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ClinicalTrials.gov public records Last synced Sep 30, 2026, 5:48 AM EDT

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Showing 1–24 of 195 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Anterior Cruciate Ligament Injuries Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes

NCT01034527
View directory record Official record
Conditions
ACL Injury
Interventions
Neuromuscular Training
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 19 Years · Female only
Enrollment
593 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 4, 2020 · Synced Sep 30, 2026, 5:48 AM EDT
Recruiting Phase 4 Interventional

Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

NCT06511232
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Interventions
Intraosseous Morphine
Drug
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years to 40 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Sep 30, 2026, 5:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Medipore Tape Study

NCT02676115
View directory record Official record
Conditions
Scarring
Interventions
Standard Post Operative Skin Care, Medipore Tape
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
15 Years to 95 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 8, 2016 · Synced Sep 30, 2026, 5:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Design and Evaluation of an Active Intervention for the Prevention of Non-contact ACL Injury

NCT01021111
View directory record Official record
Conditions
Athletic Injuries, Sprains and Strains, Wounds and Injuries, Knee Injuries
Interventions
Activity Training with Feedback
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2017 · Synced Sep 30, 2026, 5:48 AM EDT
Withdrawn Not applicable Interventional

OrthoPure™ XT Pilot Clinical Study

NCT03562299
View directory record Official record
Conditions
Knee Injuries, Anterior Cruciate Ligament (ACL) Reconstruction
Interventions
OrthoPure™ XT
Device
Lead sponsor
TRX Orthopedics
Industry
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
3
States / cities
Phoenix, Arizona • Greenwood, Indiana • Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 21, 2018 · Synced Sep 30, 2026, 5:48 AM EDT
Recruiting Not applicable Interventional

A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products

NCT06979804
View directory record Official record
Conditions
ACL Reconstruction, Meniscus Tears, Anterior Cruciate Ligament Rupture
Interventions
Semiconducting fabric sleeves, Non-semiconducting fabric sleeves
Device
Lead sponsor
Illinois Center for Orthopaedic Research and Education
Other
Eligibility
16 Years to 65 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Westmont, Illinois
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Sep 30, 2026, 5:48 AM EDT
Completed No phase listed Observational

Prospective Registry of Anterior Cruciate Ligament Reconstructions

NCT04135950
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Meniscal Tear, Cartilage Injury, Bone Bruising
Interventions
Not listed
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
Not listed
Enrollment
1,646 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2025
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Sep 30, 2026, 5:48 AM EDT
Completed Not applicable Interventional

Improving ACL Reconstruction Outcomes: CBPT

NCT03243162
View directory record Official record
Conditions
ACL Injury, ACL - Anterior Cruciate Ligament Rupture, ACL Sprain, ACL Tear
Interventions
CBPT-ACLR, Education
Behavioral · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
14 Years to 35 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Garfield Heights, Ohio • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 20, 2020 · Synced Sep 30, 2026, 5:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

External Focus of Attention Feedback to Reduce Risk of Non-contact ACL Injury

NCT04914689
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Internal focus of attention feedback, Visual internal focus of attention feedback, Auditory external focus of attention feedback
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 35 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 30, 2026, 5:48 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Knee Alignment Contributions to Anterior Cruciate Ligament (ACL) Injury

NCT00855023
View directory record Official record
Conditions
Knee Injuries
Interventions
Not listed
Lead sponsor
The Orthopaedic Center, Maryland
Other
Eligibility
18 Years to 45 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Sep 30, 2026, 5:48 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Bio ACL Reconstruction Amnion Collagen Matrix Wrap and Stem Cells

NCT03294759
View directory record Official record
Conditions
ACL - Anterior Cruciate Ligament Rupture
Interventions
Bio ACL, Control
Other
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
18 Years to 45 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Sep 30, 2026, 5:48 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery

NCT05488054
View directory record Official record
Conditions
ACL Injury, Hip Injuries
Interventions
Physical Therapy, Monitored Work-out, Moxy Oxygen Sensor Device
Procedure · Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
14 Years to 30 Years
Enrollment
226 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Avon, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Sep 30, 2026, 5:48 AM EDT
Completed Phase 4 Interventional Results available

