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ClinicalTrials.gov public records Last synced Sep 18, 2026, 1:58 PM EDT

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Showing 1–24 of 1,570 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Arrhythmias Cardiac Clear all
Completed Phase 4 Interventional Results available

Use of Protamine for Heparin Reversal After Catheter Ablation of Atrial Fibrillation

NCT03140631
View directory record Official record
Conditions
Atrial Fibrillation, Catheter Ablation
Interventions
Protamine Sulfate
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 22, 2018 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Not applicable Interventional Results available

Aveir DR i2i Study

NCT05252702
View directory record Official record
Conditions
Cardiac Pacemaker, Artificial, Cardiac Rhythm Disorder, Bradycardia
Interventions
Aveir DR Leadless Pacemaker System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
464 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
54
States / cities
Scottsdale, Arizona • Jonesboro, Arkansas • Little Rock, Arkansas + 44 more
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Phase 4 Interventional

Assessment of Cardioversion Using Transesophageal Echocardiography II (ACUTE II)

NCT00289042
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Enoxaparin
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 30, 2007 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Influence of Progesterone Administration on Drug-Induced QT Interval Lengthening

NCT01929083
View directory record Official record
Conditions
Prolonged QT Interval in EKG and Sudden Death
Interventions
Progesterone, Placebo, Ibutilide
Drug
Lead sponsor
Indiana University
Other
Eligibility
21 Years to 40 Years · Female only
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 29, 2015 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Not applicable Interventional

Comparing Pulmonary Vein Isolation to Pulmonary Vein Isolation + OPTIMA Ablation in Patients Undergoing Ablation for Atrial Fibrillation

NCT04101539
View directory record Official record
Conditions
Atrial Fibrillation Chronic
Interventions
OPTIMA-guided catheter ablation, Standard PVI
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of GAP-134 Administered Intravenously

NCT00510029
View directory record Official record
Conditions
Arrhythmia
Interventions
GAP-134
Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
18 Years to 50 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 12, 2008 · Synced Sep 18, 2026, 1:58 PM EDT
Terminated Phase 1 Interventional

Study of the Effects of BMS-919373 on the Electrical Activity of the Heart Using Pacemakers

NCT02153437
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
BMS-919373, Sotalol, Placebo for BMS-919373
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years to 85 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Not applicable Interventional Results available

Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation

NCT02548754
View directory record Official record
Conditions
Atrial Fibrillation, Inflammation
Interventions
Parasym device
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years to 90 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Sep 18, 2026, 1:58 PM EDT
Completed No phase listed Observational Results available

BlueSync Field Evaluation

NCT03518658
View directory record Official record
Conditions
Bradycardia
Interventions
Evaluation Group, Control Group (Historical)
Other
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
11
States / cities
Palo Alto, California • Hartford, Connecticut • Daytona Beach, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated May 5, 2021 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Phase 4 Interventional

Resync-AF (Rate vs Rhythm Control in AF Patients With CRT-D)

NCT01233648
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
rate control via CRT-D and AVN ablation, rhythm control via pharmacologic, electrical or ablative therapies
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Influence of Sleep Apnea on Risk of Atrial Fibrillation

NCT02576587
View directory record Official record
Conditions
Sleep Apnea, Atrial Fibrillation
Interventions
Continuous Positive Airway Pressure
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
317 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 18, 2026, 1:58 PM EDT
Suspended Not applicable Interventional

Half-normal Saline in Idiopathic Left Ventricular Outflow Tract Arrhythmias Ablation

NCT03502499
View directory record Official record
Conditions
Ventricular Arrythmia
Interventions
Half-normal saline, Normal saline
Drug
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
2
States / cities
Aurora, Colorado • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 10, 2022 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Phase 1Phase 2 Interventional

IC14 (Atibuclimab) in Arrhythmogenic Cardiomyopathy

NCT06275893
View directory record Official record
Conditions
Arrhythmogenic Right Ventricular Dysplasia, Arrhythmogenic Left Ventricular Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy 1, Arrhythmogenic Cardiomyopathy, ACM, ARVC, PKP2
Interventions
IC14
Biological
Lead sponsor
Implicit Bioscience
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
St Louis, Missouri • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Not applicable Interventional Results available

ArcticLine Feasibility Study

NCT03604263
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Flutter
Interventions
ArcticLine Cardiac Cryoablation Catheter
Device
Lead sponsor
Medtronic Cardiac Ablation Solutions
Industry
Eligibility
18 Years to 80 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Tampa, Florida • Ann Arbor, Michigan • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Sep 18, 2026, 1:58 PM EDT
Terminated No phase listed Observational

