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ClinicalTrials.gov public records Last synced Oct 18, 2026, 9:36 AM EDT

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Showing 121–144 of 340 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Aortic Valve Stenosis Clear all
Completed Not applicable Interventional

Prehabilitation to Improve Functional and Clinical Outcomes in Patients With Aortic Stenosis

NCT02597985
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Prehabilitation, Usual Care
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
60 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 23, 2021 · Synced Oct 18, 2026, 9:36 AM EDT
Not listed Not applicable Interventional

Transcatheter Aortic Valve Replacement System Pivotal Trial

NCT02163850
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Direct Flow Medical, Commercially Available
Device
Lead sponsor
Direct Flow Medical, Inc.
Industry
Eligibility
Not listed
Enrollment
878 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
3
States / cities
New York, New York • Columbus, Ohio • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 3, 2016 · Synced Oct 18, 2026, 9:36 AM EDT
Completed No phase listed Observational

Exercise in Genetic Cardiovascular Conditions

NCT02549664
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy, Long QT Syndrome
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
8 Years to 60 Years
Enrollment
4,299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
29
States / cities
Tucson, Arizona • Orange, California • San Diego, California + 24 more
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Oct 18, 2026, 9:36 AM EDT
Terminated Not applicable Interventional Results available

A Prospective Study of Fractional Flow Reserve Assessment of Intermediate Coronary Stenoses in Severe Aortic Stenosis

NCT03442400
View directory record Official record
Conditions
Coronary Artery Stenoses, Aortic Stenosis
Interventions
Volcano iFR/FFR Verrata Plus coronary pressure/flow wire
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
20 Years to 110 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 5, 2023 · Synced Oct 18, 2026, 9:36 AM EDT
Completed Not applicable Interventional Results available

The ShortCut™ Continued Access Study Protocol

NCT06211296
View directory record Official record
Conditions
Valve-in-valve Procedures, Aortic Stenosis, Coronary; Obstruction
Interventions
Shortcut
Device
Lead sponsor
Pi-cardia
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
4
States / cities
Thousand Oaks, California • Morristown, New Jersey • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 18, 2026, 9:36 AM EDT
Completed No phase listed Observational

Viz HCM (ECG Assist) Utilization Workflow Pilot

NCT06600256
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy
Interventions
Viz HCM ECG Review, Baseline Effectiveness Cohort
Behavioral
Lead sponsor
Viz.ai, Inc.
Industry
Eligibility
18 Years and older
Enrollment
217 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
5
States / cities
La Jolla, California • Ridgewood, New Jersey • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 18, 2026, 9:36 AM EDT
Recruiting No phase listed Observational

Detecting Changes in Arterial Blood Volume and Cardiac Efficiency

NCT07205341
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Not listed
Lead sponsor
HemoCept Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 18, 2026, 9:36 AM EDT
Recruiting Not applicable Interventional

Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR

NCT06689839
View directory record Official record
Conditions
Aortic Stenosis Treated With TAVI, Aortic Diseases
Interventions
F2 Filter and Delivery System, Transcatheter Aortic Valve Replacement (TAVR)
Device · Procedure
Lead sponsor
EnCompass Technologies, Inc.
Industry
Eligibility
50 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
8
States / cities
Naples, Florida • Indianappolis, Indiana • Detroit, Michigan + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Oct 18, 2026, 9:36 AM EDT
Completed Not applicable Interventional

High Intensity Exercise for Increasing Fitness in Patients With Hypertrophic Cardiomyopathy

NCT03335332
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy
Interventions
High intensity exercise, Moderate intensity exercise
Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Oct 18, 2026, 9:36 AM EDT
Enrolling by invitation No phase listed Observational

Deep Learning-enhanced Personalized Monitoring of Aortic Stenosis - The DETECT-AS Prognostic Study

NCT06749132
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Transthoracic echocardiogram
Diagnostic Test
Lead sponsor
Yale University
Other
Eligibility
65 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
New Haven, Connecticut • New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 18, 2026, 9:36 AM EDT
Recruiting Phase 4 Interventional

Patient Quality of Recovery After TAVR With Different Sedation Regimens

NCT07556523
View directory record Official record
Conditions
Transcatheter Aortic Valve Replacement (TAVR), Aortic Valve Stenosis
Interventions
Propofol, Dexmedetomidine, Midazolam, Fentanyl
Drug
Lead sponsor
David Lyubashevsky
Other
Eligibility
18 Years to 90 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Glenview, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 18, 2026, 9:36 AM EDT
Withdrawn No phase listed Observational

