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ClinicalTrials.gov public records Last synced Oct 17, 2026, 2:57 AM EDT

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Showing 1–24 of 227 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Aphasia Clear all
Completed Not applicable Interventional

Effects of Neuromodulation on Verbal Fluency in Post-stroke Aphasia

NCT02270866
View directory record Official record
Conditions
Post-stroke Aphasia
Interventions
TNM Device
Device
Lead sponsor
Scion NeuroStim
Industry
Eligibility
18 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Not applicable Interventional Results available

Brain Biomarkers of Response to Treatment for Apraxia of Speech

NCT02046941
View directory record Official record
Conditions
Aphasia, Stroke
Interventions
Speech Production Treatment
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
40 Years to 90 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Not applicable Interventional Results available

Improving Aphasia Using Electrical Brain Stimulation

NCT04963803
View directory record Official record
Conditions
Stroke, Aphasia
Interventions
Active transcranial direct current stimulation (tDCS), Sham transcranial direct current stimulation (tDCS), Language Specific Attention Treatment
Device · Behavioral
Lead sponsor
Syracuse University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jan 30, 2026 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Not applicable Interventional

tDCS and Aphasia Treatment

NCT01922245
View directory record Official record
Conditions
Aphasia
Interventions
Soterix 1x1 tDCS
Device
Lead sponsor
Hunter College of City University of New York
Other
Eligibility
18 Years to 100 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 14, 2020 · Synced Oct 17, 2026, 2:57 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

tACS to Enhance Language Abilities

NCT06092814
View directory record Official record
Conditions
Stroke, Aphasia, Acquired, Aphasia
Interventions
Active transcranial alternating current stimulation (tACS)
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Phase 1 Interventional

Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD

NCT01723553
View directory record Official record
Conditions
Atypical Alzheimers Disease, Logopenic Variant of Primary Progressive Aphasia (LPA), Posterior Cortical Atrophy (PCA)
Interventions
C-11 PiB
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 21, 2015 · Synced Oct 17, 2026, 2:57 AM EDT
Completed No phase listed Observational

Performance of AclarusDx™, a Blood-Based Transcriptomic Test for AD, in US Patients Newly Referred to a Memory Center

NCT01465360
View directory record Official record
Conditions
Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, Fronto-temporal Dementia, Primary Progressive Aphasia, Parkinson' Disease Dementia, Mixed Dementia
Interventions
Not listed
Lead sponsor
Exonhit
Industry
Eligibility
21 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
3
States / cities
Las Vegas, Nevada • Cleveland, Ohio • Lakewood, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 6, 2012 · Synced Oct 17, 2026, 2:57 AM EDT
Recruiting Not applicable Interventional

Aphasia Physical EXercise Study: Randomized Trial

NCT07281313
View directory record Official record
Conditions
Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia, Non-fluent, Aphasia Following Cerebral Infarction, Aphasia Following Nontraumatic Intracerebral Hemorrhage
Interventions
High-intensity physical exercise, Low-intensity physical exercise
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
4
States / cities
Berkeley, California • Hayward, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Not applicable Interventional Results available

Transcranial Direct Current Stimulation for Primary Progressive Aphasia

NCT02928848
View directory record Official record
Conditions
Primary Progressive Aphasia
Interventions
transcranial direct current stimulation
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
45 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2021 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Phase 2 Interventional Results available

Dextroamphetamine and tDCS to Improve the Fluency

NCT02514044
View directory record Official record
Conditions
Stroke
Interventions
Dexedrine, Active tDCS, Speech Therapy, Placebo, Sham tDCS
Drug · Device · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 3, 2018 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Not applicable Interventional

Impact of Neuromodulation on Language Impairments in Stroke Patients

NCT03699930
View directory record Official record
Conditions
Stroke, Aphasia
Interventions
tDCS, Speech and language therapy
Device · Behavioral
Lead sponsor
Casa Colina Hospital and Centers for Healthcare
Other
Eligibility
18 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Jul 7, 2023 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Not applicable Interventional

Effect of Participation in Virtual Exercise Sessions in Persons With Aphasia

NCT05455463
View directory record Official record
Conditions
Aphasia, Acquired
Interventions
Online aphasia-adapted physical activity class
Behavioral
Lead sponsor
California State University, East Bay
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Hayward, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Oct 17, 2026, 2:57 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Transcranial Direct Current Stimulation (tDCS) and Cognitive Processing

