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Showing 1–24 of 196 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Completed Phase 2 Interventional Results available

Early Treatment for Acute ACL Tear

NCT01692756
Conditions
Anterior Cruciate Ligament (ACL) Tears
Interventions
Kenalog or placebo, Kenalog then Placebo, Kenalog, Placebo
Drug
Lead sponsor
Cale Jacobs
Other
Eligibility
14 Years to 33 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Lexington, Kentucky
Completed Not applicable Interventional Accepts healthy volunteers

External Focus of Attention Feedback to Reduce Risk of Non-contact ACL Injury

NCT04914689
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Internal focus of attention feedback, Visual internal focus of attention feedback, Auditory external focus of attention feedback
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 35 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charlotte, North Carolina
Not listed Not applicable Interventional Accepts healthy volunteers

Training of Falling Techniques on Landing Mechanics

NCT04768088
Conditions
Sports Injury, Orthopedic Disorder, Knee Injuries, Anterior Cruciate Ligament Injuries
Interventions
Falling Training
Other
Lead sponsor
University of Wyoming
Other
Eligibility
14 Years to 30 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Laramie, Wyoming
Conditions
Pain, Postoperative, Anterior Cruciate Ligament Injuries, Analgesics, Opioid
Interventions
IPACK, PLACEBO
Drug
Lead sponsor
Loyola University
Other
Eligibility
16 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Maywood, Illinois
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Adding Neurocognitive Component to Balance Test

NCT06827483
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Neurocognitive Component
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 25 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL Reconstruction (Bone Patellar Tendon Bone Graft), Bridge Enhanced ACL Restoration (BEAR)
Procedure · Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
6
States / cities
Boulder, Colorado • Bloomington, Minnesota • Cleveland, Ohio + 3 more
Recruiting No phase listed Observational Accepts healthy volunteers

Baseline ACL Injury Risk Screening and Normative Data

NCT06635668
Conditions
ACL Injury, Anterior Cruciate Ligament Injuries, Musculoskeletal Injury
Interventions
Not listed
Lead sponsor
Sanford Health
Other
Eligibility
10 Years to 65 Years
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2033
U.S. locations
1
States / cities
Fargo, North Dakota
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Continuous Vs Single Shot Block After ACL

NCT04101682
Conditions
ACL Injury
Interventions
Bupivacaine
Drug
Lead sponsor
Northwell Health
Other
Eligibility
16 Years and older
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Plainview, New York
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Incrediwear Products Immediately After ACL Repair

NCT06668376
Conditions
Anterior Cruciate Ligament Tear, Medial Collateral Ligament
Interventions
Leg Sleeve, Placebo
Device
Lead sponsor
Texas Bone and Joint
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Denton, Texas
Conditions
Anterior Cruciate Ligament Tear, Pain, Postoperative, Opioid Use
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL reconstruction control, ACL Biocleanse, surgical
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 55 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
1
States / cities
Gainesville, Florida
Completed Not applicable Interventional Results available

Opiates Prescribing for Knee Arthroscopies and ACL Reconstruction

NCT03876743
Conditions
Knee Injuries, ACL Injury
Interventions
Group 1-Knee Arthroscopy, Group 2-Knee Arthroscopy, Group 1-ACL reconstruction, Group 2-ACL reconstruction
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 89 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Exparel
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Completed No phase listed Observational Results available

MDR EZ Pass and Precision Flexible Reamer

NCT03914703
Conditions
Anterior Cruciate Ligament Injury, Rotator Cuff Tear
Interventions
EZ Pass Suture Passer
Procedure
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Conditions
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
Interventions
Experimental Group, Control Group
Drug · Other
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
14 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Gulf Breeze, Florida
Conditions
ACL Tear
Interventions
ACL reconstruction, Mesenchymal stem cell implantation
Procedure
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
14 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Gulf Breeze, Florida
Conditions
Depression, Anterior Cruciate Ligament Injuries, Mental Health Issue
Interventions
Virtual Psychological Intervention: Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
13 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Detroit, Michigan
Terminated Not applicable Interventional

ACL Bone Health and Loading Study

NCT04682392
Conditions
ACL Tear
Interventions
Delfi's PTS Personalized Tourniquet System for Blood Flow Restriction Group, Standard ACL rehab
Device · Other
Lead sponsor
Candice Dunkin, MS, LAT, ATC
Other
Eligibility
16 Years to 22 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Conditions
ACL Injury
Interventions
Autologous bone grafting, Absence of autologous bone grafting
Procedure
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Hartford, Connecticut
Conditions
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Arthrofibrosis of Knee
Interventions
Werewolf FLOW 50, Control
Device · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 18 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Aurora, Colorado • Broomfield, Colorado • Highlands Ranch, Colorado
Conditions
Injury of Anterior Cruciate Ligament
Interventions
bupivacaine, continuous perineural infusion catheter
Drug · Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
14 Years to 18 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Knee Injuries
Interventions
OMS103HP, Vehicle
Drug
Lead sponsor
Omeros Corporation
Industry
Eligibility
15 Years to 65 Years
Enrollment
326 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
15
States / cities
Encinitas, California • Denver, Colorado • Englewood, Colorado + 12 more
Conditions
Anterior Cruciate Ligament Tear
Interventions
anakinra (150mg), Saline intraarticularly
Drug · Other
Lead sponsor
Cale Jacobs, PhD
Other
Eligibility
14 Years to 40 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lexington, Kentucky
Conditions
Anterior Cruciate Ligament Rupture
Interventions
BioCleanse Tibialis tendon
Other
Lead sponsor
RTI Surgical
Industry
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Phoenix, Arizona