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ClinicalTrials.gov public records Last synced Oct 3, 2026, 1:21 PM EDT

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Showing 25–48 of 71 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Anxiety and Fear Clear all
Completed Not applicable Interventional

Virtual Reality Exposure Versus In Vivo Exposure for Fear of Heights

NCT04737915
View directory record Official record
Conditions
Fear of Heights, Acrophobia, Specific Phobia, Anxiety Disorder
Interventions
Exposure Therapy (In Vivo), Exposure Therapy (Virtual Reality)
Behavioral
Lead sponsor
University of Notre Dame
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Notre Dame, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 8, 2021 · Synced Oct 3, 2026, 1:21 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Spatial Context and Fear Learning

NCT02423044
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 4, 2019 · Synced Oct 3, 2026, 1:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mentors Offering Maternal Support (M-O-M-S™): A Prenatal Program for Decreasing Maternal Anxiety and Depression

NCT03393637
View directory record Official record
Conditions
Anxiety Fear, Prenatal Depression, Infant, Low Birth Weight, Preterm Birth, Maternal
Interventions
Mentors Offering Maternal Support (M-O-M-S)
Behavioral
Lead sponsor
University of the Incarnate Word
Other
Eligibility
18 Years and older · Female only
Enrollment
1,717 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
3
States / cities
San Diego, California • San Antonio, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Oct 3, 2026, 1:21 PM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Estradiol and Fear Extinction in Anorexia Nervosa (AN)

NCT02792153
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
Estradiol
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 24, 2018 · Synced Oct 3, 2026, 1:21 PM EDT
Active, not recruiting Not applicable Interventional

Pursuing Exploration Into the Supportive Care Needs and Intervention Preferences of Survivors of Testicular Cancer

NCT07228637
View directory record Official record
Conditions
Testicular Cancer
Interventions
Acceptance and Commitment Therapy (ACT) Coaching, Education and Support Coaching
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Oct 3, 2026, 1:21 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Cannabidiol Effects on Learning and Anxiety

NCT05283382
View directory record Official record
Conditions
Anxiety and Fear
Interventions
Cannabidiol Oral Product, Placebo
Drug · Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 50 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 3, 2026, 1:21 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Addressing Anxiety in 2-3-Year-Olds: A Pilot Intervention Study

NCT04039243
View directory record Official record
Conditions
Anxiety Disorder of Childhood, Fear, Shyness
Interventions
Being Brave, Parent Education
Behavioral · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Months to 47 Months
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 3, 2026, 1:21 PM EDT
Completed Not applicable Interventional

Trial of Written Exposure for Metastatic Cancer Patients (EASE)

NCT06042400
View directory record Official record
Conditions
Metastatic Cancer, Solid Tumor Cancer, Lymphoproliferative Disorders, Anxiety, Post-traumatic Stress Symptoms, Fear of Cancer Progression
Interventions
Written Exposure Therapy
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 5, 2023 · Synced Oct 3, 2026, 1:21 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Overgeneralization of Conditioned Fear as a Pathogenic Marker of Anorexia Nervosa

NCT02148042
View directory record Official record
Conditions
Anorexia, Generalized Anxiety
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 12, 2019 · Synced Oct 3, 2026, 1:21 PM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia

NCT06644573
View directory record Official record
Conditions
Chronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior Disorder, REM Sleep Measurement, Insomnia, Insomnia Related to Specified Disorder, Insomnia Due to Other Mental Disorder, Insomnia Comorbid to Psychiatric Disorder, Insomnia Due to Anxiety and Fear, Insomnia Related to Another Mental Condition, Insomnia Disorders, Idiopathic Hypersomnia, Sleep Disorders, Circadian Rhythm, Post Trauma Nightmares, PTSD - Post Traumatic Stress Disorder, Sleep Quality, Anesthesia, Anxiety, Depression, Mental Health, Alzheimer Disease or Associated Disorder, Parkinsons, Circadian Rhythm, Circadian Dysregulation, PTSD, Post-Traumatic, Post-Traumatic Stress Disorder Complex, Military Combat Stress Reaction, Sleep, Military Activity, Veterans, Shift Work Sleep Disorder, Menopause Related Conditions, Pain, Cancer Pain, Athletes
Interventions
PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca, Continuous EEG Monitoring
Procedure · Drug · Device
Lead sponsor
Nyree Penn
Industry
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Oct 3, 2026, 1:21 PM EDT
Withdrawn Not applicable Interventional

