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Showing 1–24 of 78 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Appendicitis Clear all
Completed No phase listed Observational Accepts healthy volunteers

Point of Care 3D Ultrasound for Various Applications: A Pilot Study

NCT02831556
View directory record Official record
Conditions
Appendicitis, Evidence of Cholecystectomy, Gallstones, Pregnancy, Ectopic, Aortic Aneurysm, Kidney Stones, Intrauterine Pregnancy, Diverticulitis, Abdominal Injuries, Tumors, Pancreatitis, Digestive System Diseases, Gastrointestinal Diseases, Intraabdominal Infections, Intestinal Diseases, Pregnancy, Vascular Disease, Uterine Fibroids, Ovarian Cysts, Uterine Abnominalies, Bladder Abnominalies, Testicular Abnominalies, Polyps
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 20, 2024 · Synced Jul 25, 2026, 11:51 AM EDT
Completed Phase 2 Interventional Results available

Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis

NCT02664220
View directory record Official record
Conditions
Acute, Perforated Appendicitis
Interventions
Povidone-iodine irrigation, No irrigation
Drug · Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
2 Years to 17 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Jul 25, 2026, 11:51 AM EDT
Completed Not applicable Interventional

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) - Atrium Health

NCT05746520
View directory record Official record
Conditions
Appendicitis Surgery
Interventions
Antibiotic
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
268 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Jul 25, 2026, 11:51 AM EDT
Withdrawn Not applicable Interventional

The Effect of Gum Chewing on Postoperative Ileus

NCT00879294
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
Motion sickness wristband, Chewing Gum
Device · Dietary Supplement
Lead sponsor
Wake Forest University
Other
Eligibility
6 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Jul 25, 2026, 11:51 AM EDT
Not listed No phase listed Observational

Multi-institutional Trial of Non-operative Management of Appendicitis

NCT02271932
View directory record Official record
Conditions
Appendicitis
Interventions
Non-operative
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
8 Years to 17 Years · Male only
Enrollment
1,076 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Jul 25, 2026, 11:51 AM EDT
Terminated Phase 2 Interventional Results available

Transversus Abdominis Plane (TAP) Versus Local Anesthetic for Lap Appendectomies

NCT01575028
View directory record Official record
Conditions
Appendicitis
Interventions
Ropivacaine, Bupivacaine
Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 23, 2015 · Synced Jul 25, 2026, 11:51 AM EDT
Active, not recruiting Phase 2 Interventional

Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis

NCT04039750
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
antibiotic rinse with suction, suction only
Drug · Procedure
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
0 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jul 25, 2026, 11:51 AM EDT
Completed No phase listed Observational

Point of Care 3D Ultrasound for Pediatric Appendicitis: a Pilot Study

NCT02507674
View directory record Official record
Conditions
Appendicitis
Interventions
ultrasound
Device
Lead sponsor
Duke University
Other
Eligibility
Up to 18 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 29, 2020 · Synced Jul 25, 2026, 11:51 AM EDT
Completed Not applicable Interventional

Single Incision Laparoscopy

NCT00616616
View directory record Official record
Conditions
Appendicitis, Cholelithiasis, Malignant Hypertension
Interventions
single incision laparoscopic surgery
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Jul 25, 2026, 11:51 AM EDT
Completed Not applicable Interventional

Comparative Study of Laparoscopic Versus Open Appendectomy in Children

NCT00554008
View directory record Official record
Conditions
Appendicitis
Interventions
laparoscopic appendectomy, open appendectomy
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
Up to 18 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
3
States / cities
Los Angeles, California • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 29, 2012 · Synced Jul 25, 2026, 11:51 AM EDT
Completed No phase listed Observational

Pediatric Appendicitis Pathway Study

NCT01192620
View directory record Official record
Conditions
Appendicitis
Interventions
Not listed
Lead sponsor
Oregon Health and Science University
Other
Eligibility
3 Years to 18 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Jul 25, 2026, 11:51 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children

NCT02991937
View directory record Official record
Conditions
Appendicitis
Interventions
Piperacillin/Tazobactam, Surgical Treatment
Drug · Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
6 Years to 17 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 20, 2022 · Synced Jul 25, 2026, 11:51 AM EDT
Completed No phase listed Observational

