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Showing 1–24 of 93 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Anterior Cruciate Ligament Rupture Clear all
Completed Phase 4 Interventional Results available

Adductor Canal Block and IPACK Block vs. Isolated Adductor Canal Block for Post-Operative Analgesia Following ACL Reconstruction With Bone Patellar Tendon Bone Autograft:

NCT05286307
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
IPACK block
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Jun 10, 2026, 8:11 AM EDT
Terminated Phase 4 Interventional Results available

Analgesic Benefits of Genicular Nerve Blocks of the Posterior Knee for Patients Undergoing ACL Reconstruction

NCT02008617
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament
Interventions
Bupivacaine, Preservative free normal saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 70 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Jun 10, 2026, 8:11 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Longitudinal Assessment of Cartilage Injury and Remodeling After Anterior Cruciate Ligament Rupture and Reconstruction:

NCT03497780
View directory record Official record
Conditions
ACL - Anterior Cruciate Ligament Rupture, ACL Injury, Healthy
Interventions
Anterior cruciate ligament reconstruction
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 30 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Jun 10, 2026, 8:11 AM EDT
Completed Phase 1Phase 2 Interventional

Study to Prevent Cartilage Damage Following Acute Knee Injury.

NCT00332254
View directory record Official record
Conditions
Knee Injury
Interventions
Anakinra
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 30 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Jun 10, 2026, 8:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterizing Clinical and Biomechanical Contributions to Function Following ACL Reconstruction

NCT03132987
View directory record Official record
Conditions
ACL Tears
Interventions
Progressive strengthening program
Other
Lead sponsor
Creighton University
Other
Eligibility
14 Years to 35 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 16, 2017 · Synced Jun 10, 2026, 8:11 AM EDT
Not listed Not applicable Interventional

The Effect of Fertilized ACL Technique on Outcomes of ACL Reconstruction in Young Adults

NCT04178538
View directory record Official record
Conditions
ACL Tear, ACL Injury, Arthroscopy, Anterior Cruciate Ligament Tear
Interventions
ACL reconstruction with bone marrow, demineralized bone marix, and internal brace augmentation, Standard ACL reconstruction with all inside technique
Procedure
Lead sponsor
Marshall University
Other
Eligibility
14 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Huntington, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Jun 10, 2026, 8:11 AM EDT
Terminated Not applicable Interventional Results available

Moderated Blood Flow Restriction After Anterior Cruciate Ligament Reconstruction

NCT02911909
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
Delfi, Standard rehabilitation
Device · Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 30 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 10, 2020 · Synced Jun 10, 2026, 8:11 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of Biocleanse Allografts For ACL Reconstruction

NCT00187876
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL reconstruction control, ACL Biocleanse, surgical
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 55 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 3, 2014 · Synced Jun 10, 2026, 8:11 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction

NCT02189317
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Exparel
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 26, 2016 · Synced Jun 10, 2026, 8:11 AM EDT
Recruiting Phase 2 Interventional

Preventing Injured Knees From osteoArthritis: Severity Outcomes

NCT06096259
View directory record Official record
Conditions
Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
Interventions
Metformin, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
512 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
9
States / cities
Atlanta, Georgia • Iowa City, Iowa • Lexington, Kentucky + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Jun 10, 2026, 8:11 AM EDT
Withdrawn Phase 4 Interventional

Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction

NCT07115056
View directory record Official record
Conditions
ACL Injury, ACL Tears, ACL Surgery
Interventions
Tranexamic Acid (TXA), Placebo
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
14 Years to 22 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
6
States / cities
Evanston, Illinois • Chesterfield, Missouri • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jun 10, 2026, 8:11 AM EDT
Withdrawn Phase 2 Interventional

Can PRP Reduce Pro-Inflammatory Biomarkers Following ACL Injury

NCT03389685
View directory record Official record
Conditions
ACL - Anterior Cruciate Ligament Rupture, ACL Injury
Interventions
Platelet Rich Plasma, Saline Placebo
Biological · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 14, 2024 · Synced Jun 10, 2026, 8:11 AM EDT
Terminated Phase 2 Interventional Results available

Success of Long-acting Anti-inflammatories After Anterior Cruciate Ligament and Meniscal Injury

