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ClinicalTrials.gov public records Last synced Oct 27, 2026, 2:09 AM EDT

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Showing 1–24 of 1,309 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Arthroplasty Clear all
Recruiting Phase 4 Interventional

Evaluation of Pain Treatment After Total Knee Arthroplasty

NCT07538570
View directory record Official record
Conditions
Pain
Interventions
Suzetrigine, Placebo
Drug
Lead sponsor
Vertex Pharmaceuticals Incorporated
Industry
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Bellaire, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 27, 2026, 2:09 AM EDT
Not listed Not applicable Interventional

Trial to Reduce Antimicrobial Prophylaxis Errors (TRAPE)

NCT00114036
View directory record Official record
Conditions
Cardiovascular Surgical Procedures, Arthroplasty, Replacement, Hysterectomy
Interventions
Quality improvement strategies
Behavioral
Lead sponsor
Agency for Healthcare Research and Quality (AHRQ)
Federal
Eligibility
Not listed
Timeline
2002 – 2005
U.S. locations
3
States / cities
Oakbrook Terrace, Illinois • Winston-Salem, North Carolina • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 27, 2026, 2:09 AM EDT
Completed Phase 2 Interventional Results available

Study of CA-008 (Vocacapsaicin) in Total Knee Arthroplasty

NCT03731364
View directory record Official record
Conditions
Postsurgical Pain
Interventions
CA-008, Placebo
Drug
Lead sponsor
Concentric Analgesics
Industry
Eligibility
18 Years to 80 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Oct 27, 2026, 2:09 AM EDT
Active, not recruiting Not applicable Interventional

Rotator Cuff Sparing Total Arthroplasty

NCT01961986
View directory record Official record
Conditions
Osteoarthritis, Inflammatory Arthritis
Interventions
TSR - traditional subscapularis release, TSR - rotator cuff sparing
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Oct 27, 2026, 2:09 AM EDT
Completed No phase listed Observational

Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement

NCT02096198
View directory record Official record
Conditions
Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
Interventions
Not listed
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
20 Years to 75 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
5
States / cities
Sacramento, California • Denver, Colorado • Winston-Salem, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2019 · Synced Oct 27, 2026, 2:09 AM EDT
Not listed Phase 4 Interventional

Use of Cold and Compression Therapy With Total Knee Replacement Patients

NCT00712816
View directory record Official record
Conditions
Osteoarthritis, Total Knee Arthroplasty
Interventions
Game Ready Injury Treatment System (CoolSystems Inc.), Ice with compressive bandages
Device · Other
Lead sponsor
CoolSystems, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
10
States / cities
San Diego, California • Honolulu, Hawaii • Winfield, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2012 · Synced Oct 27, 2026, 2:09 AM EDT
Completed No phase listed Observational Results available

Interscalene Dynamometer Pilot Study

NCT01550952
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 31, 2016 · Synced Oct 27, 2026, 2:09 AM EDT
Active, not recruiting No phase listed Observational

LEGION Hinge Safety and Efficacy Study

NCT02445443
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
LEGION Hinge Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2028
U.S. locations
3
States / cities
Iowa City, Iowa • New York, New York • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 27, 2024 · Synced Oct 27, 2026, 2:09 AM EDT
Not listed No phase listed Observational

Predicting Chronic Opioid Use Following Lower Extremity Joint Arthroplasty

NCT04974463
View directory record Official record
Conditions
Joint Pain, Chronic Pain, Opioid Use
Interventions
Not listed
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Oct 27, 2026, 2:09 AM EDT
Completed Not applicable Interventional Results available

A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events

NCT00736125
View directory record Official record
Conditions
Postoperative Complications, Memory Disorders
Interventions
pulsatile saline lavage, carbon dioxide lavage
Device
Lead sponsor
Kinamed Incorporated
Industry
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Oct 27, 2026, 2:09 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Observational Examination of Thermoregulation in Total Joint Arthroplasty

NCT02225743
View directory record Official record
Conditions
Hypothermia
Interventions
Observation Of Temperature
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 24, 2019 · Synced Oct 27, 2026, 2:09 AM EDT
Recruiting Phase 3 Interventional