Assessment of Neurologic Injury Subsequent to Transcatheter Aortic Valve Replacement: A Feasibility Study

NCT01927601
View directory record Official record
Conditions
Severe Symptomatic Aortic Stenosis
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 26, 2016 · Synced Oct 18, 2026, 9:36 AM EDT
Completed No phase listed Observational

Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions

NCT01845207
View directory record Official record
Conditions
Aortic Stenosis, Cardiac Valve Replacement Complication, Fragility
Interventions
Not listed
Lead sponsor
Jewish General Hospital
Other
Eligibility
70 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
4
States / cities
Boston, Massachusetts • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 31, 2016 · Synced Oct 18, 2026, 9:36 AM EDT
Terminated No phase listed Observational

Non-Contrast Magnetic Resonance Angiography Assessment of Patients Referred for Transcatheter Aortic Valve Implantation

NCT02007967
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 22, 2016 · Synced Oct 18, 2026, 9:36 AM EDT
Completed Not applicable Interventional

Conduction Disease After Transcatheter Aortic Valve Replacement

NCT04489095
View directory record Official record
Conditions
Aortic Stenosis, Heart Block, Aortic Insufficiency
Interventions
Electrophysiology Study
Diagnostic Test
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 14, 2022 · Synced Oct 18, 2026, 9:36 AM EDT
Completed No phase listed Observational

Prospective Evaluation of Neurocognition in Patients Undergoing Transcatheter Aortic Valve Replacement

NCT05614986
View directory record Official record
Conditions
Mild Cognitive Impairment, Aortic Stenosis
Interventions
5 minute Montreal Cognitive Assessment (mini MoCA)
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
4
States / cities
Dallas, Texas • Fort Worth, Texas • Plano, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 18, 2026, 9:36 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy

NCT00879060
View directory record Official record
Conditions
Myocardial Fibrosis, Hypertrophic Cardiomyopathy
Interventions
Spironolactone, Placebo
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Oct 18, 2026, 9:36 AM EDT
Recruiting No phase listed Observational

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

NCT06777368
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Medtronic TAV, Edwards TAV
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
18 Years to 105 Years
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
71
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 58 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 18, 2026, 9:36 AM EDT
Completed Not applicable Interventional

Prehabilitation for Patients Undergoing Transcatheter Aortic Valve Replacement

NCT03107897
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Pre-habilitation
Other
Lead sponsor
WellSpan Health
Other
Eligibility
Not listed
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 9, 2023 · Synced Oct 18, 2026, 9:36 AM EDT
Not listed Not applicable Interventional

Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: The DETECT AS Trial

NCT05230225
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Physician Notification Letter
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
940 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Oct 18, 2026, 9:36 AM EDT
Completed Not applicable Interventional Results available

Safety and Efficacy Continued Access Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in Very High Risk Subjects and High Risk Subjects Who Need Aortic Valve Replacement

NCT01531374
View directory record Official record
Conditions
Severe Aortic Stenosis
Interventions
Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
Not listed
Enrollment
2,777 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
45
States / cities
Phoenix, Arizona • Los Angeles, California • Mountain View, California + 35 more
Source: ClinicalTrials.gov public record
Updated Oct 25, 2022 · Synced Oct 18, 2026, 9:36 AM EDT
Completed Phase 1 Interventional

Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access

NCT02280824
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
CA-TAVR, Amplatzer Duct Occluder
Procedure · Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
21 Years to 99 Years
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
15
States / cities
Washington D.C., District of Columbia • Atlanta, Georgia • Evanston, Illinois + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 15, 2019 · Synced Oct 18, 2026, 9:36 AM EDT
Completed Not applicable Interventional

Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study

NCT02375282
View directory record Official record
Conditions
Coronary Artery Disease, Mitral Valve Insufficiency, Aortic Valve Stenosis, Aortic Valve Regurgitation, Mitral Valve Stenosis, Coronary Artery Bypass Graft Triple Vessel
Interventions
Ambulation orderly
Procedure
Lead sponsor
Baystate Medical Center
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 18, 2026, 9:36 AM EDT
Completed No phase listed Observational

Mavacamten in Obstructive Hypertrophic Cardiomyopathy

NCT07168655
View directory record Official record
Conditions
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Interventions
Mavacamten
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Oct 18, 2026, 9:36 AM EDT