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ClinicalTrials.gov public records Last synced Oct 14, 2026, 3:49 PM EDT

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Showing 265–288 of 843 matching trials from the live ClinicalTrials.gov search.
Conditions
Wound Healing, Scarring
Interventions
Topical calcium glycerophosphate lotion
Other
Lead sponsor
AkPharma Inc.
Industry
Eligibility
45 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Egg Harbor, New Jersey
Active, not recruiting Not applicable Interventional Results available

Triathlon Tritanium Cone Augments Outcomes Study

NCT02521103
Conditions
Arthroplasty, Replacement, Knee
Interventions
Triathlon Tritanium Cone Augments
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2028
U.S. locations
9
States / cities
Zephyrhills, Florida • Chicago, Illinois • Lexington, Kentucky + 6 more
Completed Not applicable Interventional Accepts healthy volunteers Results available

Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery

NCT02638623
Conditions
Osteoarthritis
Interventions
Lactated Ringer, Placebo
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Morgantown, West Virginia
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Hypnosis Therapy on Outcomes in Total Knee Replacement

NCT05818969
Conditions
Anxiety, Opioid Use
Interventions
Hypnosis Therapy
Behavioral
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Tampa, Florida
Conditions
Arthroplasty, Replacement, Knee
Interventions
knee arthroplasty, standard polyethylene, knee arthroplasty, XLP polyethylene
Device
Lead sponsor
Chapel Hill Orthopedics Surgery & Sports Medicine
Other
Eligibility
Not listed
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Conditions
Anesthesia, Local, Pain, Postoperative
Interventions
Short-term ON-Q, Short-term ON-Q, Long-term ON-Q, Long-term ON-Q
Device · Drug
Lead sponsor
AdventHealth
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Orlando, Florida
Completed Not applicable Interventional Accepts healthy volunteers Results available

Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation

NCT00760383
Conditions
Osteoarthritis
Interventions
Essential amino acids, Alanine
Dietary Supplement
Lead sponsor
University of Oregon
Other
Eligibility
60 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
2
States / cities
Eugene, Oregon
Terminated Not applicable Interventional

Health Partner Evaluation at Princeton

NCT03386786
Conditions
Total Knee Arthroplasty; Total Hip Arthroplasty
Interventions
Health Partner, Standard Care
Behavioral
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Plainsboro, New Jersey
Conditions
Knee Arthropathy, Hip Injuries
Interventions
Virtual reality
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Jackson, Florida
Recruiting No phase listed Observational

Periprosthetic Fracture Registry (PPFx)

NCT03378557
Conditions
Periprosthetic Fractures, Periprosthetic Fracture Around Prosthetic Joint Implant
Interventions
Not listed
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
4
States / cities
Columbia, Missouri • Jersey City, New Jersey • Livingston, New Jersey + 1 more
Conditions
Knee Prosthesis, Knee Arthroplasty
Interventions
DePuy fixed-bearing Total Condylar III (TC3) TKA, DePuy PFC Rotating Platform TC3 TKA
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
40 Years to 85 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
3
States / cities
Denver, Colorado • Knoxville, Tennessee
Conditions
Osteoarthritis, Knee, Knee Replacement
Interventions
Mindfulness-based Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
45 Years to 100 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Avascular Necrosis, Rheumatoid Arthritis
Interventions
POPOP (preoperative patient optimization program), SOC (standard of care)
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Little Rock, Arkansas
Conditions
Arthroplasty, Replacement, Knee
Interventions
Radiofrequency Ablation (RFA), Simulated Radiofrequency Ablation (RFA)
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
30 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Distal Femur Fracture
Interventions
Timed Up and Go Test on subjects with ORIF of distal femur fractures, Koos Jr assesment on subjects with ORIF of distal femur fractures, Timed Up and Go Test on subjects with DFR of distal femur fracture, Koos Jr assesment on subjects with DFR of distal femur fracture
Other
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Total Knee Replacement, Arthroplasty, Patella
Interventions
Primary Total Knee Replacement Surgery
Procedure
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
New York, New York
Conditions
Total Knee Arthroplasty
Interventions
Legion™ CR Oxinium and CoCr Femoral Implants combined with Legion™/Genesis™ II XLPE High Flex Tibial Inserts
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
4
States / cities
Edina, Minnesota • Reno, Nevada • Greenville, South Carolina + 1 more
Conditions
Osteoarthritis
Interventions
Bupivacaine
Drug
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Completed Phase 4 Interventional Results available

Abaloparatide Before Total Knee Arthroplasty

NCT04167163
Conditions
Osteoporosis, Arthroplasties, Knee Replacement
Interventions
Abaloparatide
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
55 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Conditions
Total Knee Arthroplasty, Osteoarthritis, Post Operative Pain Control
Interventions
20ml bolus of 0.5% ropivicaine, 0.2% Ropivicaine at 8 milliliter/hour, 5ml bolus of 0.5% ropivicaine
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Terminated Phase 4 Interventional Results available

US Guided GNB vs Saline Injection for TKA

NCT03316118
Conditions
Postoperative Pain, Total Knee Arthroplasty, Nerve Block
Interventions
bupivacaine, saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
40 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Obstructive Sleep Apnea, Total Knee Arthroplasty
Interventions
Not listed
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 90 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Diego, California
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Use of a Novel Fibrin Sealant in Total Knee Arthroplasty

NCT01656759
Conditions
Osteoarthritis, Intraoperative Bleeding
Interventions
Evicel Fibrin Spray
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Oak Park, Illinois
Conditions
PONV
Interventions
Aprepitant Injection, Ondansetron (Zofran), Dexamethasone, Placebo
Drug · Other
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 90 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Skokie, Illinois