Mindfulness to Mitigate the Effect of Anxiety-depression-fear in Chronic Obstructive Pulmonary Disease (COPD)

NCT03385317
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Mindfulness
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 28, 2017 · Synced Oct 3, 2026, 1:21 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Social Support and Enhanced Fear Extinction

NCT04565041
View directory record Official record
Conditions
Fear, Anxiety
Interventions
Social Support
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 3, 2026, 1:21 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Self-Administered Nitrous Oxide (SANO) During Transrectal Prostate Biopsy to Reduce Patient Anxiety and Pain

NCT05803096
View directory record Official record
Conditions
Prostate Disease, Malignancy, Benign Prostatic Hyperplasia, Prostate Cancer, Prostate Adenocarcinoma, Anxiety and Fear, Pain
Interventions
Self-Administered Nitrous Oxide, Oxygen
Drug · Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 85 Years · Male only
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 30, 2024 · Synced Oct 3, 2026, 1:21 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Thimble Mindfulness App and Recovery Patch Descriptions

NCT05980247
View directory record Official record
Conditions
Needle Fear, Vaccine Hesitancy
Interventions
Thimble Application
Device
Lead sponsor
Bianca Edison
Other
Eligibility
5 Years to 11 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Oct 3, 2026, 1:21 PM EDT
Completed Not applicable Interventional

Frontal Stimulation to Modulate Threat Sensitivity in Anxious Depression

NCT04948944
View directory record Official record
Conditions
Depression, Anxiety and Fear
Interventions
transcranial direct current stimulation
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Nov 14, 2023 · Synced Oct 3, 2026, 1:21 PM EDT
Completed Not applicable Interventional Results available

Reward Processes and Rehearsal in Exposure Therapy

NCT06132425
View directory record Official record
Conditions
Anxiety Disorders, Public Speaking Fear
Interventions
Exposure, Rehearsal
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Oct 3, 2026, 1:21 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Facing Your Fears: Adolescents With ASD and Intellectual Disability

NCT05131425
View directory record Official record
Conditions
Autism Spectrum Disorder, Intellectual Disability, Anxiety, Emotion Regulation
Interventions
Facing Your Fears: ASD/ID, Treatment as Usual
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 18 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
2
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Oct 3, 2026, 1:21 PM EDT
Completed Phase 1Phase 2 Interventional

Back on My Feet: Emotional Recovery From Fall Injury

NCT01998945
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Subsyndromal Posttraumatic Stress Disorder, Fear of Falling
Interventions
Exposure-based Cognitive Behavioral Therapy, Relaxation Training
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 16, 2016 · Synced Oct 3, 2026, 1:21 PM EDT
Completed Phase 1 Interventional

Intervention for Anxiety After Falls

NCT01268657
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Specific Phobia, Anxiety
Interventions
Education, Relaxation Training, Cognitive Restructuring, Behavioral Activation, Exposure
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
65 Years to 105 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 16, 2016 · Synced Oct 3, 2026, 1:21 PM EDT
Completed Not applicable Interventional

School-based Treatment of Anxiety Research Study (STARS)

NCT01761396
View directory record Official record
Conditions
Anxiety Disorders
Interventions
CBT, UC
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
6 Years to 18 Years
Enrollment
216 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Oct 3, 2026, 1:21 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Social Support and Reduced Fear Acquisition

NCT04564976
View directory record Official record
Conditions
Fear, Anxiety
Interventions
Social support image
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 3, 2026, 1:21 PM EDT
Suspended Not applicable Interventional

Augmenting Virtual Reality Exposure Therapy for Acrophobia

NCT03917433
View directory record Official record
Conditions
Specific Phobia, Anxiety Disorders, Fear of Heights, Acrophobia
Interventions
Virtual Reality Exposure Therapy, Tactile Feedback, Point-based Rewards
Behavioral
Lead sponsor
University of Nevada, Reno
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Oct 3, 2026, 1:21 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Effects of SRX246 on an Experimental Model of Fear and Anxiety in Humans

NCT02922166
View directory record Official record
Conditions
Fear, Anxiety
Interventions
SRX246, Placebo
Drug
Lead sponsor
Azevan Pharmaceuticals
Industry
Eligibility
21 Years to 50 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Oct 3, 2026, 1:21 PM EDT
Completed Not applicable Interventional

Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation

NCT03958903
View directory record Official record
Conditions
Fear, PTSD, Panic Disorder
Interventions
Amygdala recording and stimulation using Neuropace RNS, Behavioral tasks
Device · Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 26, 2023 · Synced Oct 3, 2026, 1:21 PM EDT