Adductor Canal Block Versus Femoral Block on Pain and Quadriceps Strength

NCT05190120
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Knee Meniscus Tear
Interventions
Femoral Nerve Block, Adductor Canal Nerve Block, preoperative Femoral Nerve Block using 20ml of 0.5% ropivacaine, Preoperative Adductor canal block with 0.75%% ropivacaine 13.3ml.
Procedure · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Sep 30, 2026, 5:48 AM EDT
Enrolling by invitation Not applicable Interventional

Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients

NCT07171346
View directory record Official record
Conditions
ACL Reconstruction, ACL Surgery, ACL Injury, Electrotherapy, Muscle Atrophy or Weakness
Interventions
Zynex NexWave Electrotherapy Device
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
15 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 30, 2026, 5:48 AM EDT
Not listed Phase 4 Interventional

IPACK on Early Pain Scores After ACL Reconstruction

NCT05985629
View directory record Official record
Conditions
Pain, Postoperative, Anterior Cruciate Ligament Injuries, Analgesics, Opioid
Interventions
IPACK, PLACEBO
Drug
Lead sponsor
Loyola University
Other
Eligibility
16 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Sep 30, 2026, 5:48 AM EDT
Completed Not applicable Interventional

Low-Intensity Blood Flow Restriction Training as a Pre-Operative Rehabilitative Modality to Improve Post-Operative Outcomes for ACL Reconstruction

NCT04302558
View directory record Official record
Conditions
ACL Injury
Interventions
Exercise Blood Flow Restriction training, SHAM Exercise Blood Flow Restriction training
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 40 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 3, 2023 · Synced Sep 30, 2026, 5:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterizing Clinical and Biomechanical Contributions to Function Following ACL Reconstruction

NCT03132987
View directory record Official record
Conditions
ACL Tears
Interventions
Progressive strengthening program
Other
Lead sponsor
Creighton University
Other
Eligibility
14 Years to 35 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 17, 2017 · Synced Sep 30, 2026, 5:48 AM EDT
Completed Not applicable Interventional

Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction

NCT03209531
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Operant Conditioning, Control, Single Pulse Transcranial Magnetic Stimulation
Behavioral · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Sep 30, 2026, 5:48 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Prevention of Skeletal Muscle Adaptations to Traumatic Knee Injury and Surgery

NCT02945553
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
Neuromuscular electrical stimulation, Microstimulation
Device
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jan 5, 2021 · Synced Sep 30, 2026, 5:48 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Risk Factors for Anterior Cruciate Ligament (ACL) Injury

NCT00124319
View directory record Official record
Conditions
Knee Injuries, Athletic Injuries
Interventions
Not listed
Lead sponsor
Steve Marshall
Other
Eligibility
18 Years and older
Enrollment
4,800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
3
States / cities
Colorado Springs, Colorado • Annapolis, Maryland • West Point, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2011 · Synced Sep 30, 2026, 5:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prospective Evaluation of Osseous Integration in ACL Reconstruction Comparing Tightrope vs Interference Screw Fixation

NCT03841500
View directory record Official record
Conditions
ACL - Anterior Cruciate Ligament Rupture
Interventions
Biocomposite intereference screw femoral tunnel fixation, Endobutton (Tightrope) femoral tunnel fixation
Device
Lead sponsor
Kelsey-Seybold Clinic
Other
Eligibility
18 Years to 50 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 15, 2019 · Synced Sep 30, 2026, 5:48 AM EDT
Active, not recruiting Not applicable Interventional

Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial

NCT04039971
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
Interventions
ACL Reconstruction
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 19 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 30, 2026, 5:48 AM EDT
Not yet recruiting No phase listed Observational

Measuring Knee Laxity and Pivot Shift in ACL-Deficient Patients

NCT07688967
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Tear
Interventions
Not listed
Lead sponsor
Arthroresearch LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 30, 2026, 5:48 AM EDT
Active, not recruiting No phase listed Observational

Multicenter ACL Revision Study (MARS)

NCT00625885
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
12 Years to 65 Years
Enrollment
1,234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2030
U.S. locations
47
States / cities
La Jolla, California • Los Angeles, California • San Francisco, California + 39 more
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 30, 2026, 5:48 AM EDT