Efficacy of EXPAREL vs. Bupivacaine

NCT07212114
View directory record Official record
Conditions
Total Ankle Arthroplasty, Postsurgical Analgesia
Interventions
EXPAREL, 0.25% bupivacaine (HCl): 50 ml, 0.25% bupivacaine (HCl): 30 ml
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Oct 27, 2026, 2:09 AM EDT
Withdrawn Phase 4 Interventional

The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty

NCT06489626
View directory record Official record
Conditions
Arthritis Knee, Knee Osteoarthritis, Pain, Postoperative
Interventions
Methylprednisolone 4 milligram Tab, Dexamethasone injection
Drug
Lead sponsor
F. Johannes Plate
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Monroeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 27, 2026, 2:09 AM EDT
Completed Not applicable Interventional

Intraoperative VR for Older Patients Undergoing TKA

NCT04748549
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Virtual Reality Immersive Relaxation, Immersive Audio Experience, Sham Virtual Reality Experience
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 27, 2026, 2:09 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Study Comparing Topical Versus Intravenous Tranexamic Acid in Anterior Total Hip Arthroplasty

NCT03359525
View directory record Official record
Conditions
Tranexamic Acid Adverse Reaction
Interventions
Tranexamic Acid
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 80 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Dec 2, 2017 · Synced Oct 27, 2026, 2:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

RCT Foley Catheter Study for Elective TJA

NCT05428020
View directory record Official record
Conditions
Postoperative Urinary Retention, Total Hip Arthroplasty, Total Knee Arthroplasty
Interventions
Indwelling foley catheter, No foley catheter
Device · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
388 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 3, 2023 · Synced Oct 27, 2026, 2:09 AM EDT
Completed No phase listed Observational

THA With and Without Computer Navigation

NCT05871827
View directory record Official record
Conditions
Hip Osteoarthritis, Avascular Necrosis of Hip
Interventions
Intraoperative Fluoroscopic Computer Navigation
Procedure
Lead sponsor
Southeast Orthopedic Specialists
Network
Eligibility
18 Years to 95 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 23, 2023 · Synced Oct 27, 2026, 2:09 AM EDT
Completed Phase 2 Interventional

Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty

NCT06716749
View directory record Official record
Conditions
Primary Total Knee Arthroplasty, Intraosseous Morphine Injection, Knee Osteoarthritis
Interventions
Morphine, Vancomycin
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 27, 2026, 2:09 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Analysis of a Tapered Porous Coated Stem and a Cementless Hemispherical Acetabular Component

NCT03168750
View directory record Official record
Conditions
Osteoarthritis, Hip
Interventions
Femoral Component:Medacta Masterloc Stem and Medacta MPACT cup.
Device
Lead sponsor
Medacta USA
Industry
Eligibility
Up to 75 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
3
States / cities
Oro Valley, Arizona • West Jordan, Utah • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Oct 27, 2026, 2:09 AM EDT
Completed Not applicable Interventional

RCT Determining Best Treatment for Geriatric Acetabular Fractures

NCT03419182
View directory record Official record
Conditions
Acetabular Fracture
Interventions
Open Reduction internal Fixation, Open Reduction Internal Fixation with Total Hip Arthroscopy
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years to 100 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Oct 27, 2026, 2:09 AM EDT
Completed Not applicable Interventional Results available

Triathlon® Cruciate Retaining (CR) Total Knee System Outcomes Study

NCT00957723
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Triathlon® CR Total Knee System
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
21 Years to 80 Years
Enrollment
419 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2017
U.S. locations
11
States / cities
Phoenix, Arizona • Miami, Florida • Columbus, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2018 · Synced Oct 27, 2026, 2:09 AM EDT
Completed No phase listed Observational

Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study

NCT01307384
View directory record Official record
Conditions
Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions
Continuum Metal on Polyethylene Acetabular System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 75 Years
Enrollment
195 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2026
U.S. locations
2
States / cities
Fremont, California • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 27, 2026, 2:09 AM EDT
Not yet recruiting No phase listed Observational

Three Year Outcomes After Shoulder Arthroplasty

NCT07815535
View directory record Official record
Conditions
Arthroplasty, Replacement, Shoulder, Arthritis Shoulder, Rotator Cuff Arthropathy
Interventions
Not listed
Lead sponsor
Vani Sabesan
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
5
States / cities
Atlantis, Florida • North Liberty, Iowa • Leawood, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 27, 2026, 2:09 AM EDT