Minimally Invasive Surgery: Using Natural Orfices

NCT00530998
View directory record Official record
Conditions
Appendicitis, Cholelithiasis, Gallstones
Interventions
Transvaginal Appendectomy, Transvaginal Cholecystectomy
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Jul 25, 2026, 11:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Appendicitis Choice of Treatment Study

NCT04968782
View directory record Official record
Conditions
Acute Appendicitis
Interventions
Patients with acute appendicitis
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 22, 2022 · Synced Jul 25, 2026, 11:51 AM EDT
Completed Not applicable Interventional Results available

The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis

NCT02881996
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
IV tylenol, No IV tylenol, Ketorolac
Drug
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
2 Years to 17 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Jul 25, 2026, 11:51 AM EDT
Terminated Phase 3 Interventional Results available

A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections

NCT01110382
View directory record Official record
Conditions
Abscess, Intra-Abdominal, Abdominal Abscess, Abdomen, Acute, Abdominal Pain, Appendicitis, Rupture, Infection, Intestinal Perforation, Peritonitis, Ileus
Interventions
Doripenem, Meropenem placebo, Meropenem, Doripenem placebo, Amoxicillin/clavulanate potassium
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
3 Months to 18 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
4
States / cities
San Diego, California • Washington D.C., District of Columbia • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2014 · Synced Jul 25, 2026, 11:51 AM EDT
Recruiting Not applicable Interventional

Early Detection of Infection Using the Fitbit in Pediatric Surgical Patients

NCT06395636
View directory record Official record
Conditions
Appendectomy, Appendicitis, Appendicitis Acute
Interventions
Infection-Prediction Algorithm
Device
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
3 Years to 18 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
Chicago, Illinois • Maywood, Illinois • Winfield, Illinois
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 25, 2026, 11:51 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Local Anesthetic at Incision Site

NCT02483689
View directory record Official record
Conditions
Post Operative Pain, Appendicitis
Interventions
Pre Incisional Local Anesthetic, Pre-Incisional Saline, Post-Closure Local Anesthetic, Post-Closure Saline
Drug · Other
Lead sponsor
Valley Anesthesiology Consultants
Other
Eligibility
9 Years to 17 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Jul 25, 2026, 11:51 AM EDT
Terminated Not applicable Interventional Results available

Non-operative Management of Pediatric Appendicitis With an Appendicoltih

NCT02189668
View directory record Official record
Conditions
Appendicitis
Interventions
Antibiotics only (Zosyn then Augmentin)
Drug
Lead sponsor
Peter Minneci
Other
Eligibility
7 Years to 17 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 26, 2018 · Synced Jul 25, 2026, 11:51 AM EDT
Completed Not applicable Interventional

Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Appendectomy

NCT00981136
View directory record Official record
Conditions
Appendicitis
Interventions
Single Incision Laparoscopic Appendectomy, 3 port laparoscopic appendectomy
Procedure
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
1 Month to 18 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 14, 2013 · Synced Jul 25, 2026, 11:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Online Field Test of an Appendicitis Decision Support Tool

NCT05219786
View directory record Official record
Conditions
Appendicitis Acute
Interventions
Appendicitis Decision Support Tool, Control Infographic
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 1, 2022 · Synced Jul 25, 2026, 11:51 AM EDT
Recruiting Phase 1 Interventional

Precision Antibiotic Dosing for Appendectomy

NCT06860802
View directory record Official record
Conditions
Appendicitis (Diagnosis)
Interventions
Cefoxitin
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jul 25, 2026, 11:51 AM EDT
Completed No phase listed Observational

TRIAD Appendicitis Decision-making Surveys

NCT05887414
View directory record Official record
Conditions
Appendicitis
Interventions
Baseline, 30 Day Follow Up
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
2,542 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
17
States / cities
Baldwin Park, California • Los Angeles, California • Riverside, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Jul 25, 2026, 11:51 AM EDT
Completed Not applicable Interventional Results available

Wound Infection Alexis Wound Retractor

NCT00323453
View directory record Official record
Conditions
Appendicitis
Interventions
Open appendectomy using Alexis Wound Retractor followed by standardized wound closure, Open appendectomy with standardized wound closure
Device · Procedure
Lead sponsor
Santa Barbara Cottage Hospital
Other
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Nov 22, 2018 · Synced Jul 25, 2026, 11:51 AM EDT