. locations
- 1
- States / cities
- Seattle, Washington
- Conditions
- Complete Tear, Knee, Anterior Cruciate Ligament, Rupture of Anterior Cruciate Ligament
- Interventions
- ACL Reconstruction: Anterior Tunnel, ACL Reconstruction: Posterior Tunnel
- Procedure
- Lead sponsor
- University of Virginia
- Other
- Eligibility
- 16 Years to 50 Years
- Enrollment
- 90 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2019
- U.S. locations
- 1
- States / cities
- Charlottesville, Virginia
- Conditions
- ACL Tear
- Interventions
- Delfi's PTS Personalized Tourniquet System for Blood Flow Restriction Group, Standard ACL rehab
- Device · Other
- Lead sponsor
- Candice Dunkin, MS, LAT, ATC
- Other
- Eligibility
- 16 Years to 22 Years
- Enrollment
- 19 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2025
- U.S. locations
- 1
- States / cities
- Fort Wayne, Indiana
- Conditions
- Anterior Cruciate Ligament (ACL) Tear, Sports Injuries in Children, Analgesia, Pain, Postoperative
- Interventions
- Ropivacaine 0.2% Injectable Solution
- Drug
- Lead sponsor
- Texas Scottish Rite Hospital for Children
- Other
- Eligibility
- 13 Years to 21 Years
- Enrollment
- 160 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 1
- States / cities
- Frisco, Texas
- Conditions
- Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
- Interventions
- Bridge-Enhanced ACL Restoration (BEAR)
- Device
- Lead sponsor
- Miach Orthopaedics
- Industry
- Eligibility
- 12 Years to 80 Years
- Enrollment
- 250 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2034
- U.S. locations
- 11
- States / cities
- San Diego, California • Tampa, Florida • Atlanta, Georgia + 8 more
- Conditions
- Rupture of Anterior Cruciate Ligament
- Interventions
- Not listed
- Lead sponsor
- Vanderbilt University Medical Center
- Other
- Eligibility
- 10 Years to 80 Years
- Enrollment
- 3,294 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2002 – 2028
- U.S. locations
- 8
- States / cities
- Boulder, Colorado • Iowa City, Iowa • St Louis, Missouri + 5 more
- Conditions
- ACL Tear, Post Operative Pain
- Interventions
- Iovera, Celecoxib, Acetaminophen, Oxycodone, Tramadol, Bupivacaine Hydrochloride, Acetaminophen 500Mg Cap
- Device · Drug
- Lead sponsor
- Matthew Varacallo
- Other
- Eligibility
- 15 Years and older
- Enrollment
- 32 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2025
- U.S. locations
- 1
- States / cities
- DuBois, Pennsylvania
- Conditions
- Rupture of Anterior Cruciate Ligament
- Interventions
- Somatropin, Placebo
- Drug
- Lead sponsor
- University of Michigan
- Other
- Eligibility
- 18 Years to 35 Years · Male only
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2018
- U.S. locations
- 1
- States / cities
- Ann Arbor, Michigan
- Conditions
- Anterior Cruciate Ligament Tear
- Interventions
- anakinra (150mg), Saline intraarticularly
- Drug · Other
- Lead sponsor
- Cale Jacobs, PhD
- Other
- Eligibility
- 14 Years to 40 Years
- Enrollment
- 6 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2020
- U.S. locations
- 1
- States / cities
- Lexington, Kentucky
- Conditions
- Rupture of Anterior Cruciate Ligament
- Interventions
- Not listed
- Lead sponsor
- Vanderbilt University
- Other
- Eligibility
- 12 Years to 65 Years
- Enrollment
- 1,234 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2006 – 2029
- U.S. locations
- 47
- States / cities
- La Jolla, California • Los Angeles, California • San Francisco, California + 39 more
- Conditions
- Anterior Cruciate Ligament Tear
- Interventions
- BEAR Scaffold, Tendon Graft
- Device · Procedure
- Lead sponsor
- Miach Orthopaedics
- Industry
- Eligibility
- 14 Years to 35 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2028
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- ACL Reconstruction, Meniscus Tears, Anterior Cruciate Ligament Rupture
- Interventions
- Semiconducting fabric sleeves, Non-semiconducting fabric sleeves
- Device
- Lead sponsor
- Illinois Center for Orthopaedic Research and Education
- Other
- Eligibility
- 16 Years to 65 Years
- Enrollment
- 135 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2026
- U.S. locations
- 1
- States / cities
- Westmont, Illinois
- Conditions
- ACL Tear, Arthrofibrosis, ACL Injury
- Interventions
- Graymont X ERIS Knee Splint, Standard Hinge Knee Brace
- Device
- Lead sponsor
- Rush University Medical Center
- Other
- Eligibility
- 18 Years to 40 Years
- Enrollment
- 21 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2025
- U.S. locations
- 1
- States / cities
- Chicago, Illinois