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ClinicalTrials.gov public records Last synced Oct 3, 2026, 4:01 AM EDT

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Showing 193–216 of 476 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Arthroplasty, Replacement Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Reduced Frequency Physical Therapy in Total Knee Arthroplasty

NCT03302832
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Arthropathy
Interventions
Physical Therapy, In-home Exercise Equipment
Other
Lead sponsor
Campbell University, Incorporated
Other
Eligibility
Up to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Oct 3, 2026, 4:01 AM EDT
Terminated Not applicable Interventional

Treadmill Perturbation Training for Fall Prevention After Total Knee Replacement

NCT05736666
View directory record Official record
Conditions
Knee Osteoarthritis, Arthroplasty Complications
Interventions
Treadmill-based perturbation training, Education Control
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 3, 2026, 4:01 AM EDT
Completed Not applicable Interventional Results available

Adductor Canal Block for Total Knee Arthroplasty

NCT02453360
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Pain, Postoperative
Interventions
Adductor Canal Block, Adductor Canal Block
Procedure · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 8, 2019 · Synced Oct 3, 2026, 4:01 AM EDT
Completed Not applicable Interventional Results available

Rejuvenate Modular Outcomes Study

NCT01257568
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip
Interventions
Rejuvenate Modular Hip
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2022
U.S. locations
3
States / cities
Dearborn, Michigan • Sartell, Minnesota • Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 16, 2022 · Synced Oct 3, 2026, 4:01 AM EDT
Completed No phase listed Observational

A Retrospective Study to Evaluate the ConforMIS iUni, iDuo & iTotal® KRS

NCT03152357
View directory record Official record
Conditions
Osteoarthritis, Knee, Knee Osteoarthritis
Interventions
ConforMIS iUni, iDuo, or iTotal (CR)
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
950 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boynton Beach, Florida
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 3, 2026, 4:01 AM EDT
Not listed No phase listed Observational

Clinical, Radiographic and Laboratory Analysis of Failures of Joint Replacements

NCT01567696
View directory record Official record
Conditions
Joint
Interventions
Not listed
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 30, 2012 · Synced Oct 3, 2026, 4:01 AM EDT
Completed Phase 3 Interventional Results available

Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement

NCT01094886
View directory record Official record
Conditions
Arthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Thromboembolism
Interventions
Rivaroxaban
Drug
Lead sponsor
Ortho-McNeil Janssen Scientific Affairs, LLC
Industry
Eligibility
18 Years to 99 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
5
States / cities
Denver, Colorado • Hollywood, Florida • Tamarac, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2017 · Synced Oct 3, 2026, 4:01 AM EDT
Completed Not applicable Interventional

Local Anesthetic Infiltration and Infusion for Pain Control After Hip Replacement

NCT01409278
View directory record Official record
Conditions
Osteoarthritis
Interventions
Ropivacaine infiltration and saline infusion., Ropivacaine infiltration and infusion., Normal Saline
Procedure
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 80 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 4, 2011 · Synced Oct 3, 2026, 4:01 AM EDT
Not yet recruiting Not applicable Interventional

Knee Positioning After Total Knee Replacement

NCT07747116
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Knee Flexion, Standard Care
Other · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 3, 2026, 4:01 AM EDT
Not listed Phase 3 Interventional

Femoral Nerve Block Compared to Exparel in Total Knee Replacement

NCT02473198
View directory record Official record
Conditions
Osteoarthritis, Pain
Interventions
Exparel, Femoral Nerve Block Bupivacaine, Toradol, Morphine Sulfate
Drug
Lead sponsor
The New England Baptist Hospital
Other
Eligibility
18 Years to 73 Years
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2016 · Synced Oct 3, 2026, 4:01 AM EDT
Not listed Not applicable Interventional

Diagnostic Knee Needle Arthroscopy in Predicting Unicompartmental Knee Osteoarthritis

NCT05002387
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
NanoScope™ Operative Arthroscopy (Arthrex, Inc)
Device
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 89 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2023 · Synced Oct 3, 2026, 4:01 AM EDT
Completed Not applicable Interventional Results available

Improving Physical Activity and Gait Symmetry After Total Knee Arthroplasty

NCT04090125
View directory record Official record
Conditions
Knee Replacement, Total, Knee Arthroplasty, Total
Interventions
PAS Intervention, Attention Control
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Oct 3, 2026, 4:01 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Minimally Invasive Total Knee Replacement in Improving Rehabilitation and Function

