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ClinicalTrials.gov public records Last synced Oct 15, 2026, 2:57 PM EDT

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Showing 409–432 of 843 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Arthroplasty, Knee Replacement Clear all
Terminated Not applicable Interventional Results available

Oxford Signature vs. Conventional Global Study

NCT01763684
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis, Knee, Osteonecrosis
Interventions
Signature Custom Guides, Conventional Instrumentation
Device · Procedure
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years and older
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
7
States / cities
Elkhart, Indiana • Rockville, Maryland • Columbia, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2021 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty

NCT02980926
View directory record Official record
Conditions
Anesthesia, Spinal, Arthroplasty, Replacement, Knee, Pain Management, Early Ambulation, Ambulatory Surgical Procedures
Interventions
Mepivacaine, Bupivacaine
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
40 Years to 90 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
West Bloomfield, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 27, 2017 · Synced Oct 15, 2026, 2:57 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Oxford Partial Knee Kinematics Gait Analysis Study

NCT01454908
View directory record Official record
Conditions
Medial Knee Compartment Arthritis
Interventions
Oxford Partial Knee
Device
Lead sponsor
The CORE Institute
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Sun City West, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 19, 2011 · Synced Oct 15, 2026, 2:57 PM EDT
Suspended Phase 4 Interventional Accepts healthy volunteers

Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement

NCT02926248
View directory record Official record
Conditions
Manipulation Under Anesthesia
Interventions
Colchicine, Placebo
Drug · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Phase 2 Interventional

Perioperative Intervention to Improve Post-TKR Support and Function

NCT00566826
View directory record Official record
Conditions
Osteoarthritis, Arthroplasty, Replacement, Knee
Interventions
Patient support sessions, Treatment as usual
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
21 Years and older
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Oct 15, 2026, 2:57 PM EDT
Recruiting Not applicable Interventional

ARVIS TKA vs Conventional TKA

NCT06663384
View directory record Official record
Conditions
Osteoarthritis
Interventions
Evaluation of Augmented Reality technology in TKA compared to standard TKA
Other
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 15, 2026, 2:57 PM EDT
Not yet recruiting Phase 4 Interventional

Doxepin Alone or Combined With Ramelteon Versus Placebo for Improving Sleep Quality After Primary Total Knee Arthroplasty

NCT07598734
View directory record Official record
Conditions
Sleep Quality Post-TKA, Postoperative Knee Function, Quality of Life After Primary TKA
Interventions
Doxepin 6 mg, Ramelteon 8 mg, Placebo Tablets
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 80 Years
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 15, 2026, 2:57 PM EDT
Recruiting Not applicable Interventional

Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes

NCT06298721
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthropathy, Surgery
Interventions
Personalized outcome prediction tool + targeted interventions, Standard of Care TKA
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 15, 2026, 2:57 PM EDT
Recruiting Not applicable Interventional

Developing an Opioid Taper Intervention Before Total Joint Arthroplasty

NCT05788016
View directory record Official record
Conditions
Arthritis Knee, Arthritis Hip, Chronic Pain
Interventions
opioid taper
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Not applicable Interventional Results available

A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery

NCT05252858
View directory record Official record
Conditions
Opioid Use, Pain, Post Operative
Interventions
nCAP Signal Relief Patch, Standard of Care
Device · Other
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Oct 15, 2026, 2:57 PM EDT
Recruiting Not applicable Interventional

Observation of Wheeled Device Use After TKA

NCT06080152
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Mobility Tool
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 99 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 15, 2026, 2:57 PM EDT
Terminated Not applicable Interventional

Medial Peel Release Technique TKA Randomized Clinical Trial

NCT05154058
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis, Knee
Interventions
Medial Subperiosteal Release with Sharp Dissection, Medial Subperiosteal Release with Electrocautery
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Phase 4 Interventional Results available

Adductor Canal Block Versus Periarticular Bupivicaine Injection in Total Knee Arthroplasty

NCT02777749
View directory record Official record
Conditions
Osteoarthritis
Interventions
Bupivacaine
Drug
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement

NCT00729690
View directory record Official record
Conditions
PAIN
Interventions
Pregabalin, Placebo
Drug
Lead sponsor
Asokumar Buvanendran
Other
Eligibility
55 Years to 75 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 19, 2012 · Synced Oct 15, 2026, 2:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Anesthetic Techniques in Outpatient Total Joint Replacement Surgery in an Integrated Health Care Delivery System

NCT04203732
View directory record Official record
Conditions
Anesthesia Morbidity, Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Anesthesia Type
Procedure
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
12,466 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
South San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2021 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty

NCT00620828
View directory record Official record
Conditions
Osteoarthritis
Interventions
Placebo saline injection, Ropivicaine 0.5%
Other · Drug
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Not applicable Interventional

Hypnosis for Symptom Management in Elective Orthopedic Surgery

NCT03308071
View directory record Official record
Conditions
Hypnosis, Perioperative Care, Knee Arthroplasty, Total, Postoperative Pain, Postoperative Complications
Interventions
Hypnosis
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 25, 2021 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Phase 4 Interventional Results available

Femoral Versus Adductor Canal Continuous Peripheral Nerve Blocks for Knee Arthroplasty

NCT01759277
View directory record Official record
Conditions
Postoperative Pain Following Knee Arthroplasty
Interventions
Control: Femoral perineural local anesthetic infusion, Experimental: Adductor Canal perineural local anesthetic infusion
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2021 · Synced Oct 15, 2026, 2:57 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Gait Analysis of a Lateral-Pivot Design Total Knee Replacement

NCT04275362
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
DJO Empowr PS Knee System, Stryker Triathlon Total Knee System, Biomet Vanguard Complete Knee System, Control
Device
Lead sponsor
More Foundation
Other
Eligibility
50 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2029
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 6, 2022 · Synced Oct 15, 2026, 2:57 PM EDT
Terminated Early Phase 1 Interventional

Multimodal Pain Management Following Primary TKA

NCT02369523
View directory record Official record
Conditions
Pain
Interventions
Exparel, Ropivacaine cocktail (PIC), Bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Phase 4 Interventional Results available

Genicular Nerve Block for Total Knee Arthroplasty

NCT03706313
View directory record Official record
Conditions
Post-operative Pain
Interventions
15mL 0.25% bupivacaine, Genicular nerve block, Saline
Drug · Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Not applicable Interventional Results available

Pilot Study of PEMF Therapy in Treatment of Post-operative Pain Following Total Knee Arthroplasty

NCT02211534
View directory record Official record
Conditions
Post-Operative Pain Following Total Knee Arthroplasty
Interventions
Pulsed Electromagnetic Field Device (Provant), Sham Pulsed Electromagnetic Field Device
Device
Lead sponsor
Regenesis Biomedical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
14
States / cities
Birmingham, Alabama • Phoenix, Arizona • El Cajon, California + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2017 · Synced Oct 15, 2026, 2:57 PM EDT
Recruiting No phase listed Observational

Prospective, In-Vivo, Post-Market Safety and Efficacy Surveillance Registry of the MAXX Orthopedics, Freedom Total Knee® System

NCT06627699
View directory record Official record
Conditions
Knee Osteoarthristis, Total Knee Anthroplasty
Interventions
Total Knee Arthroplasty
Device
Lead sponsor
Maxx Orthopedics Inc
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
2
States / cities
Leawood, Kansas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Oct 15, 2026, 2:57 PM EDT
Completed Not applicable Interventional Results available

Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty

NCT01333943
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Study Group: Experimental, Control Group
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 90 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 15, 2026, 2:57 PM EDT