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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:16 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 145–168 of 1,804 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Arthritis, Degenerative Clear all

Conditions: Knee Osteoarthritis
Interventions: Active Moticon OpenGO insole, Passive shoe insole; Device
Lead sponsor: Rush University Medical Center; Other
Eligibility: 40 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Osteoarthritis
Interventions: Cementless Total Knee Arthroplasty; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 540 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2027
U.S. locations: 10
States / cities: Denver, Colorado • DeLand, Florida • Lebanon, New Hampshire + 7 more

Conditions: Chronic Pain
Interventions: Tramadol HCl ER; Drug
Lead sponsor: Bausch Health Americas, Inc.; Industry
Eligibility: 18 Years to 74 Years
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2003
U.S. locations: 1
States / cities: Duncansville, Pennsylvania

Conditions: Chronic Knee Pain, Osteoarthritis, Knee
Interventions: Nerve Block with Radiofrequency Ablation, Nerve Block with Sham Radiofrequency Ablation; Procedure
Lead sponsor: Randall Brewer, MD, CPI; Other
Eligibility: 50 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Shreveport, Louisiana

Conditions: Teach-Back Communication, Arthritis, Knee Osteoarthritis, Knee Arthropathy
Interventions: Teach-Back Lesson; Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Knee Osteoarthritis, Central Pain Syndrome
Interventions: Transcutaneous vagus nerve stimulation; Device
Lead sponsor: University of Texas, El Paso; Other
Eligibility: 45 Years to 90 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: El Paso, Texas

Conditions: Osteoarthritis
Interventions: Not listed
Lead sponsor: StemGenex; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: San Diego, California

Conditions: Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
Interventions: TTAX03, Saline; Biological
Lead sponsor: BioTissue Holdings, Inc; Industry
Eligibility: 35 Years to 85 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 10
States / cities: Birmingham, Alabama • Tucson, Arizona • La Mesa, California + 6 more

Conditions: Osteoarthritis of the Knee
Interventions: Hydroxychloroquine/Atorvastatin; Drug
Lead sponsor: Stanford University; Other
Eligibility: 40 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Stanford, California

Conditions: Knee Osteoarthritis
Interventions: Virtual Reality; Device
Lead sponsor: Tufts University; Other
Eligibility: 60 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Chestnut Hill, Massachusetts

Conditions: Osteoarthritis
Interventions: Coping skills training (CST) for chronic pain, Usual care; Behavioral · Other
Lead sponsor: Stony Brook University; Other
Eligibility: 21 Years and older
Enrollment: 257 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 3
States / cities: Setauket, New York • Smithtown and Port Jefferson, New York • Danville, Virginia

Conditions: Autoimmune Diseases, Systemic Inflammatory Process, Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis
Interventions: Fish Oil, Vitamin D, placebo pill; Drug · Dietary Supplement · Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 50 Years and older
Enrollment: 25,871 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Osteoarthritis
Interventions: Physical Therapy, Standing; Other
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 394 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Osteoarthritis, Insomnia
Interventions: Placebo, Eszopiclone; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Osteoarthritis
Interventions: Bupivacaine, Morphine, Methylprednisolone, Cefazolin, Normal saline, Midazolam, Propofol, Dexamethasone, 8 MHz. Chiba needle, 22 G / 4 inches; Drug · Device
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 80 Years
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Osteoarthritis
Interventions: Customized patient instruments, Traditional Metal Instruments; Device
Lead sponsor: Medacta USA; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 5
States / cities: Marrero, Louisiana • Billings, Montana • Meadville, Pennsylvania + 2 more

Conditions: Arthroplasty, Replacement, Knee
Interventions: Triathlon PKR; Device
Lead sponsor: Stryker Orthopaedics; Industry
Eligibility: 21 Years to 75 Years
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2023
U.S. locations: 6
States / cities: Jacksonville, Florida • Egg Harbor, New Jersey • Buffalo, New York + 3 more

Conditions: Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Knee Injuries, Cartilage, Articular, Gait
Interventions: Real-time gait biofeedback, Sham real-time gait biofeedback; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 35 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Osteoarthritis, Knee
Interventions: Collection of specimens prior to and during surgery; Other
Lead sponsor: The Stone Research Foundation for Sports Medicine and Arthritis; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Osteoarthritis, Knee
Interventions: Hylastan; Device
Lead sponsor: Genzyme, a Sanofi Company; Industry
Eligibility: 40 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 15
States / cities: Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 11 more

Conditions: Knee Osteoarthristis
Interventions: Dephy Exoboot; Device
Lead sponsor: Massachusetts Institute of Technology; Other
Eligibility: 21 Years to 100 Years
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Knee Osteoarthritis
Interventions: Tai Chi versus Attention Control; Behavioral
Lead sponsor: Tufts Medical Center; Other
Eligibility: 55 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Osteoarthritis Thumb, Thumb Carpometacarpal Joint Osteoarthritis
Interventions: TOUCH® CMC 1 Prosthesis; Device
Lead sponsor: Keri Medical SA; Industry
Eligibility: 22 Years and older
Enrollment: 163 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 4
States / cities: Aurora, Colorado • Indianapolis, Indiana • Morrisville, North Carolina + 1 more

Conditions: Osteoarthritis
Interventions: TSA with tenotomy technique, TSA with lesser tuberosity osteotomy technique, Shoulder prosthesis; Procedure · Device
Lead sponsor: Columbia University; Other
Eligibility: Not listed
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Using Pressure Detecting Insoles to Reduce Knee Loading

14022 ATTUNE Cementless RP Clinical Performance Evaluation

A Study Comparing the Effectiveness and Safety of Varying Dose Strengths (100, 200, 300 and 400 mg) of Extended-release Tramadol HCl With Placebo for the Treatment of Osteoarthritis(OA) of the Knee and/or Hip

Radiofrequency For Chronic Knee Pain Post-Arthroplasty

Analyzing Challenging Clinical Discussions in Orthopaedics

Effects of Vagus Nerve Stimulation on Central Pain Sensitivity & Parasympathetic Function in Knee Osteoarthritis

Outcomes Data of Adipose Stem Cells to Treat Osteoarthritis

Lyophilized and Micronized Particulate Human Amniotic and Umbilical Cord (TTAX03) for KL Grade 3-4 Knee OA

Hydroxychloroquine/Atorvastatin in the Treatment of Osteoarthritis (OA) of the Knee

Virtual Reality and Older Adult Knee OA

Effectiveness of a Training Program in Improving Coping Skills in People With Arthritis Pain

Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain

Ambulation Versus Standing on Postoperative Day 0

Insomnia and Osteoarthritis Study

The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)

Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique

Triathlon® Partial Knee Replacement (PKR) Outcomes Study

Optimizing Gait Biomechanics for Posttraumatic Osteoarthritis Prevention

Pathogen Screening in OA Orthopaedic Surgical Patients

Comparison of Hylastan to Methylprednisolone Acetate in Patients With Symptomatic Osteoarthritis of the Knee

Study of Wearable Interventions for Improving Mobility of Individuals With Knee Osteoarthritis

Tai Chi Mind-Body Therapy for Knee Osteoarthritis

TOUCH® CMC 1 New Enrollment US Study

Lesser Tuberosity Osteotomy for Subscapularis Repair