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Showing 1–24 of 35 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Aphakic Eye Clear all
Completed Not applicable Interventional Results available

Clinical Trial of a Hydrophilic EMV Toric Lens RAO210T in the Correction of Aphakia and Corneal Astigmatism

NCT05985304
View directory record Official record
Conditions
Cataract, Corneal Astigmatism
Interventions
RayOne EMV Toric IOL, RayOne Monofocal IOL, Cataract Surgery
Device · Procedure
Lead sponsor
Rayner Intraocular Lenses Limited
Industry
Eligibility
22 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
9
States / cities
Fayetteville, Arkansas • Grand Junction, Colorado • Alexandria, Minnesota + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Jul 22, 2026, 10:45 AM EDT
Completed No phase listed Observational

A Real-World Evidence (RWE) Long-Term Follow-Up Study to Assess Outcomes of Alcon Monofocal Intraocular Lenses

NCT05799950
View directory record Official record
Conditions
Aphakia
Interventions
AcrySof single-piece IOL, AcrySof multi-piece IOL
Device
Lead sponsor
Alcon Research
Industry
Eligibility
Not listed
Enrollment
138 participants
Timeline
2023 – 2025
U.S. locations
6
States / cities
Burbank, California • Jacksonville, Florida • Rock Island, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

EYEFILL® C. -US Viscoelastic Clinical Investigation

NCT02024711
View directory record Official record
Conditions
Cataract
Interventions
EYEFILL® C.-US Viscoelastic, Healon® Viscoelastic (CONTROL)
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
22 Years and older
Enrollment
262 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
8
States / cities
Phoenix, Arizona • Redding, California • Cape Coral, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2020 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Comparison of the Hoya Surgical Optics (HSO) iSert 251 Posterior Chamber Aspheric Aphakic Intraocular Lens to Historical / Literature Controls.

NCT01292629
View directory record Official record
Conditions
Aphakia, Cataract
Interventions
iSert 251 intraocular lens
Device
Lead sponsor
Hoya Surgical Optics, Inc.
Industry
Eligibility
50 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
5
States / cities
E. Shea Blvd, Suite C101, Arizona • Boynton Beach, Florida • Miami, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 19, 2015 · Synced Jul 22, 2026, 10:45 AM EDT
Not listed No phase listed Observational

Post-Implant Performance of the EC-3 IOL

NCT01333345
View directory record Official record
Conditions
Cataract
Interventions
Not listed
Lead sponsor
Aaren Scientific Inc.
Industry
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
2
States / cities
Venice, Florida • Dover, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 11, 2011 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Clareon PanOptix Pro vs. Clareon PanOptix - Study B

NCT06401551
View directory record Official record
Conditions
Aphakia, Presbyopia
Interventions
CPO Pro IOL, CPO IOL, Cataract Surgery
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
8
States / cities
Torrance, California • Bloomfield Hills, Michigan • Kansas City, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 22, 2026, 10:45 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Comparative Study of the Tomey OA-2000, Tomey CASIA2, and the LenStar LS900

NCT06065072
View directory record Official record
Conditions
Cataract, Aphakic Eye, Pseudophakia
Interventions
Optical measurement
Device
Lead sponsor
Tomey Corporation
Industry
Eligibility
22 Years and older
Enrollment
167 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Woburn, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 2, 2023 · Synced Jul 22, 2026, 10:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Intravitreal Injection Site and Perceived Pain

NCT05640895
View directory record Official record
Conditions
Pain
Interventions
Intravitreal injection site
Procedure
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 100 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

A Clinical Study to Evaluate The Safety and Effectiveness of Performing 0.50 Diopter Astigmatism Correction on the Commercially Available RxSight Light Adjustable Lens (LAL)

NCT04005586
View directory record Official record
Conditions
Aphakia, Cataract
Interventions
Light Delivery Device (LDD)
Device
Lead sponsor
RxSight, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Brecksville, Ohio • Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Jun 10, 2021 · Synced Jul 22, 2026, 10:45 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Clinical Trial to Evaluate the Model SC9 IOL Compared to the Model LI61SE IOL (Bausch & Lomb)

NCT03179397
View directory record Official record
Conditions
Cataract
Interventions
Model SC9, Model LI61SE
Device
Lead sponsor
CORD, LLC
Industry
Eligibility
22 Years and older
Enrollment
338 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
13
States / cities
Carlsbad, California • Laguna Hills, California • Orange, California + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Jul 22, 2026, 10:45 AM EDT
Withdrawn Not applicable Interventional

Evaluation of AcrySof IQ Vivity Extended Vision Intraocular Lenses

NCT06541795
View directory record Official record
Conditions
Aphakia, Presbyopia, Residual Refractive Cylinder
Interventions
AcrySof IQ Vivity Extended Vision IOL
Device
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Jul 22, 2026, 10:45 AM EDT
Recruiting Not applicable Interventional

Clareon TruPlus Study

NCT07502456
View directory record Official record
Conditions
Aphakia, Astigmatism
Interventions
Clareon TruPlus Monofocal Non-Toric IOL, Clareon TruPlus Monofocal Toric IOL, Phacoemulsification
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
5
States / cities
Phoenix, Arizona • Brecksville, Ohio • Mt. Pleasant, South Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Post Approval Study of the AcrySof® IQ ReSTOR® Toric IOLs