NCT01602263
View directory record Official record
Conditions
Aphasia, Autism, Schizophrenia
Interventions
Transcranial Direct Current Stimulation (tDCS)
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 79 Years
Enrollment
307 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Not applicable Interventional

Modeling Treated Recovery From Aphasia

NCT03416738
View directory record Official record
Conditions
Aphasia, Stroke, Stroke, Ischemic, Aphasia, Broca, Aphasia, Global, Aphasia, Mixed, Aphasia, Jargon, Aphasia, Expressive, Aphasia, Conduction, Aphasia, Fluent, Aphasia, Anomic
Interventions
Semantically focused treatment, Phonologically focused treatment
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
21 Years to 80 Years
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
2
States / cities
Charleston, South Carolina • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 28, 2022 · Synced Oct 17, 2026, 2:57 AM EDT
Recruiting Not applicable Interventional

Intervention for Communication Quality of Life in Primary Progressive Aphasia

NCT07219680
View directory record Official record
Conditions
Primary Progressive Aphasia(PPA), Semantic Dementia, Logopenic Progressive Aphasia (LPA), Nonfluent Aphasia, Progressive, Progressive Aphasia, Semantic Variant Primary Progressive Aphasia (svPPA), Semantic Aphasia, Logopenic Variant Primary Progressive Aphasia, Logopenic Variant of Primary Progressive Aphasia (LPA), Logopenic Progressive Aphasia, Nonfluent Variant Primary Progressive Aphasia (nfvPPA), Nonfluent Progressive Aphasia
Interventions
Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia
Behavioral
Lead sponsor
Maya Henry
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 17, 2026, 2:57 AM EDT
Active, not recruiting Not applicable Interventional

Treatment Outcomes With tDCS in Post-Stroke Aphasia

NCT03929432
View directory record Official record
Conditions
Aphasia
Interventions
Active Transcranial Direct Current Stimulation with SLT, Sham Transcranial Direct Current Stimulation with SLT
Device
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 17, 2026, 2:57 AM EDT
Completed No phase listed Observational

Florbetaben PET Imaging in PPA

NCT04720001
View directory record Official record
Conditions
Primary Progressive Aphasia, Alzheimer Disease
Interventions
Florbetaben F18, PET
Drug · Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 100 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Oct 17, 2026, 2:57 AM EDT
Not listed Early Phase 1 Interventional

Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia

NCT04816799
View directory record Official record
Conditions
Stroke, Aphasia, Apraxia of Speech
Interventions
Startle Adjuvant Rehabilitation Therapy (START)
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 100 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 22, 2022 · Synced Oct 17, 2026, 2:57 AM EDT
Terminated Not applicable Interventional Results available

Circuitry Assessment and Reinforcement Training Effects on Recovery

NCT04290988
View directory record Official record
Conditions
Aphasia, Primary Progressive Aphasia, Stroke
Interventions
EEG Neurofeedback, Sham Feedback
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Not applicable Interventional

Criterion-learning Based Naming Treatment in Aphasia

NCT06364709
View directory record Official record
Conditions
Aphasia
Interventions
Criterion-learning practice
Behavioral
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years to 89 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Elkins Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 17, 2026, 2:57 AM EDT
Not listed Phase 1 Interventional

Levetiracetam (Keppra) to Improve Chronic Aphasia in Post-stroke Patients.

NCT00227461
View directory record Official record
Conditions
Aphasia, Stroke
Interventions
Wait first, then levetiracetam, Levetiracetam first, then wait
Drug
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2021
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 17, 2021 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Not applicable Interventional Results available

Exercise as an Adjuvant to Aphasia Therapy

NCT01113879
View directory record Official record
Conditions
Aphasia
Interventions
Aerobic exercise, Stretching
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 95 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Gainesville, Florida • Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia

NCT01300624
View directory record Official record
Conditions
Aphasia
Interventions
Verb Network Strengthening Treatment
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 89 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Oct 17, 2026, 2:57 AM EDT
Completed Not applicable Interventional Results available

Adapting Acceptance and Commitment Therapy for Stroke Survivors With Aphasia

NCT04984239
View directory record Official record
Conditions
Stroke, Aphasia
Interventions
Acceptance and Commitment Therapy for aphasia
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 25, 2025 · Synced Oct 17, 2026, 2:57 AM EDT