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Showing 1–24 of 52 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Anterior Knee Pain Syndrome Clear all
Terminated Early Phase 1 Interventional

Neural Mechanisms of Muscle Control in Individuals With Knee Pain

NCT02854774
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Muscle activation exercises
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional

Effects of Dry Needling Using Spinal and Peripheral Sites Versus Peripheral Sites Only

NCT02646579
View directory record Official record
Conditions
Plantar Fasciitis, Achilles Tendinitis, Patellofemoral Pain Syndrome
Interventions
Spinal and Peripheral Dry Needling, Peripheral Dry Needling
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional

Lumbar Manipulation for Hip and Muscle Strength

NCT03101956
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
Interventions
Lumbar Spine Manipulation, Lumbar Spine Manipulation Placebo
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Strength and Coordination Training on Biomechanics and Injury in New Runners

NCT03293121
View directory record Official record
Conditions
Injuries, Patellofemoral Pain Syndrome, Iliotibial Band Syndrome
Interventions
Strength and Coordination Training, Walking
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 60 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Utilizing the Trunk as a Proximal Lever to Strengthen the Hip Musculature and Alter Lower Extremity Function

NCT03285464
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Triplanar Rotary Resistance
Other
Lead sponsor
High Point University
Other
Eligibility
18 Years and older · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 25, 2018 · Synced Jul 23, 2026, 1:25 PM EDT
Completed No phase listed Observational

Vasti Control of Patellofemoral Kinematics in Asymptomatic Volunteer

NCT00978003
View directory record Official record
Conditions
Abnormalities, Patellofemoral Pain Syndrome
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 55 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional Results available

Effectiveness Trial for Evaluating IAHA for PFPS

NCT01811654
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Intra-Articular Hyaluronic Acid-Euflexxa
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 25, 2020 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional

Rehabilitation With Patterned Electrical Neuromuscular Stimulation for Patients With Patellofemoral Pain

NCT02441712
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
PENS
Device
Lead sponsor
University of Virginia
Other
Eligibility
15 Years to 40 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 18, 2017 · Synced Jul 23, 2026, 1:25 PM EDT
Active, not recruiting Not applicable Interventional

Strength or Power Training for Patellofemoral Pain

NCT05403944
View directory record Official record
Conditions
Patellofemoral Pain
Interventions
Standard of Care Rehabilitation (SOC), Strength Training Rehabilitation Incorporating Power Exercises (STRIPE)
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 40 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
3
States / cities
Storrs, Connecticut • Orlando, Florida • Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional

Mindful Miles Pilot Feasibility Study

NCT07462429
View directory record Official record
Conditions
Patellofemoral Pain, PFP, Patellofemoral Pain Syndrome, Patellofemoral Pain, Patellofemoral Pain (PFPS)
Interventions
Progressive Mindful Physical Activity
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional

Digital Home-Exercise Therapy Application For Patients With Non-Surgical Knee Injuries

NCT04323267
View directory record Official record
Conditions
Knee Injuries, Knee Osteoarthritis, Patellofemoral Syndrome
Interventions
Limber Digital Application, Physical therapy Therapy
Device · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2020 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Hip and Core Muscle Strengthening for Patellofemoral Osteoarthritis: A Feasibility Study

NCT02825238
View directory record Official record
Conditions
Patellofemoral Osteoarthritis
Interventions
Supervised exercise program
Other
Lead sponsor
University of the Sciences in Philadelphia
Other
Eligibility
35 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional

Trial of Neurostimulation and Blood Flow Restriction for PFPS in Active Duty

NCT04086615
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
NMES and exercise supplemented with high BFR, NMES and exercise supplemented with low BFR
Device
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 44 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Fort Campbell North, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 5, 2022 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional Results available

Trial of Self-managed Approaches for Patellofemoral Pain Syndrome in Active Duty

NCT02597673
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Home Exercise Program (HEP), NMES, TENS
Other · Device
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 45 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Fort Campbell North, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional

Evaluation of a Treatment Algorithm for Patients With Patellofemoral Pain Syndrome

NCT02461095
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Impairment based approach, PFPS Algorithm approach
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
12 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
4
States / cities
Columbus, Ohio • Dublin, Ohio • New Albany, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Jul 23, 2026, 1:25 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Bilateral Knee Pain and Dry Needling

NCT05976269
View directory record Official record
Conditions
Patellofemoral Pain
Interventions
Dry needling
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2030
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Conventional Home Exercise Programs Versus Electronic Home Exercise Versus Artificial Intelligence "Virtual Therapy" for Anterior Knee Pain

NCT01696162
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Algorithm based Exercise Videos, PDF Exercise Sheets, Limited Exercise Videos
Other
Lead sponsor
Simpletherapy
Industry
Eligibility
18 Years to 64 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 16, 2014 · Synced Jul 23, 2026, 1:25 PM EDT
Recruiting Phase 3 Interventional

Comparing the Outcome of Electrical Stimulation and Physical Therapy in Patellofemoral Pain Syndrome

NCT03184545
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
EMS, Physical therapy
Device · Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 40 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 2, 2024 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Internet Enhanced, Patient-Centered Orthopedic Care: A Prospective, Randomized, Controlled Pilot Trial

NCT02025400
View directory record Official record
Conditions
Knee Injuries, Shoulder Injuries, Rotator Cuff Disease, Meniscus Tear, Patellofemoral Pain
Interventions
eRehab, Formal Physical Therapy
Other
Lead sponsor
Charlotte Sports Medicine Institute, PA
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
2
States / cities
Prince Frederick, Maryland • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 31, 2013 · Synced Jul 23, 2026, 1:25 PM EDT
Completed Not applicable Interventional

Maladaptive Psychosocial Beliefs and Adolescents With Patellofemoral Pain

NCT04752501
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Knee Pain Chronic, Patellofemoral Syndrome, Anterior Knee Pain Syndrome
Interventions
Psychologically Informed Education, Biomedical Education (Control)
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 2, 2023 · Synced Jul 23, 2026, 1:25 PM EDT
Recruiting Not applicable Interventional

Emovi 3D Knee Assessment Device Intervention for Operational Readiness

NCT06517056
View directory record Official record
Conditions
Patellofemoral Pain, Patellofemoral Pain Syndrome
Interventions
Emovi Knee Kinesiography
Device
Lead sponsor
Womack Army Medical Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Honolulu, Hawaii • Fort Liberty, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Jul 23, 2026, 1:25 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Limited Ankle Dorsiflexion and Effect on Single Limb Squats in Individuals With Patellofemoral Pain

NCT05285007
View directory record Official record
Conditions
Patellofemoral Pain
Interventions
Mobilization with Movement, No mobilization with movement and education
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 59 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jul 23, 2026, 1:25 PM EDT
Terminated Not applicable Interventional

Running Study for Runners With Chronic Knee Pain

NCT02567123
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Experimental
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 44 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Jul 23, 2026, 1:25 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Yoga for Adolescent Knee Pain

NCT06031935
View directory record Official record
Conditions
Anterior Knee Pain Syndrome
Interventions
Yoga
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
10 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2023 · Synced Jul 23, 2026, 1:25 PM EDT