NCT03733730
View directory record Official record
Conditions
Aphakia, Presbyopia, Astigmatism
Interventions
ACRYSOF IQ RESTOR +3.0 Multifocal Toric IOL, ACRYSOF IQ RESTOR +2.5 D Multifocal Toric IOL, ACRYSOF IQ RESTOR +2.5 D Multifocal IOL, Cataract Surgery
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
2,449 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
37
States / cities
Dothan, Alabama • Phoenix, Arizona • Fresno, California + 32 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2023 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional

AT ELANA 841P Posterior Chamber Intraocular Lens for Correction of Aphakia Following Cataract Removal

NCT06264232
View directory record Official record
Conditions
Cataract Senile
Interventions
Cataract Surgery
Device
Lead sponsor
Carl Zeiss Meditec, Inc.
Industry
Eligibility
22 Years to 100 Years
Enrollment
284 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
14
States / cities
Beverly Hills, California • Northridge, California • Orange, California + 11 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Jul 22, 2026, 10:45 AM EDT
Terminated No phase listed Interventional Results available

A Clinical Study to Evaluate The Safety and Effectiveness of The RxSight Light Adjustable Lens (LAL) In Subjects Desiring an Extended Depth of Focus

NCT04177771
View directory record Official record
Conditions
Aphakia, Cataract, Presbyopia
Interventions
Light Adjustable lens (LAL) and Light Delivery Device (LDD) - Pre-COVID Population, SofPort LI61AO IOL, Tecnis ZCB00 or ZTC150 IOL
Device
Lead sponsor
RxSight, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fayetteville, Arkansas
Source: ClinicalTrials.gov public record
Updated Jan 6, 2025 · Synced Jul 22, 2026, 10:45 AM EDT
Active, not recruiting Not applicable Interventional

Post Market Clinical Follow-up (PMCF) Study of Clareon Vivity & Clareon PanOptix

NCT05796453
View directory record Official record
Conditions
Aphakia, Astigmatism, Presbyopia
Interventions
Clareon Vivity IOL - Non Toric, Clareon Vivity IOL - Toric, Clareon PanOptix Trifocal IOL - Non Toric, Clareon PanOptix Trifocal IOL - Toric
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
470 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
6
States / cities
Torrance, California • Jacksonville, Florida • Liverpool, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Jul 22, 2026, 10:45 AM EDT
Active, not recruiting Not applicable Interventional

Post Market Clinical Evaluation of Clareon PanOptix Pro and Clareon PanOptix Pro Toric IOLs

NCT07161635
View directory record Official record
Conditions
Aphakia, Presbyopia
Interventions
Clareon PanOptix Pro/Pro Toric Trifocal IOL, Phacoemulsification
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Torrance, California • Kansas City, Missouri • Mt. Pleasant, South Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Comparison of Aspheric Toric & Non-toric Aphakic Intraocular Lenses

NCT01268540
View directory record Official record
Conditions
Aphakia, Cataract
Interventions
FY-60AD, NHT15, NHT30, & NHT53
Device
Lead sponsor
Hoya Surgical Optics, Inc.
Industry
Eligibility
50 Years and older
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
6
States / cities
Chino Hills, California • Santa Maria, California • Mt. Dora, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2015 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Clareon Vivity/Vivity Toric

NCT05852470
View directory record Official record
Conditions
Aphakia
Interventions
Clareon Vivity/Vivity Toric Extended Vision IOL, Clareon Monofocal/Clareon Toric IOL
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
7
States / cities
Torrance, California • Fort Collins, Colorado • Bloomfield Hills, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Clareon PanOptix Pro vs. Clareon PanOptix - Study A

NCT06400745
View directory record Official record
Conditions
Aphakia, Presbyopia
Interventions
CPO Pro IOL, CPO IOL, Cataract surgery
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
8
States / cities
Torrance, California • Bloomfield Hills, Michigan • Kansas City, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Jul 22, 2026, 10:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparative Study of the Optical Biometer for Measurements of the Eye

NCT01729962
View directory record Official record
Conditions
Normal Non-fluency, Cataract, Aphakic Eye, Eyes With Corneal Abnormality
Interventions
Not listed
Lead sponsor
Nidek Co. LTD.
Industry
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2013 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Infant Aphakia Treatment Study (IATS)

NCT00212134
View directory record Official record
Conditions
Congenital Cataract
Interventions
Contact lens correction of aphakia, Intraocular lens implantation
Device
Lead sponsor
Stanford University
Other
Eligibility
28 Days to 210 Days
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2020
U.S. locations
13
States / cities
Palo Alto, California • Miami, Florida • Atlanta, Georgia + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2024 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Study of a UV-Absorbing Acrylic Posterior Chamber Intraocular Lens

NCT00625313
View directory record Official record
Conditions
Aphakia
Interventions
HMY Model YA-60BB IOL
Device
Lead sponsor
Hoya Surgical Optics, Inc.
Industry
Eligibility
21 Years and older
Enrollment
617 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Chino Hills, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2015 · Synced Jul 22, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Clareon Toric vs Eyhance Toric

NCT05481125
View directory record Official record
Conditions
Cataract, Aphakia
Interventions
Clareon IOL, Clareon Toric IOL, Eyhance IOL, Eyhance Toric IOL, Phacoemulsification surgery
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
8
States / cities
Poughkeepsie, New York • Brecksville, Ohio • Mt. Pleasant, South Carolina + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 29, 2024 · Synced Jul 22, 2026, 10:45 AM EDT