Peripheral Venous Analysis (PIVA) for Predicting Volume Responsiveness and Fluid Status

NCT03407287
View directory record Official record
Conditions
Systemic Inflammatory Response Syndrome, Distributive Shock, Hypotension and Shock, Decompensated Congestive Heart Failure, Atrial Fibrillation, High Risk Non-cardiac Surgery
Interventions
Peripheral Intravenous Analysis (PIVA), Standard of care invasive vascular monitoring, Standard noninvasive vascular monitoring
Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 11, 2021 · Synced Sep 18, 2026, 1:58 PM EDT
Active, not recruiting No phase listed Observational

Micra Transcatheter Pacing System Post-Approval Registry

NCT02536118
View directory record Official record
Conditions
Bradycardia
Interventions
Micra Transcatheter Pacing System
Device
Lead sponsor
Medtronic
Industry
Eligibility
Not listed
Enrollment
3,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
52
States / cities
Birmingham, Alabama • Los Angeles, California • Redwood City, California + 49 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 18, 2026, 1:58 PM EDT
Terminated Not applicable Interventional Results available

Prediction and Maintenance of Sinus Rhythm Among Atrial Fibrillation Patients

NCT04313296
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Unique measurement (AutoSTRAIN) by a commercial software program (TOMTEC-ARENA)
Device
Lead sponsor
Crystal Blake-Parlin
Other
Eligibility
Not listed
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Rockport, Maine
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 18, 2026, 1:58 PM EDT
Completed No phase listed Observational

Ischemia Care Biomarkers of Acute Stroke Etiology (BASE)

NCT02014896
View directory record Official record
Conditions
Ischemic Stroke, Atrial Fibrillation, Transient Ischemic Attacks, Transient Cerebrovascular Events, Thrombotic Stroke, Stroke of Basilar Artery, Cardioembolic Stroke
Interventions
Biomarker blood draw
Other
Lead sponsor
Ischemia Care LLC
Industry
Eligibility
18 Years and older
Enrollment
1,750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
22
States / cities
Sacramento, California • San Francisco, California • Detroit, Michigan + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Sep 18, 2026, 1:58 PM EDT
Terminated Not applicable Interventional

Renal Denervation Therapy in Hypertensive Patients Undergoing A-Fib Ablation

NCT01952743
View directory record Official record
Conditions
Atrial Fibrillation, Hypertension
Interventions
AF ablation with Renal Denervation, AF ablation alone
Procedure
Lead sponsor
Siva Mulpuru
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Sep 18, 2026, 1:58 PM EDT
Recruiting Not applicable Interventional

Prospective Remapping With Concomitant Left Atrial Appendage Occlusion to Ensure Durable Electroporation Study

NCT07620262
View directory record Official record
Conditions
Atrial Fibrillation (AF)
Interventions
Remapping Procedure
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Bay Shore, New York
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 18, 2026, 1:58 PM EDT
Not yet recruiting Not applicable Interventional

Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction

NCT05464940
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Intravenous caffeine, Masked Placebo
Other
Lead sponsor
Kansas City Heart Rhythm Research Foundation
Other
Eligibility
21 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
9
States / cities
Loma Linda, California • Overland Park, Kansas • Independence, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Sep 18, 2026, 1:58 PM EDT
Completed No phase listed Observational

Arrhythmias in Hemorrhagic Myocardial Infarction During the Acute Post-PCI Phase

NCT06611384
View directory record Official record
Conditions
Acute Myocardial Infarction
Interventions
Not listed
Lead sponsor
Rohan Dharmakumar
Other
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Timeline
2022 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 18, 2026, 1:58 PM EDT
Active, not recruiting No phase listed Observational

Real-world Safety and Effectiveness Registry of Catheter Ablation of Paroxysmal Atrial Fibrillation as Initial Control Therapy With the Thermocool SmartTouch SF Catheter (A Sub-study of REAL AF Registry)

NCT07092774
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation (PAF)
Interventions
Ablation
Device
Lead sponsor
Heart Rhythm Clinical and Research Solutions, LLC
Other
Eligibility
18 Years and older
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
12
States / cities
Birmingham, Alabama • Ventura, California • Jacksonville, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 18, 2026, 1:58 PM EDT
Completed Phase 2 Interventional Results available

Colchicine and CRP in Atrial Fibrillation and AF Ablation

NCT01755949
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Colchicine, 0.6 mg PO BID, Matching placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
21 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 8, 2019 · Synced Sep 18, 2026, 1:58 PM EDT