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ClinicalTrials.gov public records Last synced Oct 3, 2026, 4:49 AM EDT

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Showing 217–240 of 476 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Arthroplasty, Replacement Clear all
Terminated No phase listed Observational

28mm Ceramic-on-Ceramic Total Hip Replacement Study

NCT01657435
View directory record Official record
Conditions
Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-traumatic Arthritis
Interventions
Ceramax Acetabular System
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
Not listed
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
12
States / cities
Sacramento, California • Denver, Colorado • Fort Collins, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Nov 19, 2019 · Synced Oct 3, 2026, 4:49 AM EDT
Terminated Phase 4 Interventional Results available

Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement

NCT00895531
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Depodur, sciatic nerve block
Drug · Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 70 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 27, 2017 · Synced Oct 3, 2026, 4:49 AM EDT
Completed Not applicable Interventional

Static Progressive Splinting in the Management of Knee Stiffness Following Total Knee Arthroplasty

NCT04837872
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Multimodal Physical Therapy (MPT)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Golden, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 13, 2021 · Synced Oct 3, 2026, 4:49 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Journavx to Treat Pain After Thumb Basal Joint Arthroplasty

NCT07723352
View directory record Official record
Conditions
Thumb Basal Joint Osteoarthritis, Postoperative Pain, Joint Replacement Surgery, Joint Replacement
Interventions
suzetrigine 100mg, Acetaminophen
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
40 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 3, 2026, 4:49 AM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty (TKA) Using the SPRINT System

NCT02468934
View directory record Official record
Conditions
Total Knee Replacement, Total Knee Arthroplasty, Pain, Postoperative Pain, Orthopedic Disorders
Interventions
SPRINT Peripheral Nerve Stimulation (PNS) System
Device
Lead sponsor
SPR Therapeutics, Inc.
Industry
Eligibility
21 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
3
States / cities
La Jolla, California • Durham, North Carolina • New Albany, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 4, 2018 · Synced Oct 3, 2026, 4:49 AM EDT
Withdrawn Phase 4 Interventional

Preoperative Antibiotic Dosing for Total Knee Arthroplasty

NCT02433704
View directory record Official record
Conditions
Acute Infection of Total Knee Replacement
Interventions
New Intraosseous, Cefazolin
Device · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 28, 2017 · Synced Oct 3, 2026, 4:49 AM EDT
Completed Not applicable Interventional

Automated Hovering for Joint Replacement Surgery

NCT03435549
View directory record Official record
Conditions
Joint Disease
Interventions
Remote monitoring, Remote monitoring plus goal setting and social support
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 85 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Oct 3, 2026, 4:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Zip® Surgical Skin Closure Device vs. Staples for Skin Closure in Subjects Having Undergone Bilateral Knee Arthroplasty

NCT02460172
View directory record Official record
Conditions
Arthroplasty, Knee Replacement, Wound Healing
Interventions
Zip Surgical Skin Closure, Steel Staples
Device
Lead sponsor
ZipLine Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 5, 2019 · Synced Oct 3, 2026, 4:49 AM EDT
Terminated Not applicable Interventional

Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study

NCT02711592
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Pain, Postoperative
Interventions
Genetic Panel for Analgesics
Genetic
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 25, 2021 · Synced Oct 3, 2026, 4:49 AM EDT
Completed Phase 4 Interventional Results available

Lumbar Plexus vs Quadratus Lumborum Block in Post-operative Pain Following Total Hip Replacement

NCT03801265
View directory record Official record
Conditions
Hip Osteoarthritis
Interventions
Lumbar plexus block, Quadratus lumborum type 3 block, Ropivacaine injection
Procedure · Drug
Lead sponsor
Sharad Khetarpal
Other
Eligibility
18 Years to 90 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 15, 2021 · Synced Oct 3, 2026, 4:49 AM EDT
Active, not recruiting Not applicable Interventional

ATTUNE Revision System in the Revision Total Knee Arthroplasty Population

NCT03153475
View directory record Official record
Conditions
Revision Total Knee Arthroplasty
Interventions
ATTUNE Revision Knee System in Revision Total Knee Arthroplasty
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2029
U.S. locations
16
States / cities
San Diego, California • Denver, Colorado • Fort Collins, Colorado + 13 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 3, 2026, 4:49 AM EDT
Withdrawn Not applicable Interventional

Vitamin D Status in Lower Extremity Joint Replacement Surgery Patients

NCT01858051
View directory record Official record
Conditions
Hypovitaminosis D
Interventions
Cholecalciferol, Placebo
Dietary Supplement
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Oct 3, 2026, 4:49 AM EDT
Not yet recruiting Not applicable Interventional

NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty

NCT07439666
View directory record Official record
Conditions
Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
Interventions
NEUROCUPLE™ Patch, Sham patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
Device · Other
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 3, 2026, 4:49 AM EDT
Terminated Not applicable Interventional

Health Partner Evaluation at Princeton

NCT03386786
View directory record Official record
Conditions
Total Knee Arthroplasty; Total Hip Arthroplasty
Interventions
Health Partner, Standard Care
Behavioral
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Plainsboro, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 2, 2020 · Synced Oct 3, 2026, 4:49 AM EDT
Recruiting Phase 3 Interventional

Opioid-Sparing Joint Replacement

NCT07348627
View directory record Official record
Conditions
Pain Management, Opioid Consumption
Interventions
Placebo, Oxycodone 5 mg, Multimodal Non-Opioid Analgesia
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 3, 2026, 4:49 AM EDT
Completed Phase 2 Interventional Results available

A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement

NCT01369511
View directory record Official record
Conditions
Muscular Atrophy
Interventions
LY2495655, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
50 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
16
States / cities
Tucson, Arizona • Laguna Hills, California • Lakewood, Colorado + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Oct 3, 2026, 4:49 AM EDT
Completed No phase listed Observational Results available

Mechanics Analysis of Patients Having a Sigma Mobile Bearing TKA

NCT01714492
View directory record Official record
Conditions
Knee Prosthesis, Knee Replacement Arthroplasty
Interventions
Sigma Posterior Stabilizing Rotating Platform TKA Beaded Poly
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
40 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
3
States / cities
Denver, Colorado • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 10, 2019 · Synced Oct 3, 2026, 4:49 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Postoperative Function Following Partial and Total Knee Replacement

NCT00492219
View directory record Official record
Conditions
Osteoarthritis, Post-traumatic Arthritis
Interventions
Vanguard M fixed-bearing or Oxford mobile-bearing prostheses, Total Knee Replacement
Device
Lead sponsor
New Lexington Clinic
Other
Eligibility
18 Years and older
Enrollment
324 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 19, 2012 · Synced Oct 3, 2026, 4:49 AM EDT
Completed No phase listed Observational Results available

A Clinical Investigation of the Discovery™ Elbow System

NCT00698867
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Avascular Necrosis, Humeral Fractures
Interventions
Not listed
Lead sponsor
Biomet Orthopedics, LLC
Industry
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2016
U.S. locations
4
States / cities
Tampa, Florida • Indianapolis, Indiana • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2017 · Synced Oct 3, 2026, 4:49 AM EDT
Completed Not applicable Interventional

The Effect of Nasal Continuous Positive Airway Pressure (N-CPAP) on Arterial pCO2 During Spinal Anesthesia

NCT01622647
View directory record Official record
Conditions
Knee Replacement Surgery
Interventions
Nasal Continuous Positive Airway Pressure (NCPAP)
Other
Lead sponsor
Pediatrix
Other
Eligibility
21 Years to 69 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Wilmington, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 6, 2013 · Synced Oct 3, 2026, 4:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Intercostobrachial Nerve Block's Effect on Pain Control After Shoulder Replacement

NCT06042608
View directory record Official record
Conditions
Postoperative Pain, Acute, Shoulder Pain
Interventions
intercostobrachial nerve block
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 3, 2026, 4:49 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Longjohn Amgen Study - Effect of Denosumab...

NCT02444585
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip
Interventions
Denosumab
Drug
Lead sponsor
University of Southern California
Other
Eligibility
55 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 10, 2020 · Synced Oct 3, 2026, 4:49 AM EDT
Completed Not applicable Interventional

The Effect of Music Therapy Intervention on Pain and Anxiety in Adult Patients Undergoing Total Shoulder Arthroplasty

NCT02692768
View directory record Official record
Conditions
Arthritis
Interventions
Live Music Therapy, Recorded Music Therapy, Control
Other
Lead sponsor
April Armstrong
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 20, 2024 · Synced Oct 3, 2026, 4:49 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

American Joint Replacement Registry

NCT01909375
View directory record Official record
Conditions
ARTHROPLASTY, REPLACEMENT
Interventions
Not listed
Lead sponsor
American Joint Replacement Registry
Other
Eligibility
Not listed
Enrollment
500,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2029
U.S. locations
1
States / cities
Rosemont, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 3, 2025 · Synced Oct 3, 2026, 4:49 AM EDT