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Showing 25–42 of 18 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Arthritis of Ankle Clear all
Active, not recruiting Not applicable Interventional

Post Approval Study2: Hintermann Series H3 Total Ankle Replacement System

NCT04770870
View directory record Official record
Conditions
Osteoarthritis Ankle, Post-Traumatic Osteoarthritis of Ankle, Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)
Interventions
Hintermann Series H3 Total Ankle Replacement System
Device
Lead sponsor
DT MedTech, LLC
Industry
Eligibility
21 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
11
States / cities
Little Rock, Arkansas • Mission Hills, California • Sarasota, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jul 23, 2026, 5:20 AM EDT
Not listed No phase listed Observational

The Use of a Dynamic Sustained Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis

NCT04831645
View directory record Official record
Conditions
Ankle Arthritis, Arthritis Foot
Interventions
DynaNail, Tibiotalocalcaneal Arthrodesis
Device · Procedure
Lead sponsor
MedShape, Inc
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Worthington, Ohio
Source: ClinicalTrials.gov public record
Updated May 24, 2021 · Synced Jul 23, 2026, 5:20 AM EDT
Completed No phase listed Observational Results available

Compression Nail for Tibiocalcaneal Arthrodesis

NCT03780452
View directory record Official record
Conditions
Subtalar Arthritis, Ankle Arthritis
Interventions
novel dynamic compression intramedullary nail
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 110 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Jul 23, 2026, 5:20 AM EDT
Completed Not applicable Interventional

2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use

NCT01284283
View directory record Official record
Conditions
Primary Arthrosis, Post Traumatic Arthritis, Rheumatoid Arthritis, Osteoarthritis
Interventions
Scandinavian Total Ankle Replacement System (STAR Ankle)
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
Not listed
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2021
U.S. locations
9
States / cities
Phoenix, Arizona • Los Angeles, California • Palo Alto, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Jul 23, 2026, 5:20 AM EDT
Completed Phase 2 Interventional Results available

OHI--Randomized Control Trial to Evaluate Efficacy, Acceptability, and Perception of Benefit of an Innovative Custom AFO

NCT02819011
View directory record Official record
Conditions
Accidental Falls, Fall Due to Loss of Equilibrium, High Risk of Falls Due to Mobility Limitation, Diabetes, Arthritis, Cancer, Peripheral Arterial Disease, Parkinson's Disease, End Stage Renal Failure on Dialysis
Interventions
MBB AFO, Control
Device · Other
Lead sponsor
Bijan Najafi, PhD
Other
Eligibility
65 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 26, 2020 · Synced Jul 23, 2026, 5:20 AM EDT
Completed No phase listed Observational Results available

ViviGen Cellular Bone Matrix for Hindfoot or Ankle Arthrodesis

NCT04138017
View directory record Official record
Conditions
Ankle Deformity, Ankle Arthritis
Interventions
ViviGen
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Jul 23, 2026, 5:20 AM EDT
Not listed Not applicable Interventional

Use of Autologous Adipose-Derived Stromal Vascular Fraction To Treat Osteoarthritis of Hip, Knee, Ankle, and Thumb Joints

NCT03166410
View directory record Official record
Conditions
Osteoarthritis
Interventions
Cell injection
Procedure
Lead sponsor
Texas Plastic Surgery
Industry
Eligibility
25 Years to 85 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Jul 23, 2026, 5:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress

NCT04562896
View directory record Official record
Conditions
Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
Interventions
Custom Carbon Fiber Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jul 23, 2026, 5:20 AM EDT
Completed No phase listed Observational

The Use of a Dynamic Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis

NCT02324907
View directory record Official record
Conditions
Ankle Arthritis
Interventions
Procedure/Surgery
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 95 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 10, 2023 · Synced Jul 23, 2026, 5:20 AM EDT
Not listed No phase listed Observational

Long-term Safety and Effectiveness of AUGMENT® Bone Graft Compared to Autologous Bone Graft

NCT02879149
View directory record Official record
Conditions
Ankle and Hindfoot Arthrodesis
Interventions
AUGMENT® Bone Graft, Standard of Care
Device · Procedure
Lead sponsor
BioMimetic Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
21
States / cities
Tucson, Arizona • Capitola, California • San Francisco, California + 18 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2018 · Synced Jul 23, 2026, 5:20 AM EDT
Recruiting No phase listed Observational

Exactech Vantage Total Ankle System Post Market Clinical Follow-Up - US Only

NCT05619588
View directory record Official record
Conditions
Ankle Rheumatoid Arthritis, Arthritis of Ankle, Failure, Prosthesis
Interventions
Not listed
Lead sponsor
Exactech
Industry
Eligibility
21 Years and older
Enrollment
370 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2031
U.S. locations
2
States / cities
Jacksonville, Florida • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Jul 23, 2026, 5:20 AM EDT
Completed No phase listed Observational

Artoss Foot and Ankle Surgery Registry

NCT04503759
View directory record Official record
Conditions
Arthritis Foot, Trauma Injury, Deformity; Bone
Interventions
NanoBone Bone Graft Substitute
Other
Lead sponsor
Artoss Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
8
States / cities
Scottsdale, Arizona • Sarasota, Florida • Joliet, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated May 12, 2024 · Synced Jul 23, 2026, 5:20 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?

NCT05652881
View directory record Official record
Conditions
Post-traumatic; Arthrosis, Tibial Fractures, Post-Traumatic Osteoarthritis of Ankle
Interventions
Joint Lavage
Procedure
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 5, 2024 · Synced Jul 23, 2026, 5:20 AM EDT
Completed Not applicable Interventional

Prevention of Post-Traumatic Osteoarthritis (OA)

NCT00054821
View directory record Official record
Conditions
Osteoarthritis
Interventions
Ankle distraction permitting motion, Ankle distraction without motion
Procedure
Lead sponsor
Ned Amendola
Other
Eligibility
Up to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2009
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 16, 2017 · Synced Jul 23, 2026, 5:20 AM EDT
Suspended No phase listed Observational

Clinical Evaluation of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement (CADENCE)

NCT03142958
View directory record Official record
Conditions
Rheumatoid Arthritis, Degenerative Arthritis, Post Traumatic Arthritis
Interventions
Integra Cadence Total Ankle System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
9
States / cities
San Francisco, California • Sarasota, Florida • Buffalo, New York + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced Jul 23, 2026, 5:20 AM EDT
Active, not recruiting No phase listed Observational

Comparing Ankle Fusion to Ankle Replacement

NCT01620541
View directory record Official record
Conditions
End-stage Ankle Arthritis (ESAA), Osteoarthritis (OA)
Interventions
Ankle Arthrodesis, Ankle Arthroplasty
Procedure
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
21 Years to 89 Years
Enrollment
516 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2027
U.S. locations
6
States / cities
Fort Collins, Colorado • Grand Rapids, Michigan • Edina, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced Jul 23, 2026, 5:20 AM EDT
Terminated Not applicable Interventional Results available

ACP for Local Application in Ankle Arthrodesis

NCT01131455
View directory record Official record
Conditions
Ankle Arthritis
Interventions
Autologous Concentrated Plasma
Biological
Lead sponsor
Columbia Orthopaedic Group, LLP
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 12, 2014 · Synced Jul 23, 2026, 5:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics

NCT05456295
View directory record Official record
Conditions
Healthy, Lower Limb Injury, Post-Traumatic Osteoarthritis
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 23, 2026, 5:20 AM EDT