NCT00710840
View directory record Official record
Conditions
Osteoarthritis
Interventions
Minimally Invasive Total Knee Arthroplasty [TKA Min], Total Knee Arthroplasty (TKA) Traditional
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Boulder, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Oct 3, 2026, 4:01 AM EDT
Not listed Phase 4 Interventional

Use of Cold and Compression Therapy With Total Knee Replacement Patients

NCT00712816
View directory record Official record
Conditions
Osteoarthritis, Total Knee Arthroplasty
Interventions
Game Ready Injury Treatment System (CoolSystems Inc.), Ice with compressive bandages
Device · Other
Lead sponsor
CoolSystems, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
10
States / cities
San Diego, California • Honolulu, Hawaii • Winfield, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2012 · Synced Oct 3, 2026, 4:01 AM EDT
Completed Not applicable Interventional

Opioid Reduction Program for Total Knee Replacement Patients

NCT05414942
View directory record Official record
Conditions
Knee Injuries, Knee Injuries and Disorders, Opioid Use
Interventions
Opioid Reduction Program
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Oct 3, 2026, 4:01 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Navio Robotic Versus Conventional Total Knee Arthroplasty

NCT03519269
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Navio™ Robotics-assisted Surgical System
Device
Lead sponsor
Columbia University
Other
Eligibility
40 Years to 85 Years
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 3, 2026, 4:01 AM EDT
Active, not recruiting Not applicable Interventional

Zimmer Trabecular Metal Total Ankle PMCF

NCT02038140
View directory record Official record
Conditions
Degenerative Arthritis, Rheumatoid Arthritis, Post Traumatic Arthritis
Interventions
Zimmer Trabecular Metal Total Ankle System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2027
U.S. locations
5
States / cities
Sacramento, California • Grand Rapids, Michigan • Charlotte, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 3, 2026, 4:01 AM EDT
Completed No phase listed Observational

Effect of Preop Nutritional Status on Outcomes of Staged Bilateral Total Knee Arthroplasty

NCT01545362
View directory record Official record
Conditions
Arthritis
Interventions
Total knee arthroplasty
Procedure
Lead sponsor
Heekin Orthopedic Research Institute
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 3, 2026, 4:01 AM EDT
Completed Not applicable Interventional Results available

Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?

NCT00492973
View directory record Official record
Conditions
Osteoarthritis, Post-traumatic; Arthrosis
Interventions
methylprednisolone acetate, active comparator
Drug
Lead sponsor
New Lexington Clinic
Other
Eligibility
18 Years to 95 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 19, 2013 · Synced Oct 3, 2026, 4:01 AM EDT
Terminated Not applicable Interventional

DexCom Hospital Study-CGM Directed Insulin Delivery

NCT05504785
View directory record Official record
Conditions
Type 2 Diabetes, Hip Osteoarthritis, Knee Osteoarthritis
Interventions
DexCom G6 continuous glucose monitor
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
30 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Oct 3, 2026, 4:01 AM EDT
Not listed Not applicable Interventional

Use of the LRU Pillow in the Acute Setting Following Total Knee Arthroplasty

NCT01814033
View directory record Official record
Conditions
Osteoarthritis
Interventions
Experimental: LRU Pillow, Control Group
Other
Lead sponsor
Newton-Wellesley Hospital
Other
Eligibility
30 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Newton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 9, 2015 · Synced Oct 3, 2026, 4:01 AM EDT
Not listed No phase listed Observational

MARS MRI in Revision THA With a Ceramic Femoral Head and Titanium Sleeve

NCT05686915
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip
Interventions
MARS MRI, Titanium Labs, Cobalt Labs, Chromium Labs
Diagnostic Test
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
18 Years to 99 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 17, 2023 · Synced Oct 3, 2026, 4:01 AM EDT
Completed Not applicable Interventional Results available

Functional Movement Retraining After Hip Replacement

NCT01878175
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip
Interventions
Functional Movement Retraining
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
19 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Oct 3, 2026, 4:01 AM EDT
Recruiting No phase listed Observational

Prospective, In-Vivo, Post-Market Safety and Efficacy Surveillance Registry of the MAXX Orthopedics, Freedom Total Knee® System

NCT06627699
View directory record Official record
Conditions
Knee Osteoarthristis, Total Knee Anthroplasty
Interventions
Total Knee Arthroplasty
Device
Lead sponsor
Maxx Orthopedics Inc
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
2
States / cities
Leawood, Kansas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Oct 3, 2026, 4:01 AM EDT