NCT04331002
View directory record Official record
Conditions
Tibial Meniscus Injuries, Tibial Meniscus Tears, Tibial Meniscus, Torn, Anterior Cruciate Ligament Tear
Interventions
Zilretta, Placebo
Drug · Other
Lead sponsor
Austin V Stone
Other
Eligibility
18 Years to 40 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jun 10, 2026, 8:11 AM EDT
Completed Phase 4 Interventional Results available

Adductor Canal Block Versus Femoral Block on Pain and Quadriceps Strength

NCT05190120
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Knee Meniscus Tear
Interventions
Femoral Nerve Block, Adductor Canal Nerve Block, preoperative Femoral Nerve Block using 20ml of 0.5% ropivacaine, Preoperative Adductor canal block with 0.75%% ropivacaine 13.3ml.
Procedure · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Jun 10, 2026, 8:11 AM EDT
Completed Not applicable Interventional

Quantifying the Benefits of Supervised vs. Unsupervised Pre-habilitation for Patients With Acute ACL Tears

NCT04593264
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries
Interventions
Self-guided pre-habilitation exercise program, Traditional pre-habilitation
Other
Lead sponsor
WellSpan Health
Other
Eligibility
13 Years to 50 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 26, 2023 · Synced Jun 10, 2026, 8:11 AM EDT
Completed Phase 2 Interventional Results available

Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears

NCT04088227
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
Interventions
Experimental Group, Control Group
Drug · Other
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
14 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Feb 16, 2025 · Synced Jun 10, 2026, 8:11 AM EDT
Recruiting Not applicable Interventional

Comparison of Methods in Post Operative Knee Arthroscopy Rehabilitation

NCT05735236
View directory record Official record
Conditions
ACL Tear
Interventions
BFR Cuff
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
16 Years to 60 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Centennial, Colorado
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Jun 10, 2026, 8:11 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Bio ACL Reconstruction Amnion Collagen Matrix Wrap and Stem Cells

NCT03294759
View directory record Official record
Conditions
ACL - Anterior Cruciate Ligament Rupture
Interventions
Bio ACL, Control
Other
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
18 Years to 45 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Jun 10, 2026, 8:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Functional and Self-reported Outcomes in Participants With a History of Musculoskeletal Knee Injury

NCT03617991
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Interventions
Exercise Group
Other
Lead sponsor
Johanna M. Hoch
Other
Eligibility
18 Years to 35 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 3, 2020 · Synced Jun 10, 2026, 8:11 AM EDT
Completed Early Phase 1 Interventional

Early Anti-inflammatory Treatment in Patients With Acute ACL Tear and Painful Effusions

NCT03429140
View directory record Official record
Conditions
Anterior Cruciate Ligament
Interventions
Gel-One, Saline Placebo
Drug · Other
Lead sponsor
Cale Jacobs, PhD
Other
Eligibility
14 Years to 33 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 12, 2022 · Synced Jun 10, 2026, 8:11 AM EDT
Recruiting No phase listed Observational

BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures

NCT06948591
View directory record Official record
Conditions
ACL Tears
Interventions
Anterior cruciate ligament reconstruction with BioBrace® augmentation, Arthroscopic anterior cruciate ligament reconstruction
Device · Procedure
Lead sponsor
CONMED Corporation
Industry
Eligibility
14 Years to 70 Years
Enrollment
500 participants
Timeline
2025 – 2030
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jun 10, 2026, 8:11 AM EDT
Enrolling by invitation Not applicable Interventional

Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament Reconstruction

NCT04650568
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Interventions
Autologous Bone Marrow Derived Mesenchymal Stem Cells, Sham incision
Device · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Jun 10, 2026, 8:11 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Female Acl Prevention Study Where we Look at Landing Techniques Pre/Post Nine Week Strenghtening Program

NCT01729312
View directory record Official record
Conditions
Prevention of ACL Thru Strengthening Program
Interventions
Not listed
Lead sponsor
Henry Ford Health System
Other
Eligibility
13 Years to 16 Years · Female only
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Farmington, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 26, 2017 · Synced Jun 10, 2026, 8:11 AM EDT
Not listed Not applicable Interventional

Quadriceps Function Prior to Anterior Cruciate Ligament Reconstruction

NCT00971451
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament
Interventions
cryotherapy, TENS
Other
Lead sponsor
University of Virginia
Other
Eligibility
15 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 7, 2011 · Synced Jun 10, 2026, 8:11 AM EDT